| Record Information |
|---|
| Version |
3.5 |
| Creation Date |
2006-08-16 07:00:23 -0600 |
| Update Date |
2013-02-15 15:18:57 -0700 |
| HMDB ID |
HMDB01303 |
| Secondary Accession Numbers |
None |
| Metabolite Identification |
|---|
| Common Name |
Zinc (II) ion |
| Description |
Zinc is an essential element, necessary for sustaining all life.Physiologically, it exists as an ion in the body. It is estimated that 3000 of the hundreds of thousands of proteins in the human body contain zinc prosthetic groups. In addition, there are over a dozen types of cells in the human body that secrete zinc ions, and the roles of these secreted zinc signals in medicine and health are now being actively studied. Intriguingly, brain cells in the mammalian forebrain are one type of cell that secretes zinc, along with its other neuronal messenger substances. Cells in the salivary gland, prostate, immune system and intestine are other types that secrete zinc. Obtaining a sufficient zinc intake during pregnancy and in young children is a problem, especially among those who cannot afford a good and varied diet. Brain development is stunted by zinc deficiency in utero and in youth. Zinc is an activator of certain enzymes, such as carbonic anhydrase. Carbonic anhydrase is important in the transport of carbon dioxide in vertebrate blood. Even though zinc is an essential requirement for a healthy body, too much zinc can be harmful. Excessive absorption of zinc can also suppress copper and iron absorption. The free zinc ion in solution is highly toxic to plants, invertebrates, and even vertebrate fish. The Free Ion Activity Model (FIAM) is well-established in the literature, and shows that just micromolar amounts of the free ion kills some organisms. |
| Structure |
Download:
MOL |
SDF |
SMILES |
InChI
Display:
2D Structure |
3D Structure
|
| Synonyms |
- Zinc
- Zinc ion
|
| Chemical Formula |
Zn |
| Average Molecular Weight |
65.409 |
| Monoisotopic Molecular Weight |
63.929146578 |
| IUPAC Name |
zinc(2+) ion |
| Traditional IUPAC Name |
zinc, ion (zn2+) |
| CAS Registry Number |
7440-66-6 |
| SMILES |
[Zn++] |
| InChI Identifier |
InChI=1S/Zn/q+2 |
| InChI Key |
PTFCDOFLOPIGGS-UHFFFAOYSA-N |
| Chemical Taxonomy |
|---|
| Kingdom |
Inorganic Compounds |
| Super Class |
Homogeneous Metal Compounds |
| Class |
Homogeneous Transition Metal Compounds |
| Sub Class |
N/A |
| Other Descriptors |
- a cation(Cyc)
- divalent metal cation(ChEBI)
- monoatomic dication(ChEBI)
- zinc cation(ChEBI)
|
| Substituents |
|
| Direct Parent |
Homogeneous Transition Metal Compounds |
| Ontology |
|---|
| Status |
Detected and Quantified |
| Origin |
|
| Biofunction |
- Anti-oxidant
- Essential minerals
|
| Application |
Not Available |
| Cellular locations |
- Cytoplasm (predicted from logP)
|
| Physical Properties |
|---|
| State |
Solid |
| Experimental Properties |
| Property |
Value |
Reference |
| Melting Point |
419.5 °C |
Not Available |
| Boiling Point |
Not Available |
Not Available |
| Water Solubility |
Not Available |
Not Available |
| LogP |
Not Available |
Not Available |
|
| Predicted Properties |
|
| Spectra |
|---|
|
Not Available
|
| Biological Properties |
|---|
| Cellular Locations |
- Cytoplasm (predicted from logP)
|
| Biofluid Locations |
- Blood
- Cerebrospinal Fluid (CSF)
- Urine
|
| Tissue Location |
|
| Pathways |
Not Available
|
| Normal Concentrations |
|---|
|
| Blood |
Detected and Quantified |
|
12.7 +/- 2.1 uM |
Elderly (>65 years old) |
Both |
Normal |
Not Available |
| Blood |
Detected and Quantified |
|
0.08838(0.08087-0.09589) uM |
Not Available |
Both |
Normal |
Not Available |
| Blood |
Detected and Quantified |
|
0.10340(0.09964-0.10731) uM |
Adult (>18 years old) |
Both |
Normal |
Not Available |
| Blood |
Detected and Quantified |
|
13.5 +/- 2.2 uM |
Adult (>18 years old) |
Both |
Normal |
Not Available |
| Blood |
Detected and Quantified |
|
16.8 +/- 6.3 uM |
Adult (>18 years old) |
Both |
Normal |
Not Available |
| Blood |
Detected and Quantified |
|
13.6 +/- 2.0 uM |
Children (1-13 year old) |
Both |
Normal |
Not Available |
| Blood |
Detected and Quantified |
|
14.2 (11.1 - 17.6) uM |
Adult (>18 years old) |
Male |
Normal |
Not Available |
| Blood |
Detected and Quantified |
|
13.0 (10.0 - 17.0) uM |
Adult (>18 years old) |
Female |
Normal |
Not Available |
| Blood |
Detected and Quantified |
|
14.0 +/- 2.20 uM |
Newborn (0-30 days old) |
Both |
Normal |
Not Available |
| Blood |
Detected and Quantified |
|
16.7 +/- 3.1 uM |
Adult (>18 years old) |
Both |
Normal |
Not Available |
| Cerebrospinal Fluid (CSF) |
Detected and Quantified |
|
3.1 +/- 3.1 uM |
Elderly (>65 years old) |
Both |
Normal |
Not Available |
| Cerebrospinal Fluid (CSF) |
Detected and Quantified |
|
0.538 +/- 0.847 uM |
Adult (>18 years old) |
Not Specified |
Normal |
Not Available |
| Cerebrospinal Fluid (CSF) |
Detected and Quantified |
|
0.49 (0.37-0.60) uM |
Children (1-13 year old) |
Both |
Normal |
Not Available |
| Urine |
Detected and Quantified |
|
0.80291(0.67027-0.94439) umol/mmol creatinine |
Not Available |
Both |
Normal |
Not Available |
| Urine |
Detected and Quantified |
|
0.66850(0.48281-0.88426) umol/mmol creatinine |
Adult (>18 years old) |
Both |
Normal |
Not Available |
| Urine |
Detected and Quantified |
|
0.460 (0.058-0.948) umol/mmol creatinine |
Adult (>18 years old) |
Both |
Normal |
by ICP MS
|
| Urine |
Detected and Quantified |
|
0.52 +/- 0.25 umol/mmol creatinine |
Adult (>18 years old) |
Male |
Normal |
Not Available |
| Urine |
Detected and Quantified |
|
0.35 +/- 0.20 umol/mmol creatinine |
Adult (>18 years old) |
Both |
Normal |
Not Available |
|
| Abnormal Concentrations |
|---|
|
| Blood |
Detected and Quantified |
|
10.7 +/- 1.8 uM |
Elderly (>65 years old) |
Both |
Alzheimer's disease |
Not Available |
| Blood |
Detected and Quantified |
|
12.0 +/- 1.5 uM |
Adult (>18 years old) |
Both |
Chronic renal failure |
Not Available |
| Blood |
Detected and Quantified |
|
12.4 +/- 2.7 uM |
Adult (>18 years old) |
Both |
Continuous ambulatory peritoneal dialysis |
Not Available |
| Blood |
Detected and Quantified |
|
11.0 +/- 2.3 uM |
Adult (>18 years old) |
Both |
Hemodialysis |
Not Available |
| Blood |
Detected and Quantified |
|
11.22 +/- 1.96 uM |
Adult (>18 years old) |
Both |
Parkinson's disease |
Not Available |
| Blood |
Detected and Quantified |
|
93.8 +/- 23.3 uM |
Adult (>18 years old) |
Both |
Multiple sclerosis |
Not Available |
| Blood |
Detected and Quantified |
|
8.0 +/- 0.2 uM |
Adult (>18 years old) |
Both |
Kidney disease |
Chronic renal failure
|
| Blood |
Detected and Quantified |
|
14.9 +/- 5.0 uM |
Adult (>18 years old) |
Both |
Hypertension |
Not Available |
| Blood |
Detected and Quantified |
|
138.5 (77.00-200.00) uM |
Adult (>18 years old) |
Both |
Hyperzincaemia and Hypercalprotectinaemia |
Not Available |
| Cerebrospinal Fluid (CSF) |
Detected and Quantified |
|
1.6 +/- 1.6 uM |
Adult (>18 years old) |
Both |
Alzheimer's disease |
Not Available |
| Cerebrospinal Fluid (CSF) |
Detected and Quantified |
|
1.83 +/- 1.38 uM |
Elderly (>65 years old) |
Not Specified |
Alzheimer's disease |
Not Available |
|
| Associated Disorders and Diseases |
|---|
| Disease References |
| Alzheimer's disease |
|---|
- Molina JA, Jimenez-Jimenez FJ, Aguilar MV, Meseguer I, Mateos-Vega CJ, Gonzalez-Munoz MJ, de Bustos F, Porta J, Orti-Pareja M, Zurdo M, Barrios E, Martinez-Para MC: Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease. J Neural Transm. 1998;105(4-5):479-88.
Pubmed: 9720975
- Bocca B, Forte G, Petrucci F, Pino A, Marchione F, Bomboi G, Senofonte O, Giubilei F, Alimonti A: Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease. Ann Ist Super Sanita. 2005;41(2):197-203.
Pubmed: 16244393
|
| Kidney disease |
|---|
- Paniagua R, Claure R, Amato D, Flores E, Perez A, Exaire E: Effects of oral administration of zinc and diiodohydroxyquinolein on plasma zinc levels of uremic patients. Nephron. 1995;69(2):147-50.
Pubmed: 7723896
|
| Multiple sclerosis |
|---|
- Forte G, Visconti A, Santucci S, Ghazaryan A, Figa-Talamanca L, Cannoni S, Bocca B, Pino A, Violante N, Alimonti A, Salvetti M, Ristori G: Quantification of chemical elements in blood of patients affected by multiple sclerosis. Ann Ist Super Sanita. 2005;41(2):213-6.
Pubmed: 16244395
|
| Parkinson's disease |
|---|
- Forte G, Alimonti A, Pino A, Stanzione P, Brescianini S, Brusa L, Sancesario G, Violante N, Bocca B: Metals and oxidative stress in patients with Parkinson's disease. Ann Ist Super Sanita. 2005;41(2):189-95.
Pubmed: 16244392
|
| Chronic renal failure |
|---|
- McGregor DO, Dellow WJ, Lever M, George PM, Robson RA, Chambers ST: Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations. Kidney Int. 2001 Jun;59(6):2267-72.
Pubmed: 11380830
|
| Continuous ambulatory peritoneal dialysis |
|---|
- McGregor DO, Dellow WJ, Lever M, George PM, Robson RA, Chambers ST: Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations. Kidney Int. 2001 Jun;59(6):2267-72.
Pubmed: 11380830
|
| Hemodialysis |
|---|
- McGregor DO, Dellow WJ, Lever M, George PM, Robson RA, Chambers ST: Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations. Kidney Int. 2001 Jun;59(6):2267-72.
Pubmed: 11380830
|
| Hypertension |
|---|
- Wang S, Ma A, Song S, Quan Q, Zhao X, Zheng X: Fasting serum free fatty acid composition, waist/hip ratio and insulin activity in essential hypertensive patients. Hypertens Res. 2008 Apr;31(4):623-32.
Pubmed: 18633173
|
| Hyperzincaemia and hypercalprotectinaemia |
|---|
- http://www.metagene.de/program/d.prg?mp=HYPERZINCAEMIA%20AND%20HYPERCALPROTECTINAEMIA
|
|
| Associated OMIM IDs |
- 104300 (Alzheimer's disease)
- 145500 (Hypertension)
- 126200 (Multiple sclerosis)
- 168600 (Parkinson's disease)
- 194470 (Hyperzincaemia and hypercalprotectinaemia)
|
| External Links |
|---|
| DrugBank ID |
DB01593 |
| Phenol Explorer Compound ID |
Not Available |
| Phenol Explorer Metabolite ID |
Not Available |
| FoodDB ID |
FDB003729 |
| KNApSAcK ID |
Not Available |
| Chemspider ID |
29723 |
| KEGG Compound ID |
C00038 |
| BioCyc ID |
ZN%2b2 |
| BiGG ID |
Not Available |
| Wikipedia Link |
Zinc |
| NuGOwiki Link |
HMDB01303 |
| Metagene Link |
HMDB01303 |
| METLIN ID |
Not Available |
| PubChem Compound |
32051 |
| PDB ID |
ZN |
| ChEBI ID |
29105 |
| References |
|---|
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available
|
| General References |
- Rakicioglu N, Samur G, Topcu A, Topcu AA: The effect of Ramadan on maternal nutrition and composition of breast milk. Pediatr Int. 2006 Jun;48(3):278-83.
Pubmed: 16732795
- Cominetti C, Garrido AB Jr, Cozzolino SM: Zinc nutritional status of morbidly obese patients before and after Roux-en-Y gastric bypass: a preliminary report. Obes Surg. 2006 Apr;16(4):448-53.
Pubmed: 16608609
- Religa D, Strozyk D, Cherny RA, Volitakis I, Haroutunian V, Winblad B, Naslund J, Bush AI: Elevated cortical zinc in Alzheimer disease. Neurology. 2006 Jul 11;67(1):69-75.
Pubmed: 16832080
- Batista MN, Cuppari L, de Fatima Campos Pedrosa L, Almeida MG, de Almeida JB, de Medeiros AC, Canziani ME: Effect of end-stage renal disease and diabetes on zinc and copper status. Biol Trace Elem Res. 2006 Jul;112(1):1-12.
Pubmed: 16943612
- Scheplyagina LA: Impact of the mother's zinc deficiency on the woman's and newborn's health status. J Trace Elem Med Biol. 2005;19(1):29-35.
Pubmed: 16240669
- Mocchegiani E, Costarelli L, Giacconi R, Cipriano C, Muti E, Rink L, Malavolta M: Zinc homeostasis in aging: two elusive faces of the same "metal". Rejuvenation Res. 2006 Summer;9(2):351-4.
Pubmed: 16706668
- de Sena KC, Arrais RF, das Gracas Almeida M, de Araujo DM, dos Santos MM, de Lima VT, de Fatima Campos Pedrosa L: Effects of zinc supplementation in patients with type 1 diabetes. Biol Trace Elem Res. 2005 Summer;105(1-3):1-9.
Pubmed: 16034148
- Tsuruoka S, Wakaumi M, Ioka T, Yamamoto H, Ando H, Sugimoto K, Fujimura A: Angiotensin II receptor blocker-induces blunted taste sensitivity: comparison of candesartan and valsartan. Br J Clin Pharmacol. 2005 Aug;60(2):204-7.
Pubmed: 16042674
- Arnold LE, DiSilvestro RA: Zinc in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2005 Aug;15(4):619-27.
Pubmed: 16190793
- An WL, Pei JJ, Nishimura T, Winblad B, Cowburn RF: Zinc-induced anti-apoptotic effects in SH-SY5Y neuroblastoma cells via the extracellular signal-regulated kinase 1/2. Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):40-7. Epub 2005 Jan 8.
Pubmed: 15857667
- Shea-Budgell M, Dojka M, Nimmo M, Lee D, Xu Z: Marginal zinc deficiency increased the susceptibility to acute lipopolysaccharide-induced liver injury in rats. Exp Biol Med (Maywood). 2006 May;231(5):553-8.
Pubmed: 16636303
- Cutinha D, Vaja S, Treacher D, Swaminathan R: Erythrocyte zinc content in critically ill patients. Clin Chem Lab Med. 2005;43(9):930-3.
Pubmed: 16176172
- Santarelli L, Di Lorenzo L, Valentino M, Bracci M, Rapisarda V, Cassano F, Elia G, Martino MG, Neri G, Apostoli P, Soleo L: [Reduced thymulin production during occupational exposure to lead] G Ital Med Lav Ergon. 2005 Jan-Mar;27 Suppl 1:68-72.
Pubmed: 15915658
- Kaczmarek A, Robak-Cholubek D, Sowa I, Jakiel G: Comparison of the levels of copper, zinc and iron in cervical mucus and in blood serum of women of childbearing age. Ann Univ Mariae Curie Sklodowska [Med]. 2004;59(1):72-5.
Pubmed: 16145958
- Kouremenou-Dona E, Dona A, Papoutsis J, Spiliopoulou C: Copper and zinc concentrations in serum of healthy Greek adults. Sci Total Environ. 2006 Apr 15;359(1-3):76-81. Epub 2005 Jun 13.
Pubmed: 15955548
- Mankad M, Sathawara NG, Doshi H, Saiyed HN, Kumar S: Seminal plasma zinc concentration and alpha-glucosidase activity with respect to semen quality. Biol Trace Elem Res. 2006 May;110(2):97-106.
Pubmed: 16757839
- Ishikawa Y, Kudo H, Kagawa Y, Sakamoto S: Increased plasma levels of zinc in obese adult females on a weight-loss program based on a hypocaloric balanced diet. In Vivo. 2005 Nov-Dec;19(6):1035-7.
Pubmed: 16277018
- Skarupskiene I, Kuzminskis V, Abdrachmanovas O, Ryselis S, Smalinskiene A: [Zinc and aluminum concentrations in blood of hemodialysis patients and its impact on the frequency of infections] Medicina (Kaunas). 2005;41 Suppl 1:65-8.
Pubmed: 15901979
- Lukaski HC: Low dietary zinc decreases erythrocyte carbonic anhydrase activities and impairs cardiorespiratory function in men during exercise. Am J Clin Nutr. 2005 May;81(5):1045-51.
Pubmed: 15883427
- Gupta SK, Singh SP, Shukla VK: Copper, zinc, and Cu/Zn ratio in carcinoma of the gallbladder. J Surg Oncol. 2005 Sep 1;91(3):204-8.
Pubmed: 16118778
|
| Enzymes |
|---|
|
|
| Name: |
Phospholipase D2
|
| Reactions: |
- a phosphatidylcholine + H2O = choline + a phosphatidate [RN:R01310]
|
| Gene Name: |
PLD2 |
| Uniprot ID: |
O14939 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
| Name: |
Methionine synthase
|
| Reactions: |
- 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine [RN:R00946]
|
| Gene Name: |
MTR |
| Uniprot ID: |
Q99707 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
| Name: |
Aminopeptidase N
|
| Reactions: |
- Release of an N-terminal amino acid, Xaa!Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide ALL_REAC (other) R00899 R04951 COFACTOR Manganese [CPD:C00034]
- Zinc [CPD:C00038]
|
| Gene Name: |
ANPEP |
| Uniprot ID: |
P15144 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Name: |
Cytosol aminopeptidase
|
| Reactions: |
- Release of N-terminal proline from a peptide ALL_REAC (other) R00135 COFACTOR Manganese [CPD:C00034]
|
| Gene Name: |
LAP3 |
| Uniprot ID: |
P28838 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
|
|
|
|
|
|
|
|
|
|
| Name: |
Rhodopsin kinase
|
| Reactions: |
- ATP + rhodopsin = ADP + phosphorhodopsin [RN:R02903]
|
| Gene Name: |
GRK1 |
| Uniprot ID: |
Q15835 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
| Name: |
Angiotensin-converting enzyme
|
| Reactions: |
- Release of a C-terminal dipeptide, oligopeptide!Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II COFACTOR Zinc [CPD:C00038] INHIBITOR (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(mercaptomethyl)-1-oxoprolyl]g lycine [CPD:C01313]
- (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(mercaptomethyl)-1-oxoprolyl]- (S)-alanine [CPD:C01314]
- (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-oxoprolyl ]glycine benzyl ester [CPD:C01315]
- (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-oxoprolyl ]-(S)-alanine benzyl ester [CPD:C01316]
|
| Gene Name: |
ACE |
| Uniprot ID: |
P12821 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
| Name: |
PR domain zinc finger protein 2
|
| Reactions: |
- S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine [RN:R03938]
|
| Gene Name: |
PRDM2 |
| Uniprot ID: |
Q13029 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
|
|
|
|
|
|
|
|
|
|
| Name: |
Matrix metalloproteinase-9
|
| Reactions: |
- Cleavage of gelatin types I and V and collagen types IV and V COFACTOR Zinc [CPD:C00038]
- Metal [CPD:C00050]
- Calcium [CPD:C00076]
|
| Gene Name: |
MMP9 |
| Uniprot ID: |
P14780 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
|
|
|
|
| Name: |
Interstitial collagenase
|
| Reactions: |
- Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775!Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue COFACTOR Zinc [CPD:C00038]
|
| Gene Name: |
MMP1 |
| Uniprot ID: |
P03956 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
| Name: |
Leucyl-cystinyl aminopeptidase
|
| Reactions: |
- Release of an N-terminal amino acid, Cys!Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however [4] COFACTOR Zinc [CPD:C00038]
|
| Gene Name: |
LNPEP |
| Uniprot ID: |
Q9UIQ6 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
| Name: |
Neprilysin
|
| Reactions: |
- Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1' COFACTOR Zinc [CPD:C00038] INHIBITOR EDTA [CPD:C00284]
- Phosphoramidon [CPD:C00563]
- (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(mercaptomethyl)-1-oxoprolyl]g lycine [CPD:C01313]
- (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(mercaptomethyl)-1-oxoprolyl]- (S)-alanine [CPD:C01314]
- (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-oxoprolyl ]glycine benzyl ester [CPD:C01315]
- (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-oxoprolyl ]-(S)-alanine benzyl ester [CPD:C01316]
- Thiorphan [CPD:C01619]
|
| Gene Name: |
MME |
| Uniprot ID: |
P08473 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
|
|
|
|
| Name: |
Dipeptidase 1
|
| Reactions: |
- Hydrolysis of dipeptides COFACTOR Zinc [CPD:C00038] INHIBITOR Cilastatin [CPD:C01675]
|
| Gene Name: |
DPEP1 |
| Uniprot ID: |
P16444 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Name: |
Neurolysin, mitochondrial
|
| Reactions: |
- Preferential cleavage in neurotensin: Pro10!Tyr COFACTOR Zinc [CPD:C00038]
- Metal [CPD:C00050]
|
| Gene Name: |
NLN |
| Uniprot ID: |
Q9BYT8 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
|
|
| Name: |
Glutamyl aminopeptidase
|
| Reactions: |
- Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide COFACTOR Zinc [CPD:C00038]
- Calcium [CPD:C00076]
|
| Gene Name: |
ENPEP |
| Uniprot ID: |
Q07075 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
| Name: |
Bone morphogenetic protein 1
|
| Reactions: |
- Cleavage of the C-terminal propeptide at Ala!Asp in type I and II procollagens and at Arg!Asp in type III COFACTOR Zinc [CPD:C00038]
- Metal [CPD:C00050] EFFECTOR Calcium [CPD:C00076]
|
| Gene Name: |
BMP1 |
| Uniprot ID: |
P13497 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
|
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|
| Name: |
Aminopeptidase B
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| Reactions: |
- Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys COFACTOR Zinc [CPD:C00038]
- Cl- [CPD:C00698]
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| Gene Name: |
RNPEP |
| Uniprot ID: |
Q9H4A4 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Mast cell carboxypeptidase A
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| Reactions: |
- Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro COFACTOR Zinc [CPD:C00038]
|
| Gene Name: |
CPA3 |
| Uniprot ID: |
P15088 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Carboxypeptidase A6
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| Reactions: |
- Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro COFACTOR Zinc [CPD:C00038]
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| Gene Name: |
CPA6 |
| Uniprot ID: |
Q8N4T0 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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|
| Name: |
Carboxypeptidase B
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| Reactions: |
- Preferential release of a C-terminal lysine or arginine amino acid COFACTOR Zinc [CPD:C00038]
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| Gene Name: |
CPB1 |
| Uniprot ID: |
P15086 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Carboxypeptidase B2
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| Reactions: |
- Release of C-terminal Arg and Lys from a polypeptide COFACTOR Zinc [CPD:C00038]
|
| Gene Name: |
CPB2 |
| Uniprot ID: |
Q96IY4 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Carboxypeptidase D
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| Reactions: |
- Releases C-terminal Arg and Lys from polypeptides COFACTOR Zinc [CPD:C00038]
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| Gene Name: |
CPD |
| Uniprot ID: |
O75976 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Insulin-degrading enzyme
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| Reactions: |
- Degradation of insulin, glucagon and other polypeptides. No action on proteins COFACTOR Zinc [CPD:C00038] INHIBITOR EDTA [CPD:C00284]
- 1,10-Phenanthroline [CPD:C00604]
- Bacitracin [CPD:C01667]
- N-Ethylmaleimide [CPD:C02441]
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| Gene Name: |
IDE |
| Uniprot ID: |
P14735 |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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