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Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2013-02-09 00:10:18 UTC
HMDB IDHMDB01314
Secondary Accession NumbersNone
Metabolite Identification
Common NameCyclic GMP
DescriptionGuanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed).
Structure
Thumb
Synonyms
  1. 3',5'-Cyclic GMP
  2. 3',5'-Guanosine
  3. 3',5'-Guanosine monophosphate
  4. cGMP
  5. Cyclic 3',5'-guanosine monophosphate
  6. Cyclic GMP
  7. Cyclic guanosine 3',5'-monophosphate
  8. Cyclic-GMP
  9. Guanosine 3',5'-cyclic phosphate
  10. Guanosine 3',5'-cyclic-monophosphate
  11. Guanosine 3',5'-monophosphate
  12. Guanosine cyclic-monophosphate
  13. Guanosine-cyclic-phosphoric-acid
Chemical FormulaC10H12N5O7P
Average Molecular Weight345.2053
Monoisotopic Molecular Weight345.047434275
IUPAC Name9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-hexahydro-1,3,5,2$l^{5}-furo[3,2-d][1,3,2$l^{5}]dioxaphosphinin-6-yl]-2-amino-6,9-dihydro-1H-purin-6-one
Traditional IUPAC Name3',5'-cyclic gmp
CAS Registry Number7665-99-8
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@@H]3COP(O)(=O)O[C@H]3[C@H]2O)C(=O)N1
InChI Identifier
InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1
InChI KeyZOOGRGPOEVQQDX-UUOKFMHZSA-N
Chemical Taxonomy
KingdomOrganic Compounds
Super ClassNucleosides, Nucleotides, and Analogues
ClassPurine Nucleotides
Sub ClassPurine Ribonucleotides
Other Descriptors
  • 3',5'-Cyclic nuclcleotides(KEGG)
  • 3',5'-cyclic Purine Nucleotides
  • 3',5'-cyclic purine nucleotide(ChEBI)
  • Aromatic Heteropolycyclic Compounds
Substituents
  • 1 Phosphoribosyl Imidazole
  • Aminopyrimidine
  • Hypoxanthine
  • Imidazole
  • Imidazopyrimidine
  • Organic Hypophosphite
  • Organic Phosphite
  • Oxolane
  • Phosphoric Acid Ester
  • Purine
  • Purinone
  • Pyrimidine
  • Pyrimidone
  • Secondary Alcohol
Direct ParentPurine Ribonucleoside Monophosphates
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Purine metabolism
  • Second messenger
ApplicationNot Available
Cellular locations
  • Extracellular
  • Nucleus
  • Golgi apparatus
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
water solubility3.79 g/LALOGPS
logP-2ALOGPS
logP-2.1ChemAxon
logS-2ALOGPS
pKa (strongest acidic)2.05ChemAxon
pKa (strongest basic)1.41ChemAxon
physiological charge-1ChemAxon
hydrogen acceptor count8ChemAxon
hydrogen donor count4ChemAxon
polar surface area170.52ChemAxon
rotatable bond count1ChemAxon
refractivity71.72ChemAxon
polarizability29.19ChemAxon
Spectra
SpectraGC-MS
Biological Properties
Cellular Locations
  • Extracellular
  • Nucleus
  • Golgi apparatus
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
Tissue Location
  • Aorta
  • Blood Vessels
  • Kidney
  • Platelet
  • Smooth Muscle
PathwaysNot Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.0055 +/- 0.0003 uMAdult (>18 years old)MaleNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.0024 +/- 0.0005 uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.0035 +/- 0.0003 uMAdult (>18 years old)BothSildenafil-induced headache details
Associated Disorders and Diseases
Disease References
Headache
  1. Kruuse C, Frandsen E, Schifter S, Thomsen LL, Birk S, Olesen J: Plasma levels of cAMP, cGMP and CGRP in sildenafil-induced headache. Cephalalgia. 2004 Jul;24(7):547-53. Pubmed: 15196297
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB022549
KNApSAcK IDNot Available
Chemspider ID22734
KEGG Compound IDC00942
BioCyc IDCGMP
BiGG ID1485267
Wikipedia LinkCyclic GMP
NuGOwiki LinkHMDB01314
Metagene LinkHMDB01314
METLIN ID6152
PubChem Compound24316
PDB ID35G
ChEBI ID16356
References
Synthesis ReferenceSekhar, Konjeti R.; Grondin, Pascal; Francis, Sharron H.; Corbin, Jackie D. Design and synthesis of xanthines and cyclic GMP analogs as potent inhibitors of PDE5. Phosphodiesterase Inhibitors (1996), 135-146.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Mashayekhi F, Aghahoseini F, Rezaie A, Zamani MJ, Khorasani R, Abdollahi M: Alteration of cyclic nucleotides levels and oxidative stress in saliva of human subjects with periodontitis. J Contemp Dent Pract. 2005 Nov 15;6(4):46-53. Pubmed: 16299606
  2. Rudman D, O'Brien MS, McKinney AS, Hoffman JC Jr, Patterson JH: Observations on the cyclic nucleotide concentrations in human cerebrospinal fluid. J Clin Endocrinol Metab. 1976 Jun;42(6):1088-97. Pubmed: 180045
  3. Martina V, Benso A, Gigliardi VR, Masha A, Origlia C, Granata R, Ghigo E: Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects. Clin Endocrinol (Oxf). 2006 Mar;64(3):260-4. Pubmed: 16487434
  4. Kotikoski H, Moilanen E, Vapaatalo H, Aine E: Biochemical markers of the L-arginine-nitric oxide pathway in the aqueous humour in glaucoma patients. Acta Ophthalmol Scand. 2002 Apr;80(2):191-5. Pubmed: 11952488
  5. Young DV, Cochran ED, Dhawan V, Earl RA, Ellis JL, Garvey DS, Janero DR, Khanapure SP, Letts LG, Melim TL, Murty MG, Shumway MJ, Wey SJ, Zemtseva IS, Selig WM: A comparison of the cyclooxygenase inhibitor-NO donors (CINOD), NMI-1182 and AZD3582, using in vitro biochemical and pharmacological methods. Biochem Pharmacol. 2005 Nov 1;70(9):1343-51. Pubmed: 16168964
  6. Dobrzynski E, Montanari D, Agata J, Zhu J, Chao J, Chao L: Adrenomedullin improves cardiac function and prevents renal damage in streptozotocin-induced diabetic rats. Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1291-8. Pubmed: 12424108
  7. Willoughby SR, Stewart S, Chirkov YY, Kennedy JA, Holmes AS, Horowitz JD: Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide. Eur Heart J. 2002 Dec;23(24):1946-54. Pubmed: 12473257
  8. Barani J, Gottsater A, Mattiasson I, Lindblad B: Platelet and leukocyte activation during aortoiliac angiography and angioplasty. Eur J Vasc Endovasc Surg. 2002 Mar;23(3):220-5. Pubmed: 11914008
  9. Schiessl B, Strasburger CJ, Bidlingmaier M, Spannagl M, Ugele B, Kainer F: Decreasing resistance in the maternal uterine and peripheral arterial system is apparently unrelated to plasma and urinary levels of nitrite/nitrate and cyclic-guanosinmonophosohate during the course of normal pregnancies. J Perinat Med. 2003;31(4):281-6. Pubmed: 12951882
  10. Bai X, Wang H, Li Z, Liu K: Correlation between blood cAMP, cGMP levels and traumatic severity in the patients with acute trauma and its clinical significance. J Huazhong Univ Sci Technolog Med Sci. 2004;24(1):68-70. Pubmed: 15165120
  11. Beltowski J, Jamroz A, Borkowska E: [Heme oxygenase and carbon monoxide in the physiology and pathology of the cardiovascular system] Postepy Hig Med Dosw (Online). 2004 Mar 3;58:83-99. Pubmed: 15069378
  12. Peracchi M, Lombardi L, Maiolo AT, Bamonti-Catena F, Toschi V, Chiorboli O, Mozzana R, Polli EE: Plasma and urine cyclic nucleotide levels in patients with acute and chronic leukemia. Blood. 1983 Mar;61(3):429-34. Pubmed: 6297636
  13. Ilecka J: Decreased cerebrospinal fluid cGMP levels in patients with amyotrophic lateral sclerosis. J Neural Transm. 2004 Feb;111(2):167-72. Epub 2003 Dec 12. Pubmed: 14767719
  14. Hunter KA, Singh GJ, Simpkins CO: Cyclic gmp is a measure of physiologic stress. J Natl Med Assoc. 2001 Jul-Aug;93(7-8):256-62. Pubmed: 11491275
  15. Zhang H, Zheng RL, Xu CY: [Relationships between lipid peroxidation or cyclic nucleotides and motility in human asthenozoosperm and normosperm] Shi Yan Sheng Wu Xue Bao. 1998 Dec;31(4):341-6. Pubmed: 12016956
  16. Engelhardt T, Galley HF, MacLennan FM, Webster NR: Saliva cyclic GMP increases during anaesthesia. Br J Anaesth. 2002 Oct;89(4):635-7. Pubmed: 12393367
  17. Galassi F, Renieri G, Sodi A, Ucci F, Vannozzi L, Masini E: Nitric oxide proxies and ocular perfusion pressure in primary open angle glaucoma. Br J Ophthalmol. 2004 Jun;88(6):757-60. Pubmed: 15148207
  18. Zhao L, Gray L, Leonardi-Bee J, Weaver CS, Heptinstall S, Bath PM: Effect of aspirin, clopidogrel and dipyridamole on soluble markers of vascular function in normal volunteers and patients with prior ischaemic stroke. Platelets. 2006 Mar;17(2):100-4. Pubmed: 16421011
  19. Martina V, Origlia C, Bruno GA, Messina M, Ferri M, Pescarmona GP: Serum DHEAS levels correlate with platelet cGMP in normal women. J Endocrinol Invest. 2001 Nov;24(10):RC28-30. Pubmed: 11765058
  20. St Pierre MV, Schlenker T, Dufour JF, Jefferson DM, Fitz JG, Arias IM: Stimulation of cyclic guanosine monophosphate production by natriuretic peptide in human biliary cells. Gastroenterology. 1998 Apr;114(4):782-90. Pubmed: 9516399

Enzymes

General function:
Involved in 3',5'-cyclic-nucleotide phosphodiesterase activity
Specific function:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Gene Name:
PDE6H
Uniprot ID:
Q13956
Molecular weight:
9074.36
General function:
Involved in catalytic activity
Specific function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
Gene Name:
PDE1A
Uniprot ID:
P54750
Molecular weight:
61251.38
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
Gene Name:
PDE8A
Uniprot ID:
O60658
Molecular weight:
86047.88
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Gene Name:
PDE1B
Uniprot ID:
Q01064
Molecular weight:
61379.235
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Gene Name:
PDE3B
Uniprot ID:
Q13370
Molecular weight:
124332.145
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
PDE6C
Uniprot ID:
P51160
Molecular weight:
99146.095
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in 3',5'-cyclic-AMP phosphodiesterase activity
Specific function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
Gene Name:
PDE7A
Uniprot ID:
Q13946
Molecular weight:
55504.475
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (By similarity).
Gene Name:
PDE3A
Uniprot ID:
Q14432
Molecular weight:
124978.06
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
Gene Name:
PDE10A
Uniprot ID:
Q9Y233
Molecular weight:
89388.7
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.
Gene Name:
PDE1C
Uniprot ID:
Q14123
Molecular weight:
72207.775
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Gene Name:
PDE4B
Uniprot ID:
Q07343
Molecular weight:
64351.765
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.
Gene Name:
PDE7B
Uniprot ID:
Q9NP56
Molecular weight:
51834.855
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.
Gene Name:
PDE9A
Uniprot ID:
O76083
Molecular weight:
61708.5
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
Gene Name:
PDE2A
Uniprot ID:
O00408
Molecular weight:
105145.485
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
This protein participates in processes of transmission and amplification of the visual signal.
Gene Name:
PDE6A
Uniprot ID:
P16499
Molecular weight:
99546.595
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
Gene Name:
PDE8B
Uniprot ID:
O95263
Molecular weight:
87973.225
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Gene Name:
PDE4C
Uniprot ID:
Q08493
Molecular weight:
79900.795
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.
Gene Name:
PDE6B
Uniprot ID:
P35913
Molecular weight:
98348.955
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Gene Name:
PDE4D
Uniprot ID:
Q08499
Molecular weight:
91114.1
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in 3',5'-cyclic-nucleotide phosphodiesterase activity
Specific function:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Gene Name:
PDE6G
Uniprot ID:
P18545
Molecular weight:
9643.09
General function:
Involved in 3',5'-cyclic-nucleotide phosphodiesterase activity
Specific function:
Not Available
Gene Name:
PDE6D
Uniprot ID:
O43924
Molecular weight:
17419.9
General function:
Involved in 3',5'-cyclic-nucleotide phosphodiesterase activity
Specific function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Gene Name:
PDE4A
Uniprot ID:
P27815
Molecular weight:
98142.155
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
Gene Name:
PDE5A
Uniprot ID:
O76074
Molecular weight:
99984.14
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase.
Gene Name:
ADCY7
Uniprot ID:
P51828
Molecular weight:
120307.175
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity).
Gene Name:
ADCY4
Uniprot ID:
Q8NFM4
Molecular weight:
119792.94
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity).
Gene Name:
ADCY6
Uniprot ID:
O43306
Molecular weight:
130614.095
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase.
Gene Name:
ADCY5
Uniprot ID:
O95622
Molecular weight:
102605.37
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).
Gene Name:
ADCY8
Uniprot ID:
P40145
Molecular weight:
140120.79
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity).
Gene Name:
ADCY9
Uniprot ID:
O60503
Molecular weight:
150699.36
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.
Gene Name:
ADCY3
Uniprot ID:
O60266
Molecular weight:
128958.905
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.
Gene Name:
ADCY1
Uniprot ID:
Q08828
Molecular weight:
123438.85
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.
Gene Name:
ADCY2
Uniprot ID:
Q08462
Molecular weight:
123602.25
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
Gene Name:
NPR2
Uniprot ID:
P20594
Molecular weight:
117020.97
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
Not Available
Gene Name:
GUCY1B3
Uniprot ID:
Q02153
Molecular weight:
70513.89
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.
Gene Name:
GUCY2D
Uniprot ID:
Q02846
Molecular weight:
120057.18
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
Not Available
Gene Name:
GUCY1A3
Uniprot ID:
Q02108
Molecular weight:
77451.825
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Gene Name:
NPR1
Uniprot ID:
P16066
Molecular weight:
118918.11
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin.
Gene Name:
GUCY2C
Uniprot ID:
P25092
Molecular weight:
123401.73
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
Has guanylyl cyclase on binding to the beta-1 subunit. Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.
Gene Name:
GUCY1A2
Uniprot ID:
P33402
Molecular weight:
81749.185
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.
Gene Name:
GUCY2F
Uniprot ID:
P51841
Molecular weight:
124848.965
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
Not Available
Gene Name:
GUCY1B2
Uniprot ID:
O75343
Molecular weight:
Not Available
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in ion channel activity
Specific function:
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones
Gene Name:
CNGA3
Uniprot ID:
Q16281
Molecular weight:
78837.4
General function:
Involved in ion channel activity
Specific function:
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones
Gene Name:
CNGB3
Uniprot ID:
Q9NQW8
Molecular weight:
92248.8
General function:
Involved in ion channel activity
Specific function:
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors
Gene Name:
CNGA1
Uniprot ID:
P29973
Molecular weight:
79584.8
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.
Gene Name:
ADCY10
Uniprot ID:
Q96PN6
Molecular weight:
169748.45
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphatedetails
General function:
Involved in catalytic activity
Specific function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Gene Name:
PDE11A
Uniprot ID:
Q9HCR9
Molecular weight:
55699.16
Reactions
Cyclic GMP + Water → Guanosine monophosphatedetails