Human Metabolome Database Version 3.5

Showing metabocard for Cyclic GMP (HMDB01314)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:10:18 -0700
HMDB ID HMDB01314
Secondary Accession Numbers None
Metabolite Identification
Common Name Cyclic GMP
Description Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed).
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. 3',5'-Cyclic GMP
  2. 3',5'-Guanosine
  3. 3',5'-Guanosine monophosphate
  4. cGMP
  5. Cyclic 3',5'-guanosine monophosphate
  6. Cyclic GMP
  7. Cyclic guanosine 3',5'-monophosphate
  8. Cyclic-GMP
  9. Guanosine 3',5'-cyclic phosphate
  10. Guanosine 3',5'-cyclic-monophosphate
  11. Guanosine 3',5'-monophosphate
  12. Guanosine cyclic-monophosphate
  13. Guanosine-cyclic-phosphoric-acid
Chemical Formula C10H12N5O7P
Average Molecular Weight 345.2053
Monoisotopic Molecular Weight 345.047434275
IUPAC Name 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-hexahydro-1,3,5,2$l^{5}-furo[3,2-d][1,3,2$l^{5}]dioxaphosphinin-6-yl]-2-amino-6,9-dihydro-1H-purin-6-one
Traditional IUPAC Name 3',5'-cyclic gmp
CAS Registry Number 7665-99-8
SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@@H]3COP(O)(=O)O[C@H]3[C@H]2O)C(=O)N1
InChI Identifier InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1
InChI Key ZOOGRGPOEVQQDX-UUOKFMHZSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Nucleosides, Nucleotides, and Analogues
Class Purine Nucleotides
Sub Class Purine Ribonucleotides
Other Descriptors
  • 3',5'-Cyclic nuclcleotides(KEGG)
  • 3',5'-cyclic Purine Nucleotides
  • 3',5'-cyclic purine nucleotide(ChEBI)
  • Aromatic Heteropolycyclic Compounds
Substituents
  • 1 Phosphoribosyl Imidazole
  • Aminopyrimidine
  • Hypoxanthine
  • Imidazole
  • Imidazopyrimidine
  • Organic Hypophosphite
  • Organic Phosphite
  • Oxolane
  • Phosphoric Acid Ester
  • Purine
  • Purinone
  • Pyrimidine
  • Pyrimidone
  • Secondary Alcohol
Direct Parent Purine Ribonucleoside Monophosphates
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Purine metabolism
  • Second messenger
Application Not Available
Cellular locations
  • Extracellular
  • Nucleus
  • Golgi apparatus
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility 3.79 g/L ALOGPS
LogP -1.98 ALOGPS
LogP -2.1 ChemAxon
LogS -1.96 ALOGPS
pKa (strongest acidic) 2.05 ChemAxon
pKa (strongest basic) 1.41 ChemAxon
Hydrogen Acceptor Count 8 ChemAxon
Hydrogen Donor Count 4 ChemAxon
Polar Surface Area 170.52 A2 ChemAxon
Rotatable Bond Count 1 ChemAxon
Refractivity 71.72 ChemAxon
Polarizability 29.19 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -1 ChemAxon
Spectra
MS/MS Spectrum GC-MS
Biological Properties
Cellular Locations
  • Extracellular
  • Nucleus
  • Golgi apparatus
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
Tissue Location
  • Kidney
  • Platelet
  • Smooth Muscle
  • Aorta
  • Blood Vessels
Pathways Not Available
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
0.0055 +/- 0.0003 uM Adult (>18 years old) Male Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.0024 +/- 0.0005 uM Adult (>18 years old) Both Normal
  • Geigy Scient...
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified 0.0035 +/- 0.0003 uM Adult (>18 years old) Both Sildenafil-induced headache
Associated Disorders and Diseases
Disease References
Headache
  • Kruuse C, Frandsen E, Schifter S, Thomsen LL, Birk S, Olesen J: Plasma levels of cAMP, cGMP and CGRP in sildenafil-induced headache. Cephalalgia. 2004 Jul;24(7):547-53. Pubmed: 15196297 Link_out
      Associated OMIM IDs None
      DrugBank ID Not Available
      DrugBank Metabolite ID Not Available
      Phenol Explorer Compound ID Not Available
      Phenol Explorer Metabolite ID Not Available
      FoodDB ID FDB022549
      KNApSAcK ID Not Available
      Chemspider ID 22734 Link_out
      KEGG Compound ID C00942 Link_out
      BioCyc ID CGMP Link_out
      BiGG ID 1485267 Link_out
      Wikipedia Link Cyclic GMP Link_out
      NuGOwiki Link HMDB01314 Link_out
      Metagene Link HMDB01314 Link_out
      METLIN ID 6152 Link_out
      PubChem Compound 24316 Link_out
      PDB ID 35G Link_out
      ChEBI ID 16356 Link_out
      References
      Synthesis Reference Sekhar, Konjeti R.; Grondin, Pascal; Francis, Sharron H.; Corbin, Jackie D. Design and synthesis of xanthines and cyclic GMP analogs as potent inhibitors of PDE5. Phosphodiesterase Inhibitors (1996), 135-146.
      Material Safety Data Sheet (MSDS) Download (PDF)
      General References
      1. Young DV, Cochran ED, Dhawan V, Earl RA, Ellis JL, Garvey DS, Janero DR, Khanapure SP, Letts LG, Melim TL, Murty MG, Shumway MJ, Wey SJ, Zemtseva IS, Selig WM: A comparison of the cyclooxygenase inhibitor-NO donors (CINOD), NMI-1182 and AZD3582, using in vitro biochemical and pharmacological methods. Biochem Pharmacol. 2005 Nov 1;70(9):1343-51. Pubmed: 16168964 Link_out
      2. Mashayekhi F, Aghahoseini F, Rezaie A, Zamani MJ, Khorasani R, Abdollahi M: Alteration of cyclic nucleotides levels and oxidative stress in saliva of human subjects with periodontitis. J Contemp Dent Pract. 2005 Nov 15;6(4):46-53. Pubmed: 16299606 Link_out
      3. Dobrzynski E, Montanari D, Agata J, Zhu J, Chao J, Chao L: Adrenomedullin improves cardiac function and prevents renal damage in streptozotocin-induced diabetic rats. Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1291-8. Pubmed: 12424108 Link_out
      4. Willoughby SR, Stewart S, Chirkov YY, Kennedy JA, Holmes AS, Horowitz JD: Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide. Eur Heart J. 2002 Dec;23(24):1946-54. Pubmed: 12473257 Link_out
      5. Barani J, Gottsater A, Mattiasson I, Lindblad B: Platelet and leukocyte activation during aortoiliac angiography and angioplasty. Eur J Vasc Endovasc Surg. 2002 Mar;23(3):220-5. Pubmed: 11914008 Link_out
      6. Schiessl B, Strasburger CJ, Bidlingmaier M, Spannagl M, Ugele B, Kainer F: Decreasing resistance in the maternal uterine and peripheral arterial system is apparently unrelated to plasma and urinary levels of nitrite/nitrate and cyclic-guanosinmonophosohate during the course of normal pregnancies. J Perinat Med. 2003;31(4):281-6. Pubmed: 12951882 Link_out
      7. Bai X, Wang H, Li Z, Liu K: Correlation between blood cAMP, cGMP levels and traumatic severity in the patients with acute trauma and its clinical significance. J Huazhong Univ Sci Technolog Med Sci. 2004;24(1):68-70. Pubmed: 15165120 Link_out
      8. Beltowski J, Jamroz A, Borkowska E: [Heme oxygenase and carbon monoxide in the physiology and pathology of the cardiovascular system] Postepy Hig Med Dosw (Online). 2004 Mar 3;58:83-99. Pubmed: 15069378 Link_out
      9. Rudman D, O'Brien MS, McKinney AS, Hoffman JC Jr, Patterson JH: Observations on the cyclic nucleotide concentrations in human cerebrospinal fluid. J Clin Endocrinol Metab. 1976 Jun;42(6):1088-97. Pubmed: 180045 Link_out
      10. Peracchi M, Lombardi L, Maiolo AT, Bamonti-Catena F, Toschi V, Chiorboli O, Mozzana R, Polli EE: Plasma and urine cyclic nucleotide levels in patients with acute and chronic leukemia. Blood. 1983 Mar;61(3):429-34. Pubmed: 6297636 Link_out
      11. Ilecka J: Decreased cerebrospinal fluid cGMP levels in patients with amyotrophic lateral sclerosis. J Neural Transm. 2004 Feb;111(2):167-72. Epub 2003 Dec 12. Pubmed: 14767719 Link_out
      12. Kotikoski H, Moilanen E, Vapaatalo H, Aine E: Biochemical markers of the L-arginine-nitric oxide pathway in the aqueous humour in glaucoma patients. Acta Ophthalmol Scand. 2002 Apr;80(2):191-5. Pubmed: 11952488 Link_out
      13. Hunter KA, Singh GJ, Simpkins CO: Cyclic gmp is a measure of physiologic stress. J Natl Med Assoc. 2001 Jul-Aug;93(7-8):256-62. Pubmed: 11491275 Link_out
      14. Zhang H, Zheng RL, Xu CY: [Relationships between lipid peroxidation or cyclic nucleotides and motility in human asthenozoosperm and normosperm] Shi Yan Sheng Wu Xue Bao. 1998 Dec;31(4):341-6. Pubmed: 12016956 Link_out
      15. Martina V, Benso A, Gigliardi VR, Masha A, Origlia C, Granata R, Ghigo E: Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects. Clin Endocrinol (Oxf). 2006 Mar;64(3):260-4. Pubmed: 16487434 Link_out
      16. Engelhardt T, Galley HF, MacLennan FM, Webster NR: Saliva cyclic GMP increases during anaesthesia. Br J Anaesth. 2002 Oct;89(4):635-7. Pubmed: 12393367 Link_out
      17. Galassi F, Renieri G, Sodi A, Ucci F, Vannozzi L, Masini E: Nitric oxide proxies and ocular perfusion pressure in primary open angle glaucoma. Br J Ophthalmol. 2004 Jun;88(6):757-60. Pubmed: 15148207 Link_out
      18. Zhao L, Gray L, Leonardi-Bee J, Weaver CS, Heptinstall S, Bath PM: Effect of aspirin, clopidogrel and dipyridamole on soluble markers of vascular function in normal volunteers and patients with prior ischaemic stroke. Platelets. 2006 Mar;17(2):100-4. Pubmed: 16421011 Link_out
      19. Martina V, Origlia C, Bruno GA, Messina M, Ferri M, Pescarmona GP: Serum DHEAS levels correlate with platelet cGMP in normal women. J Endocrinol Invest. 2001 Nov;24(10):RC28-30. Pubmed: 11765058 Link_out
      20. St Pierre MV, Schlenker T, Dufour JF, Jefferson DM, Fitz JG, Arias IM: Stimulation of cyclic guanosine monophosphate production by natriuretic peptide in human biliary cells. Gastroenterology. 1998 Apr;114(4):782-90. Pubmed: 9516399 Link_out

      Enzymes
      Name: Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
      Reactions: Not Available
      Gene Name: PDE6H
      Uniprot ID: Q13956 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE1A
      Uniprot ID: P54750 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE8A
      Uniprot ID: O60658 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE1B
      Uniprot ID: Q01064 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: cGMP-inhibited 3',5'-cyclic phosphodiesterase B
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE3B
      Uniprot ID: Q13370 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE6C
      Uniprot ID: P51160 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE7A
      Uniprot ID: Q13946 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: cGMP-inhibited 3',5'-cyclic phosphodiesterase A
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE3A
      Uniprot ID: Q14432 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE10A
      Uniprot ID: Q9Y233 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE1C
      Uniprot ID: Q14123 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE4B
      Uniprot ID: Q07343 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: cAMP-specific 3',5'-cyclic phosphodiesterase 7B
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE7B
      Uniprot ID: Q9NP56 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE9A
      Uniprot ID: O76083 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: cGMP-dependent 3',5'-cyclic phosphodiesterase
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE2A
      Uniprot ID: O00408 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE6A
      Uniprot ID: P16499 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE8B
      Uniprot ID: O95263 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4C
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE4C
      Uniprot ID: Q08493 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE6B
      Uniprot ID: P35913 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE4D
      Uniprot ID: Q08499 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
      Reactions: Not Available
      Gene Name: PDE6G
      Uniprot ID: P18545 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
      Reactions: Not Available
      Gene Name: PDE6D
      Uniprot ID: O43924 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4A
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE4A
      Uniprot ID: P27815 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: cGMP-specific 3',5'-cyclic phosphodiesterase
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE5A
      Uniprot ID: O76074 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Adenylate cyclase type 7
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: ADCY7
      Uniprot ID: P51828 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Adenylate cyclase type 4
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: ADCY4
      Uniprot ID: Q8NFM4 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Adenylate cyclase type 6
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: ADCY6
      Uniprot ID: O43306 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Adenylate cyclase type 5
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: ADCY5
      Uniprot ID: O95622 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Adenylate cyclase type 8
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: ADCY8
      Uniprot ID: P40145 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Adenylate cyclase type 9
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: ADCY9
      Uniprot ID: O60503 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Adenylate cyclase type 3
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: ADCY3
      Uniprot ID: O60266 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Adenylate cyclase type 1
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: ADCY1
      Uniprot ID: Q08828 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Adenylate cyclase type 2
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: ADCY2
      Uniprot ID: Q08462 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Atrial natriuretic peptide receptor 2
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: NPR2
      Uniprot ID: P20594 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Guanylate cyclase soluble subunit beta-1
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: GUCY1B3
      Uniprot ID: Q02153 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Retinal guanylyl cyclase 1
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: GUCY2D
      Uniprot ID: Q02846 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Guanylate cyclase soluble subunit alpha-3
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: GUCY1A3
      Uniprot ID: Q02108 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Atrial natriuretic peptide receptor 1
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: NPR1
      Uniprot ID: P16066 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Heat-stable enterotoxin receptor
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: GUCY2C
      Uniprot ID: P25092 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Guanylate cyclase soluble subunit alpha-2
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: GUCY1A2
      Uniprot ID: P33402 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Retinal guanylyl cyclase 2
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: GUCY2F
      Uniprot ID: P51841 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Guanylate cyclase soluble subunit beta-2
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: GUCY1B2
      Uniprot ID: O75343 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Cyclic nucleotide-gated cation channel alpha-3
      Reactions: Not Available
      Gene Name: CNGA3
      Uniprot ID: Q16281 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Cyclic nucleotide-gated cation channel beta-3
      Reactions: Not Available
      Gene Name: CNGB3
      Uniprot ID: Q9NQW8 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: cGMP-gated cation channel alpha-1
      Reactions: Not Available
      Gene Name: CNGA1
      Uniprot ID: P29973 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Adenylate cyclase type 10
      Reactions:
      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
      Gene Name: ADCY10
      Uniprot ID: Q96PN6 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
      Reactions:
      Cyclic GMP + Water unknown Guanosine monophosphate details
      Gene Name: PDE11A
      Uniprot ID: Q9HCR9 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA