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Record Information
Version3.6
Creation Date2006-08-16 13:07:24 UTC
Update Date2016-02-11 01:04:16 UTC
HMDB IDHMDB01315
Secondary Accession NumbersNone
Metabolite Identification
Common NamePhosphorus
DescriptionPhosphorus, in its common form, is a waxy white (or yellowish) solid that has a characteristic, disagreeable smell similar to that of garlic. Pure forms of the element are colorless and transparent. This nonmetal is not soluble in water, but is soluble in carbon disulfide. The white allotrope ignites spontaneously in air; however both white and red phosphorus burn in air to produce phosphorus pentoxide. Phosphorus is a key element in all known forms of life. Physiologically, it exists as an ion in the body. Inorganic phosphorus in the form of the phosphate PO43- plays a major role in biological molecules such as DNA and RNA where it forms part of the structural framework of these molecules. Living cells also utilize phosphate to transport cellular energy via adenosine triphosphate (ATP). Nearly every cellular process that uses energy gets it in the form of ATP. ATP is also important for phosphorylation, a key regulatory event in cells. Phospholipids are the main structural components of all cellular membranes. Calcium phosphate salts are used by animals to stiffen their bones. An average person contains a little less than 1 kg of phosphorus, about three quarters of which is present in bones and teeth in the form of apatite. A well-fed adult in the industrialized world consumes and excretes about 1-3 g of phosphorus per day in the form of phosphate. Phosphorus is an essential mineral macronutrient, which is studied extensively in soil conservation in order to understand plant uptake from soil systems. Due to its reactivity to air and many other oxygen containing substances, phosphorus is not found free in nature but it is widely distributed in many different minerals.
Structure
Thumb
Synonyms
ValueSource
15PChEBI
FosforoChEBI
PChEBI
PhosphorChEBI
PhosphoreChEBI
PhosphorusChEBI
Hittorf'S phosphorusHMDB
PhosphorousHMDB
Phosphorus-30HMDB
Red phosphorusHMDB
Violet phosphorusHMDB
White phosphorusHMDB
Chemical FormulaP
Average Molecular Weight30.9738
Monoisotopic Molecular Weight30.973761512
IUPAC Namephosphanylidyne
Traditional Namephosphanylidyne
CAS Registry Number7723-14-0
SMILES
[P]
InChI Identifier
InChI=1S/P
InChI KeyInChIKey=OAICVXFJPJFONN-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other nonmetals'.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassHomogeneous other non-metal compounds
Sub ClassNot Available
Direct ParentHomogeneous other non-metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous other non metal
  • Acyclic compound
Molecular FrameworkAcyclic compounds
External Descriptors
Ontology
StatusDetected and Quantified
Origin
  • Drug
  • Food
Biofunction
  • Essential minerals
ApplicationNot Available
Cellular locations
  • Cytoplasm (predicted from logP)
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point44.1 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity5.2 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MSNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Biological Properties
Cellular Locations
  • Cytoplasm (predicted from logP)
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue Location
  • Brain
  • Kidney
  • Liver
  • Parathyroid
Pathways
NameSMPDB LinkKEGG Link
Paclitaxel PathwaySMP00434Not Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified11900.0 (10100.0-14300.0) uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
BloodDetected and Quantified2030.0(1390.0-2600.0) uMNewborn (0-30 days old)BothNormal
    • Geigy Scientific ...
details
BloodDetected and Quantified1640.0 (1280.0-2000.0) uMChildren (1-13 years old)BothNormal
    • Geigy Scientific ...
details
BloodDetected and Quantified1540.0 (1050.0-2050.0) uMAdolescent (13-18 years old)BothNormal
    • Geigy Scientific ...
details
BloodDetected and Quantified1035.0 (710.0-1360.0) uMAdult (>18 years old)MaleNormal
    • Geigy Scientific ...
details
BloodDetected and Quantified1065.0 (770.0-1360.0) uMAdult (>18 years old)FemaleNormal
    • Geigy Scientific ...
details
Cerebrospinal Fluid (CSF)Detected and Quantified520.0 (371.0-668.0) uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
SalivaDetected and Quantified5743.571 +/- 2085.636 uMAdult (>18 years old)Not Specified
Normal
details
SalivaDetected and Quantified4184.187 +/- 1468.985 uMAdult (>18 years old)Not Specified
Normal
details
SalivaDetected and Quantified5001.00698 +/- 1417.329 uMAdolescent (13-18 years old)Not Specified
Normal
details
SalivaDetected and Quantified3373.823 +/- 894.305 uMAdolescent (13-18 years old)Not Specified
Normal
details
SalivaDetected and Quantified3470 +/- 940 uMAdult (>18 years old)Not Specified
Normal
details
SalivaDetected and Quantified2020 +/- 5040 uMAdult (>18 years old)Not Specified
Normal
details
SalivaDetected and Quantified4702.78 +/- 2433.64 uMAdult (>18 years old)BothNormal
    • Zerihun T. Dame, ...
details
UrineDetected and Quantified1799 (221-4936) umol/mmol creatinineAdult (>18 years old)Both
Normal
details
UrineDetected and Quantified1666.67-4333.33 umol/mmol creatinineAdult (>18 years old)Not SpecifiedNormal
    • Geigy scientific ...
details
UrineDetected and Quantified2993.4 (1710.5 - 0.0) umol/mmol creatinineAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
UrineDetected and Quantified1315.7 +/- 592.1 umol/mmol creatinineChildren (1-13 years old)BothNormal
    • Geigy Scientific ...
details
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified2200.00 (1400.00-3000.00) uMAdult (>18 years old)BothGlycerol intolerance syndrome details
BloodDetected and Quantified50250.00 (500.00-100000.00) uMChildren (1-13 years old)BothGlycerol intolerance syndrom details
Associated Disorders and Diseases
Disease References
Glycerol intolerance syndrome
  1. MetaGene [Link]
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB003520
KNApSAcK IDNot Available
Chemspider ID4575369
KEGG Compound IDC06262
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkPhosphorus
NuGOwiki LinkHMDB01315
Metagene LinkHMDB01315
METLIN IDNot Available
PubChem Compound5462309
PDB IDNot Available
ChEBI ID28659
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Siqueira WL, de Oliveira E, Mustacchi Z, Nicolau J: Electrolyte concentrations in saliva of children aged 6-10 years with Down syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Jul;98(1):76-9. [15243474 ]
  2. Slatopolsky E, Gonzalez E, Martin K: Pathogenesis and treatment of renal osteodystrophy. Blood Purif. 2003;21(4-5):318-26. [12944733 ]
  3. Goodman WG: Calcimimetic agents and secondary hyperparathyroidism: rationale for use and results from clinical trials. Pediatr Nephrol. 2003 Dec;18(12):1206-10. Epub 2003 Oct 28. [14586685 ]
  4. Urena P, Frazao JM: Calcimimetic agents: review and perspectives. Kidney Int Suppl. 2003 Jun;(85):S91-6. [12753275 ]
  5. Pawlowska J, Matusik H, Socha P, Ismail H, Ryzko J, Karczmarewicz E, Jankowska I, Teisseyre M, Lorenc R: Beneficial effect of liver transplantation on bone mineral density in small infants with cholestasis. Transplant Proc. 2004 Jun;36(5):1479-80. [15251362 ]
  6. Obata T, Someya Y, Suhara T, Ota Y, Hirakawa K, Ikehira H, Tanada S, Okubo Y: Neural damage due to temporal lobe epilepsy: dual-nuclei (proton and phosphorus) magnetic resonance spectroscopy study. Psychiatry Clin Neurosci. 2004 Feb;58(1):48-53. [14678457 ]
  7. Gandhy M, Damle SG: Relation of salivary inorganic phosphorus and alkaline phosphatase to the dental caries status in children. J Indian Soc Pedod Prev Dent. 2003 Dec;21(4):135-8. [14765611 ]
  8. Casari S, Rossi V, Varenna M, Gasparini M, Parafioriti A, Failoni S, Sinigaglia L: A case of oncogenic osteomalacia detected by 111In-pentetreotide total body scan. Clin Exp Rheumatol. 2003 Jul-Aug;21(4):493-6. [12942704 ]
  9. Ahn JH, Yoo CI, Lee CR, Lee JH, Lee H, Kim CY, Park JK, Sakai T, Yoon CS, Kim Y: Calcification mimicking manganese-induced increased signal intensities in T1-weighted MR images in a patient taking herbal medicine: case report. Neurotoxicology. 2003 Dec;24(6):835-8. [14637378 ]
  10. Emmett M: A comparison of clinically useful phosphorus binders for patients with chronic kidney failure. Kidney Int Suppl. 2004 Sep;(90):S25-32. [15296504 ]