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Human Metabolome Database Version 3.5

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Showing metabocard for Phosphorus (HMDB01315)

Record Information
Version 3.5
Creation Date 2006-08-16 07:07:24 -0600
Update Date 2013-02-08 11:20:49 -0700
HMDB ID HMDB01315
Secondary Accession Numbers None
Metabolite Identification
Common Name Phosphorus
Description Phosphorus, in its common form, is a waxy white (or yellowish) solid that has a characteristic, disagreeable smell similar to that of garlic. Pure forms of the element are colorless and transparent. This nonmetal is not soluble in water, but is soluble in carbon disulfide. The white allotrope ignites spontaneously in air; however both white and red phosphorus burn in air to produce phosphorus pentoxide. Phosphorus is a key element in all known forms of life. Physiologically, it exists as an ion in the body. Inorganic phosphorus in the form of the phosphate PO43- plays a major role in biological molecules such as DNA and RNA where it forms part of the structural framework of these molecules. Living cells also utilize phosphate to transport cellular energy via adenosine triphosphate (ATP). Nearly every cellular process that uses energy gets it in the form of ATP. ATP is also important for phosphorylation, a key regulatory event in cells. Phospholipids are the main structural components of all cellular membranes. Calcium phosphate salts are used by animals to stiffen their bones. An average person contains a little less than 1 kg of phosphorus, about three quarters of which is present in bones and teeth in the form of apatite. A well-fed adult in the industrialized world consumes and excretes about 1-3 g of phosphorus per day in the form of phosphate. Phosphorus is an essential mineral macronutrient, which is studied extensively in soil conservation in order to understand plant uptake from soil systems. Due to its reactivity to air and many other oxygen containing substances, phosphorus is not found free in nature but it is widely distributed in many different minerals.
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. Hittorf'S phosphorus
  2. Phosphorous
  3. Phosphorus-30
  4. Red phosphorus
  5. Violet phosphorus
  6. White phosphorus
Chemical Formula P
Average Molecular Weight 30.973762
Monoisotopic Molecular Weight 30.973761512
IUPAC Name phosphanylidyne
Traditional IUPAC Name phosphorus
CAS Registry Number 7723-14-0
SMILES [P]
InChI Identifier InChI=1S/P
InChI Key OAICVXFJPJFONN-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom Inorganic Compounds
Super Class Homogeneous Non-metal Compounds
Class Homogeneous Other Non-metal Compounds
Sub Class N/A
Other Descriptors
  • nonmetal atom(ChEBI)
  • pnictogen(ChEBI)
Substituents
  • N/A
Direct Parent Homogeneous Other Non-metal Compounds
Ontology
Status Detected and Quantified
Origin
  • Food
  • Drug
Biofunction
  • Essential minerals
Application Not Available
Cellular locations
  • Cytoplasm (predicted from logP)
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point 44.1 °C Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
LogP 0.3 ChemAxon
Hydrogen Acceptor Count 0 ChemAxon
Hydrogen Donor Count 0 ChemAxon
Polar Surface Area 0 A2 ChemAxon
Rotatable Bond Count 0 ChemAxon
Refractivity 5.2 ChemAxon
Polarizability 1.78 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge 0 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations
  • Cytoplasm (predicted from logP)
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Location
  • Kidney
  • Liver
  • Brain
  • Parathyroid
Pathways Not Available
Normal Concentrations
Biofluid Status Value Age Sex Condition Comments
Blood Detected and Quantified
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11900.0 (10100.0-14300.0) uM Adult (>18 years old) Both Normal Not Available
Blood Detected and Quantified
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2030.0(1390.0-2600.0) uM Newborn (0-30 days old) Both Normal Not Available
Blood Detected and Quantified
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1640.0 (1280.0-2000.0) uM Children (1-13 year old) Both Normal Not Available
Blood Detected and Quantified
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1540.0 (1050.0-2050.0) uM Adolescent (13-18 years old) Both Normal Not Available
Blood Detected and Quantified
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1035.0 (710.0-1360.0) uM Adult (>18 years old) Male Normal Not Available
Blood Detected and Quantified
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1065.0 (770.0-1360.0) uM Adult (>18 years old) Female Normal Not Available
Cerebrospinal Fluid (CSF) Detected and Quantified
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520.0 (371.0-668.0) uM Adult (>18 years old) Both Normal Not Available
Urine Detected and Quantified
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1799.76(220.62-4935.75) umol/mmol creatinine Adult (>18 years old) Both Normal by ICP MS
Urine Detected and Quantified
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1666.67-4333.33 umol/mmol creatinine Adult (>18 years old) Not Specified Normal Not Available
Urine Detected and Quantified
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2993.4 (1710.5 - 0.0) umol/mmol creatinine Adult (>18 years old) Both Normal Not Available
Urine Detected and Quantified
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1315.7 +/- 592.1 umol/mmol creatinine Children (1-13 year old) Both Normal Not Available
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Comments
Blood Detected and Quantified
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2200.00 (1400.00-3000.00) uM Adult (>18 years old) Both Glycerol intolerance syndrom Not Available
Blood Detected and Quantified
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50250.00 (500.00-100000.00) uM Adult (>18 years old) Both Glycerol intolerance syndrom Not Available
Associated Disorders and Diseases
Disease References
Glycerol intolerance syndrome
    • http://www.metagene.de/program/d.prg?mp=GLYCEROL%20INTOLERANCE%20SYNDROM
    Associated OMIM IDs None
    DrugBank ID Not Available
    Phenol Explorer Compound ID Not Available
    Phenol Explorer Metabolite ID Not Available
    FoodDB ID FDB003520
    KNApSAcK ID Not Available
    Chemspider ID 4575369 Link_out
    KEGG Compound ID C06262 Link_out
    BioCyc ID Not Available
    BiGG ID Not Available
    Wikipedia Link Phosphorus Link_out
    NuGOwiki Link HMDB01315 Link_out
    Metagene Link HMDB01315 Link_out
    METLIN ID Not Available
    PubChem Compound 5462309 Link_out
    PDB ID Not Available
    ChEBI ID 28659 Link_out
    References
    Synthesis Reference Not Available
    Material Safety Data Sheet (MSDS) Not Available
    General References
    1. Slatopolsky E, Gonzalez E, Martin K: Pathogenesis and treatment of renal osteodystrophy. Blood Purif. 2003;21(4-5):318-26. Pubmed: 12944733 Link_out
    2. Goodman WG: Calcimimetic agents and secondary hyperparathyroidism: rationale for use and results from clinical trials. Pediatr Nephrol. 2003 Dec;18(12):1206-10. Epub 2003 Oct 28. Pubmed: 14586685 Link_out
    3. Siqueira WL, de Oliveira E, Mustacchi Z, Nicolau J: Electrolyte concentrations in saliva of children aged 6-10 years with Down syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Jul;98(1):76-9. Pubmed: 15243474 Link_out
    4. Urena P, Frazao JM: Calcimimetic agents: review and perspectives. Kidney Int Suppl. 2003 Jun;(85):S91-6. Pubmed: 12753275 Link_out
    5. Pawlowska J, Matusik H, Socha P, Ismail H, Ryzko J, Karczmarewicz E, Jankowska I, Teisseyre M, Lorenc R: Beneficial effect of liver transplantation on bone mineral density in small infants with cholestasis. Transplant Proc. 2004 Jun;36(5):1479-80. Pubmed: 15251362 Link_out
    6. Obata T, Someya Y, Suhara T, Ota Y, Hirakawa K, Ikehira H, Tanada S, Okubo Y: Neural damage due to temporal lobe epilepsy: dual-nuclei (proton and phosphorus) magnetic resonance spectroscopy study. Psychiatry Clin Neurosci. 2004 Feb;58(1):48-53. Pubmed: 14678457 Link_out
    7. Gandhy M, Damle SG: Relation of salivary inorganic phosphorus and alkaline phosphatase to the dental caries status in children. J Indian Soc Pedod Prev Dent. 2003 Dec;21(4):135-8. Pubmed: 14765611 Link_out
    8. Casari S, Rossi V, Varenna M, Gasparini M, Parafioriti A, Failoni S, Sinigaglia L: A case of oncogenic osteomalacia detected by 111In-pentetreotide total body scan. Clin Exp Rheumatol. 2003 Jul-Aug;21(4):493-6. Pubmed: 12942704 Link_out
    9. Ahn JH, Yoo CI, Lee CR, Lee JH, Lee H, Kim CY, Park JK, Sakai T, Yoon CS, Kim Y: Calcification mimicking manganese-induced increased signal intensities in T1-weighted MR images in a patient taking herbal medicine: case report. Neurotoxicology. 2003 Dec;24(6):835-8. Pubmed: 14637378 Link_out
    10. Emmett M: A comparison of clinically useful phosphorus binders for patients with chronic kidney failure. Kidney Int Suppl. 2004 Sep;(90):S25-32. Pubmed: 15296504 Link_out