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Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2014-11-03 18:13:48 UTC
HMDB IDHMDB01341
Secondary Accession NumbersNone
Metabolite Identification
Common NameADP
DescriptionAdenosine diphosphate, abbreviated ADP, is a nucleotide. It is an ester of pyrophosphoric acid with the nucleotide adenine. ADP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine. ADP is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases.
Structure
Thumb
Synonyms
  1. Adenosindiphosphorsaeure
  2. Adenosine 5'-pyrophosphate
  3. Adenosine diphosphate
  4. Adenosine pyrophosphate
  5. Adenosine-5'-diphosphate
  6. Adenosine-5-diphosphate
  7. Adenosine-diphosphate
  8. ADP
Chemical FormulaC10H15N5O10P2
Average Molecular Weight427.2011
Monoisotopic Molecular Weight427.029414749
IUPAC Name[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid
Traditional Name{[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxyphosphonic acid
CAS Registry Number58-64-0
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
InChI Identifier
InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChI KeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
Chemical Taxonomy
KingdomOrganic Compounds
Super ClassNucleosides, Nucleotides, and Analogues
ClassPurine Nucleotides
Sub ClassPurine Ribonucleotides
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
  • Ribonucleotides(KEGG)
  • adenosine 5'-phosphate(ChEBI)
  • purine ribonucleoside 5'-diphosphate(ChEBI)
Substituents
  • 1,2 Diol
  • 1 Phosphoribosyl Imidazole
  • Aminopyrimidine
  • Glycosyl Compound
  • Imidazole
  • Imidazopyrimidine
  • Monosaccharide Phosphate
  • N Glycosyl Compound
  • Organic Hypophosphite
  • Organic Phosphite
  • Organic Pyrophosphate
  • Oxolane
  • Pentose Monosaccharide
  • Phosphoric Acid Ester
  • Purine
  • Pyrimidine
  • Saccharide
  • Secondary Alcohol
Direct ParentPurine Ribonucleoside Diphosphates
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Alanine and aspartate metabolism
  • Component of Aminosugars metabolism
  • Component of Arginine and proline metabolism
  • Component of C5-Branched dibasic acid metabolism
  • Component of Folate biosynthesis
  • Component of Fructose and mannose metabolism
  • Component of Galactose metabolism
  • Component of Glutamate metabolism
  • Component of Glutathione metabolism
  • Component of Glycerolipid metabolism
  • Component of Glycerophospholipid metabolism
  • Component of Glycine, serine and threonine metabolism
  • Component of Glycosphingolipid metabolism
  • Component of Glyoxylate and dicarboxylate metabolism
  • Component of Inositol phosphate metabolism
  • Component of Nicotinate and nicotinamide metabolism
  • Component of Nitrogen metabolism
  • Component of Pantothenate and CoA biosynthesis
  • Component of Peptidoglycan biosynthesis
  • Component of Propanoate metabolism
  • Component of Purine metabolism
  • Component of Pyrimidine metabolism
  • Component of Pyruvate metabolism
  • Component of Riboflavin metabolism
  • Component of Starch and sucrose metabolism
  • Component of Streptomycin biosynthesis
  • Component of Tetracycline biosynthesis
  • Component of Vitamin B6 metabolism
ApplicationNot Available
Cellular locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
Water Solubility3.27ALOGPS
logP-1.6ALOGPS
logP-5.3ChemAxon
logS-2.1ALOGPS
pKa (Strongest Acidic)1.77ChemAxon
pKa (Strongest Basic)4.99ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area232.6 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity84.94 m3·mol-1ChemAxon
Polarizability34.24 Å3ChemAxon
Spectra
SpectraMS/MSLC-MS1D NMR2D NMR
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Biofluid Locations
  • Blood
  • Cellular Cytoplasm
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue Location
  • All Tissues
Pathways
NameSMPDB LinkKEGG Link
Amino Sugar MetabolismSMP00045map00520
Ammonia RecyclingSMP00009map00910
Citric Acid CycleSMP00057map00020
Folate MetabolismSMP00053map00670
GluconeogenesisSMP00128map00010
Glycerolipid MetabolismSMP00039map00561
Glycine and Serine MetabolismSMP00004map00260
GlycolysisSMP00040map00010
Histidine MetabolismSMP00044map00340
Inositol Phosphate MetabolismSMP00462map00562
Lactose DegradationSMP00457Not Available
Lactose SynthesisSMP00444Not Available
Mitochondrial Electron Transport ChainSMP00355map00190
Phosphatidylinositol Phosphate MetabolismSMP00463map00562
Phytanic Acid Peroxisomal OxidationSMP00450Not Available
Purine MetabolismSMP00050map00230
Threonine and 2-Oxobutanoate DegradationSMP00452Not Available
Transfer of Acetyl Groups into MitochondriaSMP00466Not Available
Trehalose DegradationSMP00467Not Available
Urea CycleSMP00059map00330
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified160.0 +/- 14.0 uMAdult (>18 years old)MaleNormal
    • Geigy Scientific ...
details
Cellular CytoplasmDetected and Quantified270 (150-390) uMAdult (>18 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified1.90 +/- 0.025 uMAdult (>18 years old)BothNormal details
SalivaDetected and Quantified0.0257 +/- 0.0618 uMAdult (>18 years old)Female
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.169 +/- 0.234 uMAdult (>18 years old)Not Specified
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.207 +/- 0.324 uMAdult (>18 years old)Both
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified1.23 +/- 0.13 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified1.39 +/- 0.16 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified0.298 +/- 0.316 uMAdult (>18 years old)Female
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified1.26 +/- 0.19 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified0.317 +/- 0.491 uMAdult (>18 years old)Female
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.387 +/- 0.462 uMAdult (>18 years old)Not Specified
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.433 +/- 0.363 uMAdult (>18 years old)Both
Normal
    • Sugimoto et al. (...
details
UrineDetected and Quantified1.8 (1.0-3.4) umol/mmol creatinineAdult (>18 years old)Both
Normal
details
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
Cerebrospinal Fluid (CSF)Detected and Quantified1.10 +/- 0.60 uMAdult (>18 years old)BothRachialgia details
Cerebrospinal Fluid (CSF)Detected and Quantified0.91 +/- 0.46 uMAdult (>18 years old)BothSubarachnoid hemorrhage details
Cerebrospinal Fluid (CSF)Detected and Quantified0.63 +/- 0.37 uMAdult (>18 years old)BothEpilepsy details
Cerebrospinal Fluid (CSF)Detected and Quantified1.86 +/- 1.67 uMAdult (>18 years old)Both
Stroke
details
Cerebrospinal Fluid (CSF)Detected and Quantified1.62 +/- 0.96 uMAdult (>18 years old)BothNeuroinfection details
Associated Disorders and Diseases
Disease References
Subarachnoid hemorrhage
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662
Epilepsy
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662
Neuroinfection
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662
Rachialgia
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662
Stroke
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662
Associated OMIM IDs
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB021817
KNApSAcK IDNot Available
Chemspider ID5800
KEGG Compound IDC00008
BioCyc IDADP
BiGG ID33496
Wikipedia LinkADP
NuGOwiki LinkHMDB01341
Metagene LinkHMDB01341
METLIN ID6175
PubChem Compound6022
PDB IDADP
ChEBI ID16761
References
Synthesis ReferenceYamagata, Yukio. Prebiotic formation of ADP and ATP from AMP, calcium phosphates and cyanate in aqueous solution. Origins of Life and Evolution of the Biosphere (1999), 29(5), 511-520.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2(1):18. Pubmed: 15882454
  2. Cuisset T, Frere C, Quilici J, Barbou F, Morange PE, Hovasse T, Bonnet JL, Alessi MC: High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome. J Thromb Haemost. 2006 Mar;4(3):542-9. Epub 2005 Dec 22. Pubmed: 16371119
  3. Quinton TM, Kim S, Jin J, Kunapuli SP: Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost. 2005 May;3(5):1036-41. Pubmed: 15869601
  4. Saxena R, Gupta M, Gupta S, Kannan M, Ahmed RP, Choudhry VP: Inherited heterogenous defect in platelet aggregation selectively with ADP and epinephrine--a series of 25 cases. Indian J Pathol Microbiol. 2005 Jul;48(3):345-8. Pubmed: 16761747
  5. Corsonello A, Malara A, De Domenico D, Damiano MC, Mirone S, Loddo S, Ientile R, Corica F: Effects of magnesium sulphate on leptin-dependent platelet aggregation: an ex vivo study. Magnes Res. 2005 Mar;18(1):7-11. Pubmed: 15945611
  6. Imura Y, Stassen JM, Bunting S, Stockmans F, Collen D: Antithrombotic properties of L-cysteine, N-(mercaptoacetyl)-D-Tyr-Arg-Gly-Asp-sulfoxide (G4120) in a hamster platelet-rich femoral vein thrombosis model. Blood. 1992 Sep 1;80(5):1247-53. Pubmed: 1515641
  7. Cuisset T, Frere C, Quilici J, Morange PE, Nait-Saidi L, Carvajal J, Lehmann A, Lambert M, Bonnet JL, Alessi MC: Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting. J Am Coll Cardiol. 2006 Oct 3;48(7):1339-45. Epub 2006 Sep 12. Pubmed: 17010792
  8. Vigue C, Vigue L, Huszar G: Adenosine triphosphate (ATP) concentrations and ATP/adenosine diphosphate ratios in human sperm of normospermic, oligospermic, and asthenospermic specimens and in their swim-up fractions: lack of correlation between ATP parameters and sperm creatine kinase concentrations. J Androl. 1992 Jul-Aug;13(4):305-11. Pubmed: 1399831
  9. Smith SM, Judge HM, Peters G, Storey RF: Multiple antiplatelet effects of clopidogrel are not modulated by statin type in patients undergoing percutaneous coronary intervention. Platelets. 2004 Dec;15(8):465-74. Pubmed: 15763887
  10. Ji Q, Ghaly M, Hjemdahl P, Tornvall P, Li N: Contrast medium attenuates platelet activation and platelet-leukocyte cross-talk. Thromb Haemost. 2005 May;93(5):922-6. Pubmed: 15886810
  11. Morshedi M, Oehninger S, Blackmore P, Bocca S, Coddington C, Hodgen G: Investigation of some biochemical and functional effects of cryopreservation of human spermatozoa using an automated freezing-quick-thawing method. Int J Androl. 1995 Dec;18(6):279-86. Pubmed: 8719843
  12. Hua J, Suguro S, Iwabuchi K, Tsutsumi-Ishii Y, Sakamoto K, Nagaoka I: Glucosamine, a naturally occurring amino monosaccharide, suppresses the ADP-mediated platelet activation in humans. Inflamm Res. 2004 Dec;53(12):680-8. Pubmed: 15654516
  13. Shabanova EY, Mindukshev IV, Malakhovskaya EA, Vivulanets EV, Petrishchev NN, Krivchenko AI: Cooperative type of platelet hypersensitivity to ADP. Bull Exp Biol Med. 2005 Sep;140(3):282-4. Pubmed: 16307036

Only showing the first 50 proteins. There are 788 proteins in total.

Enzymes

General function:
Involved in ATP binding
Specific function:
Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.
Gene Name:
CMPK1
Uniprot ID:
P30085
Molecular weight:
20180.12
Reactions
Adenosine triphosphate + (d)CMP → ADP + (d)CDPdetails
Adenosine triphosphate + Uridine 5'-monophosphate → ADP + Uridine 5'-diphosphatedetails
Adenosine triphosphate + Cytidine monophosphate → ADP + CDPdetails
Adenosine triphosphate + dCMP → ADP + dCDPdetails
General function:
Involved in ATP binding
Specific function:
Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Gene Name:
DCK
Uniprot ID:
P27707
Molecular weight:
30518.315
Reactions
Adenosine triphosphate + Adenosine → ADP + Adenosine monophosphatedetails
Adenosine triphosphate + Deoxycytidine → ADP + dCMPdetails
General function:
Involved in ATP citrate synthase activity
Specific function:
ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
Gene Name:
ACLY
Uniprot ID:
P53396
Molecular weight:
120838.27
Reactions
ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic acid → Adenosine triphosphate + Citric acid + Coenzyme Adetails
Adenosine triphosphate + Citric acid + Coenzyme A → ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic aciddetails
General function:
Involved in acetyl-CoA carboxylase activity
Specific function:
ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Gene Name:
ACACB
Uniprot ID:
O00763
Molecular weight:
276538.575
Reactions
Adenosine triphosphate + Acetyl-CoA + Carbonic acid → ADP + Phosphoric acid + Malonyl-CoAdetails
Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + Phosphoric acid + carboxy-biotin-[carboxyl-carrier-protein]details
Adenosine triphosphate + Holo-[carboxylase] + Carbonic acid → ADP + Phosphoric acid + Carboxybiotin-carboxyl-carrier proteindetails
General function:
Involved in catalytic activity
Specific function:
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
Gene Name:
PC
Uniprot ID:
P11498
Molecular weight:
129632.565
Reactions
Adenosine triphosphate + Pyruvic acid + Carbonic acid → ADP + Phosphoric acid + Oxalacetic aciddetails
General function:
Involved in acetyl-CoA carboxylase activity
Specific function:
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Gene Name:
ACACA
Uniprot ID:
Q13085
Molecular weight:
269997.01
Reactions
Adenosine triphosphate + Acetyl-CoA + Carbonic acid → ADP + Phosphoric acid + Malonyl-CoAdetails
Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + Phosphoric acid + carboxy-biotin-[carboxyl-carrier-protein]details
Adenosine triphosphate + Holo-[carboxylase] + Carbonic acid → ADP + Phosphoric acid + Carboxybiotin-carboxyl-carrier proteindetails
General function:
Involved in thymidylate kinase activity
Specific function:
Catalyzes the conversion of dTMP to dTDP.
Gene Name:
DTYMK
Uniprot ID:
P23919
Molecular weight:
23819.105
Reactions
Adenosine triphosphate + 5-Thymidylic acid → ADP + dTDPdetails
Adenosine triphosphate + dUMP → ADP + dUDPdetails
General function:
Involved in hydrolase activity
Specific function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:
ENTPD1
Uniprot ID:
P49961
Molecular weight:
58706.0
Reactions
Adenosine triphosphate + Water → ADP + Phosphoric aciddetails
ADP + Water → Adenosine monophosphate + Phosphoric aciddetails
General function:
Involved in calcium ion binding
Specific function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:
CANT1
Uniprot ID:
Q8WVQ1
Molecular weight:
44839.24
General function:
Involved in hydrolase activity
Specific function:
Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:
ENTPD3
Uniprot ID:
O75355
Molecular weight:
59104.76
Reactions
Adenosine triphosphate + Water → ADP + Phosphoric aciddetails
ADP + Water → Adenosine monophosphate + Phosphoric aciddetails
General function:
Involved in arylesterase activity
Specific function:
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Gene Name:
PON3
Uniprot ID:
Q15166
Molecular weight:
39607.185
General function:
Involved in ATP binding
Specific function:
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
Gene Name:
UCK1
Uniprot ID:
Q9HA47
Molecular weight:
22760.43
Reactions
Adenosine triphosphate + Uridine → ADP + Uridine 5'-monophosphatedetails
Adenosine triphosphate + Cytidine → ADP + Cytidine monophosphatedetails
5-Fluorouridine + Adenosine triphosphate → 5-Fluorouridine monophosphate + ADPdetails
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity).
Gene Name:
NME4
Uniprot ID:
O00746
Molecular weight:
20658.45
Reactions
Adenosine triphosphate + nucleoside diphosphate → ADP + nucleoside triphosphatedetails
Adenosine triphosphate + ADP → ADP + Adenosine triphosphatedetails
Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphatedetails
Adenosine triphosphate + Guanosine diphosphate → ADP + Guanosine triphosphatedetails
Adenosine triphosphate + CDP → ADP + Cytidine triphosphatedetails
Adenosine triphosphate + IDP → ADP + Inosine triphosphatedetails
Adenosine triphosphate + dADP → ADP + Deoxyadenosine triphosphatedetails
Adenosine triphosphate + dGDP → ADP + dGTPdetails
Adenosine triphosphate + dTDP → ADP + Thymidine 5'-triphosphatedetails
Adenosine triphosphate + dCDP → ADP + dCTPdetails
Adenosine triphosphate + dUDP → ADP + Deoxyuridine triphosphatedetails
Adenosine triphosphate + dIDP → ADP + 2'-Deoxyinosine triphosphatedetails
General function:
Involved in oxidation reduction
Specific function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Gene Name:
RRM1
Uniprot ID:
P23921
Molecular weight:
90069.375
Reactions
dADP + Thioredoxin disulfide + Water → Thioredoxin + ADPdetails
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Gene Name:
NME1
Uniprot ID:
P15531
Molecular weight:
17148.635
Reactions
Adenosine triphosphate + nucleoside diphosphate → ADP + nucleoside triphosphatedetails
Adenosine triphosphate + ADP → ADP + Adenosine triphosphatedetails
Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphatedetails
Adenosine triphosphate + Guanosine diphosphate → ADP + Guanosine triphosphatedetails
Adenosine triphosphate + CDP → ADP + Cytidine triphosphatedetails
Adenosine triphosphate + IDP → ADP + Inosine triphosphatedetails
Adenosine triphosphate + dADP → ADP + Deoxyadenosine triphosphatedetails
Adenosine triphosphate + dGDP → ADP + dGTPdetails
Adenosine triphosphate + dTDP → ADP + Thymidine 5'-triphosphatedetails
Adenosine triphosphate + dCDP → ADP + dCTPdetails
Adenosine triphosphate + dUDP → ADP + Deoxyuridine triphosphatedetails
Adenosine triphosphate + dIDP → ADP + 2'-Deoxyinosine triphosphatedetails
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Gene Name:
NME7
Uniprot ID:
Q9Y5B8
Molecular weight:
42491.365
Reactions
Adenosine triphosphate + nucleoside diphosphate → ADP + nucleoside triphosphatedetails
Adenosine triphosphate + ADP → ADP + Adenosine triphosphatedetails
Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphatedetails
Adenosine triphosphate + Guanosine diphosphate → ADP + Guanosine triphosphatedetails
Adenosine triphosphate + CDP → ADP + Cytidine triphosphatedetails
Adenosine triphosphate + IDP → ADP + Inosine triphosphatedetails
Adenosine triphosphate + dADP → ADP + Deoxyadenosine triphosphatedetails
Adenosine triphosphate + dGDP → ADP + dGTPdetails
Adenosine triphosphate + dTDP → ADP + Thymidine 5'-triphosphatedetails
Adenosine triphosphate + dCDP → ADP + dCTPdetails
Adenosine triphosphate + dUDP → ADP + Deoxyuridine triphosphatedetails
Adenosine triphosphate + dIDP → ADP + 2'-Deoxyinosine triphosphatedetails
General function:
Involved in oxidoreductase activity
Specific function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Gene Name:
RRM2
Uniprot ID:
P31350
Molecular weight:
44877.25
Reactions
dADP + Thioredoxin disulfide + Water → Thioredoxin + ADPdetails
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
Gene Name:
NME2
Uniprot ID:
P22392
Molecular weight:
30136.92
Reactions
Adenosine triphosphate + nucleoside diphosphate → ADP + nucleoside triphosphatedetails
Adenosine triphosphate + protein L-histidine → ADP + protein N-phospho-L-histidinedetails
Adenosine triphosphate + ADP → ADP + Adenosine triphosphatedetails
Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphatedetails
Adenosine triphosphate + Guanosine diphosphate → ADP + Guanosine triphosphatedetails
Adenosine triphosphate + CDP → ADP + Cytidine triphosphatedetails
Adenosine triphosphate + IDP → ADP + Inosine triphosphatedetails
Adenosine triphosphate + dADP → ADP + Deoxyadenosine triphosphatedetails
Adenosine triphosphate + dGDP → ADP + dGTPdetails
Adenosine triphosphate + dTDP → ADP + Thymidine 5'-triphosphatedetails
Adenosine triphosphate + dCDP → ADP + dCTPdetails
Adenosine triphosphate + dUDP → ADP + Deoxyuridine triphosphatedetails
Adenosine triphosphate + dIDP → ADP + 2'-Deoxyinosine triphosphatedetails
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
Gene Name:
NME3
Uniprot ID:
Q13232
Molecular weight:
19014.85
Reactions
Adenosine triphosphate + nucleoside diphosphate → ADP + nucleoside triphosphatedetails
Adenosine triphosphate + ADP → ADP + Adenosine triphosphatedetails
Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphatedetails
Adenosine triphosphate + Guanosine diphosphate → ADP + Guanosine triphosphatedetails
Adenosine triphosphate + CDP → ADP + Cytidine triphosphatedetails
Adenosine triphosphate + IDP → ADP + Inosine triphosphatedetails
Adenosine triphosphate + dADP → ADP + Deoxyadenosine triphosphatedetails
Adenosine triphosphate + dGDP → ADP + dGTPdetails
Adenosine triphosphate + dTDP → ADP + Thymidine 5'-triphosphatedetails
Adenosine triphosphate + dCDP → ADP + dCTPdetails
Adenosine triphosphate + dUDP → ADP + Deoxyuridine triphosphatedetails
Adenosine triphosphate + dIDP → ADP + 2'-Deoxyinosine triphosphatedetails
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.
Gene Name:
NME6
Uniprot ID:
O75414
Molecular weight:
22002.965
Reactions
Adenosine triphosphate + nucleoside diphosphate → ADP + nucleoside triphosphatedetails
Adenosine triphosphate + ADP → ADP + Adenosine triphosphatedetails
Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphatedetails
Adenosine triphosphate + Guanosine diphosphate → ADP + Guanosine triphosphatedetails
Adenosine triphosphate + CDP → ADP + Cytidine triphosphatedetails
Adenosine triphosphate + IDP → ADP + Inosine triphosphatedetails
Adenosine triphosphate + dADP → ADP + Deoxyadenosine triphosphatedetails
Adenosine triphosphate + dGDP → ADP + dGTPdetails
Adenosine triphosphate + dTDP → ADP + Thymidine 5'-triphosphatedetails
Adenosine triphosphate + dCDP → ADP + dCTPdetails
Adenosine triphosphate + dUDP → ADP + Deoxyuridine triphosphatedetails
Adenosine triphosphate + dIDP → ADP + 2'-Deoxyinosine triphosphatedetails
General function:
Involved in ATP binding
Specific function:
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Gene Name:
GCK
Uniprot ID:
P35557
Molecular weight:
52191.07
Reactions
Adenosine triphosphate + D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + Beta-D-Glucose → ADP + Beta-D-Glucose 6-phosphatedetails
Adenosine triphosphate + Alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK3
Uniprot ID:
P52790
Molecular weight:
99024.56
Reactions
Adenosine triphosphate + D-Galactose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
Adenosine triphosphate + D-Mannose → ADP + Mannose 6-phosphatedetails
Adenosine triphosphate + Beta-D-Glucose → ADP + Beta-D-Glucose 6-phosphatedetails
Adenosine triphosphate + Alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + Glucosamine → ADP + Glucosamine 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK2
Uniprot ID:
P52789
Molecular weight:
102379.06
Reactions
Adenosine triphosphate + D-Galactose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
Adenosine triphosphate + D-Mannose → ADP + Mannose 6-phosphatedetails
Adenosine triphosphate + Beta-D-Glucose → ADP + Beta-D-Glucose 6-phosphatedetails
Adenosine triphosphate + Alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + Glucosamine → ADP + Glucosamine 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK1
Uniprot ID:
P19367
Molecular weight:
102485.1
Reactions
Adenosine triphosphate + D-Galactose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
Adenosine triphosphate + D-Mannose → ADP + Mannose 6-phosphatedetails
Adenosine triphosphate + Beta-D-Glucose → ADP + Beta-D-Glucose 6-phosphatedetails
Adenosine triphosphate + Alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + Glucosamine → ADP + Glucosamine 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
General function:
Involved in diacylglycerol kinase activity
Specific function:
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor. May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity
Gene Name:
DGKQ
Uniprot ID:
P52824
Molecular weight:
101154.0
General function:
Involved in diacylglycerol kinase activity
Specific function:
Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity
Gene Name:
DGKA
Uniprot ID:
P23743
Molecular weight:
82629.5
General function:
Involved in diacylglycerol kinase activity
Specific function:
Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis
Gene Name:
DGKD
Uniprot ID:
Q16760
Molecular weight:
134524.2
General function:
Involved in diacylglycerol kinase activity
Specific function:
Exhibits high phosphorylation activity for long-chain diacylglycerols
Gene Name:
DGKB
Uniprot ID:
Q9Y6T7
Molecular weight:
90594.7
General function:
Involved in diacylglycerol kinase activity
Specific function:
ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl- sn-glycerol 3-phosphate
Gene Name:
DGKI
Uniprot ID:
O75912
Molecular weight:
116996.2
General function:
Involved in diacylglycerol kinase activity
Specific function:
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity
Gene Name:
DGKZ
Uniprot ID:
Q13574
Molecular weight:
124127.3
General function:
Involved in ATP binding
Specific function:
Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.
Gene Name:
FUK
Uniprot ID:
Q8N0W3
Molecular weight:
117621.795
Reactions
Adenosine triphosphate + L-Fucose → ADP + Fucose 1-phosphatedetails
General function:
Involved in ligase activity
Specific function:
Not Available
Gene Name:
PCCB
Uniprot ID:
P05166
Molecular weight:
58215.13
Reactions
Adenosine triphosphate + Propionyl-CoA + Carbonic acid → ADP + Phosphoric acid + S-Methylmalonyl-CoAdetails
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
PCCA
Uniprot ID:
P05165
Molecular weight:
80058.295
Reactions
Adenosine triphosphate + Propionyl-CoA + Carbonic acid → ADP + Phosphoric acid + S-Methylmalonyl-CoAdetails
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
GART
Uniprot ID:
P22102
Molecular weight:
107766.295
Reactions
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine → ADP + Phosphoric acid + Glycineamideribotidedetails
Adenosine triphosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine → ADP + Phosphoric acid + 5-Aminoimidazole ribonucleotidedetails
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine → ADP + Phosphoric acid + Glycineamideribotidedetails
Adenosine triphosphate + Phosphoribosylformylglycineamidine → ADP + Phosphoric acid + 5-Aminoimidazole ribonucleotidedetails
General function:
Involved in ATP binding
Specific function:
Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.
Gene Name:
GNE
Uniprot ID:
Q9Y223
Molecular weight:
83065.25
Reactions
Adenosine triphosphate + N-acyl-D-mannosamine → ADP + N-acyl-D-mannosamine 6-phosphatedetails
Adenosine triphosphate + N-Acetylmannosamine → ADP + N-Acetyl-D-mannosamine 6-phosphatedetails
General function:
Involved in ATP binding
Specific function:
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
Gene Name:
PAPSS1
Uniprot ID:
O43252
Molecular weight:
70832.725
Reactions
Adenosine triphosphate + Adenosine phosphosulfate → ADP + Phosphoadenosine phosphosulfatedetails
Adenosine triphosphate + Adenylylselenate → ADP + 3-Phosphoadenylylselenatedetails
General function:
Involved in ATP binding
Specific function:
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth (By similarity).
Gene Name:
PAPSS2
Uniprot ID:
O95340
Molecular weight:
69969.8
Reactions
Adenosine triphosphate + Adenosine phosphosulfate → ADP + Phosphoadenosine phosphosulfatedetails
Adenosine triphosphate + Adenylylselenate → ADP + 3-Phosphoadenylylselenatedetails
General function:
Involved in catalytic activity
Specific function:
Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
Gene Name:
CPS1
Uniprot ID:
P31327
Molecular weight:
165649.075
Reactions
Adenosine triphosphate + Ammonia + CO(2) + Water → ADP + Phosphoric acid + Carbamoyl phosphatedetails
Adenosine triphosphate + Ammonia + Carbon dioxide + Water → ADP + Phosphoric acid + Carbamoyl phosphatedetails
General function:
Involved in phosphotransferase activity, alcohol group as acceptor
Specific function:
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).
Gene Name:
ADPGK
Uniprot ID:
Q9BRR6
Molecular weight:
53960.185
Reactions
ADP + D-Glucose → Adenosine monophosphate + Glucose 6-phosphatedetails
Alpha-D-Glucose + ADP → Glucose 6-phosphate + Adenosine monophosphatedetails
Beta-D-Glucose + ADP → Beta-D-Glucose 6-phosphate + Adenosine monophosphatedetails
General function:
Involved in ligase activity
Specific function:
Not Available
Gene Name:
MCCC2
Uniprot ID:
Q9HCC0
Molecular weight:
61332.65
Reactions
Adenosine triphosphate + 3-Methylcrotonyl-CoA + Carbonic acid → ADP + Phosphoric acid + 3-Methylglutaconyl-CoAdetails
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
MCCC1
Uniprot ID:
Q96RQ3
Molecular weight:
80472.45
Reactions
Adenosine triphosphate + 3-Methylcrotonyl-CoA + Carbonic acid → ADP + Phosphoric acid + 3-Methylglutaconyl-CoAdetails
General function:
Involved in glutamate-cysteine ligase activity
Specific function:
Not Available
Gene Name:
GCLC
Uniprot ID:
P48506
Molecular weight:
68629.42
Reactions
Adenosine triphosphate + L-Glutamic acid + L-Cysteine → ADP + Phosphoric acid + Gamma-Glutamylcysteinedetails
General function:
Involved in ATP binding
Specific function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.
Gene Name:
AK1
Uniprot ID:
P00568
Molecular weight:
21634.725
Reactions
Adenosine triphosphate + Adenosine monophosphate → ADPdetails
Adenosine triphosphate + Deoxyadenosine monophosphate → ADP + dADPdetails
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
AK3
Uniprot ID:
Q9UIJ7
Molecular weight:
21013.93
Reactions
NTP + Adenosine monophosphate → NDP + ADPdetails
Uridine triphosphate + Adenosine monophosphate → Uridine 5'-diphosphate + ADPdetails
General function:
Involved in ATP binding
Specific function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. May also be active with GTP (By similarity).
Gene Name:
AK4
Uniprot ID:
P27144
Molecular weight:
25267.83
Reactions
Adenosine triphosphate + Adenosine monophosphate → ADPdetails
Adenosine triphosphate + Deoxyadenosine monophosphate → ADP + dADPdetails
General function:
Involved in ATP binding
Specific function:
Adenylate kinase involved in maintaining ciliary structure and function (By similarity). Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP.
Gene Name:
AK7
Uniprot ID:
Q96M32
Molecular weight:
82657.68
Reactions
Adenosine triphosphate + Adenosine monophosphate → ADPdetails
Adenosine triphosphate + Deoxyadenosine monophosphate → ADP + dADPdetails
General function:
Involved in catalytic activity
Specific function:
Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues.
Gene Name:
FHIT
Uniprot ID:
P49789
Molecular weight:
16858.11
Reactions
P(1)-P(3)-bis(5'-adenosyl) triphosphate + Water → ADP + Adenosine monophosphatedetails
Diadenosine triphosphate + Water → ADP + Adenosine monophosphatedetails
General function:
Involved in thiamin diphosphokinase activity
Specific function:
Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.
Gene Name:
TPK1
Uniprot ID:
Q9H3S4
Molecular weight:
27265.05
Reactions
Adenosine triphosphate + Thiamine pyrophosphate → ADP + Thiamine triphosphatedetails
General function:
Involved in hydrolase activity
Specific function:
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
Gene Name:
NUDT9
Uniprot ID:
Q9BW91
Molecular weight:
35448.725
General function:
Involved in adenosine kinase activity
Specific function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Gene Name:
ADK
Uniprot ID:
P55263
Molecular weight:
38702.93
Reactions
Adenosine triphosphate + Adenosine → ADP + Adenosine monophosphatedetails

Transporters

General function:
Involved in ATP binding
Specific function:
Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Gene Name:
ATP7B
Uniprot ID:
P35670
Molecular weight:
157261.34
General function:
Involved in ATP binding
Specific function:
May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
Gene Name:
ATP7A
Uniprot ID:
Q04656
Molecular weight:
163372.275

Only showing the first 50 proteins. There are 788 proteins in total.