Human Metabolome Database Version 3.5

Showing metabocard for ADP (HMDB01341)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:10:21 -0700
HMDB ID HMDB01341
Secondary Accession Numbers None
Metabolite Identification
Common Name ADP
Description Adenosine diphosphate, abbreviated ADP, is a nucleotide. It is an ester of pyrophosphoric acid with the nucleotide adenine. ADP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine. ADP is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. Adenosindiphosphorsaeure
  2. Adenosine 5'-pyrophosphate
  3. Adenosine diphosphate
  4. Adenosine pyrophosphate
  5. Adenosine-5'-diphosphate
  6. Adenosine-5-diphosphate
  7. Adenosine-diphosphate
  8. ADP
Chemical Formula C10H15N5O10P2
Average Molecular Weight 427.2011
Monoisotopic Molecular Weight 427.029414749
IUPAC Name [({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid
Traditional IUPAC Name {[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxyphosphonic acid
CAS Registry Number 58-64-0
SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
InChI Identifier InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChI Key XTWYTFMLZFPYCI-KQYNXXCUSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Nucleosides, Nucleotides, and Analogues
Class Purine Nucleotides
Sub Class Purine Ribonucleotides
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
  • Ribonucleotides(KEGG)
  • adenosine 5'-phosphate(ChEBI)
  • purine ribonucleoside 5'-diphosphate(ChEBI)
Substituents
  • 1,2 Diol
  • 1 Phosphoribosyl Imidazole
  • Aminopyrimidine
  • Glycosyl Compound
  • Imidazole
  • Imidazopyrimidine
  • Monosaccharide Phosphate
  • N Glycosyl Compound
  • Organic Hypophosphite
  • Organic Phosphite
  • Organic Pyrophosphate
  • Oxolane
  • Pentose Monosaccharide
  • Phosphoric Acid Ester
  • Purine
  • Pyrimidine
  • Saccharide
  • Secondary Alcohol
Direct Parent Purine Ribonucleoside Diphosphates
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Alanine and aspartate metabolism
  • Component of Aminosugars metabolism
  • Component of Arginine and proline metabolism
  • Component of C5-Branched dibasic acid metabolism
  • Component of Folate biosynthesis
  • Component of Fructose and mannose metabolism
  • Component of Galactose metabolism
  • Component of Glutamate metabolism
  • Component of Glutathione metabolism
  • Component of Glycerolipid metabolism
  • Component of Glycerophospholipid metabolism
  • Component of Glycine, serine and threonine metabolism
  • Component of Glycosphingolipid metabolism
  • Component of Glyoxylate and dicarboxylate metabolism
  • Component of Inositol phosphate metabolism
  • Component of Nicotinate and nicotinamide metabolism
  • Component of Nitrogen metabolism
  • Component of Pantothenate and CoA biosynthesis
  • Component of Peptidoglycan biosynthesis
  • Component of Propanoate metabolism
  • Component of Purine metabolism
  • Component of Pyrimidine metabolism
  • Component of Pyruvate metabolism
  • Component of Riboflavin metabolism
  • Component of Starch and sucrose metabolism
  • Component of Streptomycin biosynthesis
  • Component of Tetracycline biosynthesis
  • Component of Vitamin B6 metabolism
Application Not Available
Cellular locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility 3.27 g/L ALOGPS
LogP -1.65 ALOGPS
LogP -5.3 ChemAxon
LogS -2.12 ALOGPS
pKa (strongest acidic) 1.77 ChemAxon
pKa (strongest basic) 4.99 ChemAxon
Hydrogen Acceptor Count 12 ChemAxon
Hydrogen Donor Count 6 ChemAxon
Polar Surface Area 232.6 A2 ChemAxon
Rotatable Bond Count 6 ChemAxon
Refractivity 84.94 ChemAxon
Polarizability 34.24 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -2 ChemAxon
Spectra
1H NMR Spectrum
MS/MS Spectrum Quattro_QQQ 10
MS/MS Spectrum Quattro_QQQ 25
MS/MS Spectrum Quattro_QQQ 40
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-QTOF (UPLC Q-Tof Premier, Waters)
[1H,1H] 2D NMR Spectrum
[1H,13C] 2D NMR Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Biofluid Locations
  • Blood
  • Cellular Cytoplasm
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Location
  • All Tissues
Pathways
Name SMPDB Link KEGG Link
Histidine Metabolism SMP00044 map00340 Link_out
Lactose Synthesis SMP00444 Not Available
Glycerolipid Metabolism SMP00039 map00561 Link_out
Ammonia Recycling SMP00009 map00910 Link_out
Glycolysis SMP00040 map00010 Link_out
Citric Acid Cycle SMP00057 map00020 Link_out
Gluconeogenesis SMP00128 map00010 Link_out
Purine Metabolism SMP00050 map00230 Link_out
Urea Cycle SMP00059 map00330 Link_out
Mitochondrial Electron Transport Chain SMP00355 map00190 Link_out
Phytanic Acid Peroxisomal Oxidation SMP00450 Not Available
Threonine and 2-Oxobutanoate Degradation SMP00452 Not Available
Lactose Degradation SMP00457 Not Available
Inositol Phosphate Metabolism SMP00462 map00562 Link_out
Phosphatidylinositol Phosphate Metabolism SMP00463 map00562 Link_out
Transfer of Acetyl Groups into Mitochondria SMP00466 Not Available
Trehalose Degradation SMP00467 Not Available
Amino Sugar Metabolism SMP00045 map00520 Link_out
Glycine and Serine Metabolism SMP00004 map00260 Link_out
Folate Metabolism SMP00053 map00670 Link_out
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
160.0 +/- 14.0 uM Adult (>18 years old) Male Normal
  • Geigy Scient...
Cellular Cytoplasm Detected and Quantified
270 (150-390) uM Adult (>18 years old) Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
1.90 +/- 0.025 uM Adult (>18 years old) Both Normal
Urine Detected and Quantified
1.8 (1.0-3.4) umol/mmol creatinine Adult (>18 years old) Both Comment Normal
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Cerebrospinal Fluid (CSF) Detected and Quantified 1.10 +/- 0.60 uM Adult (>18 years old) Both Rachialgia
Cerebrospinal Fluid (CSF) Detected and Quantified 0.91 +/- 0.46 uM Adult (>18 years old) Both Subarachnoid hemorrhage
Cerebrospinal Fluid (CSF) Detected and Quantified 0.63 +/- 0.37 uM Adult (>18 years old) Both Epilepsy
Cerebrospinal Fluid (CSF) Detected and Quantified 1.86 +/- 1.67 uM Adult (>18 years old) Both Comment Stroke
Cerebrospinal Fluid (CSF) Detected and Quantified 1.62 +/- 0.96 uM Adult (>18 years old) Both Neuroinfection
Associated Disorders and Diseases
Disease References
Rachialgia
  • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
      Subarachnoid hemorrhage
      • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
          Epilepsy
          • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
              Stroke
              • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
                  Neuroinfection
                  • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
                      Associated OMIM IDs
                      DrugBank ID Not Available
                      DrugBank Metabolite ID Not Available
                      Phenol Explorer Compound ID Not Available
                      Phenol Explorer Metabolite ID Not Available
                      FoodDB ID FDB021817
                      KNApSAcK ID Not Available
                      Chemspider ID 5800 Link_out
                      KEGG Compound ID C00008 Link_out
                      BioCyc ID ADP Link_out
                      BiGG ID 33496 Link_out
                      Wikipedia Link ADP Link_out
                      NuGOwiki Link HMDB01341 Link_out
                      Metagene Link HMDB01341 Link_out
                      METLIN ID 6175 Link_out
                      PubChem Compound 6022 Link_out
                      PDB ID ADP Link_out
                      ChEBI ID 16761 Link_out
                      References
                      Synthesis Reference Yamagata, Yukio. Prebiotic formation of ADP and ATP from AMP, calcium phosphates and cyanate in aqueous solution. Origins of Life and Evolution of the Biosphere (1999), 29(5), 511-520.
                      Material Safety Data Sheet (MSDS) Download (PDF)
                      General References
                      1. Quinton TM, Kim S, Jin J, Kunapuli SP: Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost. 2005 May;3(5):1036-41. Pubmed: 15869601 Link_out
                      2. Saxena R, Gupta M, Gupta S, Kannan M, Ahmed RP, Choudhry VP: Inherited heterogenous defect in platelet aggregation selectively with ADP and epinephrine--a series of 25 cases. Indian J Pathol Microbiol. 2005 Jul;48(3):345-8. Pubmed: 16761747 Link_out
                      3. Corsonello A, Malara A, De Domenico D, Damiano MC, Mirone S, Loddo S, Ientile R, Corica F: Effects of magnesium sulphate on leptin-dependent platelet aggregation: an ex vivo study. Magnes Res. 2005 Mar;18(1):7-11. Pubmed: 15945611 Link_out
                      4. Cuisset T, Frere C, Quilici J, Barbou F, Morange PE, Hovasse T, Bonnet JL, Alessi MC: High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome. J Thromb Haemost. 2006 Mar;4(3):542-9. Epub 2005 Dec 22. Pubmed: 16371119 Link_out
                      5. Imura Y, Stassen JM, Bunting S, Stockmans F, Collen D: Antithrombotic properties of L-cysteine, N-(mercaptoacetyl)-D-Tyr-Arg-Gly-Asp-sulfoxide (G4120) in a hamster platelet-rich femoral vein thrombosis model. Blood. 1992 Sep 1;80(5):1247-53. Pubmed: 1515641 Link_out
                      6. Cuisset T, Frere C, Quilici J, Morange PE, Nait-Saidi L, Carvajal J, Lehmann A, Lambert M, Bonnet JL, Alessi MC: Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting. J Am Coll Cardiol. 2006 Oct 3;48(7):1339-45. Epub 2006 Sep 12. Pubmed: 17010792 Link_out
                      7. Vigue C, Vigue L, Huszar G: Adenosine triphosphate (ATP) concentrations and ATP/adenosine diphosphate ratios in human sperm of normospermic, oligospermic, and asthenospermic specimens and in their swim-up fractions: lack of correlation between ATP parameters and sperm creatine kinase concentrations. J Androl. 1992 Jul-Aug;13(4):305-11. Pubmed: 1399831 Link_out
                      8. Smith SM, Judge HM, Peters G, Storey RF: Multiple antiplatelet effects of clopidogrel are not modulated by statin type in patients undergoing percutaneous coronary intervention. Platelets. 2004 Dec;15(8):465-74. Pubmed: 15763887 Link_out
                      9. Ji Q, Ghaly M, Hjemdahl P, Tornvall P, Li N: Contrast medium attenuates platelet activation and platelet-leukocyte cross-talk. Thromb Haemost. 2005 May;93(5):922-6. Pubmed: 15886810 Link_out
                      10. Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2(1):18. Pubmed: 15882454 Link_out
                      11. Morshedi M, Oehninger S, Blackmore P, Bocca S, Coddington C, Hodgen G: Investigation of some biochemical and functional effects of cryopreservation of human spermatozoa using an automated freezing-quick-thawing method. Int J Androl. 1995 Dec;18(6):279-86. Pubmed: 8719843 Link_out
                      12. Hua J, Suguro S, Iwabuchi K, Tsutsumi-Ishii Y, Sakamoto K, Nagaoka I: Glucosamine, a naturally occurring amino monosaccharide, suppresses the ADP-mediated platelet activation in humans. Inflamm Res. 2004 Dec;53(12):680-8. Pubmed: 15654516 Link_out
                      13. Shabanova EY, Mindukshev IV, Malakhovskaya EA, Vivulanets EV, Petrishchev NN, Krivchenko AI: Cooperative type of platelet hypersensitivity to ADP. Bull Exp Biol Med. 2005 Sep;140(3):282-4. Pubmed: 16307036 Link_out

                      Enzymes

                      Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 786 enzymes in total.

                      Name: UMP-CMP kinase
                      Reactions:
                      Adenosine triphosphate + (d)CMP unknown ADP + (d)CDP details
                      Adenosine triphosphate + Uridine 5'-monophosphate unknown ADP + Uridine 5'-diphosphate details
                      Adenosine triphosphate + Cytidine monophosphate unknown ADP + CDP details
                      Adenosine triphosphate + dCMP unknown ADP + dCDP details
                      Gene Name: CMPK1
                      Uniprot ID: P30085 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Deoxycytidine kinase
                      Reactions:
                      Adenosine triphosphate + Adenosine unknown ADP + Adenosine monophosphate details
                      Adenosine triphosphate + Deoxycytidine unknown ADP + dCMP details
                      Gene Name: DCK
                      Uniprot ID: P27707 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: ATP-citrate synthase
                      Reactions:
                      ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic acid unknown Adenosine triphosphate + Citric acid + Coenzyme A details
                      Adenosine triphosphate + Citric acid + Coenzyme A unknown ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic acid details
                      Gene Name: ACLY
                      Uniprot ID: P53396 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Acetyl-CoA carboxylase 2
                      Reactions:
                      Adenosine triphosphate + Acetyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + Malonyl-CoA details
                      Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + CO(2) unknown ADP + Phosphoric acid + carboxy-biotin-[carboxyl-carrier-protein] details
                      Adenosine triphosphate + Holo-[carboxylase] + Carbonic acid unknown ADP + Phosphoric acid + Carboxybiotin-carboxyl-carrier protein details
                      Gene Name: ACACB
                      Uniprot ID: O00763 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Pyruvate carboxylase, mitochondrial
                      Reactions:
                      Adenosine triphosphate + Pyruvic acid + Carbonic acid unknown ADP + Phosphoric acid + Oxalacetic acid details
                      Gene Name: PC
                      Uniprot ID: P11498 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Acetyl-CoA carboxylase 1
                      Reactions:
                      Adenosine triphosphate + Acetyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + Malonyl-CoA details
                      Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + CO(2) unknown ADP + Phosphoric acid + carboxy-biotin-[carboxyl-carrier-protein] details
                      Adenosine triphosphate + Holo-[carboxylase] + Carbonic acid unknown ADP + Phosphoric acid + Carboxybiotin-carboxyl-carrier protein details
                      Gene Name: ACACA
                      Uniprot ID: Q13085 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Thymidylate kinase
                      Reactions:
                      Adenosine triphosphate + 5-Thymidylic acid unknown ADP + dTDP details
                      Adenosine triphosphate + dUMP unknown ADP + dUDP details
                      Gene Name: DTYMK
                      Uniprot ID: P23919 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Ectonucleoside triphosphate diphosphohydrolase 1
                      Reactions:
                      Adenosine triphosphate + Water unknown ADP + Phosphoric acid details
                      ADP + Water unknown Adenosine monophosphate + Phosphoric acid details
                      Gene Name: ENTPD1
                      Uniprot ID: P49961 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Soluble calcium-activated nucleotidase 1
                      Reactions: Not Available
                      Gene Name: CANT1
                      Uniprot ID: Q8WVQ1 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Ectonucleoside triphosphate diphosphohydrolase 3
                      Reactions:
                      Adenosine triphosphate + Water unknown ADP + Phosphoric acid details
                      ADP + Water unknown Adenosine monophosphate + Phosphoric acid details
                      Gene Name: ENTPD3
                      Uniprot ID: O75355 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Serum paraoxonase/lactonase 3
                      Reactions: Not Available
                      Gene Name: PON3
                      Uniprot ID: Q15166 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Uridine-cytidine kinase 1
                      Reactions:
                      Adenosine triphosphate + Uridine unknown ADP + Uridine 5'-monophosphate details
                      Adenosine triphosphate + Cytidine unknown ADP + Cytidine monophosphate details
                      5-Fluorouridine + Adenosine triphosphate unknown 5-Fluorouridine monophosphate + ADP details
                      Gene Name: UCK1
                      Uniprot ID: Q9HA47 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase, mitochondrial
                      Reactions:
                      Adenosine triphosphate + nucleoside diphosphate unknown ADP + nucleoside triphosphate details
                      Adenosine triphosphate + ADP unknown ADP + Adenosine triphosphate details
                      Adenosine triphosphate + Uridine 5'-diphosphate unknown ADP + Uridine triphosphate details
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Adenosine triphosphate + CDP unknown ADP + Cytidine triphosphate details
                      Adenosine triphosphate + IDP unknown ADP + Inosine triphosphate details
                      Adenosine triphosphate + dADP unknown ADP + Deoxyadenosine triphosphate details
                      Adenosine triphosphate + dGDP unknown ADP + dGTP details
                      Adenosine triphosphate + dTDP unknown ADP + Thymidine 5'-triphosphate details
                      Adenosine triphosphate + dCDP unknown ADP + dCTP details
                      Adenosine triphosphate + dUDP unknown ADP + Deoxyuridine triphosphate details
                      Adenosine triphosphate + dIDP unknown ADP + 2'-Deoxyinosine triphosphate details
                      Gene Name: NME4
                      Uniprot ID: O00746 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Ribonucleoside-diphosphate reductase large subunit
                      Reactions:
                      dADP + Thioredoxin disulfide + Water unknown Thioredoxin + ADP details
                      Gene Name: RRM1
                      Uniprot ID: P23921 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase A
                      Reactions:
                      Adenosine triphosphate + nucleoside diphosphate unknown ADP + nucleoside triphosphate details
                      Adenosine triphosphate + ADP unknown ADP + Adenosine triphosphate details
                      Adenosine triphosphate + Uridine 5'-diphosphate unknown ADP + Uridine triphosphate details
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Adenosine triphosphate + CDP unknown ADP + Cytidine triphosphate details
                      Adenosine triphosphate + IDP unknown ADP + Inosine triphosphate details
                      Adenosine triphosphate + dADP unknown ADP + Deoxyadenosine triphosphate details
                      Adenosine triphosphate + dGDP unknown ADP + dGTP details
                      Adenosine triphosphate + dTDP unknown ADP + Thymidine 5'-triphosphate details
                      Adenosine triphosphate + dCDP unknown ADP + dCTP details
                      Adenosine triphosphate + dUDP unknown ADP + Deoxyuridine triphosphate details
                      Adenosine triphosphate + dIDP unknown ADP + 2'-Deoxyinosine triphosphate details
                      Gene Name: NME1
                      Uniprot ID: P15531 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase 7
                      Reactions:
                      Adenosine triphosphate + nucleoside diphosphate unknown ADP + nucleoside triphosphate details
                      Adenosine triphosphate + ADP unknown ADP + Adenosine triphosphate details
                      Adenosine triphosphate + Uridine 5'-diphosphate unknown ADP + Uridine triphosphate details
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Adenosine triphosphate + CDP unknown ADP + Cytidine triphosphate details
                      Adenosine triphosphate + IDP unknown ADP + Inosine triphosphate details
                      Adenosine triphosphate + dADP unknown ADP + Deoxyadenosine triphosphate details
                      Adenosine triphosphate + dGDP unknown ADP + dGTP details
                      Adenosine triphosphate + dTDP unknown ADP + Thymidine 5'-triphosphate details
                      Adenosine triphosphate + dCDP unknown ADP + dCTP details
                      Adenosine triphosphate + dUDP unknown ADP + Deoxyuridine triphosphate details
                      Adenosine triphosphate + dIDP unknown ADP + 2'-Deoxyinosine triphosphate details
                      Gene Name: NME7
                      Uniprot ID: Q9Y5B8 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Ribonucleoside-diphosphate reductase subunit M2
                      Reactions:
                      dADP + Thioredoxin disulfide + Water unknown Thioredoxin + ADP details
                      Gene Name: RRM2
                      Uniprot ID: P31350 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase B
                      Reactions:
                      Adenosine triphosphate + nucleoside diphosphate unknown ADP + nucleoside triphosphate details
                      Adenosine triphosphate + protein L-histidine unknown ADP + protein N-phospho-L-histidine details
                      Adenosine triphosphate + ADP unknown ADP + Adenosine triphosphate details
                      Adenosine triphosphate + Uridine 5'-diphosphate unknown ADP + Uridine triphosphate details
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Adenosine triphosphate + CDP unknown ADP + Cytidine triphosphate details
                      Adenosine triphosphate + IDP unknown ADP + Inosine triphosphate details
                      Adenosine triphosphate + dADP unknown ADP + Deoxyadenosine triphosphate details
                      Adenosine triphosphate + dGDP unknown ADP + dGTP details
                      Adenosine triphosphate + dTDP unknown ADP + Thymidine 5'-triphosphate details
                      Adenosine triphosphate + dCDP unknown ADP + dCTP details
                      Adenosine triphosphate + dUDP unknown ADP + Deoxyuridine triphosphate details
                      Adenosine triphosphate + dIDP unknown ADP + 2'-Deoxyinosine triphosphate details
                      Gene Name: NME2
                      Uniprot ID: P22392 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase 3
                      Reactions:
                      Adenosine triphosphate + nucleoside diphosphate unknown ADP + nucleoside triphosphate details
                      Adenosine triphosphate + ADP unknown ADP + Adenosine triphosphate details
                      Adenosine triphosphate + Uridine 5'-diphosphate unknown ADP + Uridine triphosphate details
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Adenosine triphosphate + CDP unknown ADP + Cytidine triphosphate details
                      Adenosine triphosphate + IDP unknown ADP + Inosine triphosphate details
                      Adenosine triphosphate + dADP unknown ADP + Deoxyadenosine triphosphate details
                      Adenosine triphosphate + dGDP unknown ADP + dGTP details
                      Adenosine triphosphate + dTDP unknown ADP + Thymidine 5'-triphosphate details
                      Adenosine triphosphate + dCDP unknown ADP + dCTP details
                      Adenosine triphosphate + dUDP unknown ADP + Deoxyuridine triphosphate details
                      Adenosine triphosphate + dIDP unknown ADP + 2'-Deoxyinosine triphosphate details
                      Gene Name: NME3
                      Uniprot ID: Q13232 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase 6
                      Reactions:
                      Adenosine triphosphate + nucleoside diphosphate unknown ADP + nucleoside triphosphate details
                      Adenosine triphosphate + ADP unknown ADP + Adenosine triphosphate details
                      Adenosine triphosphate + Uridine 5'-diphosphate unknown ADP + Uridine triphosphate details
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Adenosine triphosphate + CDP unknown ADP + Cytidine triphosphate details
                      Adenosine triphosphate + IDP unknown ADP + Inosine triphosphate details
                      Adenosine triphosphate + dADP unknown ADP + Deoxyadenosine triphosphate details
                      Adenosine triphosphate + dGDP unknown ADP + dGTP details
                      Adenosine triphosphate + dTDP unknown ADP + Thymidine 5'-triphosphate details
                      Adenosine triphosphate + dCDP unknown ADP + dCTP details
                      Adenosine triphosphate + dUDP unknown ADP + Deoxyuridine triphosphate details
                      Adenosine triphosphate + dIDP unknown ADP + 2'-Deoxyinosine triphosphate details
                      Gene Name: NME6
                      Uniprot ID: O75414 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Glucokinase
                      Reactions:
                      Adenosine triphosphate + D-Glucose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + Beta-D-Glucose unknown ADP + Beta-D-Glucose 6-phosphate details
                      Adenosine triphosphate + Alpha-D-Glucose unknown ADP + Glucose 6-phosphate details
                      Gene Name: GCK
                      Uniprot ID: P35557 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Hexokinase-3
                      Reactions:
                      Adenosine triphosphate + D-Galactose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + D-Glucose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + D-Fructose unknown ADP + Beta-D-Fructose 6-phosphate details
                      Adenosine triphosphate + D-Mannose unknown ADP + Mannose 6-phosphate details
                      Adenosine triphosphate + Beta-D-Glucose unknown ADP + Beta-D-Glucose 6-phosphate details
                      Adenosine triphosphate + Alpha-D-Glucose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + Glucosamine unknown ADP + Glucosamine 6-phosphate details
                      Adenosine triphosphate + D-Fructose unknown ADP + Beta-D-Fructose 6-phosphate details
                      Gene Name: HK3
                      Uniprot ID: P52790 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Hexokinase-2
                      Reactions:
                      Adenosine triphosphate + D-Galactose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + D-Glucose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + D-Fructose unknown ADP + Beta-D-Fructose 6-phosphate details
                      Adenosine triphosphate + D-Mannose unknown ADP + Mannose 6-phosphate details
                      Adenosine triphosphate + Beta-D-Glucose unknown ADP + Beta-D-Glucose 6-phosphate details
                      Adenosine triphosphate + Alpha-D-Glucose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + Glucosamine unknown ADP + Glucosamine 6-phosphate details
                      Adenosine triphosphate + D-Fructose unknown ADP + Beta-D-Fructose 6-phosphate details
                      Gene Name: HK2
                      Uniprot ID: P52789 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Hexokinase-1
                      Reactions:
                      Adenosine triphosphate + D-Galactose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + D-Glucose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + D-Fructose unknown ADP + Beta-D-Fructose 6-phosphate details
                      Adenosine triphosphate + D-Mannose unknown ADP + Mannose 6-phosphate details
                      Adenosine triphosphate + Beta-D-Glucose unknown ADP + Beta-D-Glucose 6-phosphate details
                      Adenosine triphosphate + Alpha-D-Glucose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + Glucosamine unknown ADP + Glucosamine 6-phosphate details
                      Adenosine triphosphate + D-Fructose unknown ADP + Beta-D-Fructose 6-phosphate details
                      Gene Name: HK1
                      Uniprot ID: P19367 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Diacylglycerol kinase theta
                      Reactions: Not Available
                      Gene Name: DGKQ
                      Uniprot ID: P52824 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Diacylglycerol kinase alpha
                      Reactions: Not Available
                      Gene Name: DGKA
                      Uniprot ID: P23743 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Diacylglycerol kinase delta
                      Reactions: Not Available
                      Gene Name: DGKD
                      Uniprot ID: Q16760 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Diacylglycerol kinase beta
                      Reactions: Not Available
                      Gene Name: DGKB
                      Uniprot ID: Q9Y6T7 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Diacylglycerol kinase iota
                      Reactions: Not Available
                      Gene Name: DGKI
                      Uniprot ID: O75912 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Diacylglycerol kinase zeta
                      Reactions: Not Available
                      Gene Name: DGKZ
                      Uniprot ID: Q13574 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: L-fucose kinase
                      Reactions:
                      Adenosine triphosphate + L-Fucose unknown ADP + Fucose 1-phosphate details
                      Gene Name: FUK
                      Uniprot ID: Q8N0W3 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Propionyl-CoA carboxylase beta chain, mitochondrial
                      Reactions:
                      Adenosine triphosphate + Propionyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + S-Methylmalonyl-CoA details
                      Gene Name: PCCB
                      Uniprot ID: P05166 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Propionyl-CoA carboxylase alpha chain, mitochondrial
                      Reactions:
                      Adenosine triphosphate + Propionyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + S-Methylmalonyl-CoA details
                      Gene Name: PCCA
                      Uniprot ID: P05165 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Trifunctional purine biosynthetic protein adenosine-3
                      Reactions:
                      Adenosine triphosphate + 5-Phosphoribosylamine + Glycine unknown ADP + Phosphoric acid + Glycineamideribotide details
                      Adenosine triphosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine unknown ADP + Phosphoric acid + 5-Aminoimidazole ribonucleotide details
                      Adenosine triphosphate + 5-Phosphoribosylamine + Glycine unknown ADP + Phosphoric acid + Glycineamideribotide details
                      Adenosine triphosphate + Phosphoribosylformylglycineamidine unknown ADP + Phosphoric acid + 5-Aminoimidazole ribonucleotide details
                      Gene Name: GART
                      Uniprot ID: P22102 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
                      Reactions:
                      Adenosine triphosphate + N-acyl-D-mannosamine unknown ADP + N-acyl-D-mannosamine 6-phosphate details
                      Adenosine triphosphate + N-Acetylmannosamine unknown ADP + N-Acetyl-D-mannosamine 6-phosphate details
                      Gene Name: GNE
                      Uniprot ID: Q9Y223 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
                      Reactions:
                      Adenosine triphosphate + Adenosine phosphosulfate unknown ADP + Phosphoadenosine phosphosulfate details
                      Adenosine triphosphate + Adenylylselenate unknown ADP + 3-Phosphoadenylylselenate details
                      Gene Name: PAPSS1
                      Uniprot ID: O43252 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
                      Reactions:
                      Adenosine triphosphate + Adenosine phosphosulfate unknown ADP + Phosphoadenosine phosphosulfate details
                      Adenosine triphosphate + Adenylylselenate unknown ADP + 3-Phosphoadenylylselenate details
                      Gene Name: PAPSS2
                      Uniprot ID: O95340 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Carbamoyl-phosphate synthase [ammonia], mitochondrial
                      Reactions:
                      Adenosine triphosphate + Ammonia + CO(2) + Water unknown ADP + Phosphoric acid + Carbamoyl phosphate details
                      Adenosine triphosphate + Ammonia + Carbon dioxide + Water unknown ADP + Phosphoric acid + Carbamoyl phosphate details
                      Gene Name: CPS1
                      Uniprot ID: P31327 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: ADP-dependent glucokinase
                      Reactions:
                      ADP + D-Glucose unknown Adenosine monophosphate + Glucose 6-phosphate details
                      Alpha-D-Glucose + ADP unknown Glucose 6-phosphate + Adenosine monophosphate details
                      Beta-D-Glucose + ADP unknown Beta-D-Glucose 6-phosphate + Adenosine monophosphate details
                      Gene Name: ADPGK
                      Uniprot ID: Q9BRR6 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
                      Reactions:
                      Adenosine triphosphate + 3-Methylcrotonyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + 3-Methylglutaconyl-CoA details
                      Gene Name: MCCC2
                      Uniprot ID: Q9HCC0 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
                      Reactions:
                      Adenosine triphosphate + 3-Methylcrotonyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + 3-Methylglutaconyl-CoA details
                      Gene Name: MCCC1
                      Uniprot ID: Q96RQ3 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Glutamate--cysteine ligase catalytic subunit
                      Reactions:
                      Adenosine triphosphate + L-Glutamic acid + L-Cysteine unknown ADP + Phosphoric acid + Gamma-Glutamylcysteine details
                      Gene Name: GCLC
                      Uniprot ID: P48506 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylate kinase isoenzyme 1
                      Reactions:
                      Adenosine triphosphate + Adenosine monophosphate unknown ADP details
                      Adenosine triphosphate + Deoxyadenosine monophosphate unknown ADP + dADP details
                      Gene Name: AK1
                      Uniprot ID: P00568 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: GTP:AMP phosphotransferase, mitochondrial
                      Reactions:
                      NTP + Adenosine monophosphate unknown NDP + ADP details
                      Uridine triphosphate + Adenosine monophosphate unknown Uridine 5'-diphosphate + ADP details
                      Gene Name: AK3
                      Uniprot ID: Q9UIJ7 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylate kinase isoenzyme 4, mitochondrial
                      Reactions:
                      Adenosine triphosphate + Adenosine monophosphate unknown ADP details
                      Adenosine triphosphate + Deoxyadenosine monophosphate unknown ADP + dADP details
                      Gene Name: AK4
                      Uniprot ID: P27144 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylate kinase 7
                      Reactions:
                      Adenosine triphosphate + Adenosine monophosphate unknown ADP details
                      Adenosine triphosphate + Deoxyadenosine monophosphate unknown ADP + dADP details
                      Gene Name: AK7
                      Uniprot ID: Q96M32 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Bis(5'-adenosyl)-triphosphatase
                      Reactions:
                      P(1)-P(3)-bis(5'-adenosyl) triphosphate + Water unknown ADP + Adenosine monophosphate details
                      Diadenosine triphosphate + Water unknown ADP + Adenosine monophosphate details
                      Gene Name: FHIT
                      Uniprot ID: P49789 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Thiamin pyrophosphokinase 1
                      Reactions:
                      Adenosine triphosphate + Thiamine pyrophosphate unknown ADP + Thiamine triphosphate details
                      Gene Name: TPK1
                      Uniprot ID: Q9H3S4 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: ADP-ribose pyrophosphatase, mitochondrial
                      Reactions: Not Available
                      Gene Name: NUDT9
                      Uniprot ID: Q9BW91 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenosine kinase
                      Reactions:
                      Adenosine triphosphate + Adenosine unknown ADP + Adenosine monophosphate details
                      Gene Name: ADK
                      Uniprot ID: P55263 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Transporters
                      Name: Copper-transporting ATPase 2
                      Reactions: Not Available
                      Gene Name: ATP7B
                      Uniprot ID: P35670 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Copper-transporting ATPase 1
                      Reactions: Not Available
                      Gene Name: ATP7A
                      Uniprot ID: Q04656 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA