Showing metabocard for ADP (HMDB01341)

General function:

Involved in ATP binding

Specific function:

Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.

Gene Name:

CMPK1

Uniprot ID:

P30085

Molecular weight:

20180.12

Reactions

General function:

Involved in ATP binding

Specific function:

Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

Gene Name:

DCK

Uniprot ID:

P27707

Molecular weight:

30518.315

Reactions

General function:

Involved in ATP citrate synthase activity

Specific function:

ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.

Gene Name:

ACLY

Uniprot ID:

P53396

Molecular weight:

120838.27

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Gene Name:

ACACB

Uniprot ID:

O00763

Molecular weight:

276538.575

Reactions

General function:

Involved in catalytic activity

Specific function:

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.

Gene Name:

PC

Uniprot ID:

P11498

Molecular weight:

129632.565

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Gene Name:

ACACA

Uniprot ID:

Q13085

Molecular weight:

269997.01

Reactions

General function:

Involved in thymidylate kinase activity

Specific function:

Catalyzes the conversion of dTMP to dTDP.

Gene Name:

DTYMK

Uniprot ID:

P23919

Molecular weight:

23819.105

Reactions

General function:

Involved in hydrolase activity

Specific function:

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Gene Name:

ENTPD1

Uniprot ID:

P49961

Molecular weight:

58706.0

Reactions

General function:

Involved in calcium ion binding

Specific function:

Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.

Gene Name:

CANT1

Uniprot ID:

Q8WVQ1

Molecular weight:

44839.24

General function:

Involved in hydrolase activity

Specific function:

Has a threefold preference for the hydrolysis of ATP over ADP.

Gene Name:

ENTPD3

Uniprot ID:

O75355

Molecular weight:

59104.76

Reactions

General function:

Involved in arylesterase activity

Specific function:

Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.

Gene Name:

PON3

Uniprot ID:

Q15166

Molecular weight:

39607.185

General function:

Involved in ATP binding

Specific function:

Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.

Gene Name:

UCK1

Uniprot ID:

Q9HA47

Molecular weight:

22760.43

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity).

Gene Name:

NME4

Uniprot ID:

O00746

Molecular weight:

20658.45

Reactions

General function:

Involved in oxidation reduction

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Gene Name:

RRM1

Uniprot ID:

P23921

Molecular weight:

90069.375

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.

Gene Name:

NME1

Uniprot ID:

P15531

Molecular weight:

17148.635

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Gene Name:

NME7

Uniprot ID:

Q9Y5B8

Molecular weight:

42491.365

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.

Gene Name:

RRM2

Uniprot ID:

P31350

Molecular weight:

44877.25

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.

Gene Name:

NME2

Uniprot ID:

P22392

Molecular weight:

30136.92

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.

Gene Name:

NME3

Uniprot ID:

Q13232

Molecular weight:

19014.85

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

Gene Name:

NME6

Uniprot ID:

O75414

Molecular weight:

22002.965

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.

Gene Name:

GCK

Uniprot ID:

P35557

Molecular weight:

52191.07

Reactions

General function:

Involved in ATP binding

Specific function:

Not Available

Gene Name:

HK3

Uniprot ID:

P52790

Molecular weight:

99024.56

Reactions

General function:

Involved in ATP binding

Specific function:

Not Available

Gene Name:

HK2

Uniprot ID:

P52789

Molecular weight:

102379.06

Reactions

General function:

Involved in ATP binding

Specific function:

Not Available

Gene Name:

HK1

Uniprot ID:

P19367

Molecular weight:

102485.1

Reactions

General function:

Involved in diacylglycerol kinase activity

Specific function:

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor. May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity

Gene Name:

DGKQ

Uniprot ID:

P52824

Molecular weight:

101154.0

General function:

Involved in diacylglycerol kinase activity

Specific function:

Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity

Gene Name:

DGKA

Uniprot ID:

P23743

Molecular weight:

82629.5

General function:

Involved in diacylglycerol kinase activity

Specific function:

Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis

Gene Name:

DGKD

Uniprot ID:

Q16760

Molecular weight:

134524.2

General function:

Involved in diacylglycerol kinase activity

Specific function:

Exhibits high phosphorylation activity for long-chain diacylglycerols

Gene Name:

DGKB

Uniprot ID:

Q9Y6T7

Molecular weight:

90594.7

General function:

Involved in diacylglycerol kinase activity

Specific function:

ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl- sn-glycerol 3-phosphate

Gene Name:

DGKI

Uniprot ID:

O75912

Molecular weight:

116996.2

General function:

Involved in diacylglycerol kinase activity

Specific function:

Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity

Gene Name:

DGKZ

Uniprot ID:

Q13574

Molecular weight:

124127.3

General function:

Involved in ATP binding

Specific function:

Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.

Gene Name:

FUK

Uniprot ID:

Q8N0W3

Molecular weight:

117621.795

Reactions

General function:

Involved in ligase activity

Specific function:

Not Available

Gene Name:

PCCB

Uniprot ID:

P05166

Molecular weight:

58215.13

Reactions

General function:

Involved in catalytic activity

Specific function:

Not Available

Gene Name:

PCCA

Uniprot ID:

P05165

Molecular weight:

80058.295

Reactions

General function:

Involved in catalytic activity

Specific function:

Not Available

Gene Name:

GART

Uniprot ID:

P22102

Molecular weight:

107766.295

Reactions

General function:

Involved in ATP binding

Specific function:

Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.

Gene Name:

GNE

Uniprot ID:

Q9Y223

Molecular weight:

83065.25

Reactions

General function:

Involved in ATP binding

Specific function:

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.

Gene Name:

PAPSS1

Uniprot ID:

O43252

Molecular weight:

70832.725

Reactions

General function:

Involved in ATP binding

Specific function:

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth (By similarity).

Gene Name:

PAPSS2

Uniprot ID:

O95340

Molecular weight:

69969.8

Reactions

General function:

Involved in catalytic activity

Specific function:

Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.

Gene Name:

CPS1

Uniprot ID:

P31327

Molecular weight:

165649.075

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).

Gene Name:

ADPGK

Uniprot ID:

Q9BRR6

Molecular weight:

53960.185

Reactions

General function:

Involved in ligase activity

Specific function:

Not Available

Gene Name:

MCCC2

Uniprot ID:

Q9HCC0

Molecular weight:

61332.65

Reactions

General function:

Involved in catalytic activity

Specific function:

Not Available

Gene Name:

MCCC1

Uniprot ID:

Q96RQ3

Molecular weight:

80472.45

Reactions

General function:

Involved in glutamate-cysteine ligase activity

Specific function:

Not Available

Gene Name:

GCLC

Uniprot ID:

P48506

Molecular weight:

68629.42

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.

Gene Name:

AK1

Uniprot ID:

P00568

Molecular weight:

21634.725

Reactions

General function:

Involved in ATP binding

Specific function:

Not Available

Gene Name:

AK3

Uniprot ID:

Q9UIJ7

Molecular weight:

21013.93

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. May also be active with GTP (By similarity).

Gene Name:

AK4

Uniprot ID:

P27144

Molecular weight:

25267.83

Reactions

General function:

Involved in ATP binding

Specific function:

Adenylate kinase involved in maintaining ciliary structure and function (By similarity). Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP.

Gene Name:

AK7

Uniprot ID:

Q96M32

Molecular weight:

82657.68

Reactions

General function:

Involved in catalytic activity

Specific function:

Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues.

Gene Name:

FHIT

Uniprot ID:

P49789

Molecular weight:

16858.11

Reactions

General function:

Involved in thiamin diphosphokinase activity

Specific function:

Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.

Gene Name:

TPK1

Uniprot ID:

Q9H3S4

Molecular weight:

27265.05

Reactions

General function:

Involved in hydrolase activity

Specific function:

Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.

Gene Name:

NUDT9

Uniprot ID:

Q9BW91

Molecular weight:

35448.725

General function:

Involved in adenosine kinase activity

Specific function:

ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.

Gene Name:

ADK

Uniprot ID:

P55263

Molecular weight:

38702.93

Reactions