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Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2016-02-11 01:04:23 UTC
HMDB IDHMDB01341
Secondary Accession NumbersNone
Metabolite Identification
Common NameADP
DescriptionAdenosine diphosphate, abbreviated ADP, is a nucleotide. It is an ester of pyrophosphoric acid with the nucleotide adenine. ADP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine. ADP is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases.
Structure
Thumb
Synonyms
  1. Adenosindiphosphorsaeure
  2. Adenosine 5'-pyrophosphate
  3. Adenosine diphosphate
  4. Adenosine pyrophosphate
  5. Adenosine-5'-diphosphate
  6. Adenosine-5-diphosphate
  7. Adenosine-diphosphate
  8. ADP
Chemical FormulaC10H15N5O10P2
Average Molecular Weight427.2011
Monoisotopic Molecular Weight427.029414749
IUPAC Name[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid
Traditional Nameadenosine-diphosphate
CAS Registry Number58-64-0
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
InChI Identifier
InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChI KeyInChIKey=XTWYTFMLZFPYCI-KQYNXXCUSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as purine ribonucleoside diphosphates. These are purine ribobucleotides with diphosphate group linked to the ribose moiety.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
ClassPurine nucleotides
Sub ClassPurine ribonucleotides
Direct ParentPurine ribonucleoside diphosphates
Alternative Parents
Substituents
  • Purine ribonucleoside diphosphate
  • N-glycosyl compound
  • Glycosyl compound
  • Organic pyrophosphate
  • Monosaccharide phosphate
  • 6-aminopurine
  • Purine
  • Imidazopyrimidine
  • Monoalkyl phosphate
  • Aminopyrimidine
  • Imidolactam
  • Alkyl phosphate
  • Pyrimidine
  • Primary aromatic amine
  • Phosphoric acid ester
  • Organic phosphoric acid derivative
  • Organic phosphate
  • N-substituted imidazole
  • Monosaccharide
  • Saccharide
  • Heteroaromatic compound
  • Oxolane
  • Imidazole
  • Azole
  • Secondary alcohol
  • 1,2-diol
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Alanine and aspartate metabolism
  • Component of Aminosugars metabolism
  • Component of Arginine and proline metabolism
  • Component of C5-Branched dibasic acid metabolism
  • Component of Folate biosynthesis
  • Component of Fructose and mannose metabolism
  • Component of Galactose metabolism
  • Component of Glutamate metabolism
  • Component of Glutathione metabolism
  • Component of Glycerolipid metabolism
  • Component of Glycerophospholipid metabolism
  • Component of Glycine, serine and threonine metabolism
  • Component of Glycosphingolipid metabolism
  • Component of Glyoxylate and dicarboxylate metabolism
  • Component of Inositol phosphate metabolism
  • Component of Nicotinate and nicotinamide metabolism
  • Component of Nitrogen metabolism
  • Component of Pantothenate and CoA biosynthesis
  • Component of Peptidoglycan biosynthesis
  • Component of Propanoate metabolism
  • Component of Purine metabolism
  • Component of Pyrimidine metabolism
  • Component of Pyruvate metabolism
  • Component of Riboflavin metabolism
  • Component of Starch and sucrose metabolism
  • Component of Streptomycin biosynthesis
  • Component of Tetracycline biosynthesis
  • Component of Vitamin B6 metabolism
ApplicationNot Available
Cellular locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
Water Solubility3.27 mg/mLALOGPS
logP-1.6ALOGPS
logP-5.3ChemAxon
logS-2.1ALOGPS
pKa (Strongest Acidic)1.77ChemAxon
pKa (Strongest Basic)4.99ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area232.6 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity84.94 m3·mol-1ChemAxon
Polarizability34.24 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0d04z00000-f65eba52a00479514d8eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-1z01000000-cdad0c415295c75e0b67View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-3z00000000-1f27fdf6dbd77cbe927dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0638zx4000-79c6771fae3255f75825View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-080z300000-24c7ad0d0646786963beView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-002z000000-d266bbe08f0bcb8102b4View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-00000z0000-8a788ef5a2c7ccc534e1View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-oz00n00000-fe2194fd2a27df917e5bView in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,1H] 2D NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Biofluid Locations
  • Blood
  • Cellular Cytoplasm
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue Location
  • All Tissues
Pathways
NameSMPDB LinkKEGG Link
2-Hydroxyglutric Aciduria (D And L Form)SMP00136Not Available
2-ketoglutarate dehydrogenase complex deficiencySMP00549Not Available
2-Methyl-3-Hydroxybutryl CoA Dehydrogenase DeficiencySMP00137Not Available
27-Hydroxylase DeficiencySMP00720Not Available
3-Hydroxy-3-Methylglutaryl-CoA Lyase DeficiencySMP00138Not Available
3-hydroxyisobutyric acid dehydrogenase deficiencySMP00521Not Available
3-hydroxyisobutyric aciduriaSMP00522Not Available
3-Methylcrotonyl Coa Carboxylase Deficiency Type ISMP00237Not Available
3-Methylglutaconic Aciduria Type ISMP00139Not Available
3-Methylglutaconic Aciduria Type IIISMP00140Not Available
3-Methylglutaconic Aciduria Type IVSMP00141Not Available
3-Methylthiofentanyl Action PathwaySMP00679Not Available
3-Phosphoglycerate dehydrogenase deficiencySMP00721Not Available
4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase DeficiencySMP00243Not Available
5-oxoprolinase deficiencySMP00500Not Available
5-OxoprolinuriaSMP00143Not Available
Acebutolol PathwaySMP00296Not Available
Acetaminophen Metabolism PathwaySMP00640Not Available
Adefovir Dipivoxil Metabolism PathwaySMP00629Not Available
Adefovir Dipivoxil PathwaySMP00418Not Available
Adenine phosphoribosyltransferase deficiency (APRT)SMP00535Not Available
Adenosine Deaminase DeficiencySMP00144Not Available
Adenylosuccinate Lyase DeficiencySMP00167Not Available
Adrenoleukodystrophy, X-linkedSMP00516Not Available
AICA-RibosiduriaSMP00168Not Available
Alanine MetabolismSMP00055map00250
Alendronate pathwaySMP00095Not Available
Alfentanil PathwaySMP00413Not Available
Alprenolol PathwaySMP00297Not Available
Alvimopan Action PathwaySMP00685Not Available
Amino Sugar MetabolismSMP00045map00520
Amiodarone Action PathwaySMP00665Not Available
Amlodipine PathwaySMP00376Not Available
Ammonia RecyclingSMP00009map00910
Anileridine Action PathwaySMP00674Not Available
Arbutamine Action PathwaySMP00664Not Available
Arginine and Proline MetabolismSMP00020map00330
Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)SMP00362Not Available
ArgininemiaSMP00357Not Available
Argininosuccinic AciduriaSMP00003Not Available
Atenolol PathwaySMP00298Not Available
Atorvastatin PathwaySMP00131Not Available
Azathioprine PathwaySMP00427Not Available
Benzocaine PathwaySMP00392Not Available
Beta Oxidation of Very Long Chain Fatty AcidsSMP00052map01040
Beta Ureidopropionase DeficiencySMP00172Not Available
Beta-Ketothiolase DeficiencySMP00173Not Available
Beta-mercaptolactate-cysteine disulfiduriaSMP00499Not Available
Betaxolol PathwaySMP00299Not Available
Betazole Action PathwaySMP00736Not Available
Bevantolol Action PathwaySMP00668Not Available
Bile Acid BiosynthesisSMP00035map00120
Bisoprolol PathwaySMP00300Not Available
Bopindolol Action PathwaySMP00657Not Available
Bupivacaine PathwaySMP00393Not Available
Bupranolol Action PathwaySMP00670Not Available
Buprenorphine Action PathwaySMP00684Not Available
Carbamoyl Phosphate Synthetase DeficiencySMP00002Not Available
Carfentanil PathwaySMP00414Not Available
Carnitine-acylcarnitine translocase deficiencySMP00517Not Available
Carteolol Action PathwaySMP00658Not Available
Carvedilol PathwaySMP00367Not Available
Cerebrotendinous Xanthomatosis (CTX)SMP00315Not Available
Cerivastatin PathwaySMP00111Not Available
CHILD SyndromeSMP00387Not Available
Chloroprocaine PathwaySMP00394Not Available
Cholesteryl ester storage diseaseSMP00508Not Available
Chondrodysplasia Punctata II, X Linked Dominant (CDPX2)SMP00388Not Available
Cimetidine PathwaySMP00232Not Available
Citalopram PathwaySMP00424Not Available
Citric Acid CycleSMP00057map00020
Citrullinemia Type ISMP00001Not Available
Clopidogrel Metabolism PathwaySMP00610Not Available
Clopidogrel PathwaySMP00260Not Available
Cocaine PathwaySMP00395Not Available
Codeine PathwaySMP00405Not Available
Congenital Bile Acid Synthesis Defect Type IISMP00314Not Available
Congenital Bile Acid Synthesis Defect Type IIISMP00318Not Available
Congenital disorder of glycosylation CDG-IIdSMP00579Not Available
Congenital lactic acidosisSMP00546Not Available
Creatine deficiency, guanidinoacetate methyltransferase deficiencySMP00504Not Available
Cysteine MetabolismSMP00013map00270
Cystinosis, ocular nonnephropathicSMP00722Not Available
D-glyceric aciduraSMP00529Not Available
Desipramine PathwaySMP00423Not Available
DesmosterolosisSMP00386Not Available
Dezocine Action PathwaySMP00676Not Available
Dibucaine PathwaySMP00396Not Available
Dihydromorphine Action PathwaySMP00689Not Available
Dihydropyrimidinase DeficiencySMP00178Not Available
Dihydropyrimidine Dehydrogenase Deficiency (DHPD)SMP00179Not Available
Diltiazem PathwaySMP00359Not Available
Dimethylglycine Dehydrogenase DeficiencySMP00242Not Available
Dimethylglycine Dehydrogenase DeficiencySMP00484Not Available
Dimethylthiambutene Action PathwaySMP00680Not Available
Diphenoxylate Action PathwaySMP00675Not Available
Disopyramide PathwaySMP00325Not Available
Dobutamine Action PathwaySMP00662Not Available
Docetaxel PathwaySMP00435Not Available
Doxorubicin Metabolism PathwaySMP00650Not Available
Epinephrine Action PathwaySMP00661Not Available
Erlotinib PathwaySMP00472Not Available
Escitalopram PathwaySMP00425Not Available
Esmolol PathwaySMP00301Not Available
Esomeprazole PathwaySMP00225Not Available
Ethylmorphine Action PathwaySMP00681Not Available
Etoposide Metabolism PathwaySMP00601Not Available
Etoposide PathwaySMP00442Not Available
Fabry diseaseSMP00525Not Available
Familial Hypercholanemia (FHCA)SMP00317Not Available
Familial lipoprotein lipase deficiencySMP00530Not Available
Famotidine PathwaySMP00231Not Available
Fanconi-bickel syndromeSMP00572Not Available
Felodipine PathwaySMP00377Not Available
Fentanyl PathwaySMP00415Not Available
Flecainide PathwaySMP00331Not Available
Fluoxetine PathwaySMP00426Not Available
Fluvastatin PathwaySMP00119Not Available
Folate malabsorption, hereditarySMP00724Not Available
Folate MetabolismSMP00053map00670
Fosphenytoin (Antiarrhythmic) PathwaySMP00326Not Available
Fructose and Mannose DegradationSMP00064map00051
Fructose intolerance, hereditarySMP00725Not Available
Fructose-1,6-diphosphatase deficiencySMP00562Not Available
FructosuriaSMP00561Not Available
Fumarase deficiencySMP00547Not Available
G(M2)-Gangliosidosis: Variant B, Tay-sachs diseaseSMP00534Not Available
Galactose MetabolismSMP00043map00052
GalactosemiaSMP00182Not Available
Galactosemia II (GALK)SMP00495Not Available
Galactosemia IIISMP00496Not Available
Gamma-glutamyl-transpeptidase deficiencySMP00501Not Available
Gamma-Glutamyltransferase DeficiencySMP00183Not Available
Gastric Acid ProductionSMP00589Not Available
Gaucher DiseaseSMP00349Not Available
Gemcitabine Metabolism PathwaySMP00603Not Available
Gemcitabine PathwaySMP00446Not Available
Globoid Cell LeukodystrophySMP00348Not Available
GluconeogenesisSMP00128map00010
Glucose-6-phosphate dehydrogenase deficiencySMP00518Not Available
GLUT-1 deficiency syndromeSMP00580Not Available
Glutamate MetabolismSMP00072map00250
Glutaminolysis and CancerSMP02298Not Available
Glutathione MetabolismSMP00015map00480
Glutathione Synthetase DeficiencySMP00337Not Available
Glycerol Kinase DeficiencySMP00187Not Available
Glycerolipid MetabolismSMP00039map00561
Glycine and Serine MetabolismSMP00004map00260
Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke DiseaseSMP00374Not Available
Glycogen synthetase deficiencySMP00552Not Available
Glycogenosis, Type IA. Von gierke diseaseSMP00581Not Available
Glycogenosis, Type IBSMP00573Not Available
Glycogenosis, Type ICSMP00574Not Available
Glycogenosis, Type III. Cori disease, Debrancher glycogenosisSMP00553Not Available
Glycogenosis, Type IV. Amylopectinosis, Anderson diseaseSMP00554Not Available
Glycogenosis, Type VI. Hers diseaseSMP00555Not Available
Glycogenosis, Type VII. Tarui diseaseSMP00531Not Available
GlycolysisSMP00040map00010
Gout or Kelley-Seegmiller SyndromeSMP00365Not Available
Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)SMP00188Not Available
Heroin PathwaySMP00407Not Available
Histidine MetabolismSMP00044map00340
HistidinemiaSMP00191Not Available
HomocarnosinosisSMP00385Not Available
Hydrocodone PathwaySMP00411Not Available
Hydromorphone PathwaySMP00410Not Available
Hyper-IgD syndromeSMP00509Not Available
HypercholesterolemiaSMP00209Not Available
Hyperglycinemia, non-ketoticSMP00485Not Available
Hyperinsulinism-Hyperammonemia SyndromeSMP00339Not Available
Hyperornithinemia with gyrate atrophy (HOGA)SMP00505Not Available
Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome]SMP00506Not Available
Hyperprolinemia Type ISMP00361Not Available
Hyperprolinemia Type IISMP00360Not Available
Ibandronate PathwaySMP00079Not Available
Ibutilide PathwaySMP00332Not Available
Imipramine PathwaySMP00422Not Available
Inositol MetabolismSMP00011map00562
Inositol Phosphate MetabolismSMP00462map00562
Irinotecan Metabolism PathwaySMP00600Not Available
Irinotecan PathwaySMP00433Not Available
Isobutyryl-coa dehydrogenase deficiencySMP00523Not Available
Isoprenaline Action PathwaySMP00663Not Available
Isovaleric acidemiaSMP00524Not Available
Isovaleric AciduriaSMP00238Not Available
Isradipine PathwaySMP00378Not Available
Joubert syndromeSMP00582Not Available
Ketobemidone Action PathwaySMP00690Not Available
Krabbe diseaseSMP00526Not Available
L-arginine:glycine amidinotransferase deficiencySMP00507Not Available
Labetalol PathwaySMP00368Not Available
Lactic AcidemiaSMP00313Not Available
Lactose DegradationSMP00457Not Available
Lactose IntoleranceSMP00458Not Available
Lactose SynthesisSMP00444Not Available
Lamivudine Metabolism PathwaySMP00649Not Available
Lansoprazole PathwaySMP00227Not Available
Leigh SyndromeSMP00196Not Available
Lesch-Nyhan Syndrome (LNS)SMP00364Not Available
Levallorphan Action PathwaySMP00683Not Available
Levobunolol Action PathwaySMP00666Not Available
Levobupivacaine PathwaySMP00397Not Available
Levomethadyl Acetate Action Action PathwaySMP00677Not Available
Levorphanol Action PathwaySMP00673Not Available
Lidocaine (Antiarrhythmic) PathwaySMP00328Not Available
Lidocaine (Local Anaesthetic) PathwaySMP00398Not Available
Lovastatin PathwaySMP00099Not Available
Lysosomal Acid Lipase Deficiency (Wolman Disease)SMP00319Not Available
Malonic AciduriaSMP00198Not Available
Malonyl-coa decarboxylase deficiencySMP00502Not Available
Maple Syrup Urine DiseaseSMP00199Not Available
Mepivacaine PathwaySMP00399Not Available
Mercaptopurine Metabolism PathwaySMP00609Not Available
Mercaptopurine PathwaySMP00428Not Available
Metachromatic Leukodystrophy (MLD)SMP00347Not Available
Methadone PathwaySMP00408Not Available
Methadyl Acetate Action PathwaySMP00678Not Available
Methotrexate PathwaySMP00432Not Available
Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)SMP00543Not Available
Methylmalonate Semialdehyde Dehydrogenase DeficiencySMP00384Not Available
Methylmalonic AciduriaSMP00200Not Available
Methylmalonic Aciduria Due to Cobalamin-Related DisordersSMP00201Not Available
Metiamide Action PathwaySMP00735Not Available
Metipranolol Action PathwaySMP00667Not Available
Metoprolol PathwaySMP00302Not Available
Mevalonic aciduriaSMP00510Not Available
Mexiletine PathwaySMP00329Not Available
Mitochondrial complex II deficiencySMP00548Not Available
Mitochondrial DNA depletion syndromeSMP00536Not Available
Mitochondrial Electron Transport ChainSMP00355map00190
MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)SMP00202Not Available
Molybdenum Cofactor DeficiencySMP00203Not Available
Morphine PathwaySMP00406Not Available
Mucopolysaccharidosis VI. Sly syndromeSMP00556Not Available
Muscle/Heart ContractionSMP00588Not Available
Mycophenolic Acid Metabolism PathwaySMP00652Not Available
Myoadenylate deaminase deficiencySMP00537Not Available
Nadolol PathwaySMP00303Not Available
Nalbuphine Action PathwaySMP00691Not Available
Naloxone Action PathwaySMP00688Not Available
Naltrexone Action PathwaySMP00687Not Available
Nebivolol PathwaySMP00366Not Available
Nevirapine Metabolism PathwaySMP00642Not Available
Nicotinate and Nicotinamide MetabolismSMP00048map00760
Nicotine PathwaySMP00431Not Available
Nifedipine PathwaySMP00379Not Available
Nimodipine PathwaySMP00380Not Available
Nisoldipine PathwaySMP00381Not Available
Nitrendipine PathwaySMP00382Not Available
Nizatidine PathwaySMP00233Not Available
Non Ketotic HyperglycinemiaSMP00223Not Available
Nucleotide Sugars MetabolismSMP00010map00520
Omeprazole PathwaySMP00226Not Available
Ornithine Aminotransferase Deficiency (OAT Deficiency)SMP00363Not Available
Ornithine Transcarbamylase Deficiency (OTC Deficiency)SMP00205Not Available
Oxidation of Branched Chain Fatty AcidsSMP00030Not Available
Oxprenolol PathwaySMP00304Not Available
Oxybuprocaine PathwaySMP00400Not Available
Oxycodone PathwaySMP00409Not Available
Oxymorphone PathwaySMP00412Not Available
Paclitaxel PathwaySMP00434Not Available
Pamidronate PathwaySMP00117Not Available
Pantoprazole PathwaySMP00228Not Available
Pantothenate and CoA BiosynthesisSMP00027map00770
Penbutolol PathwaySMP00305Not Available
Pentazocine Action PathwaySMP00686Not Available
Pentose Phosphate PathwaySMP00031map00030
Phenytoin (Antiarrhythmic) PathwaySMP00327Not Available
Phosphatidylinositol Phosphate MetabolismSMP00463map00562
Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1)SMP00560Not Available
Phytanic Acid Peroxisomal OxidationSMP00450Not Available
Pindolol PathwaySMP00306Not Available
Pirenzepine PathwaySMP00246Not Available
Practolol Action PathwaySMP00669Not Available
Pravastatin PathwaySMP00089Not Available
Prilocaine PathwaySMP00401Not Available
Primary hyperoxaluria II, PH2SMP00558Not Available
Primary Hyperoxaluria Type ISMP00352Not Available
Procainamide (Antiarrhythmic) PathwaySMP00324Not Available
Procaine PathwaySMP00402Not Available
Prolidase Deficiency (PD)SMP00207Not Available
Prolinemia Type IISMP00208Not Available
Propanoate MetabolismSMP00016map00640
Proparacaine PathwaySMP00403Not Available
Propionic AcidemiaSMP00236Not Available
Propoxyphene Action PathwaySMP00672Not Available
Propranolol PathwaySMP00307Not Available
Purine MetabolismSMP00050map00230
Purine Nucleoside Phosphorylase DeficiencySMP00210Not Available
Pyrimidine MetabolismSMP00046map00240
Pyruvate Carboxylase DeficiencySMP00350Not Available
Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)SMP00334Not Available
Pyruvate Dehydrogenase Complex DeficiencySMP00212Not Available
Pyruvate dehydrogenase deficiency (E2)SMP00551Not Available
Pyruvate dehydrogenase deficiency (E3)SMP00550Not Available
Pyruvate kinase deficiencySMP00559Not Available
Pyruvate MetabolismSMP00060map00620
Quinidine PathwaySMP00323Not Available
Rabeprazole PathwaySMP00229Not Available
Ranitidine PathwaySMP00230Not Available
Refsum DiseaseSMP00451Not Available
Remifentanil PathwaySMP00416Not Available
Riboflavin MetabolismSMP00070map00740
Ribose-5-phosphate isomerase deficiencySMP00519Not Available
Risedronate PathwaySMP00112Not Available
Ropivacaine PathwaySMP00404Not Available
Rosuvastatin PathwaySMP00092Not Available
Roxatidine acetate Action PathwaySMP00734Not Available
Salla Disease/Infantile Sialic Acid Storage DiseaseSMP00240Not Available
SarcosinemiaSMP00244Not Available
Selenoamino Acid MetabolismSMP00029map00450
Sialuria or French Type SialuriaSMP00216Not Available
Sialuria or French Type SialuriaSMP00217Not Available
Simvastatin Action PathwaySMP00082Not Available
Smith-Lemli-Opitz Syndrome (SLOS)SMP00389Not Available
Sotalol Action PathwaySMP00660Not Available
Sphingolipid MetabolismSMP00034map00500
Starch and Sucrose MetabolismSMP00058map00500
Steroid BiosynthesisSMP00023map00100
Succinic semialdehyde dehydrogenase deficiencySMP00567Not Available
Sucrase-isomaltase deficiencySMP00557Not Available
Sufentanil PathwaySMP00417Not Available
Sulfate/Sulfite MetabolismSMP00041map00920
Sulfite oxidase deficiencySMP00532Not Available
Tay-Sachs DiseaseSMP00390Not Available
Tenofovir Metabolism PathwaySMP00630Not Available
Tenofovir PathwaySMP00419Not Available
The oncogenic action of 2-hydroxyglutarateSMP02291Not Available
The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria SMP02359Not Available
The oncogenic action of FumarateSMP02295Not Available
The oncogenic action of L-2-hydroxyglutarate in HydroxygluaricaciduriaSMP02358Not Available
The oncogenic action of SuccinateSMP02292Not Available
Thiamine MetabolismSMP00076map00730
Thioguanine PathwaySMP00430Not Available
Threonine and 2-Oxobutanoate DegradationSMP00452Not Available
Timolol Action PathwaySMP00659Not Available
Tocainide PathwaySMP00330Not Available
Tramadol Action Action PathwaySMP00671Not Available
Tramadol Metabolism PathwaySMP00637Not Available
Transaldolase deficiencySMP00520Not Available
Transfer of Acetyl Groups into MitochondriaSMP00466Not Available
Trehalose DegradationSMP00467Not Available
Triosephosphate isomeraseSMP00563Not Available
UMP Synthase Deiciency (Orotic Aciduria)SMP00219Not Available
Urea CycleSMP00059map00330
Valine, Leucine and Isoleucine DegradationSMP00032map00280
Verapamil PathwaySMP00375Not Available
Vinblastine PathwaySMP00436Not Available
Vincristine PathwaySMP00437Not Available
Vindesine PathwaySMP00438Not Available
Vinorelbine PathwaySMP00439Not Available
Warburg EffectSMP00654Not Available
Wolman diseaseSMP00511Not Available
Xanthine Dehydrogenase Deficiency (Xanthinuria)SMP00220Not Available
Xanthinuria type ISMP00512Not Available
Xanthinuria type IISMP00513Not Available
Zellweger SyndromeSMP00316Not Available
Zoledronate PathwaySMP00107Not Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified160.0 +/- 14.0 uMAdult (>18 years old)MaleNormal
    • Geigy Scientific ...
details
Cellular CytoplasmDetected and Quantified270 (150-390) uMAdult (>18 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified1.90 +/- 0.025 uMAdult (>18 years old)BothNormal details
SalivaDetected and Quantified0.0257 +/- 0.0618 uMAdult (>18 years old)Female
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.169 +/- 0.234 uMAdult (>18 years old)Not Specified
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.207 +/- 0.324 uMAdult (>18 years old)Both
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified1.23 +/- 0.13 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified1.39 +/- 0.16 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified0.298 +/- 0.316 uMAdult (>18 years old)Female
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified1.26 +/- 0.19 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified0.317 +/- 0.491 uMAdult (>18 years old)Female
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.387 +/- 0.462 uMAdult (>18 years old)Not Specified
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.433 +/- 0.363 uMAdult (>18 years old)Both
Normal
    • Sugimoto et al. (...
details
UrineDetected and Quantified2.654 +/- 2.236 umol/mmol creatinineChildren (1 - 13 years old)Not Specified
Normal
    • Mordechai, Hien, ...
details
UrineDetected and Quantified1.8 (1.0-3.4) umol/mmol creatinineAdult (>18 years old)Both
Normal
details
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
Cerebrospinal Fluid (CSF)Detected and Quantified1.10 +/- 0.60 uMAdult (>18 years old)BothRachialgia details
Cerebrospinal Fluid (CSF)Detected and Quantified0.91 +/- 0.46 uMAdult (>18 years old)BothSubarachnoid hemorrhage details
Cerebrospinal Fluid (CSF)Detected and Quantified0.63 +/- 0.37 uMAdult (>18 years old)BothEpilepsy details
Cerebrospinal Fluid (CSF)Detected and Quantified1.86 +/- 1.67 uMAdult (>18 years old)Both
Stroke
details
Cerebrospinal Fluid (CSF)Detected and Quantified1.62 +/- 0.96 uMAdult (>18 years old)BothNeuroinfection details
UrineDetected and Quantified3.242 +/- 1.657 umol/mmol creatinineChildren (1 - 13 years old)Not Specified
Eosinophilic esophagitis
    • Mordechai, Hien, ...
details
Associated Disorders and Diseases
Disease References
Subarachnoid hemorrhage
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. [15993662 ]
Epilepsy
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. [15993662 ]
Neuroinfection
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. [15993662 ]
Rachialgia
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. [15993662 ]
Stroke
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. [15993662 ]
Associated OMIM IDs
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB021817
KNApSAcK IDNot Available
Chemspider ID5800
KEGG Compound IDC00008
BioCyc IDADP
BiGG ID33496
Wikipedia LinkADP
NuGOwiki LinkHMDB01341
Metagene LinkHMDB01341
METLIN ID6175
PubChem Compound6022
PDB IDADP
ChEBI ID16761
References
Synthesis ReferenceYamagata, Yukio. Prebiotic formation of ADP and ATP from AMP, calcium phosphates and cyanate in aqueous solution. Origins of Life and Evolution of the Biosphere (1999), 29(5), 511-520.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2(1):18. [15882454 ]
  2. Cuisset T, Frere C, Quilici J, Barbou F, Morange PE, Hovasse T, Bonnet JL, Alessi MC: High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome. J Thromb Haemost. 2006 Mar;4(3):542-9. Epub 2005 Dec 22. [16371119 ]
  3. Quinton TM, Kim S, Jin J, Kunapuli SP: Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost. 2005 May;3(5):1036-41. [15869601 ]
  4. Saxena R, Gupta M, Gupta S, Kannan M, Ahmed RP, Choudhry VP: Inherited heterogenous defect in platelet aggregation selectively with ADP and epinephrine--a series of 25 cases. Indian J Pathol Microbiol. 2005 Jul;48(3):345-8. [16761747 ]
  5. Corsonello A, Malara A, De Domenico D, Damiano MC, Mirone S, Loddo S, Ientile R, Corica F: Effects of magnesium sulphate on leptin-dependent platelet aggregation: an ex vivo study. Magnes Res. 2005 Mar;18(1):7-11. [15945611 ]
  6. Imura Y, Stassen JM, Bunting S, Stockmans F, Collen D: Antithrombotic properties of L-cysteine, N-(mercaptoacetyl)-D-Tyr-Arg-Gly-Asp-sulfoxide (G4120) in a hamster platelet-rich femoral vein thrombosis model. Blood. 1992 Sep 1;80(5):1247-53. [1515641 ]
  7. Cuisset T, Frere C, Quilici J, Morange PE, Nait-Saidi L, Carvajal J, Lehmann A, Lambert M, Bonnet JL, Alessi MC: Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting. J Am Coll Cardiol. 2006 Oct 3;48(7):1339-45. Epub 2006 Sep 12. [17010792 ]
  8. Vigue C, Vigue L, Huszar G: Adenosine triphosphate (ATP) concentrations and ATP/adenosine diphosphate ratios in human sperm of normospermic, oligospermic, and asthenospermic specimens and in their swim-up fractions: lack of correlation between ATP parameters and sperm creatine kinase concentrations. J Androl. 1992 Jul-Aug;13(4):305-11. [1399831 ]
  9. Smith SM, Judge HM, Peters G, Storey RF: Multiple antiplatelet effects of clopidogrel are not modulated by statin type in patients undergoing percutaneous coronary intervention. Platelets. 2004 Dec;15(8):465-74. [15763887 ]
  10. Ji Q, Ghaly M, Hjemdahl P, Tornvall P, Li N: Contrast medium attenuates platelet activation and platelet-leukocyte cross-talk. Thromb Haemost. 2005 May;93(5):922-6. [15886810 ]
  11. Morshedi M, Oehninger S, Blackmore P, Bocca S, Coddington C, Hodgen G: Investigation of some biochemical and functional effects of cryopreservation of human spermatozoa using an automated freezing-quick-thawing method. Int J Androl. 1995 Dec;18(6):279-86. [8719843 ]
  12. Hua J, Suguro S, Iwabuchi K, Tsutsumi-Ishii Y, Sakamoto K, Nagaoka I: Glucosamine, a naturally occurring amino monosaccharide, suppresses the ADP-mediated platelet activation in humans. Inflamm Res. 2004 Dec;53(12):680-8. [15654516 ]
  13. Shabanova EY, Mindukshev IV, Malakhovskaya EA, Vivulanets EV, Petrishchev NN, Krivchenko AI: Cooperative type of platelet hypersensitivity to ADP. Bull Exp Biol Med. 2005 Sep;140(3):282-4. [16307036 ]

Only showing the first 50 proteins. There are 788 proteins in total.

Enzymes

General function:
Involved in ATP binding
Specific function:
Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.
Gene Name:
CMPK1
Uniprot ID:
P30085
Molecular weight:
20180.12
Reactions
Adenosine triphosphate + (d)CMP → ADP + (d)CDPdetails
Adenosine triphosphate + Uridine 5'-monophosphate → ADP + Uridine 5'-diphosphatedetails
Adenosine triphosphate + Cytidine monophosphate → ADP + CDPdetails
Adenosine triphosphate + dCMP → ADP + dCDPdetails
General function:
Involved in ATP binding
Specific function:
Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Gene Name:
DCK
Uniprot ID:
P27707
Molecular weight:
30518.315
Reactions
Adenosine triphosphate + Adenosine → ADP + Adenosine monophosphatedetails
Adenosine triphosphate + Deoxycytidine → ADP + dCMPdetails
General function:
Involved in ATP citrate synthase activity
Specific function:
ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
Gene Name:
ACLY
Uniprot ID:
P53396
Molecular weight:
120838.27
Reactions
ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic acid → Adenosine triphosphate + Citric acid + Coenzyme Adetails
Adenosine triphosphate + Citric acid + Coenzyme A → ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic aciddetails
General function:
Involved in acetyl-CoA carboxylase activity
Specific function:
ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Gene Name:
ACACB
Uniprot ID:
O00763
Molecular weight:
276538.575
Reactions
Adenosine triphosphate + Acetyl-CoA + Carbonic acid → ADP + Phosphoric acid + Malonyl-CoAdetails
Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + Phosphoric acid + carboxy-biotin-[carboxyl-carrier-protein]details
Adenosine triphosphate + Holo-[carboxylase] + Carbonic acid → ADP + Phosphoric acid + Carboxybiotin-carboxyl-carrier proteindetails
General function:
Involved in catalytic activity
Specific function:
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
Gene Name:
PC
Uniprot ID:
P11498
Molecular weight:
129632.565
Reactions
Adenosine triphosphate + Pyruvic acid + Carbonic acid → ADP + Phosphoric acid + Oxalacetic aciddetails
General function:
Involved in acetyl-CoA carboxylase activity
Specific function:
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Gene Name:
ACACA
Uniprot ID:
Q13085
Molecular weight:
269997.01
Reactions
Adenosine triphosphate + Acetyl-CoA + Carbonic acid → ADP + Phosphoric acid + Malonyl-CoAdetails
Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + Phosphoric acid + carboxy-biotin-[carboxyl-carrier-protein]details
Adenosine triphosphate + Holo-[carboxylase] + Carbonic acid → ADP + Phosphoric acid + Carboxybiotin-carboxyl-carrier proteindetails
General function:
Involved in thymidylate kinase activity
Specific function:
Catalyzes the conversion of dTMP to dTDP.
Gene Name:
DTYMK
Uniprot ID:
P23919
Molecular weight:
23819.105
Reactions
Adenosine triphosphate + 5-Thymidylic acid → ADP + dTDPdetails
Adenosine triphosphate + dUMP → ADP + dUDPdetails
General function:
Involved in hydrolase activity
Specific function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:
ENTPD1
Uniprot ID:
P49961
Molecular weight:
58706.0
Reactions
Adenosine triphosphate + Water → ADP + Phosphoric aciddetails
ADP + Water → Adenosine monophosphate + Phosphoric aciddetails
General function:
Involved in calcium ion binding
Specific function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:
CANT1
Uniprot ID:
Q8WVQ1
Molecular weight:
44839.24
General function:
Involved in hydrolase activity
Specific function:
Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:
ENTPD3
Uniprot ID:
O75355
Molecular weight:
59104.76
Reactions
Adenosine triphosphate + Water → ADP + Phosphoric aciddetails
ADP + Water → Adenosine monophosphate + Phosphoric aciddetails
General function:
Involved in arylesterase activity
Specific function:
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Gene Name:
PON3
Uniprot ID:
Q15166
Molecular weight:
39607.185
General function:
Involved in ATP binding
Specific function:
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
Gene Name:
UCK1
Uniprot ID:
Q9HA47
Molecular weight:
22760.43
Reactions
Adenosine triphosphate + Uridine → ADP + Uridine 5'-monophosphatedetails
Adenosine triphosphate + Cytidine → ADP + Cytidine monophosphatedetails
5-Fluorouridine + Adenosine triphosphate → 5-Fluorouridine monophosphate + ADPdetails
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity).
Gene Name:
NME4
Uniprot ID:
O00746
Molecular weight:
20658.45
Reactions
Adenosine triphosphate + nucleoside diphosphate → ADP + nucleoside triphosphatedetails
Adenosine triphosphate + ADP → ADP + Adenosine triphosphatedetails
Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphatedetails
Adenosine triphosphate + Guanosine diphosphate → ADP + Guanosine triphosphatedetails
Adenosine triphosphate + CDP → ADP + Cytidine triphosphatedetails
Adenosine triphosphate + IDP → ADP + Inosine triphosphatedetails
Adenosine triphosphate + dADP → ADP + Deoxyadenosine triphosphatedetails
Adenosine triphosphate + dGDP → ADP + dGTPdetails
Adenosine triphosphate + dTDP → ADP + Thymidine 5'-triphosphatedetails
Adenosine triphosphate + dCDP → ADP + dCTPdetails
Adenosine triphosphate + dUDP → ADP + Deoxyuridine triphosphatedetails
Adenosine triphosphate + dIDP → ADP + 2'-Deoxyinosine triphosphatedetails
General function:
Involved in oxidation reduction
Specific function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Gene Name:
RRM1
Uniprot ID:
P23921
Molecular weight:
90069.375
Reactions
dADP + Thioredoxin disulfide + Water → Thioredoxin + ADPdetails
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Gene Name:
NME1
Uniprot ID:
P15531
Molecular weight:
17148.635
Reactions
Adenosine triphosphate + nucleoside diphosphate → ADP + nucleoside triphosphatedetails
Adenosine triphosphate + ADP → ADP + Adenosine triphosphatedetails
Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphatedetails
Adenosine triphosphate + Guanosine diphosphate → ADP + Guanosine triphosphatedetails
Adenosine triphosphate + CDP → ADP + Cytidine triphosphatedetails
Adenosine triphosphate + IDP → ADP + Inosine triphosphatedetails
Adenosine triphosphate + dADP → ADP + Deoxyadenosine triphosphatedetails
Adenosine triphosphate + dGDP → ADP + dGTPdetails
Adenosine triphosphate + dTDP → ADP + Thymidine 5'-triphosphatedetails
Adenosine triphosphate + dCDP → ADP + dCTPdetails
Adenosine triphosphate + dUDP → ADP + Deoxyuridine triphosphatedetails
Adenosine triphosphate + dIDP → ADP + 2'-Deoxyinosine triphosphatedetails
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Gene Name:
NME7
Uniprot ID:
Q9Y5B8
Molecular weight:
42491.365
Reactions
Adenosine triphosphate + nucleoside diphosphate → ADP + nucleoside triphosphatedetails
Adenosine triphosphate + ADP → ADP + Adenosine triphosphatedetails
Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphatedetails
Adenosine triphosphate + Guanosine diphosphate → ADP + Guanosine triphosphatedetails
Adenosine triphosphate + CDP → ADP + Cytidine triphosphatedetails
Adenosine triphosphate + IDP → ADP + Inosine triphosphatedetails
Adenosine triphosphate + dADP → ADP + Deoxyadenosine triphosphatedetails
Adenosine triphosphate + dGDP → ADP + dGTPdetails
Adenosine triphosphate + dTDP → ADP + Thymidine 5'-triphosphatedetails
Adenosine triphosphate + dCDP → ADP + dCTPdetails
Adenosine triphosphate + dUDP → ADP + Deoxyuridine triphosphatedetails
Adenosine triphosphate + dIDP → ADP + 2'-Deoxyinosine triphosphatedetails
General function:
Involved in oxidoreductase activity
Specific function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Gene Name:
RRM2
Uniprot ID:
P31350
Molecular weight:
44877.25
Reactions
dADP + Thioredoxin disulfide + Water → Thioredoxin + ADPdetails
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
Gene Name:
NME2
Uniprot ID:
P22392
Molecular weight:
30136.92
Reactions
Adenosine triphosphate + nucleoside diphosphate → ADP + nucleoside triphosphatedetails
Adenosine triphosphate + protein L-histidine → ADP + protein N-phospho-L-histidinedetails
Adenosine triphosphate + ADP → ADP + Adenosine triphosphatedetails
Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphatedetails
Adenosine triphosphate + Guanosine diphosphate → ADP + Guanosine triphosphatedetails
Adenosine triphosphate + CDP → ADP + Cytidine triphosphatedetails
Adenosine triphosphate + IDP → ADP + Inosine triphosphatedetails
Adenosine triphosphate + dADP → ADP + Deoxyadenosine triphosphatedetails
Adenosine triphosphate + dGDP → ADP + dGTPdetails
Adenosine triphosphate + dTDP → ADP + Thymidine 5'-triphosphatedetails
Adenosine triphosphate + dCDP → ADP + dCTPdetails
Adenosine triphosphate + dUDP → ADP + Deoxyuridine triphosphatedetails
Adenosine triphosphate + dIDP → ADP + 2'-Deoxyinosine triphosphatedetails
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
Gene Name:
NME3
Uniprot ID:
Q13232
Molecular weight:
19014.85
Reactions
Adenosine triphosphate + nucleoside diphosphate → ADP + nucleoside triphosphatedetails
Adenosine triphosphate + ADP → ADP + Adenosine triphosphatedetails
Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphatedetails
Adenosine triphosphate + Guanosine diphosphate → ADP + Guanosine triphosphatedetails
Adenosine triphosphate + CDP → ADP + Cytidine triphosphatedetails
Adenosine triphosphate + IDP → ADP + Inosine triphosphatedetails
Adenosine triphosphate + dADP → ADP + Deoxyadenosine triphosphatedetails
Adenosine triphosphate + dGDP → ADP + dGTPdetails
Adenosine triphosphate + dTDP → ADP + Thymidine 5'-triphosphatedetails
Adenosine triphosphate + dCDP → ADP + dCTPdetails
Adenosine triphosphate + dUDP → ADP + Deoxyuridine triphosphatedetails
Adenosine triphosphate + dIDP → ADP + 2'-Deoxyinosine triphosphatedetails
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.
Gene Name:
NME6
Uniprot ID:
O75414
Molecular weight:
22002.965
Reactions
Adenosine triphosphate + nucleoside diphosphate → ADP + nucleoside triphosphatedetails
Adenosine triphosphate + ADP → ADP + Adenosine triphosphatedetails
Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphatedetails
Adenosine triphosphate + Guanosine diphosphate → ADP + Guanosine triphosphatedetails
Adenosine triphosphate + CDP → ADP + Cytidine triphosphatedetails
Adenosine triphosphate + IDP → ADP + Inosine triphosphatedetails
Adenosine triphosphate + dADP → ADP + Deoxyadenosine triphosphatedetails
Adenosine triphosphate + dGDP → ADP + dGTPdetails
Adenosine triphosphate + dTDP → ADP + Thymidine 5'-triphosphatedetails
Adenosine triphosphate + dCDP → ADP + dCTPdetails
Adenosine triphosphate + dUDP → ADP + Deoxyuridine triphosphatedetails
Adenosine triphosphate + dIDP → ADP + 2'-Deoxyinosine triphosphatedetails
General function:
Involved in ATP binding
Specific function:
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Gene Name:
GCK
Uniprot ID:
P35557
Molecular weight:
52191.07
Reactions
Adenosine triphosphate + D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + Beta-D-Glucose → ADP + Beta-D-Glucose 6-phosphatedetails
Adenosine triphosphate + Alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK3
Uniprot ID:
P52790
Molecular weight:
99024.56
Reactions
Adenosine triphosphate + D-Galactose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
Adenosine triphosphate + D-Mannose → ADP + Mannose 6-phosphatedetails
Adenosine triphosphate + Beta-D-Glucose → ADP + Beta-D-Glucose 6-phosphatedetails
Adenosine triphosphate + Alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + Glucosamine → ADP + Glucosamine 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK2
Uniprot ID:
P52789
Molecular weight:
102379.06
Reactions
Adenosine triphosphate + D-Galactose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
Adenosine triphosphate + D-Mannose → ADP + Mannose 6-phosphatedetails
Adenosine triphosphate + Beta-D-Glucose → ADP + Beta-D-Glucose 6-phosphatedetails
Adenosine triphosphate + Alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + Glucosamine → ADP + Glucosamine 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK1
Uniprot ID:
P19367
Molecular weight:
102485.1
Reactions
Adenosine triphosphate + D-Galactose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
Adenosine triphosphate + D-Mannose → ADP + Mannose 6-phosphatedetails
Adenosine triphosphate + Beta-D-Glucose → ADP + Beta-D-Glucose 6-phosphatedetails
Adenosine triphosphate + Alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + Glucosamine → ADP + Glucosamine 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
General function:
Involved in diacylglycerol kinase activity
Specific function:
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor. May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity
Gene Name:
DGKQ
Uniprot ID:
P52824
Molecular weight:
101154.0
General function:
Involved in diacylglycerol kinase activity
Specific function:
Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity
Gene Name:
DGKA
Uniprot ID:
P23743
Molecular weight:
82629.5
General function:
Involved in diacylglycerol kinase activity
Specific function:
Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis
Gene Name:
DGKD
Uniprot ID:
Q16760
Molecular weight:
134524.2
General function:
Involved in diacylglycerol kinase activity
Specific function:
Exhibits high phosphorylation activity for long-chain diacylglycerols
Gene Name:
DGKB
Uniprot ID:
Q9Y6T7
Molecular weight:
90594.7
General function:
Involved in diacylglycerol kinase activity
Specific function:
ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl- sn-glycerol 3-phosphate
Gene Name:
DGKI
Uniprot ID:
O75912
Molecular weight:
116996.2
General function:
Involved in diacylglycerol kinase activity
Specific function:
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity
Gene Name:
DGKZ
Uniprot ID:
Q13574
Molecular weight:
124127.3
General function:
Involved in ATP binding
Specific function:
Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.
Gene Name:
FUK
Uniprot ID:
Q8N0W3
Molecular weight:
117621.795
Reactions
Adenosine triphosphate + L-Fucose → ADP + Fucose 1-phosphatedetails
General function:
Involved in ligase activity
Specific function:
Not Available
Gene Name:
PCCB
Uniprot ID:
P05166
Molecular weight:
58215.13
Reactions
Adenosine triphosphate + Propionyl-CoA + Carbonic acid → ADP + Phosphoric acid + S-Methylmalonyl-CoAdetails
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
PCCA
Uniprot ID:
P05165
Molecular weight:
80058.295
Reactions
Adenosine triphosphate + Propionyl-CoA + Carbonic acid → ADP + Phosphoric acid + S-Methylmalonyl-CoAdetails
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
GART
Uniprot ID:
P22102
Molecular weight:
107766.295
Reactions
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine → ADP + Phosphoric acid + Glycineamideribotidedetails
Adenosine triphosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine → ADP + Phosphoric acid + 5-Aminoimidazole ribonucleotidedetails
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine → ADP + Phosphoric acid + Glycineamideribotidedetails
Adenosine triphosphate + Phosphoribosylformylglycineamidine → ADP + Phosphoric acid + 5-Aminoimidazole ribonucleotidedetails
General function:
Involved in ATP binding
Specific function:
Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.
Gene Name:
GNE
Uniprot ID:
Q9Y223
Molecular weight:
83065.25
Reactions
Adenosine triphosphate + N-acyl-D-mannosamine → ADP + N-acyl-D-mannosamine 6-phosphatedetails
Adenosine triphosphate + N-Acetylmannosamine → ADP + N-Acetyl-D-mannosamine 6-phosphatedetails
General function:
Involved in ATP binding
Specific function:
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
Gene Name:
PAPSS1
Uniprot ID:
O43252
Molecular weight:
70832.725
Reactions
Adenosine triphosphate + Adenosine phosphosulfate → ADP + Phosphoadenosine phosphosulfatedetails
Adenosine triphosphate + Adenylylselenate → ADP + 3-Phosphoadenylylselenatedetails
General function:
Involved in ATP binding
Specific function:
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth (By similarity).
Gene Name:
PAPSS2
Uniprot ID:
O95340
Molecular weight:
69969.8
Reactions
Adenosine triphosphate + Adenosine phosphosulfate → ADP + Phosphoadenosine phosphosulfatedetails
Adenosine triphosphate + Adenylylselenate → ADP + 3-Phosphoadenylylselenatedetails
General function:
Involved in catalytic activity
Specific function:
Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
Gene Name:
CPS1
Uniprot ID:
P31327
Molecular weight:
165649.075
Reactions
Adenosine triphosphate + Ammonia + CO(2) + Water → ADP + Phosphoric acid + Carbamoyl phosphatedetails
Adenosine triphosphate + Ammonia + Carbon dioxide + Water → ADP + Phosphoric acid + Carbamoyl phosphatedetails
General function:
Involved in phosphotransferase activity, alcohol group as acceptor
Specific function:
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).
Gene Name:
ADPGK
Uniprot ID:
Q9BRR6
Molecular weight:
53960.185
Reactions
ADP + D-Glucose → Adenosine monophosphate + Glucose 6-phosphatedetails
Alpha-D-Glucose + ADP → Glucose 6-phosphate + Adenosine monophosphatedetails
Beta-D-Glucose + ADP → Beta-D-Glucose 6-phosphate + Adenosine monophosphatedetails
General function:
Involved in ligase activity
Specific function:
Not Available
Gene Name:
MCCC2
Uniprot ID:
Q9HCC0
Molecular weight:
61332.65
Reactions
Adenosine triphosphate + 3-Methylcrotonyl-CoA + Carbonic acid → ADP + Phosphoric acid + 3-Methylglutaconyl-CoAdetails
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
MCCC1
Uniprot ID:
Q96RQ3
Molecular weight:
80472.45
Reactions
Adenosine triphosphate + 3-Methylcrotonyl-CoA + Carbonic acid → ADP + Phosphoric acid + 3-Methylglutaconyl-CoAdetails
General function:
Involved in glutamate-cysteine ligase activity
Specific function:
Not Available
Gene Name:
GCLC
Uniprot ID:
P48506
Molecular weight:
68629.42
Reactions
Adenosine triphosphate + L-Glutamic acid + L-Cysteine → ADP + Phosphoric acid + Gamma-Glutamylcysteinedetails
General function:
Involved in ATP binding
Specific function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.
Gene Name:
AK1
Uniprot ID:
P00568
Molecular weight:
21634.725
Reactions
Adenosine triphosphate + Adenosine monophosphate → ADPdetails
Adenosine triphosphate + Deoxyadenosine monophosphate → ADP + dADPdetails
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
AK3
Uniprot ID:
Q9UIJ7
Molecular weight:
21013.93
Reactions
NTP + Adenosine monophosphate → NDP + ADPdetails
Uridine triphosphate + Adenosine monophosphate → Uridine 5'-diphosphate + ADPdetails
General function:
Involved in ATP binding
Specific function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. May also be active with GTP (By similarity).
Gene Name:
AK4
Uniprot ID:
P27144
Molecular weight:
25267.83
Reactions
Adenosine triphosphate + Adenosine monophosphate → ADPdetails
Adenosine triphosphate + Deoxyadenosine monophosphate → ADP + dADPdetails
General function:
Involved in ATP binding
Specific function:
Adenylate kinase involved in maintaining ciliary structure and function (By similarity). Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP.
Gene Name:
AK7
Uniprot ID:
Q96M32
Molecular weight:
82657.68
Reactions
Adenosine triphosphate + Adenosine monophosphate → ADPdetails
Adenosine triphosphate + Deoxyadenosine monophosphate → ADP + dADPdetails
General function:
Involved in catalytic activity
Specific function:
Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues.
Gene Name:
FHIT
Uniprot ID:
P49789
Molecular weight:
16858.11
Reactions
P(1)-P(3)-bis(5'-adenosyl) triphosphate + Water → ADP + Adenosine monophosphatedetails
Diadenosine triphosphate + Water → ADP + Adenosine monophosphatedetails
General function:
Involved in thiamin diphosphokinase activity
Specific function:
Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.
Gene Name:
TPK1
Uniprot ID:
Q9H3S4
Molecular weight:
27265.05
Reactions
Adenosine triphosphate + Thiamine pyrophosphate → ADP + Thiamine triphosphatedetails
General function:
Involved in hydrolase activity
Specific function:
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
Gene Name:
NUDT9
Uniprot ID:
Q9BW91
Molecular weight:
35448.725
General function:
Involved in adenosine kinase activity
Specific function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Gene Name:
ADK
Uniprot ID:
P55263
Molecular weight:
38702.93
Reactions
Adenosine triphosphate + Adenosine → ADP + Adenosine monophosphatedetails

Transporters

General function:
Involved in ATP binding
Specific function:
Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Gene Name:
ATP7B
Uniprot ID:
P35670
Molecular weight:
157261.34
General function:
Involved in ATP binding
Specific function:
May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
Gene Name:
ATP7A
Uniprot ID:
Q04656
Molecular weight:
163372.275

Only showing the first 50 proteins. There are 788 proteins in total.