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Human Metabolome Database Version 3.5

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Showing metabocard for Nitrogen (HMDB01371)

Record Information
Version 3.5
Creation Date 2006-08-16 08:01:37 -0600
Update Date 2013-02-08 11:20:57 -0700
HMDB ID HMDB01371
Secondary Accession Numbers None
Metabolite Identification
Common Name Nitrogen
Description Elemental nitrogen is a colorless, odorless, tasteless and mostly inert diatomic gas at standard conditions, constituting 78% by volume of Earth's atmosphere. Nitrogen occurs in all living organisms. It is a constituent element of amino acids and therefore of proteins and nucleic acids (DNA and RNA). Nitrogen is found in the chemical structure of almost all neurotransmitters and is a key component of alkaloids. Specific bacteria (e.g. Rhizobium trifolium) possess nitrogenase enzymes which can fix atmospheric nitrogen into a form (ammonium ion) which is chemically useful to higher organisms. Animals use nitrogen-containing amino acids from plant sources, as starting materials for all nitrogen-compound animal biochemistry, including the manufacture of proteins and nucleic acids. Animal metabolism of NO (nitric oxide) results in production of nitrite. Animal metabolism of nitrogen in proteins generally results in excretion of urea, while animal metabolism of nucleic acids results in excretion of urea and uric acid. The characteristic odor of animal flesh decay is caused by nitrogen-containing long-chain amines, such as putrescine and cadaverine. Decay of organisms and their waste products may produce small amounts of nitrate, but most decay eventually returns nitrogen content to the atmosphere, as molecular nitrogen. The circulation of nitrogen from the atmosphere through organics and then back to the atmosphere is commonly referred to as the nitrogen cycle.
Structure Thumb
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Display: 2D Structure | 3D Structure
Synonyms
  1. Dinitrogen
  2. Nitrogen
  3. Nitrogen gas
Chemical Formula N2
Average Molecular Weight 28.0134
Monoisotopic Molecular Weight 28.00614801
IUPAC Name diazyne
Traditional IUPAC Name nitrogen
CAS Registry Number 7727-37-9
SMILES N#N
InChI Identifier InChI=1S/N2/c1-2
InChI Key IJGRMHOSHXDMSA-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom Inorganic Compounds
Super Class Homogeneous Non-metal Compounds
Class Other Non-metal Organides
Sub Class Other Non-metal Nitrides
Other Descriptors
  • a non-metabolic compound(Cyc)
  • diatomic nitrogen(ChEBI)
  • elemental molecule(ChEBI)
Substituents
  • N/A
Direct Parent Other Non-metal Nitrides
Ontology
Status Expected and Not Quantified
Origin
  • Plant
  • Drug
Biofunction
  • Osmolyte, enzyme cofactor, signalling
Application Not Available
Cellular locations
  • Cytoplasm (predicted from logP)
Physical Properties
State Liquid
Experimental Properties
Property Value Reference
Melting Point -210.01 °C Not Available
Boiling Point Not Available Not Available
Water Solubility 18.1 mg/mL at 21 °C Not Available
LogP 0.67 HANSCH,C ET AL. (1995)
Predicted Properties
Property Value Source
LogP 0.31 ChemAxon
Hydrogen Acceptor Count 2 ChemAxon
Hydrogen Donor Count 0 ChemAxon
Polar Surface Area 47.58 A2 ChemAxon
Rotatable Bond Count 0 ChemAxon
Refractivity 26.23 ChemAxon
Polarizability 1.77 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge 0 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations
  • Cytoplasm (predicted from logP)
Biofluid Locations Not Available
Tissue Location
  • Skin
Pathways Not Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID Not Available
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB013398
KNApSAcK ID Not Available
Chemspider ID 922 Link_out
KEGG Compound ID C00697 Link_out
BioCyc ID NITROGEN-OXIDE Link_out
BiGG ID Not Available
Wikipedia Link Nitrogen Link_out
NuGOwiki Link HMDB01371 Link_out
Metagene Link HMDB01371 Link_out
METLIN ID Not Available
PubChem Compound 947 Link_out
PDB ID HDZ Link_out
ChEBI ID 17997 Link_out
References
Synthesis Reference Not Available
Material Safety Data Sheet (MSDS) Download (PDF)
General References
  1. Balafa C, Smith-Thomas L, Phillips J, Moustafa M, George E, Blount M, Nicol S, Westgate G, MacNeil S: Dopa oxidase activity in the hair, skin and ocular melanocytes is increased in the presence of stressed fibroblasts. Exp Dermatol. 2005 May;14(5):363-72. Pubmed: 15854130 Link_out
  2. Konya C, Sanada H, Sugama J, Kitayama Y, Ishikawa S, Togashi H, Tamura S: Skin debris and micro-organisms on the periwound skin of pressure ulcers and the influence of periwound cleansing on microbial flora. Ostomy Wound Manage. 2005 Jan;51(1):50-9. Pubmed: 15695835 Link_out