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Human Metabolome Database Version 3.5

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Showing metabocard for Niacinamide (HMDB01406)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:10:29 -0700
HMDB ID HMDB01406
Secondary Accession Numbers None
Metabolite Identification
Common Name Niacinamide
Description Niacinamide or vitamin B3 is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. Niacinamide is used to increase the effect of radiation therapy on tumor cells. Niacin (nicotinic acid) and niacinamide, while both labeled as vitamin B3 also have different applications. Niacinamide is useful in arthritis and early-onset type I diabetes while niacin is an effective reducer of high cholesterol levels.
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. 3-Carbamoylpyridine
  2. 3-Pyridinecarboxamide
  3. 3-Pyridinecarboxylic acid amide
  4. Acid amide
  5. Amid kyseliny nikotinove
  6. Amide PP
  7. Aminicotin
  8. Amixicotyn
  9. Amnicotin
  10. Austrovit PP
  11. b-Pyridinecarboxamide
  12. Benicot
  13. beta-Pyridinecarboxamide
  14. Delonin Amide
  15. Dipegyl
  16. Dipigyl
  17. Endobion
  18. Factor pp
  19. Hansamid
  20. Inovitan PP
  21. m-(Aminocarbonyl)pyridine
  22. Mediatric
  23. NAM
  24. Nandervit-N
  25. Niacevit
  26. Niacinamide
  27. Niamide
  28. Niavit PP
  29. Nicamide
  30. Nicamina
  31. Nicamindon
  32. Nicasir
  33. Nicobion
  34. Nicofort
  35. Nicogen
  36. Nicomidol
  37. Nicosan 2
  38. Nicosylamide
  39. Nicota
  40. Nicotamide
  41. Nicotilamide
  42. Nicotililamido
  43. Nicotinamida
  44. Nicotinamide
  45. Nicotinamidum
  46. Nicotine acid amide
  47. Nicotine amide
  48. Nicotinic acid amide
  49. Nicotinic amide
  50. Nicotinsaureamid
  51. Nicotol
  52. Nicotylamide
  53. Nicotylamidum
  54. Nicovel
  55. Nicovit
  56. Nicovitina
  57. Nicovitol
  58. Nicozymin
  59. Nictoamide
  60. Niko-tamin
  61. Nikotinamid
  62. Nikotinsaeureamid
  63. Niocinamide
  64. Niozymin
  65. Papulex
  66. Pelmin
  67. Pelmine
  68. Pelonin amide
  69. PP-Faktor
  70. Propamine A
  71. Pyridine-3-carboxylic acid amide
  72. Savacotyl
  73. Vi-Nicotyl
  74. Vi-noctyl
  75. Vitamin B3
  76. Vitamin PP
  77. Witamina PP
Chemical Formula C6H6N2O
Average Molecular Weight 122.1246
Monoisotopic Molecular Weight 122.048012824
IUPAC Name pyridine-3-carboxamide
Traditional IUPAC Name nicotinamide
CAS Registry Number 98-92-0
SMILES NC(=O)C1=CN=CC=C1
InChI Identifier InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
InChI Key DFPAKSUCGFBDDF-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Aromatic Heteromonocyclic Compounds
Class Pyridines and Derivatives
Sub Class N/A
Other Descriptors
  • Pyridine alkaloids(KEGG)
  • Water-soluble vitamins(KEGG)
  • a vitamin(Cyc)
  • an aliphatic amide(Cyc)
  • pyridine alkaloid(ChEBI)
  • pyridinecarboxamide(ChEBI)
Substituents
  • Carboxamide Group
  • Primary Carboxylic Acid Amide
Direct Parent Pyridines and Derivatives
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Nicotinate and nicotinamide metabolism
Application Not Available
Cellular locations
  • Extracellular
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point 130 °C Not Available
Boiling Point Not Available Not Available
Water Solubility 500 mg/mL at 25 °C Not Available
LogP -0.37 HANSCH,C ET AL. (1995)
Predicted Properties
Property Value Source
Water Solubility 50.1 g/L ALOGPS
LogP -0.45 ALOGPS
LogP -0.39 ChemAxon
LogS -0.39 ALOGPS
pKa (strongest acidic) 13.39 ChemAxon
pKa (strongest basic) 3.63 ChemAxon
Hydrogen Acceptor Count 2 ChemAxon
Hydrogen Donor Count 1 ChemAxon
Polar Surface Area 55.98 A2 ChemAxon
Rotatable Bond Count 1 ChemAxon
Refractivity 32.98 ChemAxon
Polarizability 11.71 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge 0 ChemAxon
Spectra
13C NMR Spectrum
1H NMR Spectrum
MS/MS Spectrum Quattro_QQQ 10
MS/MS Spectrum Quattro_QQQ 25
MS/MS Spectrum Quattro_QQQ 40
MS/MS Spectrum EI-B (HITACHI M-80)
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 10
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 20
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 30
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 40
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 50
MS/MS Spectrum GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)
MS/MS Spectrum GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies )
MS/MS Spectrum GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)
MS/MS Spectrum LC-ESI-QTOF (UPLC Q-Tof Premier, Waters)
MS/MS Spectrum LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30
MS/MS Spectrum LC-ESI-QTOF (UPLC Q-Tof Premier, Waters)
[1H,1H] 2D NMR Spectrum
[1H,13C] 2D NMR Spectrum
Biological Properties
Cellular Locations
  • Extracellular
Biofluid Locations
  • Blood
  • Urine
Tissue Location
  • Bladder
  • Fibroblasts
  • Neuron
  • Pancreas
  • Placenta
  • Prostate
  • Skin
  • Spleen
  • Stratum Corneum
Pathways
Name SMPDB Link KEGG Link
Nicotinate and Nicotinamide Metabolism SMP00048 map00760 Link_out
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
0.44 +/- 0.0054 uM Adult (>18 years old) Both Normal
Urine Detected and Quantified
0.30 +/- 0.51 umol/mmol creatinine Infant (0-1 year old) Both Normal
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID DB02701 Link_out
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB012485
KNApSAcK ID C00000209 Link_out
Chemspider ID 911 Link_out
KEGG Compound ID C00153 Link_out
BioCyc ID NIACINAMIDE Link_out
BiGG ID 34058 Link_out
Wikipedia Link Niacinamide Link_out
NuGOwiki Link HMDB01406 Link_out
Metagene Link HMDB01406 Link_out
METLIN ID 1497 Link_out
PubChem Compound 936 Link_out
PDB ID NCA Link_out
ChEBI ID 17154 Link_out
References
Synthesis Reference Galat, Alexander. Nicotinamide from nicotinonitrile by catalytic hydration. Journal of the American Chemical Society (1948), 70 3945.
Material Safety Data Sheet (MSDS) Download (PDF)
General References
  1. Draelos ZD, Ertel K, Berge C: Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. Cutis. 2005 Aug;76(2):135-41. Pubmed: 16209160 Link_out
  2. Soma Y, Kashima M, Imaizumi A, Takahama H, Kawakami T, Mizoguchi M: Moisturizing effects of topical nicotinamide on atopic dry skin. Int J Dermatol. 2005 Mar;44(3):197-202. Pubmed: 15807725 Link_out
  3. Final report of the safety assessment of niacinamide and niacin. Int J Toxicol. 2005;24 Suppl 5:1-31. Pubmed: 16596767 Link_out
  4. Draelos ZD, Matsubara A, Smiles K: The effect of 2% niacinamide on facial sebum production. J Cosmet Laser Ther. 2006 Jun;8(2):96-101. Pubmed: 16766489 Link_out
  5. Schulpis K, Spiropoulos A, Gavrili S, Karikas G, Grigori C, Vlachos G, Papassotiriou I: Maternal - neonatal folate and vitamin B12 serum concentrations in Greeks and in Albanian immigrants. J Hum Nutr Diet. 2004 Oct;17(5):443-8. Pubmed: 15357698 Link_out
  6. Yang L, Yao Y, Shi Y, Wang X, Shi J: [Expression of nicotinamide edenine dinucleotide dehydrogenase gene in placenta of patients with pregnancy induced hypertension] Zhonghua Fu Chan Ke Za Zhi. 2002 Nov;37(11):660-2. Pubmed: 12487919 Link_out
  7. Sonee M, Martens JR, Mukherjee SK: Nicotinamide protects HCN2 cells from the free radical generating toxin, tertiary butylhydroperoxide (t-BuOOH). Neurotox Res. 2002 Nov;4(7-8):595-599. Pubmed: 12709297 Link_out
  8. Bayraktar F, Dereli D, Ozgen AG, Yilmaz C: Plasma homocysteine levels in polycystic ovary syndrome and congenital adrenal hyperplasia. Endocr J. 2004 Dec;51(6):601-8. Pubmed: 15644580 Link_out
  9. Sonee M, Martens JR, Evers MR, Mukherjee SK: The effect of tertiary butylhydroperoxide and nicotinamide on human cortical neurons. Neurotoxicology. 2003 Jun;24(3):443-8. Pubmed: 12782109 Link_out
  10. Anisimov AG, Bolotnikov IA: [Nicotinamide decreases DNA destabilization in K562 cells treated with AlF(-4)] Tsitologiia. 1997;39(9):822-8. Pubmed: 9518388 Link_out
  11. Matuoka K, Chen KY, Takenawa T: Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation. Cell Mol Life Sci. 2001 Dec;58(14):2108-16. Pubmed: 11814060 Link_out
  12. Bartalena L, Tanda ML, Piantanida E, Lai A: Oxidative stress and Graves' ophthalmopathy: in vitro studies and therapeutic implications. Biofactors. 2003;19(3-4):155-63. Pubmed: 14757966 Link_out
  13. Bissett DL, Oblong JE, Berge CA: Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatol Surg. 2005 Jul;31(7 Pt 2):860-5; discussion 865. Pubmed: 16029679 Link_out
  14. Baeza N, Moriscot C, Figarella C, Guy-Crotte O, Vialettes B: Reg protein: a potential beta-cell-specific growth factor? Diabetes Metab. 1996 Jul;22(4):229-34. Pubmed: 8767167 Link_out
  15. Hoskin PJ, Rojas AM, Phillips H, Saunders MI: Acute and late morbidity in the treatment of advanced bladder carcinoma with accelerated radiotherapy, carbogen, and nicotinamide. Cancer. 2005 Jun 1;103(11):2287-97. Pubmed: 15834926 Link_out
  16. Rembold CM: Combination therapy of dyslipidemia in non-insulin-dependent diabetes mellitus and the metabolic syndrome. Curr Diab Rep. 2004 Oct;4(5):330-4. Pubmed: 15461896 Link_out
  17. Kawasaki E, Abiru N, Eguchi K: Prevention of type 1 diabetes: from the view point of beta cell damage. Diabetes Res Clin Pract. 2004 Dec;66 Suppl 1:S27-32. Pubmed: 15563975 Link_out
  18. Rybak ME, Pfeiffer CM: Clinical analysis of vitamin B(6): determination of pyridoxal 5'-phosphate and 4-pyridoxic acid in human serum by reversed-phase high-performance liquid chromatography with chlorite postcolumn derivatization. Anal Biochem. 2004 Oct 15;333(2):336-44. Pubmed: 15450810 Link_out
  19. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411 Link_out
Enzymes
Name: Nicotinamide N-methyltransferase
Reactions:
  • S-Adenosylmethionine + Niacinamide unknown S-Adenosylhomocysteine + 1-Methylnicotinamide
  • S-Adenosylmethionine + Niacinamide + Hydrogen Ion unknown S-Adenosylhomocysteine + 1-Methylnicotinamide
Gene Name: NNMT
Uniprot ID: P40261 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Tankyrase-2
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: TNKS2
Uniprot ID: Q9H2K2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NAD-dependent protein deacetylase sirtuin-6
Reactions:
  • NAD + an acetylprotein unknown Niacinamide + O-acetyl-ADP-ribose + a protein
Gene Name: SIRT6
Uniprot ID: Q8N6T7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Poly [ADP-ribose] polymerase 3
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: PARP3
Uniprot ID: Q9Y6F1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ecto-ADP-ribosyltransferase 3
Reactions:
  • NAD + protein-L-arginine unknown Niacinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine
  • NADP + protein-L-arginine unknown Niacinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine
Gene Name: ART3
Uniprot ID: Q13508 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ecto-ADP-ribosyltransferase 5
Reactions:
  • NAD + protein-L-arginine unknown Niacinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine
  • NADP + protein-L-arginine unknown Niacinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine
Gene Name: ART5
Uniprot ID: Q96L15 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
Reactions:
  • NAD + protein-L-arginine unknown Niacinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine
  • NADP + protein-L-arginine unknown Niacinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine
Gene Name: ART1
Uniprot ID: P52961 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Tankyrase-1
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: TNKS
Uniprot ID: O95271 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Poly [ADP-ribose] polymerase 1
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: PARP1
Uniprot ID: P09874 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: ADP-ribosyl cyclase 2
Reactions:
  • NAD + Water unknown Adenosine diphosphate ribose + Niacinamide
  • NADP + Water unknown Niacinamide + (E)-3-(2,3-Dihydroxyphenyl)-2-propenoic acid
Gene Name: BST1
Uniprot ID: Q10588 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Poly [ADP-ribose] polymerase 2
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: PARP2
Uniprot ID: Q9UGN5 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: ADP-ribosyl cyclase 1
Reactions:
  • NAD + Water unknown Adenosine diphosphate ribose + Niacinamide
  • NADP + Water unknown Niacinamide + (E)-3-(2,3-Dihydroxyphenyl)-2-propenoic acid
Gene Name: CD38
Uniprot ID: P28907 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ecto-ADP-ribosyltransferase 4
Reactions:
  • NAD + protein-L-arginine unknown Niacinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine
  • NADP + protein-L-arginine unknown Niacinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine
Gene Name: ART4
Uniprot ID: Q93070 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Poly [ADP-ribose] polymerase 4
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: PARP4
Uniprot ID: Q9UKK3 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 3A4
Reactions:
  • Quinine + NADPH + Oxygen unknown 3-Hydroxyquinine + NADP + Water
  • Taurochenodesoxycholic acid + NADPH + Oxygen unknown Taurohyocholate + NADP + Water
  • Lithocholic acid + NADPH + Oxygen unknown Hyodeoxycholic acid + NADP + Water
  • Albendazole + NADPH + Oxygen unknown albendazole S-oxide + NADP + Water
  • Eucalyptol + NADPH + Oxygen unknown 2-exo-hydroxy-1,8-cineole + NADP + Water
Gene Name: CYP3A4
Uniprot ID: P08684 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2E1
Reactions:
  • 4-Nitrophenol + NADPH + Oxygen unknown 4-Nitrocatechol + NADP + Water
Gene Name: CYP2E1
Uniprot ID: P05181 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2D6
Reactions:
  • RH + reduced flavoprotein + Oxygen unknown ROH + oxidized flavoprotein + Water
Gene Name: CYP2D6
Uniprot ID: P10635 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: L-lactate dehydrogenase A chain
Reactions:
  • L-Lactic acid + NAD unknown Pyruvic acid + NADH
  • L-Lactic acid + NAD unknown Pyruvic acid + NADH + Hydrogen Ion
  • 2-Hydroxybutyric acid + NAD unknown 2-Ketobutyric acid + NADH + Hydrogen Ion
  • 3-Mercaptolactic acid + NAD unknown 3-Mercaptopyruvic acid + NADH + Hydrogen Ion
Gene Name: LDHA
Uniprot ID: P00338 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Purine nucleoside phosphorylase
Reactions:
  • Nebularine + Phosphoric acid unknown Purine + Ribose 1-phosphate
  • Adenosine + Phosphoric acid unknown Adenine + Ribose 1-phosphate
  • Inosine + Phosphoric acid unknown Hypoxanthine + Ribose 1-phosphate
  • Deoxyguanosine + Phosphoric acid unknown Guanine + Deoxyribose 1-phosphate
  • Guanosine + Phosphoric acid unknown Guanine + Ribose 1-phosphate
  • Nicotinamide riboside + Phosphoric acid unknown Niacinamide + Ribose 1-phosphate
  • Nicotinate D-ribonucleoside + Phosphoric acid unknown Nicotinic acid + Ribose 1-phosphate + Hydrogen Ion
  • Xanthosine + Phosphoric acid unknown Xanthine + Ribose 1-phosphate
  • Deoxyuridine + Phosphoric acid unknown Uracil + Deoxyribose 1-phosphate
  • Deoxyadenosine + Phosphoric acid unknown Adenine + Deoxyribose 1-phosphate
  • Deoxyinosine + Phosphoric acid unknown Hypoxanthine + Deoxyribose 1-phosphate
Gene Name: PNP
Uniprot ID: P00491 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Nicotinamide phosphoribosyltransferase
Reactions:
  • beta-nicotinamide D-ribonucleotide + Pyrophosphate unknown Niacinamide + Phosphoribosyl pyrophosphate
Gene Name: NAMPT
Uniprot ID: P43490 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Poly [ADP-ribose] polymerase 10
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: PARP10
Uniprot ID: Q53GL7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Poly [ADP-ribose] polymerase 11
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: PARP11
Uniprot ID: Q9NR21 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Poly [ADP-ribose] polymerase 12
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: PARP12
Uniprot ID: Q9H0J9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Poly [ADP-ribose] polymerase 14
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: PARP14
Uniprot ID: Q460N5 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Poly [ADP-ribose] polymerase 15
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: PARP15
Uniprot ID: Q460N3 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Mono [ADP-ribose] polymerase PARP16
Reactions:
  • NAD + protein-L-arginine unknown Niacinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine
Gene Name: PARP16
Uniprot ID: Q8N5Y8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Poly [ADP-ribose] polymerase 6
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: PARP6
Uniprot ID: Q2NL67 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Poly [ADP-ribose] polymerase 8
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: PARP8
Uniprot ID: Q8N3A8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Poly [ADP-ribose] polymerase 9
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: PARP9
Uniprot ID: Q8IXQ6 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: TCDD-inducible poly [ADP-ribose] polymerase
Reactions:
  • NAD + (ADP-D-ribosyl)(n)-acceptor unknown Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor
Gene Name: TIPARP
Uniprot ID: Q7Z3E1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NAD-dependent protein deacetylase sirtuin-1
Reactions:
  • NAD + an acetylprotein unknown Niacinamide + O-acetyl-ADP-ribose + a protein
Gene Name: SIRT1
Uniprot ID: Q96EB6 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NAD-dependent protein deacetylase sirtuin-2
Reactions:
  • NAD + an acetylprotein unknown Niacinamide + O-acetyl-ADP-ribose + a protein
Gene Name: SIRT2
Uniprot ID: Q8IXJ6 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Reactions:
  • NAD + an acetylprotein unknown Niacinamide + O-acetyl-ADP-ribose + a protein
Gene Name: SIRT3
Uniprot ID: Q9NTG7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NAD-dependent protein deacetylase sirtuin-4
Reactions:
  • NAD + a protein unknown Niacinamide + an N-(ADP-D-ribosyl)-protein
  • NAD + an acetylprotein unknown Niacinamide + O-acetyl-ADP-ribose + a protein
Gene Name: SIRT4
Uniprot ID: Q9Y6E7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NAD-dependent protein deacylase sirtuin-5, mitochondrial
Reactions:
  • NAD + a malonylprotein unknown Niacinamide + O-malonyl-ADP-ribose + a protein
  • NAD + a succinylprotein unknown Niacinamide + O-succinyl-ADP-ribose + a protein
Gene Name: SIRT5
Uniprot ID: Q9NXA8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NAD-dependent protein deacetylase sirtuin-7
Reactions:
  • NAD + an acetylprotein unknown Niacinamide + O-acetyl-ADP-ribose + a protein
Gene Name: SIRT7
Uniprot ID: Q9NRC8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: tRNA 2'-phosphotransferase 1
Reactions:
  • 2'-phospho-[ligated tRNA] + NAD unknown mature tRNA + ADP ribose 1'',2''-phosphate + Niacinamide + Water
Gene Name: TRPT1
Uniprot ID: Q86TN4 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA