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Human Metabolome Database Version 3.5

Showing metabocard for Permanganate (HMDB01417)

• Identification
• Taxonomy
• Ontology
• Physical properties
• Spectra
• Biological properties
• Concentrations
• Links
• References

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Record Information
Version	3.5
Creation Date	2005-11-16 08:48:42 -0700
Update Date	2013-02-08 17:10:30 -0700
HMDB ID	HMDB01417
Secondary Accession Numbers	None
Metabolite Identification
Common Name	Permanganate
Description	Permanganate is a permanganate is a chemical compound that contains the permanganate ion (MnO4-). Because manganese is in the +7 oxidation state, the permanganate ion is a strong oxidizer. Permanganates are salts of permanganic acid. Permanganate is a strong oxidizer, and similar to perchlorate. Being a strong oxidizer it is in common use in qualitative analysis experiments involving redox reactions (permanganometry). (wikipedia). Various anions interact with human serum transferrin to the concomitant binding of iron and a synergistic anion to form the transferrin-anion-iron complex. In vitro, permanganate was found to partially inactivate transferrin. Transferrin treated with a 3:1 molar ratio of permanganate to active sites lost 74 or 67% of its iron-binding capacity, respectively. (PMID: 3028261 ). In the presence of permanganate, Mn3+ was formed and chelated by transferrin at physiological pH in cows and goats. Manganese in the divalent state, either free as Mn2+ or bound to alpha2-macroglobulin, is removed from blood plasma very efficiently by the liver. However, the manganic-transferrin complex normally found in circulation is not rapidly removed from plasma. The liver can remove large amounts of excess manganous manganese which it presumably excretes; the small essential fraction of the manganese absorbed is oxidized to the trivalent state and bound to transferrin. (PMID 60137 ).
Structure	Download: MOL | SDF | SMILES | InChI Display: 2D Structure | 3D Structure
Synonyms	Permanganate (MnO4-) ion Permanganate anion Permanganate ion Permanganate ion(1-) Permanganate(1-) Permanganic acid (HMnO4) ion(1-)
Chemical Formula	MnO4
Average Molecular Weight	118.9356
Monoisotopic Molecular Weight	118.917708124
IUPAC Name	manganesoylolate
Traditional IUPAC Name	permanganate
CAS Registry Number	14333-13-2
SMILES	[O-][Mn](=O)(=O)=O
InChI Identifier	InChI=1S/Mn.4O/q;;;;-1
InChI Key	NPDODHDPVPPRDJ-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom	Inorganic
Super Class	Inorganic compounds
Class	Inorganic Ions and Gases
Sub Class	Anions
Other Descriptors	None
Substituents	Anion
Direct Parent	Not Available
Ontology
Status	Expected and Not Quantified
Origin	Endogenous
Biofunction	Osmolyte, enzyme cofactor, signalling
Application	Not Available
Cellular locations	Not Available
Physical Properties
State	Solid
Experimental Properties	Property Value Reference Melting Point 240 °C Not Available Boiling Point Not Available Not Available Water Solubility 64 mg/mL at 20 °C Not Available LogP Not Available Not Available
Predicted Properties	Property Value Source Water Solubility ALOGPS LogP -2.3 ChemAxon pKa (strongest acidic) 11.44 ChemAxon Hydrogen Acceptor Count 4 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 74.27 A2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 5.77 ChemAxon Polarizability 6.08 ChemAxon Formal Charge -1 ChemAxon Physiological Charge 0 ChemAxon
Spectra
	Not Available
Biological Properties
Cellular Locations	Not Available
Biofluid Locations	Not Available
Tissue Location	Not Available
Pathways	Not Available
Normal Concentrations
	Not Available
Abnormal Concentrations
	Not Available
Associated Disorders and Diseases
Disease References	None
Associated OMIM IDs	None
External Links
DrugBank ID	Not Available
Phenol Explorer Compound ID	Not Available
Phenol Explorer Metabolite ID	Not Available
FoodDB ID	FDB022610
KNApSAcK ID	Not Available
Chemspider ID	22811
KEGG Compound ID	Not Available
BioCyc ID	Not Available
BiGG ID	Not Available
Wikipedia Link	Permanganate
NuGOwiki Link	HMDB01417
Metagene Link	HMDB01417
METLIN ID	Not Available
PubChem Compound	24401
PDB ID	Not Available
ChEBI ID	25939
References
Synthesis Reference	Atanasiu, Ion A.; Lazar, Lya B.; Constantinescu, Maria. Preparation of permanganate by both direct current and alternating current anodic dissolution of manganese and its alloys. Buletinul Institutului Politehnic Gheorghe Gheorghiu-Dej Bucuresti (1967), 29(1), 49-57.
Material Safety Data Sheet (MSDS)	Download (PDF)
General References	Koren R, Bernheim J, Schachter P, Schwartz A, Siegal A, Gal R: Black thyroid adenoma. Clinical, histochemical, and ultrastructural features. Appl Immunohistochem Mol Morphol. 2000 Mar;8(1):80-4. Pubmed: 10937053 Gelmetti C: Skin cleansing in children. J Eur Acad Dermatol Venereol. 2001 Sep;15 Suppl 1:12-5. Pubmed: 11720072 Bui CT, Rees K, Lambrinakos A, Bedir A, Cotton RG: Site-selective reactions of imperfectly matched DNA with small chemical molecules: applications in mutation detection. Bioorg Chem. 2002 Aug;30(4):216-32. Pubmed: 12392702 Sami N, Yeh SW, Ahmed AR: Blistering diseases in the elderly: diagnosis and treatment. Dermatol Clin. 2004 Jan;22(1):73-86. Pubmed: 15018011 Johnson TB, Cassidy DD: Unintentional ingestion of potassium permanganate. Pediatr Emerg Care. 2004 Mar;20(3):185-7. Pubmed: 15094579 Tabatabai G, Baehring J, Hochberg FH: Primary amyloidoma of the brain parenchyma. Arch Neurol. 2005 Mar;62(3):477-80. Pubmed: 15767515 Gajewska M, Dzierzgowska A, Pawinski T, Czerwinska K: Spectrofluorimetric assay of azathioprine and 6-mercaptopurine in human blood plasma. Acta Pol Pharm. 1992;49(4):13-6. Pubmed: 16092428 Matsuba A, Oka K, Hoshii Y, Kawamura S, Yonekawa N, Nomura S, Ikezawa Y, Kobayashi M, Ishihara T: A case report of dystrophic localized amyloidosis that developed in the left thigh. Pathol Res Pract. 2005;201(8-9):603-8. Pubmed: 16259115 Pasternak S, Wright BA, Walsh N: Soft tissue amyloidoma of the extremities: report of a case and review of the literature. Am J Dermatopathol. 2007 Apr;29(2):152-5. Pubmed: 17414436 Elghetany MT, Saleem A: Methods for staining amyloid in tissues: a review. Stain Technol. 1988 Jul;63(4):201-12. Pubmed: 2464206 Buck FS, Koss MN, Sherrod AE, Wu A, Takahashi M: Ethnic distribution of amyloidosis: an autopsy study. Mod Pathol. 1989 Jul;2(4):372-7. Pubmed: 2668942 Silveira SR, Hadler WA: A histochemical investigation on the percutaneous absorption of vitamin D synthesized into the mammal epidermis. Acta Histochem. 1985;77(1):11-8. Pubmed: 2998137 Chiba M, Inoue Y, Arakawa H, Masamune O, Ohkubo M: Behcet's disease associated with amyloidosis. Gastroenterol Jpn. 1987 Aug;22(4):487-95. Pubmed: 3311868 Silverman JF, Dabbs DJ, Norris HT, Pories WJ, Legier J, Kay S: Localized primary (AL) amyloid tumor of the breast. Cytologic, histologic, immunocytochemical and ultrastructural observations. Am J Surg Pathol. 1986 Aug;10(8):539-45. Pubmed: 3526931 Makovitzky J: Polarization optical analysis of blood cell membranes. Prog Histochem Cytochem. 1984;15(3):1-100. Pubmed: 6209743 Gal R, Korzets A, Schwartz A, Rath-Wolfson L, Gafter U: Systemic distribution of beta 2-microglobulin-derived amyloidosis in patients who undergo long-term hemodialysis. Report of seven cases and review of the literature. Arch Pathol Lab Med. 1994 Jul;118(7):718-21. Pubmed: 8024407 Ito S: High-performance liquid chromatography (HPLC) analysis of eu- and pheomelanin in melanogenesis control. J Invest Dermatol. 1993 Feb;100(2 Suppl):166S-171S. Pubmed: 8433004 Saluz HP, Jost JP: Approaches to characterize protein-DNA interactions in vivo. Crit Rev Eukaryot Gene Expr. 1993;3(1):1-29. Pubmed: 8439708 Pambuccian SE, Horyd ID, Cawte T, Huvos AG: Amyloidoma of bone, a plasma cell/plasmacytoid neoplasm. Report of three cases and review of the literature. Am J Surg Pathol. 1997 Feb;21(2):179-86. Pubmed: 9042284 Sidoni A, Alberti PF, Bravi S, Bucciarelli E: Amyloid tumours in the soft tissues of the legs. Case report and review of the literature. Virchows Arch. 1998 Jun;432(6):563-6. Pubmed: 9672199

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