Human Metabolome Database Version 3.5

Showing metabocard for Phosphate (HMDB01429)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-05-29 13:31:35 -0600
HMDB ID HMDB01429
Secondary Accession Numbers
  • HMDB05947
Metabolite Identification
Common Name Phosphate
Description Phosphate is a salt of phosphoric acid. In organic chemistry, a phosphate, or organophosphate, is an ester of phosphoric acid. Organic phosphates are important in biochemistry, biogeochemistry and ecology. Phosphate (Pi) is an essential component of life. In biological systems, phosphorus is found as a free phosphate ion in solution and is called inorganic phosphate, to distinguish it from phosphates bound in various phosphate esters. Inorganic phosphate is generally denoted Pi and at physiological (neutral) pH primarily consists of a mixture of HPO2-4 and H2PO-4 ions. phosphates are most commonly found in the form of adenosine phosphates, (AMP, ADP and ATP) and in DNA and RNA and can be released by the hydrolysis of ATP or ADP. Similar reactions exist for the other nucleoside diphosphates and triphosphates. Phosphoanhydride bonds in ADP and ATP, or other nucleoside diphosphates and triphosphates, contain high amounts of energy which give them their vital role in all living organisms. Phosphate must be actively transported into cells against its electrochemical gradient. In vertebrates, two unrelated families of Na+-dependent Pi transporters carry out this task. Remarkably, the two families transport different Pi species: whereas type II Na+/Pi cotransporters (SCL34) prefer divalent HPO4(2), type III Na+/Pi cotransporters (SLC20) transport monovalent H2PO4. The SCL34 family comprises both electrogenic and electroneutral members that are expressed in various epithelia and other polarized cells. Through regulated activity in apical membranes of the gut and kidney, they maintain body Pi homeostasis, and in salivary and mammary glands, liver, and testes they play a role in modulating the Pi content of luminal fluids. Phosphate levels in the blood play an important role in hormone signaling and in bone homeostasis. In classical endocrine regulation, low serum phosphate induces the renal production of the seco-steroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3).This active metabolite of vitamin D acts to restore circulating mineral (i.e. phosphate and calcium) levels by increasing absorption in the intestine, reabsorption in the kidney, and mobilization of calcium and phosphate from bone. Thus, chronic renal failure is associated with hyperparathyroidism, which in turn contributes to osteomalacia (softening of the bones). Another complication of chronic renal failure is hyperphosphatemia (low levels of phosphate in the blood). Hyperphosphatemia (excess levels of phosphate in the blood) is a prevalent condition in kidney dialysis patients and is associated with increased risk of mortality. Hypophosphatemia (hungry bone syndrome) has been associated to postoperative electrolyte aberrations and after parathyroidectomy. (PMID: 17581921 Link_out, 11169009 Link_out, 11039261 Link_out, 9159312 Link_out, 17625581 Link_out)Fibroblast growth factor 23 (FGF-23) has recently been recognized as a key mediator of phosphate homeostasis, its most notable effect being promotion of phosphate excretion. FGF-23 was discovered to be involved in diseases such as autosomal dominant hypophosphatemic rickets, X-linked hypophosphatemia, and tumor-induced osteomalacia in which phosphate wasting was coupled to inappropriately low levels of 1,25(OH)2D3. FGF-23 is regulated by dietary phosphate in humans. In particular it was found that phosphate restriction decreased FGF-23, and phosphate loading increased FGF-23.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. NFB Orthophosphate
  2. O-Phosphoric acid
  3. Ortho-phosphate
  4. Orthophosphate (PO43-)
  5. Orthophosphate(3-)
  6. Phosphate
  7. Phosphate (PO43-)
  8. Phosphate anion(3-)
  9. Phosphate ion (PO43-)
  10. Phosphate ion(3-)
  11. Phosphate trianion
  12. Phosphate(3-)
  13. Phosphoric acid ion(3-)
  14. Pi
Chemical Formula O4P
Average Molecular Weight 94.9714
Monoisotopic Molecular Weight 94.95342
IUPAC Name phosphate
Traditional IUPAC Name phosphate
CAS Registry Number 14265-44-2
SMILES [O-]P([O-])([O-])=O
InChI Identifier InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChI Key NBIIXXVUZAFLBC-UHFFFAOYSA-K
Chemical Taxonomy
Kingdom Inorganic Compounds
Super Class Homogeneous Non-metal Compounds
Class Non-metal Oxoanionic Compounds
Sub Class Non-metal Phosphates
Other Descriptors
  • phosphate ion(ChEBI)
Substituents
  • N/A
Direct Parent Non-metal Phosphates
Ontology
Status Detected and Quantified
Origin
  • Drug metabolite
  • Endogenous
Biofunction
  • Osmolyte, enzyme cofactor, signalling
  • Waste products
Application Not Available
Cellular locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
  • Lysosome
  • Endoplasmic reticulum
  • Golgi apparatus
  • Peroxisome
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility 1000 mg/mL MERCK INDEX (1996)
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility ALOGPS
LogP -1 ChemAxon
pKa (strongest acidic) 1.8 ChemAxon
Hydrogen Acceptor Count 4 ChemAxon
Hydrogen Donor Count 0 ChemAxon
Polar Surface Area 86.25 A2 ChemAxon
Rotatable Bond Count 0 ChemAxon
Refractivity 11.29 ChemAxon
Polarizability 4.93 ChemAxon
Formal Charge -3 ChemAxon
Physiological Charge -2 ChemAxon
Spectra
Gas-MS Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
  • Lysosome
  • Endoplasmic reticulum
  • Golgi apparatus
  • Peroxisome
Biofluid Locations
  • Blood
  • Urine
Tissue Location
  • Kidney
  • Liver
  • Prostate
Pathways Not Available
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
379.1 +/- 31.6 uM Adult (>18 years old) Male Normal
Urine Detected and Quantified
1364.27 +/- 915.27 umol/mmol creatinine Infant (0-1 year old) Both Normal
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified 450 +/- 30 uM Adult (>18 years old) Not Specified Comment Hypophosphatemia
Blood Detected and Quantified 290 +/- 50 uM Adult (>18 years old) Not Specified Comment Hypophosphatemia
Blood Detected and Quantified 653.0 +/- 126.0 uM Adult (>18 years old) Both Hemodialysis
Blood Detected and Quantified 270 (0-540) uM Adult (>18 years old) Not Specified Comment Hypophosphatemia
Blood Detected and Quantified 610 +/- 130 uM Adult (>18 years old) Not Specified Comment Hypophosphatemia
Associated Disorders and Diseases
Disease References
Hemodialysis
  • Oikawa O, Higuchi T, Yamazaki T, Yamamoto C, Fukuda N, Matsumoto K: Evaluation of serum fetuin-A relationships with biochemical parameters in patients on hemodialysis. Clin Exp Nephrol. 2007 Dec;11(4):304-8. Epub 2007 Dec 21. Pubmed: 18085392 Link_out
      Hypophosphatemia
      • Amanzadeh J, Reilly RF Jr: Hypophosphatemia: an evidence-based approach to its clinical consequences and management. Nat Clin Pract Nephrol. 2006 Mar;2(3):136-48. Pubmed: 16932412 Link_out
          Associated OMIM IDs None
          DrugBank ID Not Available
          DrugBank Metabolite ID DBMET00532 Link_out
          Phenol Explorer Compound ID Not Available
          Phenol Explorer Metabolite ID Not Available
          FoodDB ID FDB022617
          KNApSAcK ID Not Available
          Chemspider ID 1032 Link_out
          KEGG Compound ID C00009 Link_out
          BioCyc ID CPD-8587 Link_out
          BiGG ID 33499 Link_out
          Wikipedia Link Phosphate Link_out
          NuGOwiki Link HMDB01429 Link_out
          Metagene Link HMDB01429 Link_out
          METLIN ID 3231 Link_out
          PubChem Compound 1061 Link_out
          PDB ID PO4 Link_out
          ChEBI ID 18367 Link_out
          References
          Synthesis Reference Cremer, Josef; Hartmann, Fridolin; Rodis, Franz; Hinz, Arnulf. Preparation of alkali or alkaline earth phosphates with simultaneous recovery of volatile mineral acids. Ger. (1966), 2 pp. CODEN: GWXXAW DE 1227435 19661027 CAN 66:12584 AN 1967:12584
          Material Safety Data Sheet (MSDS) Download (PDF)
          General References
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          7. Tiwari S, Riazi S, Ecelbarger CA: Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes. Am J Physiol Renal Physiol. 2007 Oct;293(4):F974-84. Epub 2007 Aug 8. Pubmed: 17686957 Link_out
          8. Argraves KM, Argraves WS: HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects. J Lipid Res. 2007 Nov;48(11):2325-33. Epub 2007 Aug 13. Pubmed: 17698855 Link_out
          9. Brown BA, Kantesaria PP, McDevitt LM: Fingolimod: a novel immunosuppressant for multiple sclerosis. Ann Pharmacother. 2007 Oct;41(10):1660-8. Epub 2007 Sep 4. Pubmed: 17785617 Link_out
          10. Toussaint ND, Kerr PG: Vascular calcification and arterial stiffness in chronic kidney disease: implications and management. Nephrology (Carlton). 2007 Oct;12(5):500-9. Pubmed: 17803475 Link_out
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          12. Nauseef WM: How human neutrophils kill and degrade microbes: an integrated view. Immunol Rev. 2007 Oct;219:88-102. Pubmed: 17850484 Link_out
          13. Allen LA, McCaffrey RL: To activate or not to activate: distinct strategies used by Helicobacter pylori and Francisella tularensis to modulate the NADPH oxidase and survive in human neutrophils. Immunol Rev. 2007 Oct;219:103-17. Pubmed: 17850485 Link_out
          14. Giavazzi R, Bani MR, Taraboletti G: Tumor-host interaction in the optimization of paclitaxel-based combination therapies with vascular targeting compounds. Cancer Metastasis Rev. 2007 Dec;26(3-4):481-8. Pubmed: 17896168 Link_out
          15. Tonelli M, Wiebe N, Culleton B, Lee H, Klarenbach S, Shrive F, Manns B: Systematic review of the clinical efficacy and safety of sevelamer in dialysis patients. Nephrol Dial Transplant. 2007 Oct;22(10):2856-66. Pubmed: 17906326 Link_out
          16. Miyamoto K, Tatsumi S, Ito M, Segawa H: [New aspect of renal phosphate reabsorption and phosphate metabolism] Clin Calcium. 2007 Oct;17(10):1485-92. Pubmed: 17906398 Link_out
          17. Michigami T: [Vitamin D metabolism and action] Clin Calcium. 2007 Oct;17(10):1493-8. Pubmed: 17906399 Link_out
          18. Hoshi K: [Mechanisms of bone calcification] Clin Calcium. 2007 Oct;17(10):1499-507. Pubmed: 17906400 Link_out
          19. Takeuchi Y: [Pathophysiology in rickets/osteomalacia] Clin Calcium. 2007 Oct;17(10):1508-13. Pubmed: 17906401 Link_out
          20. Ito N, Fukumoto S: [FGF23-related hypophosphatemic rickets/osteomalacia] Clin Calcium. 2007 Oct;17(10):1514-20. Pubmed: 17906402 Link_out
          21. Sekine T: [Rickets/osteomalacia due to tubular dysfunction] Clin Calcium. 2007 Oct;17(10):1529-33. Pubmed: 17906404 Link_out
          22. Sato K: [Drug-induced osteomalacia] Clin Calcium. 2007 Oct;17(10):1536-42. Pubmed: 17906405 Link_out
          23. Hasegawa Y, Miyamoto J: [Hypophosphatemic rickets/osteomalacia. - Mainly on patients with PHEX mutations -] Clin Calcium. 2007 Oct;17(10):1592-9. Pubmed: 17906414 Link_out
          24. Bragadeesh TK, Mathur G, Clark AL, Cleland JG: Novel cardiac myosin activators for acute heart failure. Expert Opin Investig Drugs. 2007 Oct;16(10):1541-8. Pubmed: 17922619 Link_out
          25. Hem SL, Hogenesch H: Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation. Expert Rev Vaccines. 2007 Oct;6(5):685-98. Pubmed: 17931150 Link_out
          26. Worthington HV, Clarkson JE, Eden OB: Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD000978. Pubmed: 17943748 Link_out
          27. Nixon GF, Mathieson FA, Hunter I: The potential roles of sphingolipids in vascular smooth-muscle function. Biochem Soc Trans. 2007 Nov;35(Pt 5):908-9. Pubmed: 17956243 Link_out
          28. Johnson D, Shepherd RM, Gill D, Gorman T, Smith DM, Dunne MJ: Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells. Biochem Soc Trans. 2007 Nov;35(Pt 5):1208-10. Pubmed: 17956314 Link_out
          29. Ku NO, Strnad P, Zhong BH, Tao GZ, Omary MB: Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies. Hepatology. 2007 Nov;46(5):1639-49. Pubmed: 17969036 Link_out
          30. Beutler E, Duparc S: Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development. Am J Trop Med Hyg. 2007 Oct;77(4):779-89. Pubmed: 17978087 Link_out
          31. Van Brocklyn JR: Sphingolipid signaling pathways as potential therapeutic targets in gliomas. Mini Rev Med Chem. 2007 Oct;7(10):984-90. Pubmed: 17979800 Link_out
          32. Raben DM, Tu-Sekine B: Nuclear diacylglycerol kinases: regulation and roles. Front Biosci. 2008 Jan 1;13:590-7. Pubmed: 17981572 Link_out
          33. Dubin A, Estenssoro E: Mechanisms of tissue hypercarbia in sepsis. Front Biosci. 2008 Jan 1;13:1340-51. Pubmed: 17981634 Link_out
          34. Deng ZL, Sharff KA, Tang N, Song WX, Luo J, Luo X, Chen J, Bennett E, Reid R, Manning D, Xue A, Montag AG, Luu HH, Haydon RC, He TC: Regulation of osteogenic differentiation during skeletal development. Front Biosci. 2008 Jan 1;13:2001-21. Pubmed: 17981687 Link_out
          35. Liu X, Elojeimy S, Turner LS, Mahdy AE, Zeidan YH, Bielawska A, Bielawski J, Dong JY, El-Zawahry AM, Guo GW, Hannun YA, Holman DH, Rubinchik S, Szulc Z, Keane TE, Tavassoli M, Norris JS: Acid ceramidase inhibition: a novel target for cancer therapy. Front Biosci. 2008 Jan 1;13:2293-8. Pubmed: 17981711 Link_out
          36. Su N, Du X, Chen L: FGF signaling: its role in bone development and human skeleton diseases. Front Biosci. 2008 Jan 1;13:2842-65. Pubmed: 17981758 Link_out
          37. Trimble JL, Kockler DR: Statin treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Ann Pharmacother. 2007 Dec;41(12):2019-23. Epub 2007 Nov 6. Pubmed: 17986515 Link_out
          38. Zeitels SM, Burns JA: Office-based laryngeal laser surgery with the 532-nm pulsed-potassium-titanyl-phosphate laser. Curr Opin Otolaryngol Head Neck Surg. 2007 Dec;15(6):394-400. Pubmed: 17986877 Link_out
          39. Pebay A, Bonder CS, Pitson SM: Stem cell regulation by lysophospholipids. Prostaglandins Other Lipid Mediat. 2007 Nov;84(3-4):83-97. Epub 2007 Sep 5. Pubmed: 17991611 Link_out
          40. Komarova YA, Mehta D, Malik AB: Dual regulation of endothelial junctional permeability. Sci STKE. 2007 Nov 13;2007(412):re8. Pubmed: 18000237 Link_out
          41. Burger EL, Patel V: Calcium phosphates as bone graft extenders. Orthopedics. 2007 Nov;30(11):939-42. Pubmed: 18019987 Link_out
          42. Qin C, D'Souza R, Feng JQ: Dentin matrix protein 1 (DMP1): new and important roles for biomineralization and phosphate homeostasis. J Dent Res. 2007 Dec;86(12):1134-41. Pubmed: 18037646 Link_out
          43. Andress DL: Bone and mineral guidelines for patients with chronic kidney disease: a call for revision. Clin J Am Soc Nephrol. 2008 Jan;3(1):179-83. Epub 2007 Dec 5. Pubmed: 18057310 Link_out
          44. Fukumoto S: [Parathyroid and bone. Calcimimetics and bone metabolism] Clin Calcium. 2007 Dec;17(12):1865-9. Pubmed: 18057662 Link_out
          45. Fei X, Qin Z, Liang Z: Contribution of CDP/Cux, a transcription factor, to cell cycle progression. Acta Biochim Biophys Sin (Shanghai). 2007 Dec;39(12):923-30. Pubmed: 18064384 Link_out
          46. Bonomini F, Tengattini S, Fabiano A, Bianchi R, Rezzani R: Atherosclerosis and oxidative stress. Histol Histopathol. 2008 Mar;23(3):381-90. Pubmed: 18072094 Link_out
          47. Orcel P, Chapurlat R: [Fibrous dysplasia of bone] Rev Prat. 2007 Oct 31;57(16):1749-55. Pubmed: 18092715 Link_out
          48. Damron TA: Use of 3D beta-tricalcium phosphate (Vitoss) scaffolds in repairing bone defects. Nanomed. 2007 Dec;2(6):763-75. Pubmed: 18095844 Link_out
          49. Hertz A, Bruce IJ: Inorganic materials for bone repair or replacement applications. Nanomed. 2007 Dec;2(6):899-918. Pubmed: 18095853 Link_out
          50. Cappellini MD, Fiorelli G: Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008 Jan 5;371(9606):64-74. Pubmed: 18177777 Link_out
          51. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411 Link_out
          52. Virkki LV, Biber J, Murer H, Forster IC: Phosphate transporters: a tale of two solute carrier families. Am J Physiol Renal Physiol. 2007 Sep;293(3):F643-54. Epub 2007 Jun 20. Pubmed: 17581921 Link_out
          53. Pohlmeier R, Vienken J: Phosphate removal and hemodialysis conditions. Kidney Int Suppl. 2001 Feb;78:S190-4. Pubmed: 11169009 Link_out
          54. Gallar P, Ortega O, Gutierrez M, Munoz M, Hilara L, Oliet A, Rodriguez I, Gimenez E, Vigil A: [Influencing factors in the control of phosphorus in peritoneal dialysis. Therapeutic options]. Nefrologia. 2000 Jul-Aug;20(4):355-61. Pubmed: 11039261 Link_out
          55. Cruz DN, Perazella MA: Biochemical aberrations in a dialysis patient following parathyroidectomy. Am J Kidney Dis. 1997 May;29(5):759-62. Pubmed: 9159312 Link_out
          56. Nemere I: The ins and outs of phosphate homeostasis. Kidney Int. 2007 Jul;72(2):140-2. Pubmed: 17625581 Link_out

          Enzymes

          Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 328 enzymes in total.

          Name: Cytosolic 5'-nucleotidase 1B
          Reactions: Not Available
          Gene Name: NT5C1B
          Uniprot ID: Q96P26 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytosolic 5'-nucleotidase 1A
          Reactions: Not Available
          Gene Name: NT5C1A
          Uniprot ID: Q9BXI3 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: 5'(3')-deoxyribonucleotidase, cytosolic type
          Reactions: Not Available
          Gene Name: NT5C
          Uniprot ID: Q8TCD5 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: 5'(3')-deoxyribonucleotidase, mitochondrial
          Reactions: Not Available
          Gene Name: NT5M
          Uniprot ID: Q9NPB1 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: ATP-citrate synthase
          Reactions: Not Available
          Gene Name: ACLY
          Uniprot ID: P53396 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Acetyl-CoA carboxylase 2
          Reactions: Not Available
          Gene Name: ACACB
          Uniprot ID: O00763 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Pyruvate carboxylase, mitochondrial
          Reactions: Not Available
          Gene Name: PC
          Uniprot ID: P11498 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Acetyl-CoA carboxylase 1
          Reactions: Not Available
          Gene Name: ACACA
          Uniprot ID: Q13085 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Ectonucleoside triphosphate diphosphohydrolase 1
          Reactions: Not Available
          Gene Name: ENTPD1
          Uniprot ID: P49961 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Soluble calcium-activated nucleotidase 1
          Reactions: Not Available
          Gene Name: CANT1
          Uniprot ID: Q8WVQ1 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Ectonucleoside triphosphate diphosphohydrolase 3
          Reactions: Not Available
          Gene Name: ENTPD3
          Uniprot ID: O75355 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Alkaline phosphatase, placental type
          Reactions: Not Available
          Gene Name: ALPP
          Uniprot ID: P05187 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Intestinal-type alkaline phosphatase
          Reactions: Not Available
          Gene Name: ALPI
          Uniprot ID: P09923 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Lysosomal acid phosphatase
          Reactions: Not Available
          Gene Name: ACP2
          Uniprot ID: P11117 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Low molecular weight phosphotyrosine protein phosphatase
          Reactions: Not Available
          Gene Name: ACP1
          Uniprot ID: P24666 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Alkaline phosphatase, tissue-nonspecific isozyme
          Reactions: Not Available
          Gene Name: ALPL
          Uniprot ID: P05186 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Tartrate-resistant acid phosphatase type 5
          Reactions: Not Available
          Gene Name: ACP5
          Uniprot ID: P13686 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Prostatic acid phosphatase
          Reactions: Not Available
          Gene Name: ACPP
          Uniprot ID: P15309 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Alkaline phosphatase, placental-like
          Reactions: Not Available
          Gene Name: ALPPL2
          Uniprot ID: P10696 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Lipid phosphate phosphohydrolase 2
          Reactions: Not Available
          Gene Name: PPAP2C
          Uniprot ID: O43688 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Lipid phosphate phosphohydrolase 1
          Reactions: Not Available
          Gene Name: PPAP2A
          Uniprot ID: O14494 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Lipid phosphate phosphohydrolase 3
          Reactions: Not Available
          Gene Name: PPAP2B
          Uniprot ID: O14495 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Propionyl-CoA carboxylase beta chain, mitochondrial
          Reactions: Not Available
          Gene Name: PCCB
          Uniprot ID: P05166 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Propionyl-CoA carboxylase alpha chain, mitochondrial
          Reactions: Not Available
          Gene Name: PCCA
          Uniprot ID: P05165 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Trifunctional purine biosynthetic protein adenosine-3
          Reactions: Not Available
          Gene Name: GART
          Uniprot ID: P22102 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Sialic acid synthase
          Reactions: Not Available
          Gene Name: NANS
          Uniprot ID: Q9NR45 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: 3'(2'),5'-bisphosphate nucleotidase 1
          Reactions: Not Available
          Gene Name: BPNT1
          Uniprot ID: O95861 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Carbamoyl-phosphate synthase [ammonia], mitochondrial
          Reactions: Not Available
          Gene Name: CPS1
          Uniprot ID: P31327 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Type I inositol 1,4,5-trisphosphate 5-phosphatase
          Reactions: Not Available
          Gene Name: INPP5A
          Uniprot ID: Q14642 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Inositol polyphosphate 1-phosphatase
          Reactions: Not Available
          Gene Name: INPP1
          Uniprot ID: P49441 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
          Reactions: Not Available
          Gene Name: INPP5J
          Uniprot ID: Q15735 Link_out
          Protein Sequence: FASTA
          Name: Inositol polyphosphate 5-phosphatase K
          Reactions: Not Available
          Gene Name: INPP5K
          Uniprot ID: Q9BT40 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Lactase-phlorizin hydrolase
          Reactions: Not Available
          Gene Name: LCT
          Uniprot ID: P09848 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Glycogen phosphorylase, liver form
          Reactions: Not Available
          Gene Name: PYGL
          Uniprot ID: P06737 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Glycogen phosphorylase, muscle form
          Reactions: Not Available
          Gene Name: PYGM
          Uniprot ID: P11217 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Glycogen phosphorylase, brain form
          Reactions: Not Available
          Gene Name: PYGB
          Uniprot ID: P11216 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Glucose-6-phosphatase
          Reactions: Not Available
          Gene Name: G6PC
          Uniprot ID: P35575 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: S-methyl-5'-thioadenosine phosphorylase
          Reactions: Not Available
          Gene Name: MTAP
          Uniprot ID: Q13126 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: S-adenosylmethionine synthase isoform type-1
          Reactions: Not Available
          Gene Name: MAT1A
          Uniprot ID: Q00266 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
          Reactions: Not Available
          Gene Name: MCCC2
          Uniprot ID: Q9HCC0 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
          Reactions: Not Available
          Gene Name: MCCC1
          Uniprot ID: Q96RQ3 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Glutamate--cysteine ligase catalytic subunit
          Reactions: Not Available
          Gene Name: GCLC
          Uniprot ID: P48506 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Acylphosphatase-2
          Reactions: Not Available
          Gene Name: ACYP2
          Uniprot ID: P14621 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Acylphosphatase-1
          Reactions: Not Available
          Gene Name: ACYP1
          Uniprot ID: P07311 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Selenide, water dikinase 1
          Reactions: Not Available
          Gene Name: SEPHS1
          Uniprot ID: P49903 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Selenide, water dikinase 2
          Reactions: Not Available
          Gene Name: SEPHS2
          Uniprot ID: Q99611 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: CTP synthase 1
          Reactions: Not Available
          Gene Name: CTPS1
          Uniprot ID: P17812 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
          Reactions: Not Available
          Gene Name: GAPDHS
          Uniprot ID: O14556 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Glyceraldehyde-3-phosphate dehydrogenase
          Reactions: Not Available
          Gene Name: GAPDH
          Uniprot ID: P04406 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Glutathione synthetase
          Reactions: Not Available
          Gene Name: GSS
          Uniprot ID: P48637 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Transporters
          Name: Copper-transporting ATPase 2
          Reactions: Not Available
          Gene Name: ATP7B
          Uniprot ID: P35670 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Copper-transporting ATPase 1
          Reactions: Not Available
          Gene Name: ATP7A
          Uniprot ID: Q04656 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA