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Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2015-03-09 22:57:13 UTC
HMDB IDHMDB01448
Secondary Accession NumbersNone
Metabolite Identification
Common NameSulfate
DescriptionThe sulfate ion is a polyatomic anion with the empirical formula SO42- and a molecular mass of 96.06 daltons; it consists of one central sulfur atom surrounded by four equivalent oxygen atoms in a tetrahedral arrangement. The sulfate ion carries a negative two charge and is the conjugate base of the hydrogen sulfate ion, HSO4-, which is the conjugate base of H2SO4, sulfuric acid. In inorganic chemistry, a sulfate (IUPAC-recommended spelling; also sulphate in British English) is a salt of sulfuric acid. Sulfate aerosols can act as cloud condensation nuclei and this leads to greater numbers of smaller droplets of water. Lots of smaller droplets can diffuse light more efficiently than just a few larger droplets.
Structure
Thumb
Synonyms
  1. Sulfate (ion 2-)
  2. Sulfate anion
  3. Sulfate anion(2-)
  4. Sulfate dianion
  5. Sulfate ion
  6. Sulfate ion (SO42-)
  7. Sulfate(2-)
  8. Sulfuric acid ion(2-)
  9. Sulphate
Chemical FormulaO4S
Average Molecular Weight96.063
Monoisotopic Molecular Weight95.951729178
IUPAC Namesulfate
Traditional Namesulfate
CAS Registry Number14808-79-8
SMILES
[O-]S([O-])(=O)=O
InChI Identifier
InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChI KeyQAOWNCQODCNURD-UHFFFAOYSA-L
Chemical Taxonomy
KingdomInorganic Compounds
Super ClassHomogeneous Non-metal Compounds
ClassNon-metal Oxoanionic Compounds
Sub ClassNon-metal Sulfates
Other Descriptors
  • an anion(Cyc)
  • inorganic anion(ChEBI)
  • sulfur oxide(ChEBI)
  • sulfur oxoanion(ChEBI)
Substituents
  • N/A
Direct ParentNon-metal Sulfates
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
Biofunction
  • Osmolyte, enzyme cofactor, sulfur metabolism
ApplicationNot Available
Cellular locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Lysosome
  • Endoplasmic reticulum
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-0.84ChemAxon
pKa (Strongest Acidic)-3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area80.26 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity11.53 m3·mol-1ChemAxon
Polarizability5.81 Å3ChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Lysosome
  • Endoplasmic reticulum
Biofluid Locations
  • Blood
  • Saliva
  • Urine
Tissue LocationNot Available
Pathways
NameSMPDB LinkKEGG Link
Sulfate/Sulfite MetabolismSMP00041map00920
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified215.5 +/- 3.3 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified490.0 (310.0-580.0) uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
SalivaDetected and Quantified3000 +/- 4060 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified2.03 +/- 1.43 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified1.79 +/- 1.25 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified1760 +/- 1010 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified2020 +/- 1460 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified2360 +/- 1930 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified2230 +/- 2060 uMAdult (>18 years old)Both
Normal
details
UrineDetected and Quantified2407.89 (2171.05-2697.36) umol/mmol creatinineAdult (>18 years old)BothNormal
    • Geigy Scientific ...
    • West Cadwell, N.J...
    • Basel, Switzerlan...
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB022629
KNApSAcK IDNot Available
Chemspider ID1085
KEGG Compound IDC00059
BioCyc IDNH42SO4
BiGG ID33697
Wikipedia LinkSulfate
NuGOwiki LinkHMDB01448
Metagene LinkHMDB01448
METLIN ID3233
PubChem Compound1117
PDB IDSO4
ChEBI ID16189
References
Synthesis ReferenceZhang, Qiu-Ju; Wang, Xiao; Chen, Jian-Min; Zhuang, Guo-Shun. Formation of Fe(II) (aq) and sulfate via heterogeneous reaction of SO2 with Fe2O3. Gaodeng Xuexiao Huaxue Xuebao (2006), 27(7), 1347-1350.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Lortat-Jacob H: Interferon and heparan sulphate. Biochem Soc Trans. 2006 Jun;34(Pt 3):461-4. [16709188 ]
  2. Rhodes KE, Fawcett JW: Chondroitin sulphate proteoglycans: preventing plasticity or protecting the CNS? J Anat. 2004 Jan;204(1):33-48. [14690476 ]
  3. Eisenhofer G, Coughtrie MW, Goldstein DS: Dopamine sulphate: an enigma resolved. Clin Exp Pharmacol Physiol Suppl. 1999 Apr;26:S41-53. [10386253 ]
  4. Ho HS, Lim SH, Loo S: The use of magnesium sulphate in the intensive care management of an Asian patient with tetanus. Ann Acad Med Singapore. 1999 Jul;28(4):586-9. [10561778 ]
  5. Perrimon N, Bernfield M: Specificities of heparan sulphate proteoglycans in developmental processes. Nature. 2000 Apr 13;404(6779):725-8. [10783877 ]
  6. Duley L, Henderson-Smart D: Magnesium sulphate versus diazepam for eclampsia. Cochrane Database Syst Rev. 2000;(2):CD000127. [10796145 ]
  7. Duley L, Henderson-Smart D: Magnesium sulphate versus phenytoin for eclampsia. Cochrane Database Syst Rev. 2000;(2):CD000128. [10796146 ]
  8. Duffy PE, Fried M: Malaria during pregnancy: parasites, antibodies and chondroitin sulphate A. Biochem Soc Trans. 1999 Aug;27(4):478-82. [10917625 ]
  9. Bateman KL, Delehedde M, Sergeant N, Wartelle I, Vidyasagar R, Fernig DG: Heparan sulphate. Regulation of growth factors in the mammary gland. Adv Exp Med Biol. 2000;480:65-9. [10959410 ]
  10. McCormick C, Duncan G, Tufaro F: Herpes simplex virus: discovering the link between heparan sulphate and hereditary bone tumours. Rev Med Virol. 2000 Nov-Dec;10(6):373-84. [11114076 ]
  11. Manyemba J: Magnesium sulphate for eclampsia: putting the evidence into clinical practice. Cent Afr J Med. 2000 Jun;46(6):166-9. [11235060 ]
  12. Duley L, Gulmezoglu AM: Magnesium sulphate versus lytic cocktail for eclampsia. Cochrane Database Syst Rev. 2001;(1):CD002960. [11279786 ]
  13. Kornacka MK: [Magnesium sulphate in the treatment of ischemic-hypoxic neonatal encephalopathy] Neurol Neurochir Pol. 2001 Mar-Apr;35(2):299-308. [11599227 ]
  14. Karas Z: [Skin patch test with nickel sulphate--an attempt of broader interpretation of the results] Pol Merkur Lekarski. 2002 Aug;13(74):143-6. [12420348 ]
  15. Morgenstern DA, Asher RA, Fawcett JW: Chondroitin sulphate proteoglycans in the CNS injury response. Prog Brain Res. 2002;137:313-32. [12440375 ]
  16. Crowther CA, Hiller JE, Doyle LW: Magnesium sulphate for preventing preterm birth in threatened preterm labour. Cochrane Database Syst Rev. 2002;(4):CD001060. [12519550 ]
  17. Kakuta Y, Li L, Pedersen LC, Pedersen LG, Negishi M: Heparan sulphate N-sulphotransferase activity: reaction mechanism and substrate recognition. Biochem Soc Trans. 2003 Apr;31(2):331-4. [12653630 ]
  18. Properzi F, Asher RA, Fawcett JW: Chondroitin sulphate proteoglycans in the central nervous system: changes and synthesis after injury. Biochem Soc Trans. 2003 Apr;31(2):335-6. [12653631 ]
  19. Kjellen L: Glucosaminyl N-deacetylase/N-sulphotransferases in heparan sulphate biosynthesis and biology. Biochem Soc Trans. 2003 Apr;31(2):340-2. [12653633 ]
  20. Catlow K, Deakin JA, Delehedde M, Fernig DG, Gallagher JT, Pavao MS, Lyon M: Hepatocyte growth factor/scatter factor and its interaction with heparan sulphate and dermatan sulphate. Biochem Soc Trans. 2003 Apr;31(2):352-3. [12653636 ]
  21. Smetana R, Stuhlinger HG, Kiss K, Glogar DH: Intravenous magnesium sulphate in acute myocardial infarction--is the answer "MAGIC"? Magnes Res. 2003 Mar;16(1):65-9. [12735485 ]
  22. Duley L, Gulmezoglu AM, Henderson-Smart DJ: Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane Database Syst Rev. 2003;(2):CD000025. [12804383 ]
  23. van Horssen J, Wesseling P, van den Heuvel LP, de Waal RM, Verbeek MM: Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders. Lancet Neurol. 2003 Aug;2(8):482-92. [12878436 ]
  24. Markovich D, Murer H: The SLC13 gene family of sodium sulphate/carboxylate cotransporters. Pflugers Arch. 2004 Feb;447(5):594-602. Epub 2003 Aug 12. [12915942 ]
  25. Nenci GG: Dermatan sulphate as an antithrombotic drug. Pathophysiol Haemost Thromb. 2002 Sep-Dec;32(5-6):303-7. [13679662 ]
  26. Duley L, Henderson-Smart D: Magnesium sulphate versus diazepam for eclampsia. Cochrane Database Syst Rev. 2003;(4):CD000127. [14583910 ]
  27. Duley L, Henderson-Smart D: Magnesium sulphate versus phenytoin for eclampsia. Cochrane Database Syst Rev. 2003;(4):CD000128. [14583911 ]
  28. Thijs L, Fagard R, Forette F, Nawrot T, Staessen JA: Are low dehydroepiandrosterone sulphate levels predictive for cardiovascular diseases? A review of prospective and retrospective studies. Acta Cardiol. 2003 Oct;58(5):403-10. [14609305 ]
  29. Gallagher JT, Turnbull JE: Heparan sulphate in the binding and activation of basic fibroblast growth factor. Glycobiology. 1992 Dec;2(6):523-8. [1472758 ]
  30. Crespo-Santiago D: [The extracellular matrix of the central nervous system: chondroitin sulphate type proteoglycans and neural repair] Rev Neurol. 2004 May 1-15;38(9):843-51. [15152354 ]
  31. Gallagher JT, Turnbull JE, Lyon M: Patterns of sulphation in heparan sulphate: polymorphism based on a common structural theme. Int J Biochem. 1992 Apr;24(4):553-60. [1516727 ]
  32. Cheuk DK, Chau TC, Lee SL: A meta-analysis on intravenous magnesium sulphate for treating acute asthma. Arch Dis Child. 2005 Jan;90(1):74-7. [15613519 ]
  33. Mittendorf R, Pryde PG: A review of the role for magnesium sulphate in preterm labour. BJOG. 2005 Mar;112 Suppl 1:84-8. [15715602 ]
  34. Duley L: Evidence and practice: the magnesium sulphate story. Best Pract Res Clin Obstet Gynaecol. 2005 Feb;19(1):57-74. [15749066 ]
  35. Rusnati M, Oreste P, Zoppetti G, Presta M: Biotechnological engineering of heparin/heparan sulphate: a novel area of multi-target drug discovery. Curr Pharm Des. 2005;11(19):2489-99. [16026302 ]
  36. Hacker U, Nybakken K, Perrimon N: Heparan sulphate proteoglycans: the sweet side of development. Nat Rev Mol Cell Biol. 2005 Jul;6(7):530-41. [16072037 ]
  37. Rozenberg P: [Magnesium sulphate for the management of preeclampsia] Gynecol Obstet Fertil. 2006 Jan;34(1):54-9. Epub 2006 Jan 6. [16406662 ]
  38. Vives RR, Lortat-Jacob H, Fender P: Heparan sulphate proteoglycans and viral vectors : ally or foe? Curr Gene Ther. 2006 Feb;6(1):35-44. [16475944 ]
  39. Kemp LE, Mulloy B, Gherardi E: Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors. Biochem Soc Trans. 2006 Jun;34(Pt 3):414-7. [16709175 ]
  40. Gallagher JT: Multiprotein signalling complexes: regional assembly on heparan sulphate. Biochem Soc Trans. 2006 Jun;34(Pt 3):438-41. [16709181 ]
  41. Harmer NJ: Insights into the role of heparan sulphate in fibroblast growth factor signalling. Biochem Soc Trans. 2006 Jun;34(Pt 3):442-5. [16709182 ]
  42. Stringer SE: The role of heparan sulphate proteoglycans in angiogenesis. Biochem Soc Trans. 2006 Jun;34(Pt 3):451-3. [16709184 ]
  43. Kurup S, Abramsson A, Li JP, Lindahl U, Kjellen L, Betsholtz C, Gerhardt H, Spillmann D: Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment. Biochem Soc Trans. 2006 Jun;34(Pt 3):454-5. [16709185 ]
  44. Rider CC: Heparin/heparan sulphate binding in the TGF-beta cytokine superfamily. Biochem Soc Trans. 2006 Jun;34(Pt 3):458-60. [16709187 ]
  45. Parish CR: The role of heparan sulphate in inflammation. Nat Rev Immunol. 2006 Sep;6(9):633-43. Epub 2006 Aug 18. [16917509 ]
  46. Campo GM, Avenoso A, Campo S, Ferlazzo AM, Calatroni A: Chondroitin sulphate: antioxidant properties and beneficial effects. Mini Rev Med Chem. 2006 Dec;6(12):1311-20. [17168807 ]
  47. Bishop JR, Schuksz M, Esko JD: Heparan sulphate proteoglycans fine-tune mammalian physiology. Nature. 2007 Apr 26;446(7139):1030-7. [17460664 ]
  48. Heisel J, Forster KK: [Therapy of osteoarthritis crystalline glucosamine sulphate/a review of the clinical effcacy] Arzneimittelforschung. 2007;57(4):203-17. [17515291 ]
  49. Doyle LW, Crowther CA, Middleton P, Marret S: Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD004661. [17636771 ]
  50. Del Rio JA, Soriano E: Overcoming chondroitin sulphate proteoglycan inhibition of axon growth in the injured brain: lessons from chondroitinase ABC. Curr Pharm Des. 2007;13(24):2485-92. [17692016 ]
  51. Peng L, Ye L, Guo X, Tan H, Zhou X, Wang C, Li R: Evaluation of formocresol versus ferric sulphate primary molar pulpotomy: a systematic review and meta-analysis. Int Endod J. 2007 Oct;40(10):751-7. Epub 2007 Aug 22. [17714467 ]
  52. Bianchi-Bosisio A, D'Agrosa F, Gaboardi F, Gianazza E, Righetti PG: Sodium dodecyl sulphate electrophoresis of urinary proteins. J Chromatogr. 1991 Sep 13;569(1-2):243-60. [1939488 ]
  53. Sutton DN, Tremlett MR, Woodcock TE, Nielsen MS: Management of autonomic dysfunction in severe tetanus: the use of magnesium sulphate and clonidine. Intensive Care Med. 1990;16(2):75-80. [2094230 ]
  54. Murer H, Markovich D, Biber J: Renal and small intestinal sodium-dependent symporters of phosphate and sulphate. J Exp Biol. 1994 Nov;196:167-81. [7823020 ]
  55. Thiele B, Steinbach F: Dextran sulphate induces a PKC and actin independent internalisation of CD4. Immunol Lett. 1994 Sep;42(1-2):105-10. [7829123 ]
  56. Scott JE: Keratan sulphate--a 'reserve' polysaccharide? Eur J Clin Chem Clin Biochem. 1994 Apr;32(4):217-23. [8038262 ]
  57. van Heerden PV, Jenkins IR, Woods WP, Rossi E, Cameron PD: Death by tanning--a case of fatal basic chromium sulphate poisoning. Intensive Care Med. 1994;20(2):145-7. [8201096 ]
  58. Rosen SD, Bertozzi CR: Two selectins converge on sulphate. Leukocyte adhesion. Curr Biol. 1996 Mar 1;6(3):261-4. [8805242 ]
  59. Izzo AA, Gaginella TS, Capasso F: The osmotic and intrinsic mechanisms of the pharmacological laxative action of oral high doses of magnesium sulphate. Importance of the release of digestive polypeptides and nitric oxide. Magnes Res. 1996 Jun;9(2):133-8. [8878010 ]
  60. Khaw KT: Dehydroepiandrosterone, dehydroepiandrosterone sulphate and cardiovascular disease. J Endocrinol. 1996 Sep;150 Suppl:S149-53. [8943798 ]
  61. Coombe DR: The role of stromal cell heparan sulphate in regulating haemopoiesis. Leuk Lymphoma. 1996 May;21(5-6):399-406. [9172804 ]
  62. Stringer SE, Gallagher JT: Heparan sulphate. Int J Biochem Cell Biol. 1997 May;29(5):709-14. [9251237 ]
  63. McGrath JA, Eady RA: Heparan sulphate proteoglycan and wound healing in skin. J Pathol. 1997 Nov;183(3):251-2. [9422978 ]
  64. Gallagher JT: Structure-activity relationship of heparan sulphate. Biochem Soc Trans. 1997 Nov;25(4):1206-9. [9449976 ]

Enzymes

General function:
Involved in catalytic activity
Specific function:
Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.
Gene Name:
ENPP1
Uniprot ID:
P22413
Molecular weight:
104923.58
General function:
Involved in catalytic activity
Specific function:
Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD (By similarity).
Gene Name:
ENPP3
Uniprot ID:
O14638
Molecular weight:
100123.54
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
ARSD
Uniprot ID:
P51689
Molecular weight:
64859.3
General function:
Involved in catalytic activity
Specific function:
Hydrolyzes cerebroside sulfate.
Gene Name:
ARSA
Uniprot ID:
P15289
Molecular weight:
53805.87
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
ARSB
Uniprot ID:
P15848
Molecular weight:
Not Available
General function:
Involved in catalytic activity
Specific function:
May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates
Gene Name:
ARSE
Uniprot ID:
P51690
Molecular weight:
65668.4
General function:
Involved in ATP binding
Specific function:
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
Gene Name:
PAPSS1
Uniprot ID:
O43252
Molecular weight:
70832.725
General function:
Involved in ATP binding
Specific function:
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth (By similarity).
Gene Name:
PAPSS2
Uniprot ID:
O95340
Molecular weight:
69969.8
General function:
Involved in catalytic activity
Specific function:
Conversion of sulfated steroid precursors to estrogens during pregnancy.
Gene Name:
STS
Uniprot ID:
P08842
Molecular weight:
65491.72
General function:
Involved in glutathione transferase activity
Specific function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Gene Name:
GSTM2
Uniprot ID:
P28161
Molecular weight:
25744.395
General function:
Involved in glutathione transferase activity
Specific function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Gene Name:
GSTM1
Uniprot ID:
P09488
Molecular weight:
25711.555
General function:
Involved in glutathione transferase activity
Specific function:
Also functions as a glutathione peroxidase.
Gene Name:
MGST3
Uniprot ID:
O14880
Molecular weight:
16516.185
General function:
Involved in glutathione transferase activity
Specific function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
Gene Name:
GSTM3
Uniprot ID:
P21266
Molecular weight:
26559.32
General function:
Involved in glutathione transferase activity
Specific function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Gene Name:
GSTA1
Uniprot ID:
P08263
Molecular weight:
25630.785
General function:
Involved in catalytic activity
Specific function:
Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.
Gene Name:
GSTZ1
Uniprot ID:
O43708
Molecular weight:
17895.68
General function:
Involved in glutathione transferase activity
Specific function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Gene Name:
GSTM5
Uniprot ID:
P46439
Molecular weight:
25674.455
General function:
Involved in enzyme activator activity
Specific function:
Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.
Gene Name:
MGST2
Uniprot ID:
Q99735
Molecular weight:
16620.4
General function:
Involved in glutathione transferase activity
Specific function:
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Gene Name:
GSTO1
Uniprot ID:
P78417
Molecular weight:
27565.6
General function:
Involved in glutathione transferase activity
Specific function:
Not Available
Gene Name:
GSTA5
Uniprot ID:
Q7RTV2
Molecular weight:
25721.725
General function:
Involved in glutathione transferase activity
Specific function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Gene Name:
GSTA2
Uniprot ID:
P09210
Molecular weight:
25663.675
General function:
Involved in glutathione transferase activity
Specific function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively.
Gene Name:
GSTA3
Uniprot ID:
Q16772
Molecular weight:
25301.355
General function:
Involved in glutathione transferase activity
Specific function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).
Gene Name:
GSTA4
Uniprot ID:
O15217
Molecular weight:
25703.905
General function:
Involved in glutathione transferase activity
Specific function:
Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
Gene Name:
GSTO2
Uniprot ID:
Q9H4Y5
Molecular weight:
24399.09
General function:
Posttranslational modification, protein turnover, chaperones
Specific function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
Gene Name:
GSTT1
Uniprot ID:
P30711
Molecular weight:
27334.755
General function:
Involved in glutathione transferase activity
Specific function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Gene Name:
GSTP1
Uniprot ID:
P09211
Molecular weight:
23355.625
General function:
Involved in heme binding
Specific function:
Not Available
Gene Name:
SUOX
Uniprot ID:
P51687
Molecular weight:
60282.59
General function:
Involved in catalytic activity
Specific function:
Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
Gene Name:
IDS
Uniprot ID:
P22304
Molecular weight:
Not Available
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
GNS
Uniprot ID:
P15586
Molecular weight:
Not Available
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
GALNS
Uniprot ID:
P34059
Molecular weight:
Not Available
General function:
Inorganic ion transport and metabolism
Specific function:
Sulfate transporter. May play a role in endochondral bone formation.
Gene Name:
SLC26A2
Uniprot ID:
P50443
Molecular weight:
81660.71
General function:
Involved in transporter activity
Specific function:
Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV)
Gene Name:
SLC13A4
Uniprot ID:
Q9UKG4
Molecular weight:
69357.9
General function:
Involved in secondary active sulfate transmembrane transporter activity
Specific function:
Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).
Gene Name:
SLC26A11
Uniprot ID:
Q86WA9
Molecular weight:
65298.305
General function:
Involved in protein disulfide oxidoreductase activity
Specific function:
Not Available
Gene Name:
LOC51064
Uniprot ID:
Q6FII1
Molecular weight:
25496.6
General function:
Posttranslational modification, protein turnover, chaperones
Specific function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.
Gene Name:
GSTT2
Uniprot ID:
P0CG29
Molecular weight:
Not Available