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Record Information
Version4.0
Creation Date2005-11-16 15:48:42 UTC
Update Date2017-09-27 08:24:07 UTC
HMDB IDHMDB0001478
Secondary Accession Numbers
  • HMDB01478
Metabolite Identification
Common NameGallium
DescriptionDiscovered in 1875, gallium is a trivalent metal that shares certain chemical characteristics with Fe 3+, Al3+ and In3+. An important property of gallium is its high affinity binding to transferrin, the iron transport protein in the circulation. Approximately one third of transferrin in blood is occupied by iron, leaving the remainder free to bind and transport gallium to cells that display transferrin receptors. In support of this mechanism is the finding that during radiogallium tumor imaging (Ga-67 scanning) in patients, Ga-67 in the circulation is bound almost exclusively to transferrin. A recent study examining the distribution of nonradioactive gallium in the circulation after its gastrointestinal uptake from gallium maltolate (an oral formulation of gallium) has confirmed that it binds to transferrin
Structure
Thumb
Synonyms
ValueSource
[GaH3]ChEBI
GaH3ChEBI
Chemical FormulaGaH3
Average Molecular Weight72.747
Monoisotopic Molecular Weight71.949056008
IUPAC Namegallane
Traditional Namegallane
CAS Registry Number7440-55-3
SMILES
[GaH3]
InChI Identifier
InChI=1S/Ga.3H
InChI KeyPHMDYZQXPPOZDG-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as miscellaneous mixed metal/non-metals. These are inorganic compounds containing non-metal as well as metal atoms but not belonging to afore mentioned classes.
KingdomChemical entities
Super ClassInorganic compounds
ClassMixed metal/non-metal compounds
Sub ClassMiscellaneous mixed metal/non-metals
Direct ParentMiscellaneous mixed metal/non-metals
Alternative ParentsNot Available
Substituents
  • Miscellaneous mixed metal/non-metal
Molecular FrameworkNot Available
External Descriptors
Ontology
Disposition

Biological Location:

  Biofluid and excreta:

Source:

Physical Properties
StateLiquid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-0.98ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity2.4 m³·mol⁻¹ChemAxon
Polarizability3.42 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular LocationsNot Available
Biofluid Locations
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue LocationNot Available
PathwaysNot Available
NameSMPDB/PathwhizKEGG
No entries found
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
Cerebrospinal Fluid (CSF)Detected and Quantified<0.0005 uMAdult (>18 years old)BothNormal details
SalivaDetected and Quantified0.028 +/- 0.009 uMAdult (>18 years old)BothNormal
    • Zerihun T. Dame, ...
details
UrineDetected and Quantified0.0056 (0.0012-0.0150) umol/mmol creatinineAdult (>18 years old)Both
Normal
details
UrineDetected and Quantified0.0002 +/- 0.0002 umol/mmol creatinineAdult (>18 years old)Not SpecifiedNormal details
UrineDetected and Quantified0.0003 - 0.0006 umol/mmol creatinineAdult (>18 years old)Not SpecifiedNormal details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDNot Available
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkGallium
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI ID33326
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Jakupec MA, Keppler BK: Gallium in cancer treatment. Curr Top Med Chem. 2004;4(15):1575-83. [PubMed:15579097 ]
  2. Chitambar CR: Gallium compounds as antineoplastic agents. Curr Opin Oncol. 2004 Nov;16(6):547-52. [PubMed:15627016 ]