Human Metabolome Database Version 3.5

Showing metabocard for Pyridoxal 5'-phosphate (HMDB01491)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:10:39 -0700
HMDB ID HMDB01491
Secondary Accession Numbers None
Metabolite Identification
Common Name Pyridoxal 5'-phosphate
Description This is the active form of vitamin B6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (pyridoxamine). -- Pubchem; Pyridoxal-phosphate (PLP, pyridoxal-5'-phosphate) is a cofactor of many enzymatic reactions. It is the active form of vitamin B6 which comprises three natural organic compounds, pyridoxal, pyridoxamine and pyridoxine. -- Wikipedia.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. Apolon B6
  2. Biosechs
  3. Codecarboxylase
  4. Coenzyme B6
  5. Hairoxal
  6. Hexermin-P
  7. Hi-Pyridoxin
  8. Hiadelon
  9. Himitan
  10. PAL-P
  11. Phosphopyridoxal
  12. Phosphopyridoxal coenzyme
  13. Pidopidon
  14. Piodel
  15. PLP
  16. Pydoxal
  17. Pyridoxal 5'-phosphate
  18. Pyridoxal 5-phosphate
  19. Pyridoxal P
  20. Pyridoxal phosphate
  21. Pyridoxal-P
  22. Pyridoxyl phosphate
  23. Pyromijin
  24. Sechvitan
  25. Vitahexin-P
  26. Vitazechs
Chemical Formula C8H10NO6P
Average Molecular Weight 247.1419
Monoisotopic Molecular Weight 247.024573569
IUPAC Name [(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methoxy]phosphonic acid
Traditional IUPAC Name (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methoxyphosphonic acid
CAS Registry Number 54-47-7
SMILES CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O
InChI Identifier InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChI Key NGVDGCNFYWLIFO-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Aromatic Heteromonocyclic Compounds
Class Pyridines and Derivatives
Sub Class Pyridine Carboxaldehydes
Other Descriptors
  • Aromatic Heteromonocyclic Compounds
  • Pyridine Carboxaldehydes
  • vitamin B6 phosphate(ChEBI)
Substituents
  • Aldehyde
  • Organic Hypophosphite
  • Organic Phosphite
  • Phosphoric Acid Ester
Direct Parent Pyridoxals and Derivatives
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Vitamin B6 metabolism
  • Enzyme co-factor
Application Not Available
Cellular locations
  • Mitochondria
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point 255 °C Not Available
Boiling Point Not Available Not Available
Water Solubility 28 mg/mL Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility 5.7 g/L ALOGPS
LogP -0.55 ALOGPS
LogP -2.1 ChemAxon
LogS -1.64 ALOGPS
pKa (strongest acidic) 1.68 ChemAxon
pKa (strongest basic) 4.11 ChemAxon
Hydrogen Acceptor Count 6 ChemAxon
Hydrogen Donor Count 3 ChemAxon
Polar Surface Area 116.95 A2 ChemAxon
Rotatable Bond Count 4 ChemAxon
Refractivity 54.75 ChemAxon
Polarizability 20.91 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -2 ChemAxon
Spectra
1H NMR Spectrum
MS/MS Spectrum Quattro_QQQ 10
MS/MS Spectrum Quattro_QQQ 25
MS/MS Spectrum Quattro_QQQ 40
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 10
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 20
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 30
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 40
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 50
MS/MS Spectrum LC-ESI-QTOF (UPLC Q-Tof Premier, Waters)
MS/MS Spectrum LC-ESI-QTOF (UPLC Q-Tof Premier, Waters)
MS/MS Spectrum LC-ESI-QTOF (UPLC Q-Tof Premier, Waters)
MS/MS Spectrum LC-ESI-QTOF (UPLC Q-Tof Premier, Waters)
MS/MS Spectrum GC-MS
[1H,1H] 2D NMR Spectrum
[1H,13C] 2D NMR Spectrum
Biological Properties
Cellular Locations
  • Mitochondria
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
Tissue Location
  • Muscle
  • Neuron
  • Erythrocyte
  • Kidney
  • Liver
Pathways
Name SMPDB Link KEGG Link
Glucose-Alanine Cycle SMP00127 Not Available
Malate-Aspartate Shuttle SMP00129 Not Available
Vitamin B6 Metabolism SMP00017 map00750 Link_out
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
0.046 (0.035-0.06) uM Adult (>18 years old) Both Normal
Blood Detected and Quantified
0.042 (0.0076-1.26) uM Adult (>18 years old) Both Normal
Blood Detected and Quantified
0.030 uM Adult (>18 years old) Female Comment Normal
Blood Detected and Quantified
0.061 +/- 0.052 uM Children (1-13 year old) Both Normal
  • Geigy Scient...
Blood Detected and Quantified
0.056 +/- 0.042 uM Newborn (0-30 days old) Both Normal
  • Geigy Scient...
Blood Detected and Quantified
0.068 +/- 0.015 uM Adult (>18 years old) Female Normal
  • Geigy Scient...
Blood Detected and Quantified
0.075 +/- 0.022 uM Adult (>18 years old) Male Normal
  • Geigy Scient...
Blood Detected and Quantified
0.0047 +/- 0.00072 uM Adult (>18 years old) Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.0515 +/- 0.0166 uM Newborn (0-30 days old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.0431 +/- 0.0193 uM Infant (0-1 year old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.0305 +/- 0.0111 uM Children (1-13 year old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.0207 +/- 0.0069 uM Children (1-13 year old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.0654 +/- 0.0173 uM Infant (0-1 year old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.0531 +/- 0.0186 uM Infant (0-1 year old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.0312 +/- 0.0049 uM Children (1-13 year old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.032-0.078 uM Children (1-13 year old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.044-0.089 uM Children (1-13 year old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.000972 +/- 0.000283 uM Adult (>18 years old) Not Specified Normal
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified 0.024 (0.019-0.031) uM Adult (>18 years old) Both Rheumatoid arthritis
Cerebrospinal Fluid (CSF) Detected and Quantified 0.064 uM Children (1-13 year old) Not Specified Truncus arteriosus, seizures and dystonia
Cerebrospinal Fluid (CSF) Detected and Quantified 0.00243 +/- 0.00138 uM Adult (>18 years old) Not Specified celiac disease
Cerebrospinal Fluid (CSF) Detected and Quantified 0.0119 (0.0036-0.018) uM Newborn (0-30 days old) Not Specified PNPO deficiency
Cerebrospinal Fluid (CSF) Detected and Quantified 0.0036 uM Newborn (0-30 days old) Not Specified PNPO deficiency
Cerebrospinal Fluid (CSF) Detected and Quantified 0.012 uM Newborn (0-30 days old) Not Specified PNPO deficiency
Cerebrospinal Fluid (CSF) Detected and Quantified 0.014 uM Newborn (0-30 days old) Not Specified PNPO deficiency
Cerebrospinal Fluid (CSF) Detected and Quantified 0.018 uM Newborn (0-30 days old) Not Specified PNPO deficiency
Cerebrospinal Fluid (CSF) Detected and Quantified 0.00243 +/- 0.00138 uM Adult (>18 years old) Not Specified celiac disease
Associated Disorders and Diseases
Disease References
Rheumatoid arthritis
  • Chiang EP, Smith DE, Selhub J, Dallal G, Wang YC, Roubenoff R: Inflammation causes tissue-specific depletion of vitamin B6. Arthritis Res Ther. 2005;7(6):R1254-62. Epub 2005 Sep 13. Pubmed: 16277678 Link_out
      Associated OMIM IDs
      DrugBank ID Not Available
      DrugBank Metabolite ID Not Available
      Phenol Explorer Compound ID Not Available
      Phenol Explorer Metabolite ID Not Available
      FoodDB ID FDB021820
      KNApSAcK ID Not Available
      Chemspider ID 1022 Link_out
      KEGG Compound ID C00018 Link_out
      BioCyc ID PYRIDOXAL_PHOSPHATE Link_out
      BiGG ID 33526 Link_out
      Wikipedia Link Pyridoxal 5'-phosphate Link_out
      NuGOwiki Link HMDB01491 Link_out
      Metagene Link HMDB01491 Link_out
      METLIN ID 6275 Link_out
      PubChem Compound 1051 Link_out
      PDB ID PLP Link_out
      ChEBI ID 18405 Link_out
      References
      Synthesis Reference Not Available
      Material Safety Data Sheet (MSDS) Download (PDF)
      General References
      1. Huang YC, Lan PH, Cheng CH, Lee BJ, Kan MN: Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan. Eur J Clin Nutr. 2002 May;56(5):387-92. Pubmed: 12001008 Link_out
      2. Chiang EP, Bagley PJ, Roubenoff R, Nadeau M, Selhub J: Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status. J Nutr. 2003 Apr;133(4):1056-9. Pubmed: 12672918 Link_out
      3. Chiang EP, Selhub J, Bagley PJ, Dallal G, Roubenoff R: Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. Arthritis Res Ther. 2005;7(6):R1404-11. Epub 2005 Oct 14. Pubmed: 16277693 Link_out
      4. Heiskanen K, Kallio M, Salmenpera L, Siimes MA, Ruokonen I, Perheentupa J: Vitamin B-6 status during childhood: tracking from 2 months to 11 years of age. J Nutr. 1995 Dec;125(12):2985-92. Pubmed: 7500176 Link_out
      5. Longhi RC, Fleisher LD, Tallan HH, Gaull GE: Cystathionine beta-synthase deficiency: a qualitative abnormality of the deficient enzyme modified by vitamin B6 therapy. Pediatr Res. 1977 Feb;11(2):100-3. Pubmed: 840498 Link_out
      6. Fonda ML: Vitamin B6 metabolism and binding to proteins in the blood of alcoholic and nonalcoholic men. Alcohol Clin Exp Res. 1993 Dec;17(6):1171-8. Pubmed: 8116826 Link_out
      7. Lee BJ, Huang MC, Chung LJ, Cheng CH, Lin KL, Su KH, Huang YC: Folic acid and vitamin B12 are more effective than vitamin B6 in lowering fasting plasma homocysteine concentration in patients with coronary artery disease. Eur J Clin Nutr. 2004 Mar;58(3):481-7. Pubmed: 14985687 Link_out
      8. Schuster K, Bailey LB, Cerda JJ, Gregory JF 3rd: Urinary 4-pyridoxic acid excretion in 24-hour versus random urine samples as a measurement of vitamin B6 status in humans. Am J Clin Nutr. 1984 Mar;39(3):466-70. Pubmed: 6695847 Link_out
      9. Heiskanen K, Siimes MA, Perheentupa J, Salmenpera L: Reference ranges for erythrocyte pyridoxal 5'-phosphate concentration and the erythrocyte aspartate transaminase stimulation test in lactating mothers and their infants. Am J Clin Nutr. 1994 Jun;59(6):1297-303. Pubmed: 8198054 Link_out
      10. Selvaag E, Bohmer T, Benkestock K: Reduced serum concentrations of riboflavine and ascorbic acid, and blood thiamine pyrophosphate and pyridoxal-5-phosphate in geriatric patients with and without pressure sores. J Nutr Health Aging. 2002;6(1):75-7. Pubmed: 11813090 Link_out
      11. Iqbal SJ, Plaha DS, Linforth GH, Dalgleish R: Hypophosphatasia: diagnostic application of linked DNA markers in the dominantly inherited adult form. Clin Sci (Lond). 1999 Jul;97(1):73-8. Pubmed: 10369796 Link_out
      12. Heiskanen K, Siimes MA, Salmenpera L, Perheentupa J: Low vitamin B6 status associated with slow growth in healthy breast-fed infants. Pediatr Res. 1995 Nov;38(5):740-6. Pubmed: 8552443 Link_out
      13. Huang YC, Chang SJ, Chiu YT, Chang HH, Cheng CH: The status of plasma homocysteine and related B-vitamins in healthy young vegetarians and nonvegetarians. Eur J Nutr. 2003 Apr;42(2):84-90. Pubmed: 12638029 Link_out
      14. Huang YC, Chang HH, Huang SC, Cheng CH, Lee BJ, Cheng SY, Su KH: Plasma pyridoxal 5'-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill. Nutrition. 2005 Jul-Aug;21(7-8):779-85. Pubmed: 15975484 Link_out
      15. Chiang EP, Bagley PJ, Selhub J, Nadeau M, Roubenoff R: Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis. Am J Med. 2003 Mar;114(4):283-7. Pubmed: 12681455 Link_out
      16. Lacour B, Parry C, Drueke T, Touam M, Kreis H, Bailly M, Durand D: Pyridoxal 5'-phosphate deficiency in uremic undialyzed, hemodialyzed, and non-uremic kidney transplant patients. Clin Chim Acta. 1983 Jan 24;127(2):205-15. Pubmed: 6337752 Link_out
      17. Seki T: Combination treatment of high-dose pyridoxal phosphate and low-dose ACTH in children with West syndrome and related disorders. Jpn J Psychiatry Neurol. 1990 Jun;44(2):219-37. Pubmed: 1701836 Link_out
      18. Akopov MA, Kagan ZS, Berezov TT, Filiptsev PIa: [Kinetics and thermodynamics of heat inactivation of L-threonine-L-serine dehydratase from human liver] Biokhimiia. 1978 Nov;43(11):2027-32. Pubmed: 737218 Link_out
      19. Descombes E, Hanck AB, Fellay G: Water soluble vitamins in chronic hemodialysis patients and need for supplementation. Kidney Int. 1993 Jun;43(6):1319-28. Pubmed: 8315945 Link_out
      20. Stolzenberg-Solomon RZ, Albanes D, Nieto FJ, Hartman TJ, Tangrea JA, Rautalahti M, Sehlub J, Virtamo J, Taylor PR: Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokers. J Natl Cancer Inst. 1999 Mar 17;91(6):535-41. Pubmed: 10088624 Link_out

      Enzymes

      Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 87 enzymes in total.

      Name: 5-aminolevulinate synthase, erythroid-specific, mitochondrial
      Reactions: Not Available
      Gene Name: ALAS2
      Uniprot ID: P22557 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: 5-aminolevulinate synthase, nonspecific, mitochondrial
      Reactions: Not Available
      Gene Name: ALAS1
      Uniprot ID: P13196 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
      Reactions: Not Available
      Gene Name: GCAT
      Uniprot ID: O75600 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Methylenetetrahydrofolate reductase
      Reactions: Not Available
      Gene Name: MTHFR
      Uniprot ID: P42898 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: 4-aminobutyrate aminotransferase, mitochondrial
      Reactions: Not Available
      Gene Name: ABAT
      Uniprot ID: P80404 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Tyrosine aminotransferase
      Reactions: Not Available
      Gene Name: TAT
      Uniprot ID: P17735 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Aromatic-L-amino-acid decarboxylase
      Reactions: Not Available
      Gene Name: DDC
      Uniprot ID: P20711 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Aspartate aminotransferase, cytoplasmic
      Reactions: Not Available
      Gene Name: GOT1
      Uniprot ID: P17174 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Aspartate aminotransferase, mitochondrial
      Reactions: Not Available
      Gene Name: GOT2
      Uniprot ID: P00505 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Branched-chain-amino-acid aminotransferase, cytosolic
      Reactions: Not Available
      Gene Name: BCAT1
      Uniprot ID: P54687 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Kynureninase
      Reactions: Not Available
      Gene Name: KYNU
      Uniprot ID: Q16719 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Glucose-6-phosphate 1-dehydrogenase
      Reactions: Not Available
      Gene Name: G6PD
      Uniprot ID: P11413 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Glycogen phosphorylase, liver form
      Reactions: Not Available
      Gene Name: PYGL
      Uniprot ID: P06737 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Glycogen phosphorylase, muscle form
      Reactions: Not Available
      Gene Name: PYGM
      Uniprot ID: P11217 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Glycogen phosphorylase, brain form
      Reactions: Not Available
      Gene Name: PYGB
      Uniprot ID: P11216 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
      Reactions: Not Available
      Gene Name: AADAT
      Uniprot ID: Q8N5Z0 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Alanine--glyoxylate aminotransferase 2, mitochondrial
      Reactions: Not Available
      Gene Name: AGXT2
      Uniprot ID: Q9BYV1 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Ornithine aminotransferase, mitochondrial
      Reactions: Not Available
      Gene Name: OAT
      Uniprot ID: P04181 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Kynurenine--oxoglutarate transaminase 1
      Reactions: Not Available
      Gene Name: CCBL1
      Uniprot ID: Q16773 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Branched-chain-amino-acid aminotransferase, mitochondrial
      Reactions: Not Available
      Gene Name: BCAT2
      Uniprot ID: O15382 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Cystathionine gamma-lyase
      Reactions: Not Available
      Gene Name: CTH
      Uniprot ID: P32929 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: L-serine dehydratase/L-threonine deaminase
      Reactions: Not Available
      Gene Name: SDS
      Uniprot ID: P20132 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Pyridoxine-5'-phosphate oxidase
      Reactions:
      Pyridoxamine 5'-phosphate + Water + Oxygen unknown Pyridoxal 5'-phosphate + Ammonia + Hydrogen peroxide details
      Pyridoxine 5'-phosphate + Oxygen unknown Pyridoxal 5'-phosphate + Hydrogen peroxide details
      Gene Name: PNPO
      Uniprot ID: Q9NVS9 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Formimidoyltransferase-cyclodeaminase
      Reactions: Not Available
      Gene Name: FTCD
      Uniprot ID: O95954 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Glutamate decarboxylase 2
      Reactions: Not Available
      Gene Name: GAD2
      Uniprot ID: Q05329 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Glutamate decarboxylase 1
      Reactions: Not Available
      Gene Name: GAD1
      Uniprot ID: Q99259 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Cystathionine beta-synthase
      Reactions: Not Available
      Gene Name: CBS
      Uniprot ID: P35520 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Serine--pyruvate aminotransferase
      Reactions: Not Available
      Gene Name: AGXT
      Uniprot ID: P21549 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Serine hydroxymethyltransferase, mitochondrial
      Reactions: Not Available
      Gene Name: SHMT2
      Uniprot ID: P34897 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Serine hydroxymethyltransferase, cytosolic
      Reactions: Not Available
      Gene Name: SHMT1
      Uniprot ID: P34896 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Glycine dehydrogenase [decarboxylating], mitochondrial
      Reactions: Not Available
      Gene Name: GLDC
      Uniprot ID: P23378 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Alanine aminotransferase 1
      Reactions: Not Available
      Gene Name: GPT
      Uniprot ID: P24298 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphoserine aminotransferase
      Reactions: Not Available
      Gene Name: PSAT1
      Uniprot ID: Q9Y617 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histidine decarboxylase
      Reactions: Not Available
      Gene Name: HDC
      Uniprot ID: P19113 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Serine palmitoyltransferase 1
      Reactions: Not Available
      Gene Name: SPTLC1
      Uniprot ID: O15269 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Serine palmitoyltransferase 2
      Reactions: Not Available
      Gene Name: SPTLC2
      Uniprot ID: O15270 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Cysteine sulfinic acid decarboxylase
      Reactions: Not Available
      Gene Name: CSAD
      Uniprot ID: Q9Y600 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Ornithine decarboxylase
      Reactions: Not Available
      Gene Name: ODC1
      Uniprot ID: P11926 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Sphingosine-1-phosphate lyase 1
      Reactions: Not Available
      Gene Name: SGPL1
      Uniprot ID: O95470 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Pyridoxal kinase
      Reactions:
      Adenosine triphosphate + Pyridoxal unknown ADP + Pyridoxal 5'-phosphate details
      Gene Name: PDXK
      Uniprot ID: O00764 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Arginine decarboxylase
      Reactions: Not Available
      Gene Name: ADC
      Uniprot ID: Q96A70 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylserine decarboxylase proenzyme
      Reactions: Not Available
      Gene Name: PISD
      Uniprot ID: Q9UG56 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Cysteine desulfurase, mitochondrial
      Reactions: Not Available
      Gene Name: NFS1
      Uniprot ID: Q9Y697 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Proline synthase co-transcribed bacterial homolog protein
      Reactions: Not Available
      Gene Name: PROSC
      Uniprot ID: O94903 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Aminoadipate aminotransferase, isoform CRA_b
      Reactions: Not Available
      Gene Name: AADAT
      Uniprot ID: Q4W5N8 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Threonine synthase-like 1
      Reactions: Not Available
      Gene Name: THNSL1
      Uniprot ID: Q8IYQ7 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Ethanolamine-phosphate phospho-lyase
      Reactions: Not Available
      Gene Name: AGXT2L1
      Uniprot ID: Q8TBG4 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Alanine aminotransferase 2
      Reactions: Not Available
      Gene Name: GPT2
      Uniprot ID: Q8TD30 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Pyridoxal phosphate phosphatase
      Reactions:
      Pyridoxal 5'-phosphate + Water unknown Pyridoxal + Phosphoric acid details
      Gene Name: PDXP
      Uniprot ID: Q96GD0 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Selenocysteine lyase
      Reactions: Not Available
      Gene Name: SCLY
      Uniprot ID: Q96I15 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA