Human Metabolome Database Version 3.5

Showing metabocard for All-trans-retinoic acid (HMDB01852)

Record Information
Version 3.5
Creation Date 2006-02-16 04:10:57 -0700
Update Date 2013-05-29 13:32:28 -0600
HMDB ID HMDB01852
Secondary Accession Numbers None
Metabolite Identification
Common Name All-trans-retinoic acid
Description All-trans-retinoic acid is an isomer of retinoic acid, the oxidized form of Vitamin A. Retinoic acid functions in determining position along embryonic anterior/posterior axis in chordates. It acts through Hox genes, which ultimately controls anterior/posterior patterning in early developmental stages (PMID: 17495912 Link_out). It is an important regulator of gene expression during growth and development, and in neoplasms. As a drug, all-trans-retinoic acid is known as tretinoin. Tretinoin is derived from maternal vitamin A and is essential for normal growth and embryonic development. An excess of tretinoin can be teratogenic. Tretinoin is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute).
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  2. (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  3. 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  4. 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  5. Acide retinoique (French)
  6. All-(E)-Retinoate
  7. All-(E)-Retinoic acid
  8. All-trans-Retinoate
  9. All-trans-Retinoic acid
  10. All-trans-Tretinoin
  11. All-trans-Vitamin A acid
  12. All-trans-Vitamin A1 acid
  13. beta-Retinoate
  14. beta-Retinoic acid
  15. Retinoate
  16. Retinoic acid
  17. trans-Retinoate
  18. trans-Retinoic acid
  19. Tretin M
  20. Tretinoine (French)
  21. Vitamin A acid
Chemical Formula C20H28O2
Average Molecular Weight 300.4351
Monoisotopic Molecular Weight 300.20893014
IUPAC Name (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
Traditional IUPAC Name alitretinoin
CAS Registry Number 302-79-4
SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
InChI Identifier InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChI Key SHGAZHPCJJPHSC-YCNIQYBTSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Lipids
Class Prenol Lipids
Sub Class Retinoids
Other Descriptors
  • Aliphatic Homomonocyclic Compounds
  • Branched Fatty Acids
  • Carbocyclic Fatty Acids
  • Organic Compounds
  • Unsaturated Fatty Acids
Substituents
  • Allyl Alcohol
  • Carboxylic Acid
  • Cyclohexene
  • Enone
  • Isoprene
Direct Parent Retinoids
Ontology
Status Detected and Quantified
Origin
  • Endogenous
  • Food
Biofunction
  • Cell signaling
  • Component of Retinol metabolism
  • Fuel and energy storage
  • Fuel or energy source
  • Membrane integrity/stability
Application
  • Nutrients
  • Stabilizers
  • Surfactants and Emulsifiers
Cellular locations
  • Cytoplasm
  • Extracellular
  • Membrane (predicted from logP)
  • Nucleus
  • Endoplasmic reticulum
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point 181 °C Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP 6.30 HANSCH,C ET AL. (1995)
Predicted Properties
Property Value Source
Water Solubility 0.0048 g/L ALOGPS
LogP 5.66 ALOGPS
LogP 5.01 ChemAxon
LogS -4.80 ALOGPS
pKa (strongest acidic) 5 ChemAxon
Hydrogen Acceptor Count 2 ChemAxon
Hydrogen Donor Count 1 ChemAxon
Polar Surface Area 37.3 A2 ChemAxon
Rotatable Bond Count 5 ChemAxon
Refractivity 97.79 ChemAxon
Polarizability 36.85 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -1 ChemAxon
Spectra
1H NMR Spectrum
MS/MS Spectrum Quattro_QQQ 10
MS/MS Spectrum Quattro_QQQ 25
MS/MS Spectrum Quattro_QQQ 40
MS/MS Spectrum LC-ESI-QTOF (UPLC Q-Tof Premier, Waters)
[1H,13C] 2D NMR Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Membrane (predicted from logP)
  • Nucleus
  • Endoplasmic reticulum
Biofluid Locations
  • Blood
Tissue Location
  • Bladder
  • Fibroblasts
  • Intestine
  • Neuron
  • Pancreas
  • Placenta
  • Testes
  • Kidney
  • Liver
  • Brain
  • Myelin
  • Prostate
  • Adrenal Gland
  • Skin
  • Adipose Tissue
  • Adrenal Cortex
  • Lung
  • Platelet
  • Spleen
  • Stratum Corneum
Pathways Not Available
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
0.20 +/- 0.18 uM Adult (>18 years old) Female Normal
  • Geigy Scient...
Blood Detected and Quantified
0.0145 +/- 0.0092 uM Adult (>18 years old) Both Normal
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID Not Available
DrugBank Metabolite ID Not Available
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB022710
KNApSAcK ID Not Available
Chemspider ID 392618 Link_out
KEGG Compound ID C00777 Link_out
BioCyc ID RETINOATE Link_out
BiGG ID 35948 Link_out
Wikipedia Link Retinoic acid Link_out
NuGOwiki Link HMDB01852 Link_out
Metagene Link HMDB01852 Link_out
METLIN ID 2277 Link_out
PubChem Compound 444795 Link_out
PDB ID REA Link_out
ChEBI ID 15367 Link_out
References
Synthesis Reference Solladie, Guy; Girardin, Andre. Highly stereoselective synthesis of vitamin A and all-trans retinoic acid by low-valent titanium induced reductive elimination. Tetrahedron Letters (1988), 29(2), 213-16.
Material Safety Data Sheet (MSDS) Download (PDF)
General References
  1. Barua AB, Olson JA: Retinoyl beta-glucuronide: an endogenous compound of human blood. Am J Clin Nutr. 1986 Apr;43(4):481-5. Pubmed: 3962900 Link_out
  2. Napoli JL, Posch KP, Fiorella PD, Boerman MH: Physiological occurrence, biosynthesis and metabolism of retinoic acid: evidence for roles of cellular retinol-binding protein (CRBP) and cellular retinoic acid-binding protein (CRABP) in the pathway of retinoic acid homeostasis. Biomed Pharmacother. 1991;45(4-5):131-43. Pubmed: 1932598 Link_out
  3. Giannini G, Di Marcotullio L, Ristori E, Zani M, Crescenzi M, Scarpa S, Piaggio G, Vacca A, Peverali FA, Diana F, Screpanti I, Frati L, Gulino A: HMGI(Y) and HMGI-C genes are expressed in neuroblastoma cell lines and tumors and affect retinoic acid responsiveness. Cancer Res. 1999 May 15;59(10):2484-92. Pubmed: 10344762 Link_out
  4. Lee YF, Bao BY, Chang C: Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor. Biochem Biophys Res Commun. 2004 Oct 22;323(3):876-83. Pubmed: 15381082 Link_out
  5. Mercader J, Ribot J, Murano I, Felipe F, Cinti S, Bonet ML, Palou A: Remodeling of white adipose tissue after retinoic acid administration in mice. Endocrinology. 2006 Nov;147(11):5325-32. Epub 2006 Jul 13. Pubmed: 16840543 Link_out
  6. Natsume N, Kondo S, Matsuyama Y, Sumida K, Inou H, Kawakami N, Sandell LJ, Iwata H: Analysis of cartilage-derived retinoic acid-sensitive protein in cerebrospinal fluid From patients With spinal diseases. Spine. 2001 Jan 15;26(2):157-60. Pubmed: 11154535 Link_out
  7. Baron JM, Heise R, Blaner WS, Neis M, Joussen S, Dreuw A, Marquardt Y, Saurat JH, Merk HF, Bickers DR, Jugert FK: Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53. Pubmed: 15982314 Link_out
  8. Paez-Pereda M, Kovalovsky D, Hopfner U, Theodoropoulou M, Pagotto U, Uhl E, Losa M, Stalla J, Grubler Y, Missale C, Arzt E, Stalla GK: Retinoic acid prevents experimental Cushing syndrome. J Clin Invest. 2001 Oct;108(8):1123-31. Pubmed: 11602619 Link_out
  9. Czernik PJ, Little JM, Barone GW, Raufman JP, Radominska-Pandya A: Glucuronidation of estrogens and retinoic acid and expression of UDP-glucuronosyltransferase 2B7 in human intestinal mucosa. Drug Metab Dispos. 2000 Oct;28(10):1210-6. Pubmed: 10997942 Link_out
  10. Saito S, Kondo S, Mishima S, Ishiguro N, Hasegawa Y, Sandell LJ, Iwata H: Analysis of cartilage-derived retinoic-acid-sensitive protein (CD-RAP) in synovial fluid from patients with osteoarthritis and rheumatoid arthritis. J Bone Joint Surg Br. 2002 Sep;84(7):1066-9. Pubmed: 12358374 Link_out
  11. Meyer E, Lambert WE, De Leenheer AP: Simultaneous determination of endogenous retinoic acid isomers and retinol in human plasma by isocratic normal-phase HPLC with ultraviolet detection. Clin Chem. 1994 Jan;40(1):48-57. Pubmed: 8287543 Link_out
  12. Masgrau-Peya E, Salomon D, Saurat JH, Meda P: In vivo modulation of connexins 43 and 26 of human epidermis by topical retinoic acid treatment. J Histochem Cytochem. 1997 Sep;45(9):1207-15. Pubmed: 9283608 Link_out
  13. Lopez-Boado YS, Klaus M, Dawson MI, Lopez-Otin C: Retinoic acid-induced expression of apolipoprotein D and concomitant growth arrest in human breast cancer cells are mediated through a retinoic acid receptor RARalpha-dependent signaling pathway. J Biol Chem. 1996 Dec 13;271(50):32105-11. Pubmed: 8943263 Link_out
  14. Stewart ME, Benoit AM, Downing DT, Strauss JS: Suppression of sebum secretion with 13-cis-retinoic acid: effect on individual skin surface lipids and implications for their anatomic origin. J Invest Dermatol. 1984 Jan;82(1):74-8. Pubmed: 6228612 Link_out
  15. Tse HK, Leung MB, Woolf AS, Menke AL, Hastie ND, Gosling JA, Pang CP, Shum AS: Implication of Wt1 in the pathogenesis of nephrogenic failure in a mouse model of retinoic acid-induced caudal regression syndrome. Am J Pathol. 2005 May;166(5):1295-307. Pubmed: 15855632 Link_out
  16. Patel JB, Huynh CK, Handratta VD, Gediya LK, Brodie AM, Goloubeva OG, Clement OO, Nanne IP, Soprano DR, Njar VC: Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice. J Med Chem. 2004 Dec 30;47(27):6716-29. Pubmed: 15615521 Link_out
  17. Thiboutot D, Martin P, Volikos L, Gilliland K: Oxidative activity of the type 2 isozyme of 17beta-hydroxysteroid dehydrogenase (17beta-HSD) predominates in human sebaceous glands. J Invest Dermatol. 1998 Sep;111(3):390-5. Pubmed: 9740229 Link_out
  18. Holland LZ: Developmental biology: a chordate with a difference. Nature. 2007 May 10;447(7141):153-5. Pubmed: 17495912 Link_out

Enzymes

Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 57 enzymes in total.

Name: Retinal dehydrogenase 1
Reactions:
Retinal + NAD + Water unknown All-trans-retinoic acid + NADH + Hydrogen Ion details
Gene Name: ALDH1A1
Uniprot ID: P00352 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Retinal dehydrogenase 2
Reactions:
Retinal + NAD + Water unknown All-trans-retinoic acid + NADH + Hydrogen Ion details
Gene Name: ALDH1A2
Uniprot ID: O94788 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 4A11
Reactions:
All-trans-retinoic acid + NADPH + Hydrogen Ion + Oxygen unknown all-trans-18-Hydroxyretinoic acid + NADP + Water details
Gene Name: CYP4A11
Uniprot ID: Q02928 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 2B28
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT2B28
Uniprot ID: Q9BY64 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 2B4
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT2B4
Uniprot ID: P06133 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 1-4
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT1A4
Uniprot ID: P22310 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 2B10
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT2B10
Uniprot ID: P36537 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 2B7
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT2B7
Uniprot ID: P16662 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 2B15
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT2B15
Uniprot ID: P54855 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 2A1
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT2A1
Uniprot ID: Q9Y4X1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 1-1
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT1A1
Uniprot ID: P22309 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 1-9
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT1A9
Uniprot ID: O60656 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 1-8
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT1A8
Uniprot ID: Q9HAW9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 1-3
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT1A3
Uniprot ID: P35503 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 1-10
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT1A10
Uniprot ID: Q9HAW8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 2B17
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT2B17
Uniprot ID: O75795 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 1-6
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT1A6
Uniprot ID: P19224 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 1-5
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT1A5
Uniprot ID: P35504 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 2B11
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT2B11
Uniprot ID: O75310 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: UDP-glucuronosyltransferase 1-7
Reactions:
All-trans-retinoic acid + Uridine diphosphate glucuronic acid unknown Retinoyl b-glucuronide + Uridine 5'-diphosphate details
Gene Name: UGT1A7
Uniprot ID: Q9HAW7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 3A4
Reactions: Not Available
Gene Name: CYP3A4
Uniprot ID: P08684 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2C9
Reactions: Not Available
Gene Name: CYP2C9
Uniprot ID: P11712 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2C19
Reactions: Not Available
Gene Name: CYP2C19
Uniprot ID: P33261 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2E1
Reactions: Not Available
Gene Name: CYP2E1
Uniprot ID: P05181 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 3A43
Reactions: Not Available
Gene Name: CYP3A43
Uniprot ID: Q9HB55 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 1B1
Reactions: Not Available
Gene Name: CYP1B1
Uniprot ID: Q16678 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2C18
Reactions: Not Available
Gene Name: CYP2C18
Uniprot ID: P33260 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2F1
Reactions: Not Available
Gene Name: CYP2F1
Uniprot ID: P24903 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 4X1
Reactions: Not Available
Gene Name: CYP4X1
Uniprot ID: Q8N118 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2B6
Reactions: Not Available
Gene Name: CYP2B6
Uniprot ID: P20813 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 3A5
Reactions: Not Available
Gene Name: CYP3A5
Uniprot ID: P20815 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2A13
Reactions: Not Available
Gene Name: CYP2A13
Uniprot ID: Q16696 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 3A7
Reactions: Not Available
Gene Name: CYP3A7
Uniprot ID: P24462 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 4B1
Reactions: Not Available
Gene Name: CYP4B1
Uniprot ID: P13584 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 4Z1
Reactions: Not Available
Gene Name: CYP4Z1
Uniprot ID: Q86W10 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 1A2
Reactions: Not Available
Gene Name: CYP1A2
Uniprot ID: P05177 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 19A1
Reactions: Not Available
Gene Name: CYP19A1
Uniprot ID: P11511 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2C8
Reactions: Not Available
Gene Name: CYP2C8
Uniprot ID: P10632 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2S1
Reactions: Not Available
Gene Name: CYP2S1
Uniprot ID: Q96SQ9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2J2
Reactions: Not Available
Gene Name: CYP2J2
Uniprot ID: P51589 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2A7
Reactions: Not Available
Gene Name: CYP2A7
Uniprot ID: P20853 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2A6
Reactions: Not Available
Gene Name: CYP2A6
Uniprot ID: P11509 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Retinoic acid receptor gamma
Reactions: Not Available
Gene Name: RARG
Uniprot ID: P13631 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Retinoic acid receptor responder protein 1
Reactions: Not Available
Gene Name: RARRES1
Uniprot ID: P49788 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Retinoic acid receptor alpha
Reactions: Not Available
Gene Name: RARA
Uniprot ID: P10276 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Retinoic acid receptor beta
Reactions: Not Available
Gene Name: RARB
Uniprot ID: P10826 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Retinoic acid receptor RXR-beta
Reactions: Not Available
Gene Name: RXRB
Uniprot ID: P28702 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Retinoic acid receptor RXR-gamma
Reactions: Not Available
Gene Name: RXRG
Uniprot ID: P48443 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Retinoic acid receptor RXR-alpha
Reactions: Not Available
Gene Name: RXRA
Uniprot ID: P19793 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 4A22
Reactions:
All-trans-retinoic acid + NADPH + Hydrogen Ion + Oxygen unknown all-trans-18-Hydroxyretinoic acid + NADP + Water details
Gene Name: CYP4A22
Uniprot ID: Q5TCH4 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Transporters
Name: Cellular retinoic acid-binding protein 1
Reactions: Not Available
Gene Name: CRABP1
Uniprot ID: P29762 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cellular retinoic acid-binding protein 2
Reactions: Not Available
Gene Name: CRABP2
Uniprot ID: P29373 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA