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Record Information
Version3.6
Creation Date2006-02-21 07:56:51 UTC
Update Date2016-02-11 01:05:01 UTC
HMDB IDHMDB01854
Secondary Accession NumbersNone
Metabolite Identification
Common NameTellurium
DescriptionTellurium is a trace element that belongs chemically to the VIa group in the periodic chemical table that has the symbol Te and atomic number 52. Tellurium is a brittle silver-white metalloid which looks like tin, and is related to selenium and sulfur. Physiologically, it exists as an ion in the body. The ingestion of tellurium compounds has been known to be associated with a garlic-like odor of the breath, thus indicating that tellurium is absorbed by the gut, metabolized by tissues, and excreted through routes other than the feces. Little is known about the Te biological activity, particularly with respect to potential chemical interactions with Se-containing components in the organism. Tellurium is a non-competitive inhibitor of squalene epoxidase and has been associated with neuropathy. Late fetal stages of prenatal development appeared uniquely sensitive to organic tellurium exposure. All tellurium compounds are highly toxic. (PMID: 17873396 , 15596254 , 10048717 ).
Structure
Thumb
Synonyms
ValueSource
Aurum paradoxumHMDB
TelloyHMDB
TellurHMDB
Tellurium atomHMDB
Tellurium elementHMDB
Chemical FormulaTe
Average Molecular Weight127.6
Monoisotopic Molecular Weight129.906222753
IUPAC Nameλ⁴-tellanetetraylium
Traditional Nameλ⁴-tellanetetraylium
CAS Registry Number13494-80-9
SMILES
[Te+4]
InChI Identifier
InChI=1S/Te/q+4
InChI KeyInChIKey=LHBANKJAFPUZQV-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of inorganic compounds known as homogeneous metalloid compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a metalloid atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous metalloid compounds
Sub ClassNot Available
Direct ParentHomogeneous metalloid compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous metalloid
  • Acyclic compound
Molecular FrameworkAcyclic compounds
External DescriptorsNot Available
Ontology
StatusDetected and Quantified
Origin
  • Toxin/Pollutant
Biofunction
  • Semi-essential minerals
  • Trace minerals
ApplicationNot Available
Cellular locationsNot Available
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point449.5 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0ChemAxon
Physiological Charge4ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular LocationsNot Available
Biofluid Locations
  • Blood
  • Saliva
  • Urine
Tissue Location
  • Bile
  • Urine
PathwaysNot Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot ApplicableNot AvailableNot Available
Normal
  • Not Applicable
details
SalivaDetected and Quantified0.021 +/- 0.02 uMAdult (>18 years old)BothNormal
    • Zerihun T. Dame, ...
details
UrineDetected and Quantified0.494 umol/mmol creatinineAdult (>18 years old)BothNormal
    details
    Abnormal Concentrations
    Not Available
    Associated Disorders and Diseases
    Disease ReferencesNone
    Associated OMIM IDsNone
    DrugBank IDNot Available
    DrugBank Metabolite IDNot Available
    Phenol Explorer Compound IDNot Available
    Phenol Explorer Metabolite IDNot Available
    FoodDB IDFDB003718
    KNApSAcK IDNot Available
    Chemspider ID103035
    KEGG Compound IDNot Available
    BioCyc IDNot Available
    BiGG IDNot Available
    Wikipedia LinkTellurium
    NuGOwiki LinkHMDB01854
    Metagene LinkHMDB01854
    METLIN IDNot Available
    PubChem Compound115151
    PDB IDNot Available
    ChEBI ID30452
    References
    Synthesis ReferenceDetty, Michael R.; Luss, Henry R.; McKelvey, John M.; Geer, Susan M. 12-Te-5 pertelluranes from 1,2-oxatellurolyl-1-ium halides. Synthesis, structure, and reactivity. The quest for delocalization in 10-Te-3 telluranes and 12-Te-5 pertelluranes of thiath
    Material Safety Data Sheet (MSDS)Download (PDF)
    General References
    1. Wagner-Recio M, Toews AD, Morell P: Tellurium blocks cholesterol synthesis by inhibiting squalene metabolism: preferential vulnerability to this metabolic block leads to peripheral nervous system demyelination. J Neurochem. 1991 Dec;57(6):1891-901. [1940905 ]
    2. Eybl V, Kotyzova D, Sykora J, Topolcan O, Pikner R, Mihaljevic M, Brtko J, Glattre E: Effects of selenium and tellurium on the activity of selenoenzymes glutathione peroxidase and type I iodothyronine deiodinase, trace element thyroid level, and thyroid hormone status in rats. Biol Trace Elem Res. 2007 Summer;117(1-3):105-14. [17873396 ]
    3. Stangherlin EC, Favero AM, Zeni G, Rocha JB, Nogueira CW: Teratogenic vulnerability of Wistar rats to diphenyl ditelluride. Toxicology. 2005 Feb 14;207(2):231-9. [15596254 ]
    4. Gajkowska B, Smialek M, Ostrowski RP, Piotrowski P, Frontczak-Baniewicz M: The experimental squalene encephaloneuropathy in the rat. Exp Toxicol Pathol. 1999 Jan;51(1):75-80. [10048717 ]