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Record Information
Version3.6
Creation Date2006-05-22 14:17:29 UTC
Update Date2016-02-11 01:05:08 UTC
HMDB IDHMDB01960
Secondary Accession NumbersNone
Metabolite Identification
Common NameTin
DescriptionTin is a trace element that is required in bone formation. It has the atomic symbol Sn, atomic number 50, and atomic weight 118.71. (PubChem). Experimental studies over the last decade have suggested an association between thymus immune and homeostatic function and exogenous tin. It has been hypothesized that the thymus gland synthesizes and secretes one or more tin bearing factors that enhance immune defenses against malignancy and retard the gradual loss of immune capacity with senescence. (PMID 2195720 ). Physiologically, it exists as an ion in the body. Inorganic tin salts are poorly absorbed and rapidly excreted in the faeces; as a result they have a low toxicity. Only about 5 per cent is absorbed from the gastrointestinal tract, widely distributed in the body, then excreted by the kidney. Some tin is deposited in lung and bone. Some tin salts can cause renal necrosis after parenteral doses. Mutagenic studies on metallic tin and its compounds have been negative. Long-term animal carcinogenic studies have shown fewer malignant tumors in animals exposed to tin than in controls. Human volunteers developed mild signs of toxicity with tin, given in fruit juices, at a concentration of 1400 mg per litre. The WHO 1973 permissible limit for tin in tinned food is 250 micrograms per kg. The adult daily intake of tin was about 17 mg per day in 1940, but it has now decreased to about 3.5 mg, due to improvements in technique of tinning with enamel overcoat and crimped lids to minimize exposure to tin and lead solder. (PMID 3291572 ).
Structure
Thumb
Synonyms
ValueSource
CI pigment metal 5HMDB
haro Mix ZT-514HMDB
InnohepHMDB
Metallic tinHMDB
Silver matt powderHMDB
SNHMDB
StanumHMDB
Tin flakeHMDB
Tin powderHMDB
TindamaxHMDB
ZINNHMDB
Chemical FormulaH4Sn
Average Molecular Weight122.74
Monoisotopic Molecular Weight123.933496699
IUPAC Nameλ⁸-tin(4+) ion
Traditional Nameλ⁸-tin(4+) ion
CAS Registry Number7440-31-5
SMILES
[SnH4+4]
InChI Identifier
InChI=1S/Sn.4H/q+4;;;;
InChI KeyInChIKey=PXQLTWWGPFDWNT-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of inorganic compounds known as miscellaneous mixed metal/non-metals. These are inorganic compounds containing non-metal as well as metal atoms but not belonging to afore mentioned classes.
KingdomInorganic compounds
Super ClassMixed metal/non-metal compounds
ClassMiscellaneous mixed metal/non-metals
Sub ClassNot Available
Direct ParentMiscellaneous mixed metal/non-metals
Alternative ParentsNot Available
Substituents
  • Miscellaneous mixed metal/non-metal
  • Acyclic compound
Molecular FrameworkAcyclic compounds
External DescriptorsNot Available
Ontology
StatusDetected and Quantified
OriginNot Available
Biofunction
  • Osmolyte, enzyme cofactor, signalling
ApplicationNot Available
Cellular locationsNot Available
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point231.93 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-1.8ChemAxon
Physiological Charge4ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity3.2 m3·mol-1ChemAxon
Polarizability4.7 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular LocationsNot Available
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue LocationNot Available
PathwaysNot Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.013 +/- 0.0051 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.0065 +/- 0.0039 uMElderly (>65 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.05 (0.03-0.18) uMAdult (>18 years old)BothNormal details
SalivaDetected and Quantified0.020 +/- 0.02 uMAdult (>18 years old)BothNormal
    • Zerihun T. Dame, ...
details
UrineDetected and Quantified0.0011 (0.00016-0.0069) umol/mmol creatinineAdult (>18 years old)Both
Normal
details
UrineDetected and Quantified<0.00552 umol/mmol creatinineAdult (>18 years old)Not SpecifiedNormal details
UrineDetected and Quantified< 0.00552 umol/mmol creatinineAdult (>18 years old)Not SpecifiedNormal details
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.004 +/- 0.0018 uMAdult (>18 years old)BothParkinson's disease details
BloodDetected and Quantified0.016 +/- 0.009 uMAdult (>18 years old)BothMultiple sclerosis details
BloodDetected and Quantified0.011 +/- 0.0056 uMAdult (>18 years old)BothAlzheimer's disease details
Associated Disorders and Diseases
Disease References
Alzheimer's disease
  1. Bocca B, Forte G, Petrucci F, Pino A, Marchione F, Bomboi G, Senofonte O, Giubilei F, Alimonti A: Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease. Ann Ist Super Sanita. 2005;41(2):197-203. [16244393 ]
Multiple sclerosis
  1. Forte G, Visconti A, Santucci S, Ghazaryan A, Figa-Talamanca L, Cannoni S, Bocca B, Pino A, Violante N, Alimonti A, Salvetti M, Ristori G: Quantification of chemical elements in blood of patients affected by multiple sclerosis. Ann Ist Super Sanita. 2005;41(2):213-6. [16244395 ]
Parkinson's disease
  1. Forte G, Alimonti A, Pino A, Stanzione P, Brescianini S, Brusa L, Sancesario G, Violante N, Bocca B: Metals and oxidative stress in patients with Parkinson's disease. Ann Ist Super Sanita. 2005;41(2):189-95. [16244392 ]
Associated OMIM IDs
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB003722
KNApSAcK IDNot Available
Chemspider ID10620886
KEGG Compound IDNot Available
BioCyc IDCPD-8961
BiGG IDNot Available
Wikipedia LinkTin
NuGOwiki LinkHMDB01960
Metagene LinkHMDB01960
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI ID32990
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Cardarelli N: Tin and the thymus gland: a review. Thymus. 1990 Jun;15(4):223-31. [2195720 ]
  2. Winship KA: Toxicity of tin and its compounds. Adverse Drug React Acute Poisoning Rev. 1988 Spring;7(1):19-38. [3291572 ]