Human Metabolome Database Version 3.5

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Showing metabocard for Water (HMDB02111)

enzymes (729) transporters (2)

Blood
Urine

Record Information

Version

3.5

Creation Date

2006-05-22 08:17:36 -0600

Update Date

2013-02-08 17:11:24 -0700

HMDB ID

HMDB02111

Secondary Accession Numbers

None

Metabolite Identification

Common Name

Water

Description

Water is a chemical substance that is essential to all known forms of life. It appears colorless to the naked eye in small quantities, though it is actually slightly blue in color. It covers 71% of Earth's surface. Current estimates suggest that there are 1.4 billion cubic kilometers (330 million m3) of it available on Earth, and it exists in many forms. It appears mostly in the oceans (saltwater) and polar ice caps, but it is also present as clouds, rain water, rivers, freshwater aquifers, lakes, and sea ice. Water in these bodies perpetually moves through a cycle of evaporation, precipitation, and runoff to the sea. Clean water is essential to human life. In many parts of the world, it is in short supply. From a biological standpoint, water has many distinct properties that are critical for the proliferation of life that set it apart from other substances. It carries out this role by allowing organic compounds to react in ways that ultimately allow replication. All known forms of life depend on water. Water is vital both as a solvent in which many of the body's solutes dissolve and as an essential part of many metabolic processes within the body. Metabolism is the sum total of anabolism and catabolism. In anabolism, water is removed from molecules (through energy requiring enzymatic chemical reactions) in order to grow larger molecules (e.g. starches, triglycerides and proteins for storage of fuels and information). In catabolism, water is used to break bonds in order to generate smaller molecules (e.g. glucose, fatty acids and amino acids to be used for fuels for energy use or other purposes). Water is thus essential and central to these metabolic processes. Water is also central to photosynthesis and respiration. Photosynthetic cells use the sun's energy to split off water's hydrogen from oxygen. Hydrogen is combined with CO2 (absorbed from air or water) to form glucose and release oxygen. All living cells use such fuels and oxidize the hydrogen and carbon to capture the sun's energy and reform water and CO2 in the process (cellular respiration). Water is also central to acid-base neutrality and enzyme function. An acid, a hydrogen ion (H+, that is, a proton) donor, can be neutralized by a base, a proton acceptor such as hydroxide ion (OH-) to form water. Water is considered to be neutral, with a pH (the negative log of the hydrogen ion concentration) of 7. Acids have pH values less than 7 while bases have values greater than 7. Stomach acid (HCl) is useful to digestion. However, its corrosive effect on the esophagus during reflux can temporarily be neutralized by ingestion of a base such as aluminum hydroxide to produce the neutral molecules water and the salt aluminum chloride. Human biochemistry that involves enzymes usually performs optimally around a biologically neutral pH of 7.4. (Wikipedia).

Structure

Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure

Synonyms

Dihydrogen oxide
Steam

Chemical Formula

H₂O

Average Molecular Weight

18.0153

Monoisotopic Molecular Weight

18.010564686

IUPAC Name

water

Traditional IUPAC Name

water

CAS Registry Number

7732-18-5

SMILES

InChI Identifier

InChI=1S/H2O/h1H2

InChI Key

XLYOFNOQVPJJNP-UHFFFAOYSA-N

Chemical Taxonomy

Kingdom

Inorganic Compounds

Super Class

Homogeneous Non-metal Compounds

Class

Other Non-metal Organides

Sub Class

Other Non-metal Oxides

Other Descriptors

a small molecule(Cyc)
inorganic hydroxy compound(ChEBI)
mononuclear parent hydride(ChEBI)
oxygen hydride(ChEBI)

Substituents

Direct Parent

Other Non-metal Oxides

Ontology

Status

Detected and Quantified

Origin

Food

Drug

Endogenous

Cosmetic

Plant

Biofunction

Osmolyte, enzyme cofactor, signalling

Application

Not Available

Cellular locations

Cytoplasm
Extracellular
Mitochondria
Nucleus
Lysosome
Endoplasmic reticulum
Golgi apparatus
Peroxisome

Physical Properties

State

Liquid

Experimental Properties

Property	Value	Reference
Melting Point	0 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	55.5 mol/L	Not Available
LogP	-1.38	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
Water Solubility		ALOGPS
LogP	-0.65	ChemAxon
pKa (strongest acidic)	15.7	ChemAxon
pKa (strongest basic)	-1.8	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	25.3 A²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	3.7	ChemAxon
Polarizability	1.51	ChemAxon
Formal Charge	0	ChemAxon
Physiological Charge	0	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm
Extracellular
Mitochondria
Nucleus
Lysosome
Endoplasmic reticulum
Golgi apparatus
Peroxisome

Biofluid Locations

Amniotic Fluid
Aqueous Humour
Ascites Fluid
Blood
Breast Milk
Cerebrospinal Fluid (CSF)
Lymph
Saliva
Sweat
Tears

Tissue Location

All Tissues

Pathways

Name	SMPDB Link	KEGG Link
Citric Acid Cycle	SMP00057	map00020
Gluconeogenesis	SMP00128	map00010
Phenylalanine and Tyrosine Metabolism	SMP00008	map00360
Urea Cycle	SMP00059	map00330
Glucose-Alanine Cycle	SMP00127	Not Available
Mitochondrial Electron Transport Chain	SMP00355	map00190
D-Arginine and D-Ornithine Metabolism	SMP00036	map00472
Ammonia Recycling	SMP00009	map00910
Glycolysis	SMP00040	map00010
Ethanol Degradation	SMP00449	Not Available
Homocysteine Degradation	SMP00455	Not Available
Lactose Degradation	SMP00457	Not Available
Pyruvaldehyde Degradation	SMP00459	Not Available
Carnitine Synthesis	SMP00465	Not Available
Transfer of Acetyl Groups into Mitochondria	SMP00466	Not Available
Trehalose Degradation	SMP00467	Not Available
Degradation of Superoxides	SMP00468	Not Available
Catecholamine Biosynthesis	SMP00012	map00350
Plasmalogen Synthesis	SMP00479	Not Available
Arachidonic Acid Metabolism	SMP00075	map00590
Amino Sugar Metabolism	SMP00045	map00520
Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids	SMP00480	Not Available
Glycine and Serine Metabolism	SMP00004	map00260
Spermidine and Spermine Biosynthesis	SMP00445	Not Available
Folate Metabolism	SMP00053	map00670
Pterine Biosynthesis	SMP00005	map00790
Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids	SMP00482	Not Available
Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids	SMP00481	Not Available

Normal Concentrations

Biofluid	Status	Value	Age	Sex	Condition	Comments
Amniotic Fluid	Detected and Quantified	55,000,000 uM	Adult (>18 years old)	Both	Normal	Not Available
Aqueous Humour	Detected and Quantified	55,000,000 uM	Adult (>18 years old)	Both	Normal	Not Available
Ascites Fluid	Detected and Quantified	55,000,000 uM	Adult (>18 years old)	Both	Normal	Not Available
Blood	Detected and Quantified	55,000,000 uM	Adult (>18 years old)	Both	Normal	Not Available
Breast Milk	Detected and Quantified	55,000,000 uM	Adult (>18 years old)	Both	Normal	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	55,000,000 uM	Adult (>18 years old)	Both	Normal	Not Available
Lymph	Detected and Quantified	55,000,000 uM	Adult (>18 years old)	Both	Normal	Not Available
Saliva	Detected and Quantified	55,000,000 uM	Adult (>18 years old)	Both	Normal	Not Available
Sweat	Detected and Quantified	55,000,000 uM	Adult (>18 years old)	Both	Normal	Not Available
Tears	Detected and Quantified	55,000,000 uM	Adult (>18 years old)	Both	Normal	Not Available

Abnormal Concentrations

Not Available

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

Phenol Explorer Metabolite ID

Not Available

FoodDB ID

FDB013390

KNApSAcK ID

Not Available

Chemspider ID

937

KEGG Compound ID

C00001

BioCyc ID

Not Available

BiGG ID

Wikipedia Link

NuGOwiki Link

Metagene Link

METLIN ID

PubChem Compound

PDB ID

ChEBI ID

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Download (PDF)

General References

Not Available

Enzymes

Name:	Deoxycytidylate deaminase
Reactions:	dCMP + H2O = dUMP + NH3 [RN:R01663]
Gene Name:	DCTD
Uniprot ID:	P32321
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytosolic 5'-nucleotidase 1B
Reactions:	a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate [RN:R07297]
Gene Name:	NT5C1B
Uniprot ID:	Q96P26
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytosolic 5'-nucleotidase 1A
Reactions:	a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate [RN:R07297]
Gene Name:	NT5C1A
Uniprot ID:	Q9BXI3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	5'(3')-deoxyribonucleotidase, cytosolic type
Reactions:
Gene Name:	NT5C
Uniprot ID:	Q8TCD5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	5'(3')-deoxyribonucleotidase, mitochondrial
Reactions:
Gene Name:	NT5M
Uniprot ID:	Q9NPB1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-coenzyme A thioesterase 12
Reactions:	acetyl-CoA + H2O = CoA + acetate [RN:R00227]
Gene Name:	ACOT12
Uniprot ID:	Q8WYK0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Fatty acid synthase
Reactions:	a (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = a hexadec-2-enoyl-[acyl-carrier protein] + H2O [RN:R04462]
Gene Name:	FASN
Uniprot ID:	P49327
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hydroxymethylglutaryl-CoA synthase, mitochondrial
Reactions:	acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA [RN:R01978]
Gene Name:	HMGCS2
Uniprot ID:	P54868
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Citrate synthase, mitochondrial
Reactions:	acetyl-CoA + H2O + oxaloacetate = citrate + CoA [RN:R00351]
Gene Name:	CS
Uniprot ID:	O75390
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Reactions:	acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA [RN:R01978]
Gene Name:	HMGCS1
Uniprot ID:	Q01581
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-protein thioesterase 1
Reactions:
Gene Name:	LYPLA1
Uniprot ID:	O75608
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Group XV phospholipase A2
Reactions:
Gene Name:	PLA2G15
Uniprot ID:	Q8NCC3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Calcium-dependent phospholipase A2
Reactions:	phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate [RN:R01313]
Gene Name:	PLA2G5
Uniprot ID:	P39877
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Group IIF secretory phospholipase A2
Reactions:	phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate [RN:R01313]
Gene Name:	PLA2G2F
Uniprot ID:	Q9BZM2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytosolic phospholipase A2
Reactions:	2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate [RN:R07291]
Gene Name:	PLA2G4A
Uniprot ID:	P47712
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phospholipase A2
Reactions:	phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate [RN:R01313]
Gene Name:	PLA2G1B
Uniprot ID:	P04054
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Group XIIB secretory phospholipase A2-like protein
Reactions:
Gene Name:	PLA2G12B
Uniprot ID:	Q9BX93
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Group 10 secretory phospholipase A2
Reactions:	phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate [RN:R01313]
Gene Name:	PLA2G10
Uniprot ID:	O15496
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Group IIE secretory phospholipase A2
Reactions:	phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate [RN:R01313]
Gene Name:	PLA2G2E
Uniprot ID:	Q9NZK7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-protein thioesterase 2
Reactions:
Gene Name:	LYPLA2
Uniprot ID:	O95372
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	85 kDa calcium-independent phospholipase A2
Reactions:	phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate [RN:R01313]
Gene Name:	PLA2G6
Uniprot ID:	O60733
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Eosinophil lysophospholipase
Reactions:	2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate [RN:R07291]
Gene Name:	CLC
Uniprot ID:	Q05315
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Group IID secretory phospholipase A2
Reactions:	phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate [RN:R01313]
Gene Name:	PLA2G2D
Uniprot ID:	Q9UNK4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phospholipase D2
Reactions:	a phosphatidylcholine + H2O = choline + a phosphatidate [RN:R01310]
Gene Name:	PLD2
Uniprot ID:	O14939
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleoside triphosphate diphosphohydrolase 1
Reactions:	ATP + 2 H2O = AMP + 2 phosphate [RN:R00085]
Gene Name:	ENTPD1
Uniprot ID:	P49961
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Soluble calcium-activated nucleotidase 1
Reactions:	a nucleoside diphosphate + H2O = a nucleotide + phosphate [RN:R00329]
Gene Name:	CANT1
Uniprot ID:	Q8WVQ1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleoside triphosphate diphosphohydrolase 3
Reactions:	ATP + 2 H2O = AMP + 2 phosphate [RN:R00085]
Gene Name:	ENTPD3
Uniprot ID:	O75355
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosinase
Reactions:	L-tyrosine + L-dopa + O2 = L-dopa + dopaquinone + H2O [RN:R02078]
Gene Name:	TYR
Uniprot ID:	P14679
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serum paraoxonase/lactonase 3
Reactions:	an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol [RN:R03979]
Gene Name:	PON3
Uniprot ID:	Q15166
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alkaline phosphatase, placental type
Reactions:	a phosphate monoester + H2O = an alcohol + phosphate [RN:R00626]
Gene Name:	ALPP
Uniprot ID:	P05187
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serum paraoxonase/arylesterase 2
Reactions:	an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine [RN:R08970]
Gene Name:	PON2
Uniprot ID:	Q15165
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Intestinal-type alkaline phosphatase
Reactions:	a phosphate monoester + H2O = an alcohol + phosphate [RN:R00626]
Gene Name:	ALPI
Uniprot ID:	P09923
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alkaline phosphatase, tissue-nonspecific isozyme
Reactions:	a phosphate monoester + H2O = an alcohol + phosphate [RN:R00626]
Gene Name:	ALPL
Uniprot ID:	P05186
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tartrate-resistant acid phosphatase type 5
Reactions:	a phosphate monoester + H2O = an alcohol + phosphate [RN:R00626]
Gene Name:	ACP5
Uniprot ID:	P13686
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Prostatic acid phosphatase
Reactions:	a phosphate monoester + H2O = an alcohol + phosphate [RN:R00626]
Gene Name:	ACPP
Uniprot ID:	P15309
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alkaline phosphatase, placental-like
Reactions:	a phosphate monoester + H2O = an alcohol + phosphate [RN:R00626]
Gene Name:	ALPPL2
Uniprot ID:	P10696
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ribonucleoside-diphosphate reductase large subunit
Reactions:	2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin [RN:R04294]
Gene Name:	RRM1
Uniprot ID:	P23921
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ribonucleoside-diphosphate reductase subunit M2
Reactions:	2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin [RN:R04294]
Gene Name:	RRM2
Uniprot ID:	P31350
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Reactions:	a dinucleotide + H2O = 2 mononucleotides [RN:R00056]
Gene Name:	ENPP1
Uniprot ID:	P22413
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal sarcosine oxidase
Reactions:	L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 [RN:R02204]
Gene Name:	PIPOX
Uniprot ID:	Q9P0Z9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
Reactions:	(1) N1-acetylspermidine + O2 + H2O = putrescine + 3-acetamidopropanal + H2O2 [RN:R09074] (2) N1-acetylspermine + O2 + H2O = spermidine + 3-acetamidopropanal + H2O2 [RN:R03899]
Gene Name:	PAOX
Uniprot ID:	Q6QHF9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde oxidase
Reactions:	an aldehyde + H2O + O2 = a carboxylic acid + H2O2 [RN:R00635]
Gene Name:	AOX1
Uniprot ID:	Q06278
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lathosterol oxidase
Reactions:	5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O [RN:R03310 R07215]
Gene Name:	SC5DL
Uniprot ID:	O75845
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylaniline monooxygenase [N-oxide-forming] 5
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO5
Uniprot ID:	P49326
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	D-aspartate oxidase
Reactions:	D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2 [RN:R00359]
Gene Name:	DDO
Uniprot ID:	Q99489
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Heme oxygenase 2
Reactions:	heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O [RN:R00311]
Gene Name:	HMOX2
Uniprot ID:	P30519
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylaniline monooxygenase [N-oxide-forming] 2
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO2
Uniprot ID:	Q99518
Protein Sequence:	FASTA

Name:	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Reactions:	(S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H + H+ [RN:R00707 R00708]
Gene Name:	ALDH4A1
Uniprot ID:	P30038
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Amine oxidase [flavin-containing] B
Reactions:	RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 [RN:R01853]
Gene Name:	MAOB
Uniprot ID:	P27338
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal acyl-coenzyme A oxidase 2
Reactions:	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26- oyl-CoA + reduced acceptor [RN:R07374]
Gene Name:	ACOX2
Uniprot ID:	Q99424
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylaniline monooxygenase [N-oxide-forming] 4
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO4
Uniprot ID:	P31512
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Reactions:	1-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine [RN:R04362]
Gene Name:	ENPP2
Uniprot ID:	Q13822
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Amine oxidase [flavin-containing] A
Reactions:	RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 [RN:R01853]
Gene Name:	MAOA
Uniprot ID:	P21397
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylaniline monooxygenase [N-oxide-forming] 3
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO3
Uniprot ID:	P31513
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Xanthine dehydrogenase/oxidase
Reactions:	xanthine + H2O + O2 = urate + H2O2 [RN:R02107]
Gene Name:	XDH
Uniprot ID:	P47989
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Reactions:	a dinucleotide + H2O = 2 mononucleotides [RN:R00056]
Gene Name:	ENPP3
Uniprot ID:	O14638
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Heme oxygenase 1
Reactions:	heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O [RN:R00311]
Gene Name:	HMOX1
Uniprot ID:	P09601
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retinal dehydrogenase 1
Reactions:	retinal + NAD+ + H2O = retinoate + NADH + 2 H+ [RN:R02123]
Gene Name:	ALDH1A1
Uniprot ID:	P00352
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylglycine dehydrogenase, mitochondrial
Reactions:	N,N-dimethylglycine + acceptor + H2O = sarcosine + formaldehyde + reduced acceptor [RN:R01565]
Gene Name:	DMGDH
Uniprot ID:	Q9UI17
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retinal dehydrogenase 2
Reactions:	retinal + NAD+ + H2O = retinoate + NADH + 2 H+ [RN:R02123]
Gene Name:	ALDH1A2
Uniprot ID:	O94788
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	D-amino-acid oxidase
Reactions:	a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2 [RN:R01340]
Gene Name:	DAO
Uniprot ID:	P14920
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glucosamine-6-phosphate isomerase 1
Reactions:	D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3 [RN:R00765]
Gene Name:	GNPDA1
Uniprot ID:	P46926
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pancreatic triacylglycerol lipase
Reactions:	triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369]
Gene Name:	PNLIP
Uniprot ID:	P16233
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
Reactions:	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Gene Name:	PLCB1
Uniprot ID:	Q9NQ66
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4
Reactions:	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Gene Name:	PLCB4
Uniprot ID:	Q15147
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2
Reactions:	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Gene Name:	PLCB2
Uniprot ID:	Q00722
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hepatic triacylglycerol lipase
Reactions:	triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369]
Gene Name:	LIPC
Uniprot ID:	P11150
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lysosomal acid lipase/cholesteryl ester hydrolase
Reactions:	a steryl ester + H2O = a sterol + a fatty acid [RN:R02115]
Gene Name:	LIPA
Uniprot ID:	P38571
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3
Reactions:	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Gene Name:	PLCB3
Uniprot ID:	Q01970
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pancreatic lipase-related protein 1
Reactions:	triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369]
Gene Name:	PNLIPRP1
Uniprot ID:	P54315
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
Reactions:	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Gene Name:	PLCG2
Uniprot ID:	P16885
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lipid phosphate phosphohydrolase 2
Reactions:	a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate [RN:R02239]
Gene Name:	PPAP2C
Uniprot ID:	O43688
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Patatin-like phospholipase domain-containing protein 3
Reactions:	triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369]
Gene Name:	PNPLA3
Uniprot ID:	Q9NST1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Gastric triacylglycerol lipase
Reactions:	triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369]
Gene Name:	LIPF
Uniprot ID:	P07098
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lipid phosphate phosphohydrolase 1
Reactions:	a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate [RN:R02239]
Gene Name:	PPAP2A
Uniprot ID:	O14494
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Endothelial lipase
Reactions:	triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369]
Gene Name:	LIPG
Uniprot ID:	Q9Y5X9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bile salt-activated lipase
Reactions:	a steryl ester + H2O = a sterol + a fatty acid [RN:R02115]
Gene Name:	CEL
Uniprot ID:	P19835
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lipid phosphate phosphohydrolase 3
Reactions:	a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate [RN:R02239]
Gene Name:	PPAP2B
Uniprot ID:	O14495
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pancreatic lipase-related protein 2
Reactions:	triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369]
Gene Name:	PNLIPRP2
Uniprot ID:	P54317
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Succinate-semialdehyde dehydrogenase, mitochondrial
Reactions:	succinate semialdehyde + NAD+ + H2O = succinate + NADH + 2 H+ [RN:R00713]
Gene Name:	ALDH5A1
Uniprot ID:	P51649
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Coproporphyrinogen-III oxidase, mitochondrial
Reactions:	coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O [RN:R03220]
Gene Name:	CPOX
Uniprot ID:	P36551
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peptidyl-glycine alpha-amidating monooxygenase
Reactions:	peptidylamidoglycolate = peptidyl amide + glyoxylate [RN:R03874]
Gene Name:	PAM
Uniprot ID:	P19021
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dopamine beta-hydroxylase
Reactions:	3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O [RN:R02535]
Gene Name:	DBH
Uniprot ID:	P09172
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	C-4 methylsterol oxidase
Reactions:	(1) (1a) 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NAD(P)+ + H2O [RN:R04501 R05736] (2) (1b) 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + NAD(P)+ + 2 H2O [RN:R05733 R05737] (3) (1c) 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + NAD(P)H + H+ + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(P)+ + H2O [RN:R05734 R05738]
Gene Name:	SC4MOL
Uniprot ID:	Q15800
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
Reactions:	3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(P)+ = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NAD(P)H [RN:R04483 R07149]
Gene Name:	NSDHL
Uniprot ID:	Q15738
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lanosterol 14-alpha demethylase
Reactions:	obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 3 NADP+ + 4 H2O [RN:R05731]
Gene Name:	CYP51A1
Uniprot ID:	Q16850
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine 3-monooxygenase
Reactions:	L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin [RN:R07212]
Gene Name:	TH
Uniprot ID:	P07101
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Thyroid peroxidase
Reactions:	2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O [RN:R02810]
Gene Name:	TPO
Uniprot ID:	P07202
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lactoperoxidase
Reactions:	donor + H2O2 = oxidized donor + 2 H2O [RN:R03532]
Gene Name:	LPO
Uniprot ID:	P22079
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phenylalanine-4-hydroxylase
Reactions:	L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4a-hydroxytetrahydrobiopterin [RN:R07211]
Gene Name:	PAH
Uniprot ID:	P00439
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Myeloperoxidase
Reactions:	donor + H2O2 = oxidized donor + 2 H2O [RN:R03532]
Gene Name:	MPO
Uniprot ID:	P05164
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Eosinophil peroxidase
Reactions:	donor + H2O2 = oxidized donor + 2 H2O [RN:R03532]
Gene Name:	EPX
Uniprot ID:	P11678
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sucrase-isomaltase, intestinal
Reactions:	Hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action [RN:R00801 R06087] ALL_REAC R00801 R06087(G) > R00802 R06088(G)
Gene Name:	SI
Uniprot ID:	P14410
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	4-trimethylaminobutyraldehyde dehydrogenase
Reactions:	4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH + 2 H+ [RN:R03283]
Gene Name:	ALDH9A1
Uniprot ID:	P49189
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alpha-aminoadipic semialdehyde dehydrogenase
Reactions:	L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+ [RN:R03102 R03103]
Gene Name:	ALDH7A1
Uniprot ID:	P49419
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde dehydrogenase family 1 member A3
Reactions:	an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+ [RN:R00538 R00634]
Gene Name:	ALDH1A3
Uniprot ID:	P47895
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde dehydrogenase, mitochondrial
Reactions:	an aldehyde + NAD+ + H2O = an acid + NADH + H+ [RN:R00538]
Gene Name:	ALDH2
Uniprot ID:	P05091
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Fatty aldehyde dehydrogenase
Reactions:	an aldehyde + NAD+ + H2O = an acid + NADH + H+ [RN:R00538]
Gene Name:	ALDH3A2
Uniprot ID:	P51648
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde dehydrogenase X, mitochondrial
Reactions:	an aldehyde + NAD+ + H2O = an acid + NADH + H+ [RN:R00538]
Gene Name:	ALDH1B1
Uniprot ID:	P30837
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Arginase-1
Reactions:	L-arginine + H2O = L-ornithine + urea [RN:R00551]
Gene Name:	ARG1
Uniprot ID:	P05089
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lipoprotein lipase
Reactions:	triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369]
Gene Name:	LPL
Uniprot ID:	P06858
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-CoA desaturase
Reactions:	stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R02222]
Gene Name:	SCD
Uniprot ID:	O00767
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Monoglyceride lipase
Reactions:	Hydrolyses glycerol monoesters of long-chain fatty acids ALL_REAC (other) R01351 R01352 REFERENCE 1 [PMID:6776896] AUTHORS Mentlein R, Heiland S, Heymann E. TITLE Simultaneous purification and comparative characterization of six serine hydrolases from rat liver microsomes. JOURNAL Arch. Biochem. Biophys. 200 (1980) 547-59. ORGANISM Rattus norvegicus [GN:rno] REFERENCE 2 [PMID:5916497] AUTHORS Pope JL, McPherson JC, Tidwell HC. TITLE A study of a monoglyceride-hydrolyzing enzyme of intestinal mucosa. JOURNAL J. Biol. Chem. 241 (1966) 2306-10. ORGANISM Rattus norvegicus [GN:rno]
Gene Name:	MGLL
Uniprot ID:	Q99685
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Galactocerebrosidase
Reactions:	D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine [RN:R03617]
Gene Name:	GALC
Uniprot ID:	P54803
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Arylsulfatase D
Reactions:
Gene Name:	ARSD
Uniprot ID:	P51689
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sialidase-2
Reactions:	Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates ALL_REAC (other) R03491 R04018 R04634 R04650 R05115 R05117 R05996(G) R05998(G) R05999(G) R06012(G) R06147(G) R06253(G) INHIBITOR 2-Deoxy-2,3-dehydro-N-acetylneuraminic acid [CPD:C04580]
Gene Name:	NEU2
Uniprot ID:	Q9Y3R4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Arylsulfatase A
Reactions:	a cerebroside 3-sulfate + H2O = a cerebroside + sulfate [RN:R04856 R06280]
Gene Name:	ARSA
Uniprot ID:	P15289
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Arylsulfatase B
Reactions:	Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate [RN:R07823] ALL_REAC R07823(G)
Gene Name:	ARSB
Uniprot ID:	P15848
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sialidase-4
Reactions:	Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates ALL_REAC (other) R03491 R04018 R04634 R04650 R05115 R05117 R05996(G) R05998(G) R05999(G) R06012(G) R06147(G) R06253(G) INHIBITOR 2-Deoxy-2,3-dehydro-N-acetylneuraminic acid [CPD:C04580]
Gene Name:	NEU4
Uniprot ID:	Q8WWR8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Arylsulfatase E
Reactions:
Gene Name:	ARSE
Uniprot ID:	P51690
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Kynureninase
Reactions:	L-kynurenine + H2O = anthranilate + L-alanine [RN:R00987]
Gene Name:	KYNU
Uniprot ID:	Q16719
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Annexin A3
Reactions:
Gene Name:	ANXA3
Uniprot ID:	P12429
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	6-phosphogluconolactonase
Reactions:	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate [RN:R02035]
Gene Name:	PGLS
Uniprot ID:	O95336
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	GDH/6PGL endoplasmic bifunctional protein
Reactions:	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate [RN:R02035]
Gene Name:	H6PD
Uniprot ID:	O95479
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Trifunctional purine biosynthetic protein adenosine-3
Reactions:	ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide [RN:R04144]
Gene Name:	GART
Uniprot ID:	P22102
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Reactions:	UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine [RN:R00420]
Gene Name:	GNE
Uniprot ID:	Q9Y223
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sialic acid synthase
Reactions:	phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate [RN:R02769]
Gene Name:	NANS
Uniprot ID:	Q9NR45
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	3'(2'),5'-bisphosphate nucleotidase 1
Reactions:	adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate [RN:R00188]
Gene Name:	BPNT1
Uniprot ID:	O95861
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Uroporphyrinogen-III synthase
Reactions:	hydroxymethylbilane = uroporphyrinogen III + H2O [RN:R03165]
Gene Name:	UROS
Uniprot ID:	P10746
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Porphobilinogen deaminase
Reactions:	4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3 [RN:R00084]
Gene Name:	HMBS
Uniprot ID:	P08397
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbamoyl-phosphate synthase [ammonia], mitochondrial
Reactions:	2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate [RN:R00149]
Gene Name:	CPS1
Uniprot ID:	P31327
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Type I inositol-1,4,5-trisphosphate 5-phosphatase
Reactions:	(1) D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate [RN:R03394] (2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate [RN:R03430]
Gene Name:	INPP5A
Uniprot ID:	Q14642
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Inositol polyphosphate 1-phosphatase
Reactions:	1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate [RN:R03393]
Gene Name:	INPP1
Uniprot ID:	P49441
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
Reactions:	(1) D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate [RN:R03394] (2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate [RN:R03430]
Gene Name:	INPP5J
Uniprot ID:	Q15735
Protein Sequence:	FASTA

Name:	Inositol polyphosphate 5-phosphatase K
Reactions:	(1) D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate [RN:R03394] (2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate [RN:R03430]
Gene Name:	INPP5K
Uniprot ID:	Q9BT40
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lactase-phlorizin hydrolase
Reactions:	lactose + H2O = D-galactose + D-glucose [RN:R01100 R06114]
Gene Name:	LCT
Uniprot ID:	P09848
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Neutral alpha-glucosidase AB
Reactions:	Hydrolysis of terminal (1->3)-alpha-D-glucosidic links in (1->3)-alpha-D-glucans ALL_REAC (other) R05980(G) R05981(G)
Gene Name:	GANAB
Uniprot ID:	Q14697
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glycogen debranching enzyme
Reactions:	Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin ALL_REAC (other) R02109 R06158(G)
Gene Name:	AGL
Uniprot ID:	P35573
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Trehalase
Reactions:	alpha,alpha-trehalose + H2O = 2 D-glucose [RN:R00010 R06103]
Gene Name:	TREH
Uniprot ID:	O43280
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glucose-6-phosphatase
Reactions:	D-glucose 6-phosphate + H2O = D-glucose + phosphate [RN:R00303]
Gene Name:	G6PC
Uniprot ID:	P35575
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal bifunctional enzyme
Reactions:	(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA [RN:R04100]
Gene Name:	EHHADH
Uniprot ID:	Q08426
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	GDP-mannose 4,6 dehydratase
Reactions:	GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O [RN:R00888]
Gene Name:	GMDS
Uniprot ID:	O60547
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Enoyl-CoA hydratase, mitochondrial
Reactions:	(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O [RN:R02685 R07314]
Gene Name:	ECHS1
Uniprot ID:	P30084
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Trifunctional enzyme subunit alpha, mitochondrial
Reactions:	(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O [RN:R02685 R07314]
Gene Name:	HADHA
Uniprot ID:	P40939
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Amiloride-sensitive amine oxidase [copper-containing]
Reactions:	histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2 [RN:R02150]
Gene Name:	ABP1
Uniprot ID:	P19801
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Membrane primary amine oxidase
Reactions:	RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2 [RN:R01853]
Gene Name:	AOC3
Uniprot ID:	Q16853
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retina-specific copper amine oxidase
Reactions:	RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2 [RN:R01853]
Gene Name:	AOC2
Uniprot ID:	O75106
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4A11
Reactions:	octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O [RN:R02879]
Gene Name:	CYP4A11
Uniprot ID:	Q02928
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	S-adenosylmethionine synthase isoform type-1
Reactions:	ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine [RN:R00177]
Gene Name:	MAT1A
Uniprot ID:	Q00266
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Inosine triphosphate pyrophosphatase
Reactions:	a nucleoside triphosphate + H2O = a nucleotide + diphosphate [RN:R01532]
Gene Name:	ITPA
Uniprot ID:	Q9BY32
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Reactions:	dUTP + H2O = dUMP + diphosphate [RN:R02100]
Gene Name:	DUT
Uniprot ID:	P33316
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alpha-N-acetylgalactosaminidase
Reactions:	Hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides ALL_REAC (other) R04183 R05966(G)
Gene Name:	NAGA
Uniprot ID:	P17050
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 11B1, mitochondrial
Reactions:	a steroid + reduced adrenal ferredoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O [RN:R02726]
Gene Name:	CYP11B1
Uniprot ID:	P15538
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aminopeptidase N
Reactions:	Release of an N-terminal amino acid, Xaa!Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide ALL_REAC (other) R00899 R04951 COFACTOR Manganese [CPD:C00034] Zinc [CPD:C00038]
Gene Name:	ANPEP
Uniprot ID:	P15144
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Reactions:	L-lysine-[procollagen] + 2-oxoglutarate + O2 = (2S,5R)- 5-hydroxy-L-lysine-[procollagen] + succinate + CO2
Gene Name:	PLOD1
Uniprot ID:	Q02809
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Reactions:	L-lysine-[procollagen] + 2-oxoglutarate + O2 = (2S,5R)- 5-hydroxy-L-lysine-[procollagen] + succinate + CO2
Gene Name:	PLOD2
Uniprot ID:	O00469
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
Reactions:	L-lysine-[procollagen] + 2-oxoglutarate + O2 = (2S,5R)- 5-hydroxy-L-lysine-[procollagen] + succinate + CO2
Gene Name:	PLOD3
Uniprot ID:	O60568
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tryptophan 5-hydroxylase 1
Reactions:	L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin [RN:R07213]
Gene Name:	TPH1
Uniprot ID:	P17752
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ferritin, mitochondrial
Reactions:	4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O [RN:R00078]
Gene Name:	FTMT
Uniprot ID:	Q8N4E7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tryptophan 5-hydroxylase 2
Reactions:	L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin [RN:R07213]
Gene Name:	TPH2
Uniprot ID:	Q8IWU9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-Ala-His dipeptidase
Reactions:	Preferential hydrolysis of the beta-Ala!His dipeptide (carnosine), and also anserine, Xaa!His dipeptides and other dipeptides including homocarnosine [RN:R01166 R03288] ALL_REAC R01166 R03288 COFACTOR Citrate [CPD:C00158] Cadmium [CPD:C01413]
Gene Name:	CNDP1
Uniprot ID:	Q96KN2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal multifunctional enzyme type 2
Reactions:	(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O [RN:R04813]
Gene Name:	HSD17B4
Uniprot ID:	P51659
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Steryl-sulfatase
Reactions:	3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate [RN:R03404]
Gene Name:	STS
Uniprot ID:	P08842
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Liver carboxylesterase 1
Reactions:	a carboxylic ester + H2O = an alcohol + a carboxylate [RN:R00630]
Gene Name:	CES1
Uniprot ID:	P23141
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carboxylesterase 2
Reactions:	a carboxylic ester + H2O = an alcohol + a carboxylate [RN:R00630]
Gene Name:	CES2
Uniprot ID:	O00748
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cholesterol 7-alpha-monooxygenase
Reactions:	cholesterol + NADPH + H+ + O2 = 7alpha-hydroxycholesterol + NADP+ + H2O [RN:R01463]
Gene Name:	CYP7A1
Uniprot ID:	P22680
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acetylcholinesterase
Reactions:	acetylcholine + H2O = choline + acetate [RN:R01026]
Gene Name:	ACHE
Uniprot ID:	P22303
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cholinesterase
Reactions:	an acylcholine + H2O = choline + a carboxylate [RN:R01029]
Gene Name:	BCHE
Uniprot ID:	P06276
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peptidyl-tRNA hydrolase 2, mitochondrial
Reactions:	N-Substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA [RN:R04238]
Gene Name:	PTRH2
Uniprot ID:	Q9Y3E5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Platelet-activating factor acetylhydrolase IB subunit gamma
Reactions:	1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate [RN:R04452]
Gene Name:	PAFAH1B3
Uniprot ID:	Q15102
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Platelet-activating factor acetylhydrolase IB subunit beta
Reactions:	1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate [RN:R04452]
Gene Name:	PAFAH1B2
Uniprot ID:	P68402
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hormone-sensitive lipase
Reactions:	(1) diacylglycerol + H2O = monoacylglycerol + a carboxylate [RN:R05209] (2) triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369] (3) monoacylglycerol + H2O = glycerol + a carboxylate [RN:R07293]
Gene Name:	LIPE
Uniprot ID:	Q05469
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Group 3 secretory phospholipase A2
Reactions:	phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate [RN:R01313]
Gene Name:	PLA2G3
Uniprot ID:	Q9NZ20
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Platelet-activating factor acetylhydrolase 2, cytoplasmic
Reactions:	1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate [RN:R04452]
Gene Name:	PAFAH2
Uniprot ID:	Q99487
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sialate O-acetylesterase
Reactions:	N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate [RN:R01810]
Gene Name:	SIAE
Uniprot ID:	Q9HAT2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyloxyacyl hydrolase
Reactions:	3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid [RN:R05792]
Gene Name:	AOAH
Uniprot ID:	P28039
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cystathionine gamma-lyase
Reactions:	(1) L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate (overall reaction) [RN:R01001] (2) (1a) L-cystathionine = L-cysteine + 2-ammoniobut-2-enoate [RN:R08632] (3) (1b) 2-ammoniobut-2-enoate + H2O = 2-oxobutanoate + NH3 (spontaneous) [RN:R08637]
Gene Name:	CTH
Uniprot ID:	P32929
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde dehydrogenase family 3 member B2
Reactions:	an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+ [RN:R00538 R00634]
Gene Name:	ALDH3B2
Uniprot ID:	P48448
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde dehydrogenase family 3 member B1
Reactions:	an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+ [RN:R00538 R00634]
Gene Name:	ALDH3B1
Uniprot ID:	P43353
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dihydropyrimidinase
Reactions:	5,6-dihydrouracil + H2O = 3-ureidopropanoate [RN:R02269]
Gene Name:	DPYS
Uniprot ID:	Q14117
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-ureidopropionase
Reactions:	N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3 [RN:R00905]
Gene Name:	UPB1
Uniprot ID:	Q9UBR1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Biotinidase
Reactions:	biotin amide + H2O = biotin + NH3 [RN:R01076]
Gene Name:	BTD
Uniprot ID:	P43251
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bile acid-CoA:amino acid N-acyltransferase
Reactions:	palmitoyl-CoA + H2O = CoA + palmitate [RN:R01274]
Gene Name:	BAAT
Uniprot ID:	Q14032
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acylphosphatase-2
Reactions:	an acylphosphate + H2O = a carboxylate + phosphate [RN:R00539]
Gene Name:	ACYP2
Uniprot ID:	P14621
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acylphosphatase-1
Reactions:	an acylphosphate + H2O = a carboxylate + phosphate [RN:R00539]
Gene Name:	ACYP1
Uniprot ID:	P07311
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aminoacylase-1
Reactions:	an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid [RN:R01263]
Gene Name:	ACY1
Uniprot ID:	Q03154
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aspartoacylase
Reactions:	N-acyl-L-aspartate + H2O = a carboxylate + L-aspartate [RN:R00546]
Gene Name:	ASPA
Uniprot ID:	P45381
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Platelet-activating factor acetylhydrolase IB subunit alpha
Reactions:
Gene Name:	PAFAH1B1
Uniprot ID:	P43034
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aspartoacylase-2
Reactions:	--- []
Gene Name:	ACY3
Uniprot ID:	Q96HD9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE6H
Uniprot ID:	Q13956
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE1A
Uniprot ID:	P54750
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE8A
Uniprot ID:	O60658
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE1B
Uniprot ID:	Q01064
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE3B
Uniprot ID:	Q13370
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Reactions:	guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate [RN:R01234]
Gene Name:	PDE6C
Uniprot ID:	P51160
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Asparagine synthetase [glutamine-hydrolyzing]
Reactions:	(1) ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate [RN:R00578] (2) (1a) L-glutamine + H2O = L-glutamate + NH3 [RN:R00256] (3) (1b) ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine [RN:R00483]
Gene Name:	ASNS
Uniprot ID:	P08243
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	AMP deaminase 3
Reactions:	AMP + H2O = IMP + NH3 [RN:R00181]
Gene Name:	AMPD3
Uniprot ID:	Q01432
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	AMP deaminase 2
Reactions:	AMP + H2O = IMP + NH3 [RN:R00181]
Gene Name:	AMPD2
Uniprot ID:	Q01433
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cGMP-inhibited 3',5'-cyclic phosphodiesterase A
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE3A
Uniprot ID:	Q14432
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Reactions:	guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate [RN:R01234]
Gene Name:	PDE10A
Uniprot ID:	Q9Y233
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE1C
Uniprot ID:	Q14123
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE4B
Uniprot ID:	Q07343
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE7B
Uniprot ID:	Q9NP56
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bis(5'-adenosyl)-triphosphatase
Reactions:	P1,P3-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP [RN:R00187]
Gene Name:	FHIT
Uniprot ID:	P49789
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Reactions:	guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate [RN:R01234]
Gene Name:	PDE9A
Uniprot ID:	O76083
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cGMP-dependent 3',5'-cyclic phosphodiesterase
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE2A
Uniprot ID:	O00408
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
Reactions:	P1,P4-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP [RN:R01232]
Gene Name:	NUDT2
Uniprot ID:	P50583
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Reactions:	guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate [RN:R01234]
Gene Name:	PDE6A
Uniprot ID:	P16499
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ADP-sugar pyrophosphatase
Reactions:	ADP-ribose + H2O = AMP + D-ribose 5-phosphate [RN:R01054]
Gene Name:	NUDT5
Uniprot ID:	Q9UKK9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE8B
Uniprot ID:	O95263
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE4C
Uniprot ID:	Q08493
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Reactions:	guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate [RN:R01234]
Gene Name:	PDE6B
Uniprot ID:	P35913
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE4D
Uniprot ID:	Q08499
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE6G
Uniprot ID:	P18545
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Reactions:
Gene Name:	PDE6D
Uniprot ID:	O43924
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE4A
Uniprot ID:	P27815
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Selenide, water dikinase 1
Reactions:	ATP + selenide + H2O = AMP + selenophosphate + phosphate [RN:R03595]
Gene Name:	SEPHS1
Uniprot ID:	P49903
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cGMP-specific 3',5'-cyclic phosphodiesterase
Reactions:	guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate [RN:R01234]
Gene Name:	PDE5A
Uniprot ID:	O76074
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	AMP deaminase 1
Reactions:	AMP + H2O = IMP + NH3 [RN:R00181]
Gene Name:	AMPD1
Uniprot ID:	P23109
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Selenide, water dikinase 2
Reactions:	ATP + selenide + H2O = AMP + selenophosphate + phosphate [RN:R03595]
Gene Name:	SEPHS2
Uniprot ID:	Q99611
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative adenosylhomocysteinase 3
Reactions:	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine [RN:R00192]
Gene Name:	AHCYL2
Uniprot ID:	Q96HN2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenosylhomocysteinase
Reactions:	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine [RN:R00192]
Gene Name:	AHCY
Uniprot ID:	P23526
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative adenosylhomocysteinase 2
Reactions:	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine [RN:R00192]
Gene Name:	AHCYL1
Uniprot ID:	O43865
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenosine deaminase
Reactions:	adenosine + H2O = inosine + NH3 [RN:R01560]
Gene Name:	ADA
Uniprot ID:	P00813
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutamate dehydrogenase 2, mitochondrial
Reactions:	L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+ [RN:R00243 R00248]
Gene Name:	GLUD2
Uniprot ID:	P49448
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein-arginine deiminase type-6
Reactions:	protein L-arginine + H2O = protein L-citrulline + NH3 [RN:R02621]
Gene Name:	PADI6
Uniprot ID:	Q6TGC4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	L-serine dehydratase/L-threonine deaminase
Reactions:	L-threonine = 2-oxobutanoate + NH3 [RN:R00996]
Gene Name:	SDS
Uniprot ID:	P20132
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein-arginine deiminase type-4
Reactions:	protein L-arginine + H2O = protein L-citrulline + NH3 [RN:R02621]
Gene Name:	PADI4
Uniprot ID:	Q9UM07
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pyridoxine-5'-phosphate oxidase
Reactions:	(1) pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2 [RN:R00277] (2) pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2 [RN:R00278]
Gene Name:	PNPO
Uniprot ID:	Q9NVS9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutaminase liver isoform, mitochondrial
Reactions:	L-glutamine + H2O = L-glutamate + NH3 [RN:R00256]
Gene Name:	GLS2
Uniprot ID:	Q9UI32
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	CTP synthase 1
Reactions:	ATP + UTP + NH3 = ADP + phosphate + CTP [RN:R00571]
Gene Name:	CTPS
Uniprot ID:	P17812
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein-arginine deiminase type-3
Reactions:	protein L-arginine + H2O = protein L-citrulline + NH3 [RN:R02621]
Gene Name:	PADI3
Uniprot ID:	Q9ULW8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutaminase kidney isoform, mitochondrial
Reactions:	L-glutamine + H2O = L-glutamate + NH3 [RN:R00256]
Gene Name:	GLS
Uniprot ID:	O94925
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein-arginine deiminase type-2
Reactions:	protein L-arginine + H2O = protein L-citrulline + NH3 [RN:R02621]
Gene Name:	PADI2
Uniprot ID:	Q9Y2J8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein-arginine deiminase type-1
Reactions:	protein L-arginine + H2O = protein L-citrulline + NH3 [RN:R02621]
Gene Name:	PADI1
Uniprot ID:	Q9ULC6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aminomethyltransferase, mitochondrial
Reactions:	[protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3 [RN:R04125]
Gene Name:	AMT
Uniprot ID:	P48728
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Guanine deaminase
Reactions:	guanine + H2O = xanthine + NH3 [RN:R01676]
Gene Name:	GDA
Uniprot ID:	Q9Y2T3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutamate dehydrogenase 1, mitochondrial
Reactions:	L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+ [RN:R00243 R00248]
Gene Name:	GLUD1
Uniprot ID:	P00367
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein-lysine 6-oxidase
Reactions:	peptidyl-L-lysyl-peptide + O2 + H2O = peptidyl-allysyl-peptide + NH3 + H2O2 [RN:R04239]
Gene Name:	LOX
Uniprot ID:	P28300
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Fumarylacetoacetase
Reactions:	4-fumarylacetoacetate + H2O = acetoacetate + fumarate [RN:R01364]
Gene Name:	FAH
Uniprot ID:	P16930
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alpha-galactosidase A
Reactions:	Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids ALL_REAC (other) R01101 R01103 R01104 R01194 R01329 R02926 R03618 R03634 R04019 R04470 R05549 R05961(G) R06070(G) R06091(G) R06093(G) R06094(G) R06096(G) R06142(G) R06152(G)
Gene Name:	GLA
Uniprot ID:	P06280
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cholesterol side-chain cleavage enzyme, mitochondrial
Reactions:	cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O [RN:R02724]
Gene Name:	CYP11A1
Uniprot ID:	P05108
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aconitate hydratase, mitochondrial
Reactions:	(1) citrate = isocitrate [RN:R01324] (2) (1a) citrate = cis-aconitate + H2O [RN:R01325] (3) (1b) cis-aconitate + H2O = isocitrate [RN:R01900]
Gene Name:	ACO2
Uniprot ID:	Q99798
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytoplasmic aconitate hydratase
Reactions:	(1) citrate = isocitrate [RN:R01324] (2) (1a) citrate = cis-aconitate + H2O [RN:R01325] (3) (1b) cis-aconitate + H2O = isocitrate [RN:R01900]
Gene Name:	ACO1
Uniprot ID:	P21399
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Gamma-glutamyltranspeptidase 1
Reactions:	(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid [RN:R04159]
Gene Name:	GGT1
Uniprot ID:	P19440
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
Reactions:	Nomega,Nomega'-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline [RN:R02513]
Gene Name:	DDAH2
Uniprot ID:	O95865
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sphingomyelin phosphodiesterase
Reactions:	sphingomyelin + H2O = N-acylsphingosine + choline phosphate [RN:R02541]
Gene Name:	SMPD1
Uniprot ID:	P17405
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cystathionine beta-synthase
Reactions:	L-serine + L-homocysteine = L-cystathionine + H2O [RN:R01290]
Gene Name:	CBS
Uniprot ID:	P35520
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alcohol dehydrogenase class-3
Reactions:	S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+ [RN:R06983 R07140]
Gene Name:	ADH5
Uniprot ID:	P11766
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alcohol dehydrogenase 1B
Reactions:	an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
Gene Name:	ADH1B
Uniprot ID:	P00325
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alcohol dehydrogenase class 4 mu/sigma chain
Reactions:	an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
Gene Name:	ADH7
Uniprot ID:	P40394
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alcohol dehydrogenase 1A
Reactions:	an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
Gene Name:	ADH1A
Uniprot ID:	P07327
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alcohol dehydrogenase 6
Reactions:	an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
Gene Name:	ADH6
Uniprot ID:	P28332
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alcohol dehydrogenase 1C
Reactions:	an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
Gene Name:	ADH1C
Uniprot ID:	P00326
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine hydroxymethyltransferase, mitochondrial
Reactions:	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine [RN:R00945]
Gene Name:	SHMT2
Uniprot ID:	P34897
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sarcosine dehydrogenase, mitochondrial
Reactions:	sarcosine + acceptor + H2O = glycine + formaldehyde + reduced acceptor [RN:R00611]
Gene Name:	SARDH
Uniprot ID:	Q9UL12
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine hydroxymethyltransferase, cytosolic
Reactions:	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine [RN:R00945]
Gene Name:	SHMT1
Uniprot ID:	P34896
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Reactions:	beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate [RN:R00763]
Gene Name:	PFKFB3
Uniprot ID:	Q16875
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Reactions:	beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate [RN:R00763]
Gene Name:	PFKFB4
Uniprot ID:	Q16877
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Reactions:	beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate [RN:R00763]
Gene Name:	PFKFB1
Uniprot ID:	P16118
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Fructose-1,6-bisphosphatase isozyme 2
Reactions:	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate [RN:R00762]
Gene Name:	FBP2
Uniprot ID:	O00757
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Fructose-1,6-bisphosphatase 1
Reactions:	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate [RN:R00762]
Gene Name:	FBP1
Uniprot ID:	P09467
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Reactions:	beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate [RN:R00763]
Gene Name:	PFKFB2
Uniprot ID:	O60825
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase Mu 2
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	GSTM2
Uniprot ID:	P28161
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione peroxidase 7
Reactions:	2 glutathione + H2O2 = glutathione disulfide + 2 H2O [RN:R00274]
Gene Name:	GPX7
Uniprot ID:	Q96SL4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Epididymal secretory glutathione peroxidase
Reactions:	2 glutathione + H2O2 = glutathione disulfide + 2 H2O [RN:R00274]
Gene Name:	GPX5
Uniprot ID:	O75715
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase Mu 1
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	GSTM1
Uniprot ID:	P09488
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hydroxyacylglutathione hydrolase, mitochondrial
Reactions:	S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate [RN:R04090]
Gene Name:	HAGH
Uniprot ID:	Q16775
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Microsomal glutathione S-transferase 3
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	MGST3
Uniprot ID:	O14880
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase Mu 3
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	GSTM3
Uniprot ID:	P21266
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase A1
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	GSTA1
Uniprot ID:	P08263
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Maleylacetoacetate isomerase
Reactions:	4-maleylacetoacetate = 4-fumarylacetoacetate [RN:R03181]
Gene Name:	GSTZ1
Uniprot ID:	O43708
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase Mu 5
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	GSTM5
Uniprot ID:	P46439
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Microsomal glutathione S-transferase 2
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	MGST2
Uniprot ID:	Q99735
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase omega-1
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	GSTO1
Uniprot ID:	P78417
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase A5
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	GSTA5
Uniprot ID:	Q7RTV2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase A2
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	GSTA2
Uniprot ID:	P09210
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione peroxidase 6
Reactions:	2 glutathione + H2O2 = glutathione disulfide + 2 H2O [RN:R00274]
Gene Name:	GPX6
Uniprot ID:	P59796
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase A3
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	GSTA3
Uniprot ID:	Q16772
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase A4
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	GSTA4
Uniprot ID:	O15217
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione peroxidase 1
Reactions:	2 glutathione + H2O2 = glutathione disulfide + 2 H2O [RN:R00274]
Gene Name:	GPX1
Uniprot ID:	P07203
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
Reactions:	2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O [RN:R03167]
Gene Name:	GPX4
Uniprot ID:	P36969
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione peroxidase 3
Reactions:	2 glutathione + H2O2 = glutathione disulfide + 2 H2O [RN:R00274]
Gene Name:	GPX3
Uniprot ID:	P22352
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase omega-2
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	GSTO2
Uniprot ID:	Q9H4Y5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase theta-1
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	GSTT1
Uniprot ID:	P30711
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione peroxidase 2
Reactions:	2 glutathione + H2O2 = glutathione disulfide + 2 H2O [RN:R00274]
Gene Name:	GPX2
Uniprot ID:	P18283
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase P
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	GSTP1
Uniprot ID:	P09211
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-glucuronidase
Reactions:	a beta-D-glucuronoside + H2O = D-glucuronate + an alcohol [RN:R01478]
Gene Name:	GUSB
Uniprot ID:	P08236
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Inositol oxygenase
Reactions:	myo-inositol + O2 = D-glucuronate + H2O [RN:R01184]
Gene Name:	MIOX
Uniprot ID:	Q9UGB7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-galactosidase
Reactions:	Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides ALL_REAC (other) R01100 R01105 R01678 R03355 R04633 R04783 R05112 R05994(G) R06010(G) R06098(G) R06099(G) R06114(G) R06144(G) R06202(G) R07807(G)
Gene Name:	GLB1
Uniprot ID:	P16278
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	3-keto-steroid reductase
Reactions:	4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP+ = 4alpha-methyl-5alpha-cholest-7-en-3-one + NADPH + H+ [RN:R05691]
Gene Name:	HSD17B7
Uniprot ID:	P56937
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	5-oxoprolinase
Reactions:	ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate [RN:R00251]
Gene Name:	OPLAH
Uniprot ID:	O14841
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Inositol monophosphatase 1
Reactions:	myo-inositol phosphate + H2O = myo-inositol + phosphate [RN:R07343]
Gene Name:	IMPA1
Uniprot ID:	P29218
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytosol aminopeptidase
Reactions:	Release of N-terminal proline from a peptide ALL_REAC (other) R00135 COFACTOR Manganese [CPD:C00034]
Gene Name:	LAP3
Uniprot ID:	P28838
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alpha-mannosidase 2
Reactions:	Hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man5(GlcNAc)3 ALL_REAC (other) R05984(G)
Gene Name:	MAN2A1
Uniprot ID:	Q16706
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
Reactions:	Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 ALL_REAC (other) R05982(G) R06722(G)
Gene Name:	MAN1A2
Uniprot ID:	O60476
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Reactions:	Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 ALL_REAC (other) R05982(G) R06722(G)
Gene Name:	MAN1B1
Uniprot ID:	Q9UKM7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
Reactions:	Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 ALL_REAC (other) R05982(G) R06722(G)
Gene Name:	MAN1A1
Uniprot ID:	P33908
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-hexosaminidase subunit beta
Reactions:	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides ALL_REAC (other) R00022 R03492 R04184 R04586 R05963(G) R06001(G) R06004(G) R06141(G) R07809(G) R07810(G)
Gene Name:	HEXB
Uniprot ID:	P07686
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-hexosaminidase subunit alpha
Reactions:	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides ALL_REAC (other) R00022 R03492 R04184 R04586 R05963(G) R06001(G) R06004(G) R06141(G) R07809(G) R07810(G)
Gene Name:	HEXA
Uniprot ID:	P06865
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tissue alpha-L-fucosidase
Reactions:	an alpha-L-fucoside + H2O = L-fucose + an alcohol [RN:R03162]
Gene Name:	FUCA1
Uniprot ID:	P04066
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Plasma alpha-L-fucosidase
Reactions:	an alpha-L-fucoside + H2O = L-fucose + an alcohol [RN:R03162]
Gene Name:	FUCA2
Uniprot ID:	Q9BTY2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleoside triphosphate diphosphohydrolase 6
Reactions:	a nucleoside diphosphate + H2O = a nucleotide + phosphate [RN:R00329]
Gene Name:	ENTPD6
Uniprot ID:	O75354
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleoside triphosphate diphosphohydrolase 5
Reactions:	a nucleoside diphosphate + H2O = a nucleotide + phosphate [RN:R00329]
Gene Name:	ENTPD5
Uniprot ID:	O75356
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Inosine-5'-monophosphate dehydrogenase 2
Reactions:	inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+ [RN:R01130]
Gene Name:	IMPDH2
Uniprot ID:	P12268
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bifunctional purine biosynthesis protein PURH
Reactions:	IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [RN:R01127]
Gene Name:	ATIC
Uniprot ID:	P31939
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphoserine phosphatase
Reactions:	O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate [RN:R00582 R02853]
Gene Name:	PSPH
Uniprot ID:	P78330
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	dTDP-D-glucose 4,6-dehydratase
Reactions:	dTDP-glucose = dTDP-4-dehydro-6-deoxy-D-glucose + H2O [RN:R06513]
Gene Name:	TGDS
Uniprot ID:	O95455
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	UDP-glucose 6-dehydrogenase
Reactions:	UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH + 2 H+ [RN:R00286]
Gene Name:	UGDH
Uniprot ID:	O60701
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Urocanate hydratase
Reactions:	3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O [RN:R02914]
Gene Name:	UROC1
Uniprot ID:	Q96N76
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ADP-ribosyl cyclase 2
Reactions:	NAD+ + H2O = ADP-ribose + nicotinamide [RN:R00102]
Gene Name:	BST1
Uniprot ID:	Q10588
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ADP-ribosyl cyclase 1
Reactions:	NAD+ + H2O = ADP-ribose + nicotinamide [RN:R00102]
Gene Name:	CD38
Uniprot ID:	P28907
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	C-1-tetrahydrofolate synthase, cytoplasmic
Reactions:	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate [RN:R00943]
Gene Name:	MTHFD1
Uniprot ID:	P11586
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nitric oxide synthase, inducible
Reactions:	L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+ [RN:R00557]
Gene Name:	NOS2
Uniprot ID:	P35228
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	10-formyltetrahydrofolate dehydrogenase
Reactions:	10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH + H+ [RN:R00941]
Gene Name:	ALDH1L1
Uniprot ID:	O75891
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	GTP cyclohydrolase 1
Reactions:	GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate [RN:R00424]
Gene Name:	GCH1
Uniprot ID:	P30793
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Arachidonate 5-lipoxygenase
Reactions:	(1) arachidonate + O2 = (5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O (overall reaction) [RN:R08527] (2) (1a) arachidonate + O2 = (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate [RN:R01595] (3) (1b) (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate = (5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O [RN:R03058]
Gene Name:	ALOX5
Uniprot ID:	P09917
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Prostaglandin G/H synthase 2
Reactions:	arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O [RN:R01599]
Gene Name:	PTGS2
Uniprot ID:	P35354
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Prostaglandin G/H synthase 1
Reactions:	arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O [RN:R01599]
Gene Name:	PTGS1
Uniprot ID:	P23219
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Methylglutaconyl-CoA hydratase, mitochondrial
Reactions:	(S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O [RN:R02085]
Gene Name:	AUH
Uniprot ID:	Q13825
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Leukotriene-B(4) omega-hydroxylase 1
Reactions:	(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14- tetraenoate + NADP+ + H2O [RN:R03866]
Gene Name:	CYP4F2
Uniprot ID:	P78329
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Leukotriene-B(4) omega-hydroxylase 2
Reactions:	(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14- tetraenoate + NADP+ + H2O [RN:R03866]
Gene Name:	CYP4F3
Uniprot ID:	Q08477
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Leukotriene A-4 hydrolase
Reactions:	(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate [RN:R03057]
Gene Name:	LTA4H
Uniprot ID:	P09960
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 3A4
Reactions:	(1) taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O [RN:R07205] (2) lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O [RN:R07206]
Gene Name:	CYP3A4
Uniprot ID:	P08684
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protoporphyrinogen oxidase
Reactions:	protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2 [RN:R03222]
Gene Name:	PPOX
Uniprot ID:	P50336
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acidic mammalian chitinase
Reactions:	Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins ALL_REAC (other) R01206 R02334 R06081(G) R06082(G) INHIBITOR Allosamidine [CPD:C05346]
Gene Name:	CHIA
Uniprot ID:	Q9BZP6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Reactions:	glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose [RN:R04373]
Gene Name:	NAGPA
Uniprot ID:	Q9UK23
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Chitotriosidase-1
Reactions:	Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins ALL_REAC (other) R01206 R02334 R06081(G) R06082(G) INHIBITOR Allosamidine [CPD:C05346]
Gene Name:	CHIT1
Uniprot ID:	Q13231
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Arginase-2, mitochondrial
Reactions:	L-arginine + H2O = L-ornithine + urea [RN:R00551]
Gene Name:	ARG2
Uniprot ID:	P78540
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2C9
Reactions:	(R)-limonene + NADPH + H+ + O2 = (+)-trans-carveol + NADP+ + H2O [RN:R06119]
Gene Name:	CYP2C9
Uniprot ID:	P11712
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sterol 26-hydroxylase, mitochondrial
Reactions:	5beta-cholestane-3alpha,7alpha,12alpha-triol + NADPH + H+ + O2 = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + NADP+ + H2O [RN:R04807]
Gene Name:	CYP27A1
Uniprot ID:	Q02318
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2C19
Reactions:	(R)-limonene + NADPH + H+ + O2 = (+)-trans-carveol + NADP+ + H2O [RN:R06119]
Gene Name:	CYP2C19
Uniprot ID:	P33261
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Reactions:	calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O [RN:R03610]
Gene Name:	CYP27B1
Uniprot ID:	O15528
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Steroid 17-alpha-hydroxylase/17,20 lyase
Reactions:	a steroid + AH2 + O2 = a 17alpha-hydroxysteroid + A + H2O [RN:R02131]
Gene Name:	CYP17A1
Uniprot ID:	P05093
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytosolic acyl coenzyme A thioester hydrolase
Reactions:	palmitoyl-CoA + H2O = CoA + palmitate [RN:R01274]
Gene Name:	ACOT7
Uniprot ID:	O00154
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-coenzyme A thioesterase 2, mitochondrial
Reactions:	palmitoyl-CoA + H2O = CoA + palmitate [RN:R01274]
Gene Name:	ACOT2
Uniprot ID:	P49753
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-coenzyme A thioesterase 4
Reactions:	palmitoyl-CoA + H2O = CoA + palmitate [RN:R01274]
Gene Name:	ACOT4
Uniprot ID:	Q8N9L9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-coenzyme A thioesterase 8
Reactions:	choloyl-CoA + H2O = cholate + CoA [RN:R07296]
Gene Name:	ACOT8
Uniprot ID:	O14734
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Palmitoyl-protein thioesterase 1
Reactions:	palmitoyl[protein] + H2O = palmitate + protein [RN:R01705]
Gene Name:	PPT1
Uniprot ID:	P50897
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lysosomal thioesterase PPT2
Reactions:	--- []
Gene Name:	PPT2
Uniprot ID:	Q9UMR5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sulfite oxidase, mitochondrial
Reactions:	sulfite + O2 + H2O = sulfate + H2O2 [RN:R00533]
Gene Name:	SUOX
Uniprot ID:	P51687
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Inorganic pyrophosphatase
Reactions:	diphosphate + H2O = 2 phosphate [RN:R00004]
Gene Name:	PPA1
Uniprot ID:	Q15181
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	mRNA-capping enzyme
Reactions:	a 5'-phosphopolynucleotide + H2O = a polynucleotide + phosphate [RN:R02249]
Gene Name:	RNGTT
Uniprot ID:	O60942
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acid ceramidase
Reactions:	N-acylsphingosine + H2O = a carboxylate + sphingosine [RN:R01493]
Gene Name:	ASAH1
Uniprot ID:	Q13510
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-enolase
Reactions:	2-phospho-D-glycerate = phosphoenolpyruvate + H2O [RN:R00658]
Gene Name:	ENO3
Uniprot ID:	P13929
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Gamma-enolase
Reactions:	2-phospho-D-glycerate = phosphoenolpyruvate + H2O [RN:R00658]
Gene Name:	ENO2
Uniprot ID:	P09104
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alpha-enolase
Reactions:	2-phospho-D-glycerate = phosphoenolpyruvate + H2O [RN:R00658]
Gene Name:	ENO1
Uniprot ID:	P06733
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
Reactions:	sphingomyelin + H2O = N-acylsphingosine + choline phosphate [RN:R02541]
Gene Name:	ENPP7
Uniprot ID:	Q6UWV6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sphingomyelin phosphodiesterase 2
Reactions:	sphingomyelin + H2O = N-acylsphingosine + choline phosphate [RN:R02541]
Gene Name:	SMPD2
Uniprot ID:	O60906
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Uridine diphosphate glucose pyrophosphatase
Reactions:	UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate [RN:R03986]
Gene Name:	NUDT14
Uniprot ID:	O95848
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peptide deformylase, mitochondrial
Reactions:	formyl-L-methionyl peptide + H2O = formate + methionyl peptide [RN:R05635]
Gene Name:	PDF
Uniprot ID:	Q9HBH1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Inositol monophosphatase 2
Reactions:	myo-inositol phosphate + H2O = myo-inositol + phosphate [RN:R07343]
Gene Name:	IMPA2
Uniprot ID:	O14732
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable phospholipid-transporting ATPase IG
Reactions:	ATP + H2O + phospholipidin = ADP + phosphate + phospholipidout [RN:R00086]
Gene Name:	ATP11C
Uniprot ID:	Q8NB49
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable phospholipid-transporting ATPase IH
Reactions:	ATP + H2O + phospholipidin = ADP + phosphate + phospholipidout [RN:R00086]
Gene Name:	ATP11A
Uniprot ID:	P98196
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Plasma membrane calcium-transporting ATPase 3
Reactions:	ATP + H2O + Ca2+cis = ADP + phosphate + Ca2+trans [RN:R00086]
Gene Name:	ATP2B3
Uniprot ID:	Q16720
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Katanin p60 ATPase-containing subunit A1
Reactions:	ATP + H2O = ADP + phosphate [RN:R00086]
Gene Name:	KATNA1
Uniprot ID:	O75449
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase subunit G 3
Reactions:
Gene Name:	ATP6V1G3
Uniprot ID:	Q96LB4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable phospholipid-transporting ATPase VA
Reactions:	ATP + H2O + phospholipidin = ADP + phosphate + phospholipidout [RN:R00086]
Gene Name:	ATP10A
Uniprot ID:	O60312
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase subunit G 1
Reactions:
Gene Name:	ATP6V1G1
Uniprot ID:	O75348
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable phospholipid-transporting ATPase IC
Reactions:	ATP + H2O + phospholipidin = ADP + phosphate + phospholipidout [RN:R00086]
Gene Name:	ATP8B1
Uniprot ID:	O43520
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sodium/potassium-transporting ATPase subunit beta-3
Reactions:
Gene Name:	ATP1B3
Uniprot ID:	P54709
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Plasma membrane calcium-transporting ATPase 1
Reactions:	ATP + H2O + Ca2+cis = ADP + phosphate + Ca2+trans [RN:R00086]
Gene Name:	ATP2B1
Uniprot ID:	P20020
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP synthase subunit epsilon, mitochondrial
Reactions:
Gene Name:	ATP5E
Uniprot ID:	P56381
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP synthase subunit delta, mitochondrial
Reactions:	--- []
Gene Name:	ATP5D
Uniprot ID:	P30049
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable phospholipid-transporting ATPase IIA
Reactions:	ATP + H2O + phospholipidin = ADP + phosphate + phospholipidout [RN:R00086]
Gene Name:	ATP9A
Uniprot ID:	O75110
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sodium/potassium-transporting ATPase subunit beta-2
Reactions:
Gene Name:	ATP1B2
Uniprot ID:	P14415
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Plasma membrane calcium-transporting ATPase 2
Reactions:	ATP + H2O + Ca2+cis = ADP + phosphate + Ca2+trans [RN:R00086]
Gene Name:	ATP2B2
Uniprot ID:	Q01814
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sodium/potassium-transporting ATPase subunit beta-1
Reactions:
Gene Name:	ATP1B1
Uniprot ID:	P05026
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable phospholipid-transporting ATPase VD
Reactions:	ATP + H2O + phospholipidin = ADP + phosphate + phospholipidout [RN:R00086]
Gene Name:	ATP10D
Uniprot ID:	Q9P241
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Reactions:	ATP + H2O + Ca2+cis = ADP + phosphate + Ca2+trans [RN:R00086]
Gene Name:	ATP2A3
Uniprot ID:	Q93084
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase subunit C 1
Reactions:	--- []
Gene Name:	ATP6V1C1
Uniprot ID:	P21283
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase subunit G 2
Reactions:
Gene Name:	ATP6V1G2
Uniprot ID:	O95670
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP synthase subunit O, mitochondrial
Reactions:
Gene Name:	ATP5O
Uniprot ID:	P48047
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP synthase-coupling factor 6, mitochondrial
Reactions:
Gene Name:	ATP5J
Uniprot ID:	P18859
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bifunctional polynucleotide phosphatase/kinase
Reactions:	a 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate [RN:R02248]
Gene Name:	PNKP
Uniprot ID:	Q96T60
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase subunit B, kidney isoform
Reactions:
Gene Name:	ATP6V1B1
Uniprot ID:	P15313
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Potassium-transporting ATPase alpha chain 2
Reactions:	ATP + H2O + H+in + K+out = ADP + phosphate + H+out + K+in [RN:R00086]
Gene Name:	ATP12A
Uniprot ID:	P54707
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase 116 kDa subunit a isoform 4
Reactions:	--- []
Gene Name:	ATP6V0A4
Uniprot ID:	Q9HBG4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein ATP1B4
Reactions:
Gene Name:	ATP1B4
Uniprot ID:	Q9UN42
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP synthase protein 8
Reactions:
Gene Name:	MT-ATP8
Uniprot ID:	P03928
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP synthase subunit e, mitochondrial
Reactions:
Gene Name:	ATP5I
Uniprot ID:	P56385
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase catalytic subunit A
Reactions:	ATP + H2O + H+in = ADP + phosphate + H+out [RN:R00086]
Gene Name:	ATP6V1A
Uniprot ID:	P38606
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP synthase subunit gamma, mitochondrial
Reactions:
Gene Name:	ATP5C1
Uniprot ID:	P36542
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Plasma membrane calcium-transporting ATPase 4
Reactions:	ATP + H2O + Ca2+cis = ADP + phosphate + Ca2+trans [RN:R00086]
Gene Name:	ATP2B4
Uniprot ID:	P23634
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase subunit d 1
Reactions:
Gene Name:	ATP6V0D1
Uniprot ID:	P61421
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable phospholipid-transporting ATPase IA
Reactions:	ATP + H2O + phospholipidin = ADP + phosphate + phospholipidout [RN:R00086]
Gene Name:	ATP8A1
Uniprot ID:	Q9Y2Q0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sodium/potassium-transporting ATPase subunit alpha-1
Reactions:	ATP + H2O + Na+in + K+out = ADP + phosphate + Na+out + K+in [RN:R00086]
Gene Name:	ATP1A1
Uniprot ID:	P05023
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Calcium-transporting ATPase type 2C member 1
Reactions:	ATP + H2O + Ca2+cis = ADP + phosphate + Ca2+trans [RN:R00086]
Gene Name:	ATP2C1
Uniprot ID:	P98194
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase subunit B, brain isoform
Reactions:	--- []
Gene Name:	ATP6V1B2
Uniprot ID:	P21281
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sodium/potassium-transporting ATPase subunit alpha-3
Reactions:	ATP + H2O + Na+in + K+out = ADP + phosphate + Na+out + K+in [RN:R00086]
Gene Name:	ATP1A3
Uniprot ID:	P13637
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP synthase subunit b, mitochondrial
Reactions:
Gene Name:	ATP5F1
Uniprot ID:	P24539
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Vesicle-fusing ATPase
Reactions:	ATP + H2O = ADP + phosphate [RN:R00086]
Gene Name:	NSF
Uniprot ID:	P46459
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Potassium-transporting ATPase subunit beta
Reactions:
Gene Name:	ATP4B
Uniprot ID:	P51164
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP synthase subunit alpha, mitochondrial
Reactions:
Gene Name:	ATP5A1
Uniprot ID:	P25705
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable phospholipid-transporting ATPase IIB
Reactions:	ATP + H2O + phospholipidin = ADP + phosphate + phospholipidout [RN:R00086]
Gene Name:	ATP9B
Uniprot ID:	O43861
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Potassium-transporting ATPase alpha chain 1
Reactions:	ATP + H2O + H+in + K+out = ADP + phosphate + H+out + K+in [RN:R00086]
Gene Name:	ATP4A
Uniprot ID:	P20648
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable phospholipid-transporting ATPase IM
Reactions:	ATP + H2O + phospholipidin = ADP + phosphate + phospholipidout [RN:R00086]
Gene Name:	ATP8B4
Uniprot ID:	Q8TF62
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleoside triphosphate diphosphohydrolase 2
Reactions:	--- []
Gene Name:	ENTPD2
Uniprot ID:	Q9Y5L3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase 16 kDa proteolipid subunit
Reactions:
Gene Name:	ATP6V0C
Uniprot ID:	P27449
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable phospholipid-transporting ATPase IF
Reactions:	ATP + H2O + phospholipidin = ADP + phosphate + phospholipidout [RN:R00086]
Gene Name:	ATP11B
Uniprot ID:	Q9Y2G3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase subunit e 1
Reactions:
Gene Name:	ATP6V0E1
Uniprot ID:	O15342
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable phospholipid-transporting ATPase IK
Reactions:	ATP + H2O + phospholipidin = ADP + phosphate + phospholipidout [RN:R00086]
Gene Name:	ATP8B3
Uniprot ID:	O60423
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP synthase subunit d, mitochondrial
Reactions:
Gene Name:	ATP5H
Uniprot ID:	O75947
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP synthase subunit f, mitochondrial
Reactions:
Gene Name:	ATP5J2
Uniprot ID:	P56134
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sodium/potassium-transporting ATPase subunit alpha-2
Reactions:	ATP + H2O + Na+in + K+out = ADP + phosphate + Na+out + K+in [RN:R00086]
Gene Name:	ATP1A2
Uniprot ID:	P50993
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2E1
Reactions:	--- []
Gene Name:	CYP2E1
Uniprot ID:	P05181
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 3A43
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP3A43
Uniprot ID:	Q9HB55
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 1B1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP1B1
Uniprot ID:	Q16678
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2C18
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2C18
Uniprot ID:	P33260
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2F1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2F1
Uniprot ID:	P24903
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4X1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP4X1
Uniprot ID:	Q8N118
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2B6
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2B6
Uniprot ID:	P20813
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 3A5
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP3A5
Uniprot ID:	P20815
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2A13
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2A13
Uniprot ID:	Q16696
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 3A7
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP3A7
Uniprot ID:	P24462
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4B1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP4B1
Uniprot ID:	P13584
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4Z1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP4Z1
Uniprot ID:	Q86W10
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 1A2
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP1A2
Uniprot ID:	P05177
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 19A1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP19A1
Uniprot ID:	P11511
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2C8
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2C8
Uniprot ID:	P10632
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2S1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2S1
Uniprot ID:	Q96SQ9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2J2
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2J2
Uniprot ID:	P51589
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2A7
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2A7
Uniprot ID:	P20853
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2A6
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2A6
Uniprot ID:	P11509
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Inositol polyphosphate 5-phosphatase OCRL-1
Reactions:	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate [RN:R04404]
Gene Name:	OCRL
Uniprot ID:	Q01968
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Reactions:	phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 4,5-bisphosphate + phosphate [RN:R04513]
Gene Name:	PTEN
Uniprot ID:	P60484
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Synaptojanin-2
Reactions:	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate [RN:R04404]
Gene Name:	SYNJ2
Uniprot ID:	O15056
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	72 kDa inositol polyphosphate 5-phosphatase
Reactions:	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate [RN:R04404]
Gene Name:	INPP5E
Uniprot ID:	Q9NRR6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Synaptojanin-1
Reactions:	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate [RN:R04404]
Gene Name:	SYNJ1
Uniprot ID:	O43426
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Thiamine-triphosphatase
Reactions:	thiamine triphosphate + H2O = thiamine diphosphate + phosphate [RN:R00618]
Gene Name:	THTPA
Uniprot ID:	Q9BU02
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Catalase
Reactions:	2 H2O2 = O2 + 2 H2O [RN:R00009]
Gene Name:	CAT
Uniprot ID:	P04040
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphatidylinositol-glycan-specific phospholipase D
Reactions:	6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate [RN:R06623]
Gene Name:	GPLD1
Uniprot ID:	P80108
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dolichyldiphosphatase 1
Reactions:	dolichyl diphosphate + H2O = dolichyl phosphate + phosphate [RN:R01004]
Gene Name:	DOLPP1
Uniprot ID:	Q86YN1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alpha-L-iduronidase
Reactions:	Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate ALL_REAC (other) R07813(G) R07822(G) REFERENCE 1 [PMID:4993544] AUTHORS Matalon R, Cifonelli JA, Dorfman A. TITLE L-iduronidase in cultured human fibroblasts and liver. JOURNAL Biochem. Biophys. Res. Commun. 42 (1971) 340-5. ORGANISM Homo sapiens [GN:hsa] REFERENCE 2 [PMID:30407] AUTHORS Rome LH, Garvin AJ, Neufeld EF. TITLE Human kidney alpha-L-iduronidase: purification and characterization. JOURNAL Arch. Biochem. Biophys. 189 (1978) 344-53. ORGANISM Homo sapiens [GN:hsa] REFERENCE 3 AUTHORS Srivastava, R.M., Hudson, N., Seymour, F.R. and Weissman, B. TITLE Preparation of (aryl alpha-L-idopyranosid)uronic acids. JOURNAL Carbohydr. Res. 60 (1978) 315-326.
Gene Name:	IDUA
Uniprot ID:	P35475
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Iduronate 2-sulfatase
Reactions:	Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin [RN:R07812 R07821] ALL_REAC R07812(G) R07821(G) REFERENCE 1 [PMID:6816283] AUTHORS Archer IM, Harper PS, Wusteman FS. TITLE Multiple forms of iduronate 2-sulphate sulphatase in human tissues and body fluids. JOURNAL Biochim. Biophys. Acta. 708 (1982) 134-40. ORGANISM Homo sapiens [GN:hsa] REFERENCE 2 [PMID:4269173] AUTHORS Bach G, Eisenberg F Jr, Cantz M, Neufeld EF. TITLE The defect in the Hunter syndrome: deficiency of sulfoiduronate sulfatase. JOURNAL Proc. Natl. Acad. Sci. U. S. A. 70 (1973) 2134-8. ORGANISM Homo sapiens [GN:hsa] REFERENCE 3 [PMID:6945876] AUTHORS Di Natale P, Ronsisvalle L. TITLE Identification and partial characterization of two enzyme forms of iduronate sulfatase from human placenta. JOURNAL Biochim. Biophys. Acta. 661 (1981) 106-11. ORGANISM Homo sapiens [GN:hsa] REFERENCE 4 [PMID:6950934] AUTHORS Yutaka T, Fluharty AL, Stevens RL, Kihara H. TITLE Purification and some properties of human liver iduronate sulfatase. JOURNAL J. Biochem. (Tokyo). 91 (1982) 433-41. ORGANISM Homo sapiens [GN:hsa]
Gene Name:	IDS
Uniprot ID:	P22304
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alpha-N-acetylglucosaminidase
Reactions:	Hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides ALL_REAC (other) R07816(G)
Gene Name:	NAGLU
Uniprot ID:	P54802
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	N-acetylglucosamine-6-sulfatase
Reactions:	Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate [RN:R07808 R07819] ALL_REAC R07808(G) R07819(G)
Gene Name:	GNS
Uniprot ID:	P15586
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	25-hydroxycholesterol 7-alpha-hydroxylase
Reactions:	(1) cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O [RN:R07209] (2) cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O [RN:R07372]
Gene Name:	CYP7B1
Uniprot ID:	O75881
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 1
Reactions:	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O [RN:R00081]
Gene Name:	MT-CO1
Uniprot ID:	P00395
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP1CB
Uniprot ID:	P62140
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Epoxide hydrolase 2
Reactions:	an epoxide + H2O = a glycol [RN:R02822]
Gene Name:	EPHX2
Uniprot ID:	P34913
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Epoxide hydrolase 1
Reactions:	cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol [RN:R07627]
Gene Name:	EPHX1
Uniprot ID:	P07099
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glucosylceramidase
Reactions:	D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine [RN:R01498]
Gene Name:	GBA
Uniprot ID:	P04062
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Type II inositol-1,4,5-trisphosphate 5-phosphatase
Reactions:	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate [RN:R04404]
Gene Name:	INPP5B
Uniprot ID:	P32019
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Elongation factor 1-alpha 1
Reactions:
Gene Name:	EEF1A1
Uniprot ID:	P68104
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Elongation factor 1-alpha 2
Reactions:
Gene Name:	EEF1A2
Uniprot ID:	Q05639
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Laforin
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	EPM2A
Uniprot ID:	O95278
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP1CC
Uniprot ID:	P36873
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pantetheinase
Reactions:	(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol [RN:R02973]
Gene Name:	VNN1
Uniprot ID:	O95497
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Proline dehydrogenase, mitochondrial
Reactions:	L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor [RN:R01253]
Gene Name:	PRODH
Uniprot ID:	O43272
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peptidoglycan recognition protein 1
Reactions:
Gene Name:	PGLYRP1
Uniprot ID:	O75594
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbonic anhydrase 1
Reactions:	H2CO3 = CO2 + H2O [RN:R00132]
Gene Name:	CA1
Uniprot ID:	P00915
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbonic anhydrase 2
Reactions:	H2CO3 = CO2 + H2O [RN:R00132]
Gene Name:	CA2
Uniprot ID:	P00918
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alpha-amylase 1
Reactions:	Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units ALL_REAC (other) R02108 R06209(G)
Gene Name:	AMY1A
Uniprot ID:	P04745
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pancreatic alpha-amylase
Reactions:	Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units ALL_REAC (other) R02108 R06209(G)
Gene Name:	AMY2A
Uniprot ID:	P04746
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Natriuretic peptides B
Reactions:
Gene Name:	NPPB
Uniprot ID:	P16860
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alpha-amylase 2B
Reactions:	Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units ALL_REAC (other) R02108 R06209(G)
Gene Name:	AMY2B
Uniprot ID:	P19961
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	N-acetylgalactosamine-6-sulfatase
Reactions:	Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate [RN:R07806] ALL_REAC R07806(G) REFERENCE 1 [PMID:6939689] AUTHORS Epstein EH Jr, Leventhal ME. TITLE Steroid sulfatase of human leukocytes and epidermis and the diagnosis of recessive X-linked ichthyosis. JOURNAL J. Clin. Invest. 67 (1981) 1257-62. ORGANISM Homo sapiens [GN:hsa] REFERENCE 2 [PMID:6213226] AUTHORS Glossl J, Kresse H. TITLE Impaired degradation of keratan sulphate by Morquio A fibroblasts. JOURNAL Biochem. J. 203 (1982) 335-8. ORGANISM Homo sapiens [GN:hsa] REFERENCE 3 [PMID:7213753] AUTHORS Lim CT, Horwitz AL. TITLE Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase. JOURNAL Biochim. Biophys. Acta. 657 (1981) 344-55. ORGANISM Homo sapiens [GN:hsa] REFERENCE 4 [PMID:6814909] AUTHORS Sorensen SH, Noren O, Sjostrom H, Danielsen EM. TITLE Amphiphilic pig intestinal microvillus maltase/glucoamylase. Structure and specificity. JOURNAL Eur. J. Biochem. 126 (1982) 559-68. ORGANISM Sus scofa [GN:ssc] REFERENCE 5 [PMID:6809361] AUTHORS Yutaka T, Okada S, Kato T, Inui K, Yabuuhi H. TITLE Galactose 6-sulfate sulfatase activity in Morquio syndrome. JOURNAL Clin. Chim. Acta. 122 (1982) 169-80. ORGANISM shark
Gene Name:	GALNS
Uniprot ID:	P34059
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Vitamin K epoxide reductase complex subunit 1
Reactions:	2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol [RN:R03511]
Gene Name:	VKORC1
Uniprot ID:	Q9BQB6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 7A1, mitochondrial
Reactions:	--- []
Gene Name:	COX7A1
Uniprot ID:	P24310
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbonic anhydrase 5A, mitochondrial
Reactions:	H2CO3 = CO2 + H2O [RN:R00132]
Gene Name:	CA5A
Uniprot ID:	P35218
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	2',3'-cyclic-nucleotide 3'-phosphodiesterase
Reactions:	nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate [RN:R03422]
Gene Name:	CNP
Uniprot ID:	P09543
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase CYLD
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	CYLD
Uniprot ID:	Q9NQC7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein phosphatase non-receptor type 6
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPN6
Uniprot ID:	P29350
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxiredoxin-5, mitochondrial
Reactions:	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH [RN:R07180]
Gene Name:	PRDX5
Uniprot ID:	P30044
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbonic anhydrase 3
Reactions:	H2CO3 = CO2 + H2O [RN:R00132]
Gene Name:	CA3
Uniprot ID:	P07451
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aquaporin-3
Reactions:
Gene Name:	AQP3
Uniprot ID:	Q92482
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Receptor-type tyrosine-protein phosphatase C
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPRC
Uniprot ID:	P08575
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Kynurenine 3-monooxygenase
Reactions:	L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O [RN:R01960]
Gene Name:	KMO
Uniprot ID:	O15229
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable peptidyl-tRNA hydrolase
Reactions:	N-Substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA [RN:R04238]
Gene Name:	PTRH1
Uniprot ID:	Q86Y79
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Agmatinase, mitochondrial
Reactions:	agmatine + H2O = putrescine + urea [RN:R01157]
Gene Name:	AGMAT
Uniprot ID:	Q9BSE5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Receptor-type tyrosine-protein phosphatase alpha
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPRA
Uniprot ID:	P18433
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Myotubularin
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	MTM1
Uniprot ID:	Q13496
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 2
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP2
Uniprot ID:	Q05923
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pterin-4-alpha-carbinolamine dehydratase
Reactions:	(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a- hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O [RN:R04734]
Gene Name:	PCBD1
Uniprot ID:	P61457
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aquaporin-2
Reactions:
Gene Name:	AQP2
Uniprot ID:	P41181
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Elongation factor 2
Reactions:
Gene Name:	EEF2
Uniprot ID:	P13639
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxiredoxin-1
Reactions:	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH [RN:R07180]
Gene Name:	PRDX1
Uniprot ID:	Q06830
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase 116 kDa subunit a isoform 2
Reactions:
Gene Name:	ATP6V0A2
Uniprot ID:	Q9Y487
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxiredoxin-2
Reactions:	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH [RN:R07180]
Gene Name:	PRDX2
Uniprot ID:	P32119
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbonic anhydrase 5B, mitochondrial
Reactions:	H2CO3 = CO2 + H2O [RN:R00132]
Gene Name:	CA5B
Uniprot ID:	Q9Y2D0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 7A2, mitochondrial
Reactions:
Gene Name:	COX7A2
Uniprot ID:	P14406
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Myotubularin-related protein 3
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	MTMR3
Uniprot ID:	Q13615
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cholesterol 25-hydroxylase
Reactions:	cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O [RN:R07218]
Gene Name:	CH25H
Uniprot ID:	O95992
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	AID
Reactions:
Gene Name:	AID
Uniprot ID:	Q546Y9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytosolic beta-glucosidase
Reactions:	Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose ALL_REAC (other) R00026 R02887 R03527 R04949 R04998 R06077(G) R06092(G)
Gene Name:	GBA3
Uniprot ID:	Q9H227
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Thioredoxin-dependent peroxide reductase, mitochondrial
Reactions:	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH [RN:R07180]
Gene Name:	PRDX3
Uniprot ID:	P30048
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Maltase-glucoamylase, intestinal
Reactions:	Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of D-glucose ALL_REAC (other) R00028 R00801 R00802 R06084(G) R06087(G) R06088(G) INHIBITOR Castanospermine [CPD:C02256]
Gene Name:	MGAM
Uniprot ID:	O43451
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbonic anhydrase 12
Reactions:	H2CO3 = CO2 + H2O [RN:R00132]
Gene Name:	CA12
Uniprot ID:	O43570
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphoethanolamine/phosphocholine phosphatase
Reactions:	(1) O-phosphoethanolamine + H2O = ethanolamine + phosphate [RN:R06870] (2) phosphocholine + H2O = choline + phosphate [RN:R06871]
Gene Name:	PHOSPHO1
Uniprot ID:	Q8TCT1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP synthase lipid-binding protein, mitochondrial
Reactions:
Gene Name:	ATP5G3
Uniprot ID:	P48201
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbonic anhydrase 4
Reactions:	H2CO3 = CO2 + H2O [RN:R00132]
Gene Name:	CA4
Uniprot ID:	P22748
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sodium/potassium-transporting ATPase subunit alpha-4
Reactions:	ATP + H2O + Na+in + K+out = ADP + phosphate + Na+out + K+in [RN:R00086]
Gene Name:	ATP1A4
Uniprot ID:	Q13733
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 6A2, mitochondrial
Reactions:	--- []
Gene Name:	COX6A2
Uniprot ID:	Q02221
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 7B, mitochondrial
Reactions:	--- []
Gene Name:	COX7B
Uniprot ID:	P24311
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 7C, mitochondrial
Reactions:	--- []
Gene Name:	COX7C
Uniprot ID:	P15954
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 5B, mitochondrial
Reactions:	--- []
Gene Name:	COX5B
Uniprot ID:	P10606
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbonic anhydrase 9
Reactions:	H2CO3 = CO2 + H2O [RN:R00132]
Gene Name:	CA9
Uniprot ID:	Q16790
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 6B1
Reactions:	--- []
Gene Name:	COX6B1
Uniprot ID:	P14854
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytosolic 5'-nucleotidase 3
Reactions:	a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate [RN:R07297]
Gene Name:	NT5C3
Uniprot ID:	Q9H0P0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 7B2, mitochondrial
Reactions:
Gene Name:	COX7B2
Uniprot ID:	Q8TF08
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Reactions:	--- []
Gene Name:	COX4I1
Uniprot ID:	P13073
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ENTPD4 protein
Reactions:
Gene Name:	ENTPD4
Uniprot ID:	Q8NE73
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 6B2
Reactions:
Gene Name:	COX6B2
Uniprot ID:	Q6YFQ2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutamine-dependent NAD(+) synthetase
Reactions:	ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate [RN:R00257]
Gene Name:	NADSYN1
Uniprot ID:	Q6IA69
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbonic anhydrase 13
Reactions:	H2CO3 = CO2 + H2O [RN:R00132]
Gene Name:	CA13
Uniprot ID:	Q8N1Q1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Reactions:
Gene Name:	INPPL1
Uniprot ID:	O15357
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP synthase lipid-binding protein, mitochondrial
Reactions:
Gene Name:	ATP5G1
Uniprot ID:	P05496
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 8A, mitochondrial
Reactions:	--- []
Gene Name:	COX8A
Uniprot ID:	P10176
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Type II inositol-3,4-bisphosphate 4-phosphatase
Reactions:	1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate [RN:R07299]
Gene Name:	INPP4B
Uniprot ID:	O15327
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 6C
Reactions:	--- []
Gene Name:	COX6C
Uniprot ID:	P09669
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 7A-related protein, mitochondrial
Reactions:
Gene Name:	COX7A2L
Uniprot ID:	O14548
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	CAD protein
Reactions:	(1) 2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate [RN:R00575] (2) L-glutamine + H2O = L-glutamate + NH3 [RN:R00256] (3) 2 ATP + HCO3- = 2 ADP + phosphate + carbamoyl phosphate [RN:R07641]
Gene Name:	CAD
Uniprot ID:	P27708
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 8C, mitochondrial
Reactions:
Gene Name:	COX8C
Uniprot ID:	Q7Z4L0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	L-asparaginase
Reactions:	L-asparagine + H2O = L-aspartate + NH3 [RN:R00485]
Gene Name:	ASRGL1
Uniprot ID:	Q7L266
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative N-acetylglucosamine-6-phosphate deacetylase
Reactions:	N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate [RN:R02059]
Gene Name:	AMDHD2
Uniprot ID:	Q9Y303
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pyridoxal phosphate phosphatase
Reactions:	pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate [RN:R00173]
Gene Name:	PDXP
Uniprot ID:	Q96GD0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Methionine adenosyltransferase 2 subunit beta
Reactions:
Gene Name:	MAT2B
Uniprot ID:	Q9NZL9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase subunit H
Reactions:
Gene Name:	ATP6V1H
Uniprot ID:	Q9UI12
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase subunit D
Reactions:
Gene Name:	ATP6V1D
Uniprot ID:	Q9Y5K8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase subunit d 2
Reactions:
Gene Name:	ATP6V0D2
Uniprot ID:	Q8N8Y2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase subunit E 2
Reactions:
Gene Name:	ATP6V1E2
Uniprot ID:	Q96A05
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase subunit C 2
Reactions:
Gene Name:	ATP6V1C2
Uniprot ID:	Q8NEY4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	CTP synthase 2
Reactions:	ATP + UTP + NH3 = ADP + phosphate + CTP [RN:R00571]
Gene Name:	CTPS2
Uniprot ID:	Q9NRF8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Reactions:	guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate [RN:R01234]
Gene Name:	PDE11A
Uniprot ID:	Q9HCR9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphoglycolate phosphatase
Reactions:	2-phosphoglycolate + H2O = glycolate + phosphate [RN:R01334]
Gene Name:	PGP
Uniprot ID:	A6NDG6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4
Reactions:	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Gene Name:	PLCD4
Uniprot ID:	Q9BRC7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3
Reactions:	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Gene Name:	PLCD3
Uniprot ID:	Q8N3E9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Reactions:	3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate [RN:R03352]
Gene Name:	HIBCH
Uniprot ID:	Q6NVY1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbonic anhydrase 7
Reactions:	H2CO3 = CO2 + H2O [RN:R00132]
Gene Name:	CA7
Uniprot ID:	P43166
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cholesterol 24-hydroxylase
Reactions:	cholesterol + NADPH + H+ + O2 = (24S)-24-hydroxycholesterol + NADP+ + H2O [RN:R07207]
Gene Name:	CYP46A1
Uniprot ID:	Q9Y6A2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Inorganic pyrophosphatase 2, mitochondrial
Reactions:	diphosphate + H2O = 2 phosphate [RN:R00004]
Gene Name:	PPA2
Uniprot ID:	Q9H2U2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glucose-6-phosphatase 2
Reactions:	D-glucose 6-phosphate + H2O = D-glucose + phosphate [RN:R00303]
Gene Name:	G6PC2
Uniprot ID:	Q9NQR9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
Reactions:	Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 ALL_REAC (other) R05982(G) R06722(G)
Gene Name:	MAN1C1
Uniprot ID:	Q9NR34
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hydroxyacylglutathione hydrolase-like protein
Reactions:
Gene Name:	HAGHL
Uniprot ID:	Q6PII5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Neutral alpha-glucosidase C
Reactions:	Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of D-glucose ALL_REAC (other) R00028 R00801 R00802 R06084(G) R06087(G) R06088(G) INHIBITOR Castanospermine [CPD:C02256]
Gene Name:	GANC
Uniprot ID:	Q8TET4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Type I inositol-3,4-bisphosphate 4-phosphatase
Reactions:	1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate [RN:R07299]
Gene Name:	INPP4A
Uniprot ID:	Q96PE3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sphingomyelin phosphodiesterase 3
Reactions:	sphingomyelin + H2O = N-acylsphingosine + choline phosphate [RN:R02541]
Gene Name:	SMPD3
Uniprot ID:	Q9NY59
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 2
Reactions:
Gene Name:	MT-CO2
Uniprot ID:	P00403
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 6A1, mitochondrial
Reactions:
Gene Name:	COX6A1
Uniprot ID:	P12074
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Reactions:
Gene Name:	COX4I2
Uniprot ID:	Q96KJ9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4A22
Reactions:	octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O [RN:R02879]
Gene Name:	CYP4A22
Uniprot ID:	Q5TCH4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Stearoyl-CoA desaturase 5
Reactions:	stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R02222]
Gene Name:	SCD5
Uniprot ID:	Q86SK9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable phospholipid-transporting ATPase ID
Reactions:	ATP + H2O + phospholipidin = ADP + phosphate + phospholipidout [RN:R00086]
Gene Name:	ATP8B2
Uniprot ID:	P98198
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lysophosphatidic acid phosphatase type 6
Reactions:	a phosphate monoester + H2O = an alcohol + phosphate [RN:R00626]
Gene Name:	ACP6
Uniprot ID:	Q9NPH0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	N-acylneuraminate-9-phosphatase
Reactions:	N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate [RN:R02597]
Gene Name:	NANP
Uniprot ID:	Q8TBE9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Gamma-glutamyltransferase 6
Reactions:	(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid [RN:R04159]
Gene Name:	GGT6
Uniprot ID:	Q6P531
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative uncharacterized protein DKFZp686B0215
Reactions:
Gene Name:	DKFZp686B0215
Uniprot ID:	Q5HYI4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Fumarate hydratase
Reactions:
Gene Name:	FH
Uniprot ID:	B1ANK7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Monofunctional C1-tetrahydrofolate synthase, mitochondrial
Reactions:	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate [RN:R00943]
Gene Name:	MTHFD1L
Uniprot ID:	Q6UB35
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Reactions:
Gene Name:	MTHFD2
Uniprot ID:	Q7Z650
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glycerophosphodiester phosphodiesterase 1
Reactions:	1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate [RN:R01193]
Gene Name:	GDE1
Uniprot ID:	Q9NZC3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable arylformamidase
Reactions:	N-formyl-L-kynurenine + H2O = formate + L-kynurenine [RN:R01959]
Gene Name:	AFMID
Uniprot ID:	Q63HM1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Multiple inositol polyphosphate phosphatase 1
Reactions:	myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate [RN:R07584]
Gene Name:	MINPP1
Uniprot ID:	Q9UNW1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein-tyrosine phosphatase mitochondrial 1
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPMT1
Uniprot ID:	Q8WUK0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-CoA synthetase family member 4
Reactions:
Gene Name:	AASDH
Uniprot ID:	Q4L235
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aminoadipate-semialdehyde synthase
Reactions:
Gene Name:	AASS
Uniprot ID:	A4D0W4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal NADH pyrophosphatase NUDT12
Reactions:	NAD+ + H2O = AMP + NMN [RN:R00103]
Gene Name:	NUDT12
Uniprot ID:	Q9BQG2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ribonucleoside-diphosphate reductase subunit M2 B
Reactions:	2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin [RN:R04294]
Gene Name:	RRM2B
Uniprot ID:	Q7LG56
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Inosine-5'-monophosphate dehydrogenase
Reactions:	inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+ [RN:R01130]
Gene Name:	IMPDH1
Uniprot ID:	A4D0Z6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450, family 1, subfamily A, polypeptide 1
Reactions:
Gene Name:	CYP1A1
Uniprot ID:	A0N0X8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleoside triphosphate diphosphohydrolase 8
Reactions:	ATP + 2 H2O = AMP + 2 phosphate [RN:R00085]
Gene Name:	ENTPD8
Uniprot ID:	Q5MY95
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP3CA
Uniprot ID:	Q08209
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP3CB
Uniprot ID:	P16298
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP3CC
Uniprot ID:	P48454
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase with EF-hands 1
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPEF1
Uniprot ID:	O14829
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase with EF-hands 2
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPEF2
Uniprot ID:	O14830
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein tyrosine phosphatase type IVA 3
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTP4A3
Uniprot ID:	O75365
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein prune homolog
Reactions:	diphosphate + H2O = 2 phosphate [RN:R00004]
Gene Name:	PRUNE
Uniprot ID:	Q86TP1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein phosphatase non-receptor type 7
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPN7
Uniprot ID:	P35236
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Prenylcysteine oxidase 1
Reactions:	an S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2 [RN:R07360]
Gene Name:	PCYOX1
Uniprot ID:	Q9UHG3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
Reactions:	[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate [RN:R03450]
Gene Name:	PDP2
Uniprot ID:	Q9P2J9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sulfhydryl oxidase 1
Reactions:	4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O [RN:R00057]
Gene Name:	QSOX1
Uniprot ID:	O00391
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sulfhydryl oxidase 2
Reactions:	4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O [RN:R00057]
Gene Name:	QSOX2
Uniprot ID:	Q6ZRP7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dynamin-1-like protein
Reactions:	GTP + H2O = GDP + phosphate [RN:R00335]
Gene Name:	DNM1L
Uniprot ID:	O00429
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dynamin-1
Reactions:	GTP + H2O = GDP + phosphate [RN:R00335]
Gene Name:	DNM1
Uniprot ID:	Q05193
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dynamin-2
Reactions:	GTP + H2O = GDP + phosphate [RN:R00335]
Gene Name:	DNM2
Uniprot ID:	P50570
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Elongation factor G, mitochondrial
Reactions:
Gene Name:	GFM1
Uniprot ID:	Q96RP9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ribosome-releasing factor 2, mitochondrial
Reactions:
Gene Name:	GFM2
Uniprot ID:	Q969S9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Elongation factor Tu, mitochondrial
Reactions:
Gene Name:	TUFM
Uniprot ID:	P49411
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Elongation factor Tu GTP-binding domain-containing protein 1
Reactions:
Gene Name:	EFTUD1
Uniprot ID:	Q7Z2Z2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ferritin heavy chain
Reactions:	4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O [RN:R00078]
Gene Name:	FTH1
Uniprot ID:	P02794
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable imidazolonepropionase
Reactions:	(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+ [RN:R02288]
Gene Name:	AMDHD1
Uniprot ID:	Q96NU7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP1CA
Uniprot ID:	P62136
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP2CB
Uniprot ID:	P62714
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase 4 catalytic subunit
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP4C
Uniprot ID:	P60510
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase 5
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP5C
Uniprot ID:	P53041
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase 6 catalytic subunit
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP6C
Uniprot ID:	O00743
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Enolase-phosphatase E1
Reactions:	(1) 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate (overall reaction) [RN:R07395] (2) (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (probably spontaneous) [RN:R07393] (3) (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate [RN:R07394]
Gene Name:	ENOPH1
Uniprot ID:	Q9UHY7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Eyes absent homolog 1
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	EYA1
Uniprot ID:	Q99502
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Eyes absent homolog 2
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	EYA2
Uniprot ID:	O00167
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Eyes absent homolog 3
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	EYA3
Uniprot ID:	Q99504
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sphingomyelin phosphodiesterase 4
Reactions:	sphingomyelin + H2O = N-acylsphingosine + choline phosphate [RN:R02541]
Gene Name:	SMPD4
Uniprot ID:	Q9NXE4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Diphosphoinositol polyphosphate phosphohydrolase 3-beta
Reactions:	diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate [RN:R05777]
Gene Name:	NUDT11
Uniprot ID:	Q96G61
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Diphosphoinositol polyphosphate phosphohydrolase 1
Reactions:	diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate [RN:R05777]
Gene Name:	NUDT3
Uniprot ID:	O95989
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Diphosphoinositol polyphosphate phosphohydrolase 2
Reactions:	diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate [RN:R05777]
Gene Name:	NUDT4
Uniprot ID:	Q9NZJ9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
Reactions:	[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate [RN:R03450]
Gene Name:	PDP1
Uniprot ID:	Q9P0J1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1A
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1A
Uniprot ID:	P35813
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1B
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1B
Uniprot ID:	O75688
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1D
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1D
Uniprot ID:	O15297
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1E
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1E
Uniprot ID:	Q8WY54
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1F
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1F
Uniprot ID:	P49593
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1G
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1G
Uniprot ID:	O15355
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1M
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1M
Uniprot ID:	Q96MI6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-like domain-containing CTD phosphatase 1
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	UBLCP1
Uniprot ID:	Q8WVY7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 18
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP18
Uniprot ID:	Q8NEJ0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	PH domain leucine-rich repeat-containing protein phosphatase 2
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PHLPP2
Uniprot ID:	Q6ZVD8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	PH domain leucine-rich repeat-containing protein phosphatase 1
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PHLPP1
Uniprot ID:	O60346
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase CDC14A
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	CDC14A
Uniprot ID:	Q9UNH5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase CDC14B
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	CDC14B
Uniprot ID:	O60729
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cyclin-dependent kinase inhibitor 3
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	CDKN3
Uniprot ID:	Q16667
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	RNA polymerase II subunit A C-terminal domain phosphatase
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	CTDP1
Uniprot ID:	Q9Y5B0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 10
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP10
Uniprot ID:	Q9Y6W6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 12
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP12
Uniprot ID:	Q9UNI6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 13
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP13
Uniprot ID:	Q9UII6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 16
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP16
Uniprot ID:	Q9BY84
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 19
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP19
Uniprot ID:	Q8WTR2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 1
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP1
Uniprot ID:	P28562
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 3
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP3
Uniprot ID:	P51452
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 4
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP4
Uniprot ID:	Q13115
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 5
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP5
Uniprot ID:	Q16690
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 6
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP6
Uniprot ID:	Q16828
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 7
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP7
Uniprot ID:	Q16829
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 8
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP8
Uniprot ID:	Q13202
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	M-phase inducer phosphatase 1
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	CDC25A
Uniprot ID:	P30304
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	M-phase inducer phosphatase 3
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	CDC25C
Uniprot ID:	P30307
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein phosphatase non-receptor type 11
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPN11
Uniprot ID:	Q06124
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein phosphatase non-receptor type 14
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPN14
Uniprot ID:	Q15678
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein phosphatase non-receptor type 18
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPN18
Uniprot ID:	Q99952
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein phosphatase non-receptor type 21
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPN21
Uniprot ID:	Q16825
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein phosphatase non-receptor type 22
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPN22
Uniprot ID:	Q9Y2R2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein phosphatase non-receptor type 2
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPN2
Uniprot ID:	P17706
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein phosphatase non-receptor type 3
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPN3
Uniprot ID:	P26045
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein phosphatase non-receptor type 4
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPN4
Uniprot ID:	P29074
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein phosphatase non-receptor type 9
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPN9
Uniprot ID:	P43378
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Receptor-type tyrosine-protein phosphatase N2
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPRN2
Uniprot ID:	Q92932
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Receptor-type tyrosine-protein phosphatase epsilon
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPRE
Uniprot ID:	P23469
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Receptor-type tyrosine-protein phosphatase F
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPRF
Uniprot ID:	P10586
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Receptor-type tyrosine-protein phosphatase gamma
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPRG
Uniprot ID:	P23470
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Receptor-type tyrosine-protein phosphatase eta
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPRJ
Uniprot ID:	Q12913
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Receptor-type tyrosine-protein phosphatase kappa
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPRK
Uniprot ID:	Q15262
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Receptor-type tyrosine-protein phosphatase O
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPRO
Uniprot ID:	Q16827
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Receptor-type tyrosine-protein phosphatase R
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPRR
Uniprot ID:	Q15256
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Receptor-type tyrosine-protein phosphatase U
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPRU
Uniprot ID:	Q92729
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Receptor-type tyrosine-protein phosphatase zeta
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPRZ1
Uniprot ID:	P23471
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein tyrosine phosphatase type IVA 1
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTP4A1
Uniprot ID:	Q93096
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein tyrosine phosphatase type IVA 2
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTP4A2
Uniprot ID:	Q12974
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative tyrosine-protein phosphatase TPTE
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	TPTE
Uniprot ID:	P56180
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytosolic phospholipase A2 beta
Reactions:	phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate [RN:R01313]
Gene Name:	PLA2G4B
Uniprot ID:	P0C869
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alkaline ceramidase 2
Reactions:	N-acylsphingosine + H2O = a carboxylate + sphingosine [RN:R01493]
Gene Name:	ACER2
Uniprot ID:	Q5QJU3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Deoxyhypusine hydroxylase
Reactions:	protein N6-(4-aminobutyl)-L-lysine + AH2 + O2 = protein N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine + A + H2O [RN:R04437]
Gene Name:	DOHH
Uniprot ID:	Q9BU89
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450, family 21, subfamily A, polypeptide 2
Reactions:
Gene Name:	CYP21A2
Uniprot ID:	Q08AG9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glucosamine-6-phosphate isomerase 2
Reactions:	D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3 [RN:R00765]
Gene Name:	GNPDA2
Uniprot ID:	Q8TDQ7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2D6
Reactions:
Gene Name:	CYP2D6
Uniprot ID:	Q6NWU0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	GGT7 protein
Reactions:
Gene Name:	GGT7
Uniprot ID:	A0PJJ9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Gamma-glutamyltransferase 5
Reactions:
Gene Name:	GGT5
Uniprot ID:	P36269
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phospholipase D1 variant
Reactions:
Gene Name:	Not Available
Uniprot ID:	Q59EA4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase kappa 1
Reactions:
Gene Name:	LOC51064
Uniprot ID:	Q6FII1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peptidoglycan recognition protein 3
Reactions:
Gene Name:	PGLYRP3
Uniprot ID:	Q96LB9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peptidoglycan recognition protein 4 (PGLYRP4 protein)
Reactions:
Gene Name:	PGLYRP4
Uniprot ID:	Q96LB8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hyaluronidase-1
Reactions:	Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate ALL_REAC (other) R07824(G) R07825(G)
Gene Name:	HYAL1
Uniprot ID:	Q12794
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
Reactions:
Gene Name:	SPAM1
Uniprot ID:	P38567
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hyaluronidase-2
Reactions:	Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate ALL_REAC (other) R07824(G) R07825(G)
Gene Name:	HYAL2
Uniprot ID:	Q12891
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NEU1 protein
Reactions:
Gene Name:	NEU1
Uniprot ID:	Q5JQI0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Testicular acid phosphatase
Reactions:	a phosphate monoester + H2O = an alcohol + phosphate [RN:R00626]
Gene Name:	ACPT
Uniprot ID:	Q9BZG2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 14
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP14
Uniprot ID:	O95147
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative uncharacterized protein DUSP15
Reactions:
Gene Name:	DUSP15
Uniprot ID:	Q9H1R2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
Reactions:
Gene Name:	PPP2R3B
Uniprot ID:	Q9Y5P8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	CTDSP1
Uniprot ID:	Q9GZU7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 21
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP21
Uniprot ID:	Q9H596
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative uncharacterized protein DKFZp686I0955
Reactions:
Gene Name:	DKFZp686I0955
Uniprot ID:	Q5HYC3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3, isoform CRA_c)
Reactions:
Gene Name:	TCIRG1
Uniprot ID:	Q13488
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V-type proton ATPase subunit e 2
Reactions:
Gene Name:	ATP6V0E2
Uniprot ID:	Q8NHE4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative uncharacterized protein ATP6V1E1
Reactions:
Gene Name:	ATP6V1E1
Uniprot ID:	P36543
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Vacuolar-type H(+)-ATPase
Reactions:
Gene Name:	Not Available
Uniprot ID:	Q53X12
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATPase, H+ transporting, lysosomal accessory protein 1 (ATPase, H+ transporting, lysosomal accessory protein 1, isoform CRA_d) (cDNA FLJ78461, highly similar to Homo sapiens ATPase, H+ transporting, lysosomal accessory protein 1 (ATP6AP1), mRNA) (Fragment
Reactions:
Gene Name:	ATP6AP1
Uniprot ID:	Q15904
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
Reactions:
Gene Name:	ATP6V1F
Uniprot ID:	A4D1K0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	CP protein
Reactions:
Gene Name:	CP
Uniprot ID:	A5PL27
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbonic anhydrase 6
Reactions:	H2CO3 = CO2 + H2O [RN:R00132]
Gene Name:	CA6
Uniprot ID:	P23280
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein tyrosine phosphatase domain-containing protein 1
Reactions:
Gene Name:	PTPDC1
Uniprot ID:	A2A3K4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein tyrosine phosphatase receptor type D
Reactions:
Gene Name:	PTPRD
Uniprot ID:	Q2HXI4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Receptor-type tyrosine-protein phosphatase H
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPRH
Uniprot ID:	Q9HD43
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	PTPRM protein
Reactions:
Gene Name:	PTPRM
Uniprot ID:	A7MBN1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Receptor-type tyrosine-protein phosphatase-like N
Reactions:
Gene Name:	PTPRN
Uniprot ID:	Q16849
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein tyrosine phosphatase, receptor type, sigma isoform 3 variant
Reactions:
Gene Name:	Not Available
Uniprot ID:	Q59FX6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carboxylesterase 7
Reactions:	a carboxylic ester + H2O = an alcohol + a carboxylate [RN:R00630]
Gene Name:	CES7
Uniprot ID:	Q6NT32
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxiredoxin-4
Reactions:	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH [RN:R07180]
Gene Name:	PRDX4
Uniprot ID:	Q13162
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carboxymethylenebutenolidase homolog
Reactions:
Gene Name:	CMBL
Uniprot ID:	Q96DG6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 16
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP16
Uniprot ID:	Q9Y5T5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	STAM-binding protein
Reactions:
Gene Name:	STAMBP
Uniprot ID:	O95630
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase
Reactions:	ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol [RN:R02418]
Gene Name:	Em:AC008079.1
Uniprot ID:	Q53Y90
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 51
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP51
Uniprot ID:	Q70EK9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 33
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP33
Uniprot ID:	Q8TEY7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 22
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP22
Uniprot ID:	Q9UPT9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 47
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP47
Uniprot ID:	Q96K76
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 40
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP40
Uniprot ID:	Q9NVE5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 35
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP35
Uniprot ID:	Q9P2H5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 36
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP36
Uniprot ID:	Q9P275
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 29
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP29
Uniprot ID:	Q9HBJ7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 46
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP46
Uniprot ID:	P62068
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase
Reactions:	ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol [RN:R02418]
Gene Name:	USP4
Uniprot ID:	Q08AK7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 1
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP1
Uniprot ID:	O94782
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 7
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP7
Uniprot ID:	Q93009
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 5
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP5
Uniprot ID:	P45974
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable ubiquitin carboxyl-terminal hydrolase FAF-X
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP9X
Uniprot ID:	Q93008
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable ubiquitin carboxyl-terminal hydrolase FAF-Y
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP9Y
Uniprot ID:	O00507
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 26
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP26
Uniprot ID:	Q9BXU7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase
Reactions:	ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol [RN:R02418]
Gene Name:	USP42
Uniprot ID:	Q9H9J4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 32
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP32
Uniprot ID:	Q8NFA0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 30
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP30
Uniprot ID:	Q70CQ3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 13
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP13
Uniprot ID:	Q92995
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase
Reactions:	ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol [RN:R02418]
Gene Name:	USP14
Uniprot ID:	A6NJA2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 6
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP6
Uniprot ID:	P35125
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 10
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP10
Uniprot ID:	Q14694
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 8
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP8
Uniprot ID:	P40818
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 15
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP15
Uniprot ID:	Q9Y4E8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 3
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP3
Uniprot ID:	Q9Y6I4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lysozyme-like protein 1
Reactions:	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Gene Name:	LYZL1
Uniprot ID:	Q6UWQ5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pterin-4-alpha-carbinolamine dehydratase 2
Reactions:	(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a- hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O [RN:R04734]
Gene Name:	PCBD2
Uniprot ID:	Q9H0N5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NOS1 mutant
Reactions:
Gene Name:	NOS1
Uniprot ID:	B3VK56
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative uncharacterized protein ACP1
Reactions:
Gene Name:	ACP1
Uniprot ID:	B5MCC7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP2CA
Uniprot ID:	B3KUN1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	[Protein ADP-ribosylarginine] hydrolase
Reactions:	(1) protein-Nomega-(ADP-D-ribosyl)-L-arginine + H2O = ADP-ribose + protein-L-arginine [RN:R07626] (2) Nomega-(ADP-D-ribosyl)-L-arginine + H2O = ADP-ribose + L-arginine [RN:R01886]
Gene Name:	ADPRH
Uniprot ID:	P54922
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aquaporin-1
Reactions:
Gene Name:	AQP1
Uniprot ID:	P29972
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aquaporin-4
Reactions:
Gene Name:	AQP4
Uniprot ID:	P55087
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aquaporin-10
Reactions:
Gene Name:	AQP10
Uniprot ID:	Q96PS8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbonic anhydrase-related protein
Reactions:
Gene Name:	CA8
Uniprot ID:	P35219
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 11
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP11
Uniprot ID:	P51784
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 38
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP38
Uniprot ID:	Q8NB14
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Reactions:
Gene Name:	AASDHPPT
Uniprot ID:	Q9NRN7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 21
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP21
Uniprot ID:	Q9UK80
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 37
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP37
Uniprot ID:	Q86T82
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein phosphatase non-receptor type 23
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	PTPN23
Uniprot ID:	Q9H3S7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 2
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP2
Uniprot ID:	O75604
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 28
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP28
Uniprot ID:	Q96RU2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione S-transferase theta-2
Reactions:	RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512]
Gene Name:	GSTT2
Uniprot ID:	P0CG29
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 20
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP20
Uniprot ID:	Q9Y2K6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	S-acyl fatty acid synthase thioesterase, medium chain
Reactions:	an oleoyl-[acyl-carrier protein] + H2O = an [acyl-carrier protein] + oleate [RN:R02814]
Gene Name:	OLAH
Uniprot ID:	Q9NV23
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carboxyl-terminal hydrolase 25
Reactions:	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Gene Name:	USP25
Uniprot ID:	Q9UHP3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Transporters

Name:	Copper-transporting ATPase 2
Reactions:	ATP + H2O + Cu2+in = ADP + phosphate + Cu2+out [RN:R00086]
Gene Name:	ATP7B
Uniprot ID:	P35670
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Copper-transporting ATPase 1
Reactions:	ATP + H2O + Cu2+in = ADP + phosphate + Cu2+out [RN:R00086]
Gene Name:	ATP7A
Uniprot ID:	Q04656
Protein Sequence:	FASTA
Gene Sequence:	FASTA