Human Metabolome Database Version 3.5

HMDB has recently undergone some major changes, if you are experiencing problems please click here to provide us with feedback.

Showing metabocard for Phosphoric acid (HMDB02142)

enzymes (247)

Blood
Urine

Record Information

Version

3.5

Creation Date

2006-05-22 08:17:38 -0600

Update Date

2013-04-24 11:56:44 -0600

HMDB ID

HMDB02142

Secondary Accession Numbers

None

Metabolite Identification

Common Name

Phosphoric acid

Description

Phosphoric acid, also known as orthophosphoric acid or phosphoric(V) acid, is a mineral acid with the chemical formula H3PO4. Alternatively, orthophosphoric acid molecules can combine with themselves to form a variety of compounds referred to as phosphoric acids in a more general way. For a discussion of these, see Phosphoric acids and Phosphates. Appears to exist only as a food additive and produced synthetically. --Wikipedia.

Structure

Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure

Synonyms

Acide phosphorique (FRENCH)
Acido fosforico [Italian]
Acidum phosphoricum
Diphosphate tetrasodium
Fosforzuuroplossingen [Dutch]
Marphos
NFB
Ortho- phosphoric acid
Orthophosphoric acid
Phosphoric acid (ACD/Name 4.0)
Phosphorsaeure
Phosphorsaeureloesungen [German]
Sodium Pyrophosphate
Sodium pyrophosphate decahydrate
Sodium pyrophosphate decahydrate BioChemica
Sonac
Tetra-Sodium pyrophosphate
Tetrasodium pyrophosphate 10-hydrate
Tetrasodium Pyrophosphate Decahydrate
White phosphoric acid

Chemical Formula

H₃O₄P

Average Molecular Weight

97.9952

Monoisotopic Molecular Weight

97.976895096

IUPAC Name

phosphoric acid

Traditional IUPAC Name

phosphoric acid

CAS Registry Number

7664-38-2

SMILES

OP(O)(O)=O

InChI Identifier

InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)

InChI Key

NBIIXXVUZAFLBC-UHFFFAOYSA-N

Chemical Taxonomy

Kingdom

Inorganic Compounds

Super Class

Homogeneous Non-metal Compounds

Class

Non-metal Oxoanionic Compounds

Sub Class

Non-metal Phosphates

Other Descriptors

phosphoric acids(ChEBI)

Substituents

Direct Parent

Non-metal Phosphates

Ontology

Status

Detected and Quantified

Origin

Endogenous

Biofunction

Osmolyte, enzyme cofactor, signalling

Application

Not Available

Cellular locations

Cytoplasm (predicted from logP)

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	42.35 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	-1.436	Not Available

Predicted Properties

Property	Value	Source
Water Solubility		ALOGPS
LogP	-1	ChemAxon
pKa (strongest acidic)	1.8	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	77.76 A²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	14.65	ChemAxon
Polarizability	5.81	ChemAxon
Formal Charge	0	ChemAxon
Physiological Charge	-2	ChemAxon

Spectra

Gas-MS Spectrum

MS/MS Spectrum Quattro_QQQ 10

MS/MS Spectrum Quattro_QQQ 25

MS/MS Spectrum Quattro_QQQ 40

MS/MS Spectrum GC-MS

Biological Properties

Cellular Locations

Cytoplasm (predicted from logP)

Biofluid Locations

Blood
Urine

Tissue Location

Not Available

Pathways

Not Available

Normal Concentrations

Biofluid	Status	Value	Age	Sex	Condition	Comments
Blood	Detected and Quantified	820.4 uM	Adult (>18 years old)	Not Specified	Normal	Not Available
Blood	Detected and Quantified	1100.0 (810.0-1450.0) uM	Adult (>18 years old)	Both	Normal	Not Available
Urine	Detected and Quantified	784 (425-1170) umol/mmol creatinine	Adult (>18 years old)	Both	Normal	Urine compound detected by GC-MS
Urine	Detected and Quantified	1000-4900 umol/mmol creatinine	Adult (>18 years old)	Both	Normal	Not Available

Abnormal Concentrations

Not Available

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

Phenol Explorer Metabolite ID

Not Available

FoodDB ID

FDB013380

KNApSAcK ID

Not Available

Chemspider ID

979

KEGG Compound ID

C00009

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Phosphoric acid Link_out

NuGOwiki Link

HMDB02142

Metagene Link

HMDB02142

METLIN ID

Not Available

PubChem Compound

1004

PDB ID

Not Available

ChEBI ID

26078

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Faiman C, Moorhouse JA: Diurnal variation in the levels of glucose and related substances in healthy and diabetic subjects during starvation. Clin Sci. 1967 Feb;32(1):111-26. Pubmed: 5336272

Enzymes

Name:	Acetyl-coenzyme A synthetase 2-like, mitochondrial
Reactions:	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA [RN:R00235]
Gene Name:	ACSS1
Uniprot ID:	Q9NUB1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serum paraoxonase/lactonase 3
Reactions:	an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol [RN:R03979]
Gene Name:	PON3
Uniprot ID:	Q15166
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Fucose-1-phosphate guanylyltransferase
Reactions:	GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose [RN:R01951]
Gene Name:	FPGT
Uniprot ID:	O14772
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Squalene synthase
Reactions:	(1) (1a) 2 farnesyl diphosphate = diphosphate + presqualene diphosphate [RN:R00702] (2) (1b) presqualene diphosphate + NAD(P)H + H+ = squalene + diphosphate + NAD(P)+ [RN:R02872]
Gene Name:	FDFT1
Uniprot ID:	P37268
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phenylalanyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe [RN:R03660]
Gene Name:	FARS2
Uniprot ID:	O95363
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nicotinamide mononucleotide adenylyltransferase 1
Reactions:	ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+ [RN:R03005]
Gene Name:	NMNAT1
Uniprot ID:	Q9HAN9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nicotinamide mononucleotide adenylyltransferase 3
Reactions:	ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+ [RN:R03005]
Gene Name:	NMNAT3
Uniprot ID:	Q96T66
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Reactions:	nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R03348]
Gene Name:	QPRT
Uniprot ID:	Q15274
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nicotinamide mononucleotide adenylyltransferase 2
Reactions:	ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+ [RN:R03005]
Gene Name:	NMNAT2
Uniprot ID:	Q9BZQ4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Reactions:	ATP + sulfate = diphosphate + adenylyl sulfate [RN:R00529]
Gene Name:	PAPSS1
Uniprot ID:	O43252
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Reactions:	ATP + sulfate = diphosphate + adenylyl sulfate [RN:R00529]
Gene Name:	PAPSS2
Uniprot ID:	O95340
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	N-acylneuraminate cytidylyltransferase
Reactions:	CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate [RN:R02599]
Gene Name:	CMAS
Uniprot ID:	Q8NFW8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	S-adenosylmethionine synthase isoform type-1
Reactions:	ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine [RN:R00177]
Gene Name:	MAT1A
Uniprot ID:	Q00266
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Inosine triphosphate pyrophosphatase
Reactions:	a nucleoside triphosphate + H2O = a nucleotide + diphosphate [RN:R01532]
Gene Name:	ITPA
Uniprot ID:	Q9BY32
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Reactions:	dUTP + H2O = dUMP + diphosphate [RN:R02100]
Gene Name:	DUT
Uniprot ID:	P33316
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenine phosphoribosyltransferase
Reactions:	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R00190]
Gene Name:	APRT
Uniprot ID:	P07741
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hypoxanthine-guanine phosphoribosyltransferase
Reactions:	IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01132]
Gene Name:	HPRT1
Uniprot ID:	P00492
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Biotin--protein ligase
Reactions:	ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)] [RN:R04562]
Gene Name:	HLCS
Uniprot ID:	P50747
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phenylalanyl-tRNA synthetase beta chain
Reactions:	ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe [RN:R03660]
Gene Name:	FARSB
Uniprot ID:	Q9NSD9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 A
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2A
Uniprot ID:	P49459
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NEDD8-conjugating enzyme Ubc12
Reactions:
Gene Name:	UBE2M
Uniprot ID:	P61081
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin/ISG15-conjugating enzyme E2 L6
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2L6
Uniprot ID:	O14933
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glycyl-tRNA synthetase
Reactions:	ATP + glycine + tRNAGly = AMP + diphosphate + glycyl-tRNAGly [RN:R03654]
Gene Name:	GARS
Uniprot ID:	P41250
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bifunctional aminoacyl-tRNA synthetase
Reactions:	ATP + L-glutamate + tRNAGlu = AMP + diphosphate + L-glutamyl-tRNAGlu [RN:R05578]
Gene Name:	EPRS
Uniprot ID:	P07814
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Long-chain-fatty-acid--CoA ligase 4
Reactions:	ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name:	ACSL4
Uniprot ID:	O60488
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tryptophanyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-tryptophan + tRNATrp = AMP + diphosphate + L-tryptophyl-tRNATrp [RN:R03664]
Gene Name:	WARS
Uniprot ID:	P23381
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Long-chain-fatty-acid--CoA ligase 1
Reactions:	ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name:	ACSL1
Uniprot ID:	P33121
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 G1
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2G1
Uniprot ID:	P62253
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutaminyl-tRNA synthetase
Reactions:	ATP + L-glutamine + tRNAGln = AMP + diphosphate + L-glutaminyl-tRNAGln [RN:R03652]
Gene Name:	QARS
Uniprot ID:	P47897
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Threonyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-threonine + tRNAThr = AMP + diphosphate + L-threonyl-tRNAThr [RN:R03663]
Gene Name:	TARS
Uniprot ID:	P26639
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Asparagine synthetase [glutamine-hydrolyzing]
Reactions:	(1) ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate [RN:R00578] (2) (1a) L-glutamine + H2O = L-glutamate + NH3 [RN:R00256] (3) (1b) ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine [RN:R00483]
Gene Name:	ASNS
Uniprot ID:	P08243
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 E2
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2E2
Uniprot ID:	Q96LR5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 D2
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2D2
Uniprot ID:	P62837
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA ligase 4
Reactions:	ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m [RN:R00381]
Gene Name:	LIG4
Uniprot ID:	P49917
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Arginyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-arginine + tRNAArg = AMP + diphosphate + L-arginyl-tRNAArg [RN:R03646]
Gene Name:	RARS
Uniprot ID:	P54136
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 E3
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2E3
Uniprot ID:	Q969T4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 B
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2B
Uniprot ID:	P63146
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable leucyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-leucine + tRNALeu = AMP + diphosphate + L-leucyl-tRNALeu [RN:R03657]
Gene Name:	LARS2
Uniprot ID:	Q15031
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 J2
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2J2
Uniprot ID:	Q8N2K1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 L3
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2L3
Uniprot ID:	P68036
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	RNA 3'-terminal phosphate cyclase
Reactions:	ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate [RN:R04274]
Gene Name:	RTCD1
Uniprot ID:	O00442
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-tyrosine + tRNATyr = AMP + diphosphate + L-tyrosyl-tRNATyr [RN:R02918]
Gene Name:	YARS
Uniprot ID:	P54577
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA ligase 3
Reactions:	ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m [RN:R00381]
Gene Name:	LIG3
Uniprot ID:	P49916
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aspartyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp [RN:R05577]
Gene Name:	DARS
Uniprot ID:	P14868
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 D3
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2D3
Uniprot ID:	P61077
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Asparaginyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-asparagine + tRNAAsn = AMP + diphosphate + L-asparaginyl-tRNAAsn [RN:R03648]
Gene Name:	NARS
Uniprot ID:	O43776
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lysyl-tRNA synthetase
Reactions:	ATP + L-lysine + tRNALys = AMP + diphosphate + L-lysyl-tRNALys [RN:R03658]
Gene Name:	KARS
Uniprot ID:	Q15046
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Isoleucyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle [RN:R03656]
Gene Name:	IARS
Uniprot ID:	P41252
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-like modifier-activating enzyme 1
Reactions:
Gene Name:	UBA1
Uniprot ID:	P22314
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-tyrosine + tRNATyr = AMP + diphosphate + L-tyrosyl-tRNATyr [RN:R02918]
Gene Name:	YARS2
Uniprot ID:	Q9Y2Z4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 E1
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2E1
Uniprot ID:	P51965
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Long-chain-fatty-acid--CoA ligase 6
Reactions:	ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name:	ACSL6
Uniprot ID:	Q9UKU0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Methionyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet [RN:R03659]
Gene Name:	MARS
Uniprot ID:	P56192
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alanyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-alanine + tRNAAla = AMP + diphosphate + L-alanyl-tRNAAla [RN:R03038]
Gene Name:	AARS
Uniprot ID:	P49588
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tryptophanyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-tryptophan + tRNATrp = AMP + diphosphate + L-tryptophyl-tRNATrp [RN:R03664]
Gene Name:	WARS2
Uniprot ID:	Q9UGM6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ribose-phosphate pyrophosphokinase 1
Reactions:	ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01049]
Gene Name:	PRPS1
Uniprot ID:	P60891
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Seryl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer [RN:R03662]
Gene Name:	SARS2
Uniprot ID:	Q9NP81
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ribose-phosphate pyrophosphokinase 2
Reactions:	ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01049]
Gene Name:	PRPS2
Uniprot ID:	P11908
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	SUMO-conjugating enzyme UBC9
Reactions:
Gene Name:	UBE2I
Uniprot ID:	P63279
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable histidyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis [RN:R03655]
Gene Name:	HARS2
Uniprot ID:	P49590
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 J1
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2J1
Uniprot ID:	Q9Y385
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Long-chain-fatty-acid--CoA ligase 5
Reactions:	ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name:	ACSL5
Uniprot ID:	Q9ULC5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Histidyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis [RN:R03655]
Gene Name:	HARS
Uniprot ID:	P12081
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Seryl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer [RN:R03662]
Gene Name:	SARS
Uniprot ID:	P49591
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Long-chain-fatty-acid--CoA ligase 3
Reactions:	ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name:	ACSL3
Uniprot ID:	O95573
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Leucyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-leucine + tRNALeu = AMP + diphosphate + L-leucyl-tRNALeu [RN:R03657]
Gene Name:	LARS
Uniprot ID:	Q9P2J5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 C
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2C
Uniprot ID:	O00762
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Valyl-tRNA synthetase
Reactions:	ATP + L-valine + tRNAVal = AMP + diphosphate + L-valyl-tRNAVal [RN:R03665]
Gene Name:	VARS
Uniprot ID:	P26640
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 N
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2N
Uniprot ID:	P61088
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Argininosuccinate synthase
Reactions:	ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate [RN:R01954]
Gene Name:	ASS1
Uniprot ID:	P00966
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA ligase 1
Reactions:	ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m [RN:R00381]
Gene Name:	LIG1
Uniprot ID:	P18858
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylate cyclase type 7
Reactions:	ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
Gene Name:	ADCY7
Uniprot ID:	P51828
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylate cyclase type 4
Reactions:	ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
Gene Name:	ADCY4
Uniprot ID:	Q8NFM4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylate cyclase type 6
Reactions:	ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
Gene Name:	ADCY6
Uniprot ID:	O43306
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylate cyclase type 5
Reactions:	ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
Gene Name:	ADCY5
Uniprot ID:	O95622
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylate cyclase type 8
Reactions:	ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
Gene Name:	ADCY8
Uniprot ID:	P40145
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylate cyclase type 9
Reactions:	ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
Gene Name:	ADCY9
Uniprot ID:	O60503
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylate cyclase type 3
Reactions:	ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
Gene Name:	ADCY3
Uniprot ID:	O60266
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylate cyclase type 1
Reactions:	ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
Gene Name:	ADCY1
Uniprot ID:	Q08828
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Choline-phosphate cytidylyltransferase B
Reactions:	CTP + choline phosphate = diphosphate + CDP-choline [RN:R01890]
Gene Name:	PCYT1B
Uniprot ID:	Q9Y5K3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA-directed RNA polymerase III subunit RPC4
Reactions:
Gene Name:	POLR3D
Uniprot ID:	P05423
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA-directed RNA polymerase II subunit RPB1
Reactions:	nucleoside triphosphate + RNAn = diphosphate + RNAn+1 [RN:R00444]
Gene Name:	POLR2A
Uniprot ID:	P24928
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA-directed RNA polymerase, mitochondrial
Reactions:	nucleoside triphosphate + RNAn = diphosphate + RNAn+1 [RN:R00444]
Gene Name:	POLRMT
Uniprot ID:	O00411
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA-directed RNA polymerase I subunit RPA2
Reactions:	nucleoside triphosphate + RNAn = diphosphate + RNAn+1 [RN:R00444]
Gene Name:	POLR1B
Uniprot ID:	Q9H9Y6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphatidate cytidylyltransferase 2
Reactions:	CTP + phosphatidate = diphosphate + CDP-diacylglycerol [RN:R01799]
Gene Name:	CDS2
Uniprot ID:	O95674
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Choline-phosphate cytidylyltransferase A
Reactions:	CTP + choline phosphate = diphosphate + CDP-choline [RN:R01890]
Gene Name:	PCYT1A
Uniprot ID:	P49585
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA-directed RNA polymerase I subunit RPA49
Reactions:
Gene Name:	POLR1E
Uniprot ID:	Q9GZS1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA-directed RNA polymerase III subunit RPC8
Reactions:
Gene Name:	POLR3H
Uniprot ID:	Q9Y535
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA-directed RNA polymerase III subunit RPC10
Reactions:
Gene Name:	POLR3K
Uniprot ID:	Q9Y2Y1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphatidate cytidylyltransferase 1
Reactions:	CTP + phosphatidate = diphosphate + CDP-diacylglycerol [RN:R01799]
Gene Name:	CDS1
Uniprot ID:	Q92903
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylate cyclase type 2
Reactions:	ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
Gene Name:	ADCY2
Uniprot ID:	Q08462
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Geranylgeranyl pyrophosphate synthase
Reactions:	trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate [RN:R02061]
Gene Name:	GGPS1
Uniprot ID:	O95749
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Farnesyl pyrophosphate synthase
Reactions:	geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate [RN:R02003]
Gene Name:	FDPS
Uniprot ID:	P14324
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase beta
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLB
Uniprot ID:	P06746
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase alpha catalytic subunit
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLA1
Uniprot ID:	P09884
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase lambda
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLL
Uniprot ID:	Q9UGP5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase epsilon subunit 4
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLE4
Uniprot ID:	Q9NR33
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase eta
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLH
Uniprot ID:	Q9Y253
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase delta catalytic subunit
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLD1
Uniprot ID:	P28340
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase zeta catalytic subunit
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	REV3L
Uniprot ID:	O60673
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase epsilon catalytic subunit A
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLE
Uniprot ID:	Q07864
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase mu
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLM
Uniprot ID:	Q9NP87
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase kappa
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLK
Uniprot ID:	Q9UBT6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase epsilon subunit 3
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLE3
Uniprot ID:	Q9NRF9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase subunit gamma-1
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLG
Uniprot ID:	P54098
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase iota
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLI
Uniprot ID:	Q9UNA4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase epsilon subunit 2
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLE2
Uniprot ID:	P56282
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Atrial natriuretic peptide receptor 2
Reactions:	GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Gene Name:	NPR2
Uniprot ID:	P20594
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Guanylate cyclase soluble subunit beta-1
Reactions:	GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Gene Name:	GUCY1B3
Uniprot ID:	Q02153
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retinal guanylyl cyclase 1
Reactions:	GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Gene Name:	GUCY2D
Uniprot ID:	Q02846
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Guanylate cyclase soluble subunit alpha-3
Reactions:	GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Gene Name:	GUCY1A3
Uniprot ID:	Q02108
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Atrial natriuretic peptide receptor 1
Reactions:	GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Gene Name:	NPR1
Uniprot ID:	P16066
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Heat-stable enterotoxin receptor
Reactions:	GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Gene Name:	GUCY2C
Uniprot ID:	P25092
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Inorganic pyrophosphatase
Reactions:	diphosphate + H2O = 2 phosphate [RN:R00004]
Gene Name:	PPA1
Uniprot ID:	Q15181
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Guanylate cyclase soluble subunit alpha-2
Reactions:	GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Gene Name:	GUCY1A2
Uniprot ID:	P33402
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	UTP--glucose-1-phosphate uridylyltransferase
Reactions:	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose [RN:R00289]
Gene Name:	UGP2
Uniprot ID:	Q16851
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA nucleotidylexotransferase
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	DNTT
Uniprot ID:	P04053
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retinal guanylyl cyclase 2
Reactions:	GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Gene Name:	GUCY2F
Uniprot ID:	P51841
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Poly(A) polymerase alpha
Reactions:	ATP + RNAn = diphosphate + RNAn+1 [RN:R00435]
Gene Name:	PAPOLA
Uniprot ID:	P51003
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	UDP-N-acetylhexosamine pyrophosphorylase
Reactions:	UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-glucosamine [RN:R00416]
Gene Name:	UAP1
Uniprot ID:	Q16222
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	mRNA-capping enzyme
Reactions:	a 5'-phosphopolynucleotide + H2O = a polynucleotide + phosphate [RN:R02249]
Gene Name:	RNGTT
Uniprot ID:	O60942
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Poly(A) polymerase gamma
Reactions:	ATP + RNAn = diphosphate + RNAn+1 [RN:R00435]
Gene Name:	PAPOLG
Uniprot ID:	Q9BWT3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bifunctional coenzyme A synthase
Reactions:	ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA [RN:R03035]
Gene Name:	COASY
Uniprot ID:	Q13057
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase NEDD4-like
Reactions:
Gene Name:	NEDD4L
Uniprot ID:	Q96PU5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase Mdm2
Reactions:
Gene Name:	MDM2
Uniprot ID:	Q00987
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Telomerase reverse transcriptase
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	TERT
Uniprot ID:	O14746
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphopantothenoylcysteine synthetase
Reactions:	--- - CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine [RN:R04231]
Gene Name:	PPCS
Uniprot ID:	Q9HAB8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bile acyl-CoA synthetase
Reactions:	(1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA [RN:R02794] (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA [RN:R04580]
Gene Name:	SLC27A5
Uniprot ID:	Q9Y2P5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutamine-dependent NAD(+) synthetase
Reactions:	ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate [RN:R00257]
Gene Name:	NADSYN1
Uniprot ID:	Q6IA69
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Methionine adenosyltransferase 2 subunit beta
Reactions:
Gene Name:	MAT2B
Uniprot ID:	Q9NZL9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acetoacetyl-CoA synthetase
Reactions:	ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA [RN:R01357]
Gene Name:	AACS
Uniprot ID:	Q86V21
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-coenzyme A synthetase ACSM1, mitochondrial
Reactions:	ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
Gene Name:	ACSM1
Uniprot ID:	Q08AH1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Inorganic pyrophosphatase 2, mitochondrial
Reactions:	diphosphate + H2O = 2 phosphate [RN:R00004]
Gene Name:	PPA2
Uniprot ID:	Q9H2U2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable arginyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-arginine + tRNAArg = AMP + diphosphate + L-arginyl-tRNAArg [RN:R03646]
Gene Name:	RARS2
Uniprot ID:	Q5T160
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable cysteinyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-cysteine + tRNACys = AMP + diphosphate + L-cysteinyl-tRNACys [RN:R03650]
Gene Name:	CARS2
Uniprot ID:	Q9HA77
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable glutamyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-glutamate + tRNAGlu = AMP + diphosphate + L-glutamyl-tRNAGlu [RN:R05578]
Gene Name:	EARS2
Uniprot ID:	Q5JPH6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-CoA synthetase family member 4
Reactions:
Gene Name:	AASDH
Uniprot ID:	Q4L235
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ACSS2 protein
Reactions:
Gene Name:	ACSS2
Uniprot ID:	Q96FY7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	FAD synthase
Reactions:	ATP + FMN = diphosphate + FAD [RN:R00161]
Gene Name:	FLAD1
Uniprot ID:	Q8NFF5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Valyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-valine + tRNAVal = AMP + diphosphate + L-valyl-tRNAVal [RN:R03665]
Gene Name:	VARS2
Uniprot ID:	Q5ST30
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase CBL
Reactions:	--- []
Gene Name:	CBL
Uniprot ID:	P22681
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Signal transduction protein CBL-C
Reactions:
Gene Name:	CBLC
Uniprot ID:	Q9ULV8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable E3 ubiquitin-protein ligase HERC1
Reactions:
Gene Name:	HERC1
Uniprot ID:	Q15751
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase HERC2
Reactions:
Gene Name:	HERC2
Uniprot ID:	O95714
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nuclear respiratory factor 1
Reactions:
Gene Name:	NRF1
Uniprot ID:	Q16656
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nicotinamide phosphoribosyltransferase
Reactions:	nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01271]
Gene Name:	NAMPT
Uniprot ID:	P43490
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable threonyl-tRNA synthetase 2, cytoplasmic
Reactions:	ATP + L-threonine + tRNAThr = AMP + diphosphate + L-threonyl-tRNAThr [RN:R03663]
Gene Name:	TARSL2
Uniprot ID:	A2RTX5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Threonyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-threonine + tRNAThr = AMP + diphosphate + L-threonyl-tRNAThr [RN:R03663]
Gene Name:	TARS2
Uniprot ID:	Q9BW92
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Methionyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet [RN:R03659]
Gene Name:	MARS2
Uniprot ID:	Q96GW9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aspartyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp [RN:R05577]
Gene Name:	DARS2
Uniprot ID:	Q6PI48
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cysteinyl-tRNA synthetase, isoform CRA_e
Reactions:	--- - ATP + L-cysteine + tRNACys = AMP + diphosphate + L-cysteinyl-tRNACys [RN:R03650]
Gene Name:	DKFZp686F1612
Uniprot ID:	P49589
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	FARSLA protein
Reactions:
Gene Name:	FARSLA
Uniprot ID:	Q6IBR2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable asparaginyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-asparagine + tRNAAsn = AMP + diphosphate + L-asparaginyl-tRNAAsn [RN:R03648]
Gene Name:	NARS2
Uniprot ID:	Q96I59
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	SUMO-activating enzyme subunit 2
Reactions:
Gene Name:	UBA2
Uniprot ID:	Q9UBT2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase HUWE1
Reactions:
Gene Name:	HUWE1
Uniprot ID:	Q7Z6Z7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase Topors
Reactions:
Gene Name:	TOPORS
Uniprot ID:	Q9NS56
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	STIP1 homology and U-box containing protein 1 (STIP1 homology and U- box containing protein 1, isoform CRA_c)
Reactions:
Gene Name:	STUB1
Uniprot ID:	Q9UNE7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin conjugation factor E4 B
Reactions:
Gene Name:	UBE4B
Uniprot ID:	O95155
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Membrane-associated ring finger (C3HC4) 6 (Membrane-associated ring finger (C3HC4) 6, isoform CRA_a)
Reactions:
Gene Name:	MARCH6
Uniprot ID:	O60337
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	TGIF-interacting ubiquitin ligase 1
Reactions:
Gene Name:	Not Available
Uniprot ID:	Q9H0M0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NEDD4-like E3 ubiquitin-protein ligase WWP2
Reactions:
Gene Name:	WWP2
Uniprot ID:	O00308
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH3
Reactions:
Gene Name:	MARCH3
Uniprot ID:	Q86UD3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NEDD8-conjugating enzyme UBE2F
Reactions:
Gene Name:	UBE2F
Uniprot ID:	Q969M7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 U
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2U
Uniprot ID:	Q5VVX9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable E3 ubiquitin-protein ligase MARCH10
Reactions:
Gene Name:	MARCH10
Uniprot ID:	Q8NA82
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase UBR1
Reactions:
Gene Name:	UBR1
Uniprot ID:	Q8IWV7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH8
Reactions:
Gene Name:	MARCH8
Uniprot ID:	Q5T0T0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase ZNRF2
Reactions:
Gene Name:	ZNRF2
Uniprot ID:	Q8NHG8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase TRIM32
Reactions:
Gene Name:	TRIM32
Uniprot ID:	Q13049
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable E3 ubiquitin-protein ligase MYCBP2
Reactions:
Gene Name:	MYCBP2
Uniprot ID:	O75592
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MGRN1
Reactions:
Gene Name:	MGRN1
Uniprot ID:	O60291
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase UBR2
Reactions:
Gene Name:	UBR2
Uniprot ID:	Q8IWV8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase UBR4
Reactions:
Gene Name:	UBR4
Uniprot ID:	Q5T4S7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase AMFR
Reactions:
Gene Name:	AMFR
Uniprot ID:	Q9UKV5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 S
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2S
Uniprot ID:	Q16763
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pre-mRNA-processing factor 19
Reactions:
Gene Name:	PRPF19
Uniprot ID:	Q9UMS4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Myosin regulatory light chain interacting protein (Myosin regulatory light chain interacting protein, isoform CRA_a)
Reactions:
Gene Name:	MYLIP
Uniprot ID:	Q8WY64
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	HNP95
Reactions:
Gene Name:	hNp95
Uniprot ID:	Q96T88
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative ubiquitin-conjugating enzyme E2 N-like
Reactions:
Gene Name:	UBE2NL
Uniprot ID:	Q5JXB2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Midline-1
Reactions:
Gene Name:	MID1
Uniprot ID:	O15344
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase NEDD4
Reactions:
Gene Name:	NEDD4
Uniprot ID:	P46934
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	CCR4-NOT transcription complex subunit 4
Reactions:
Gene Name:	CNOT4
Uniprot ID:	O95628
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH2
Reactions:
Gene Name:	MARCH2
Uniprot ID:	Q9P0N8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase UBR5
Reactions:
Gene Name:	UBR5
Uniprot ID:	O95071
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase TRIM33
Reactions:
Gene Name:	TRIM33
Uniprot ID:	Q9UPN9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH5
Reactions:
Gene Name:	MARCH5
Uniprot ID:	Q9NX47
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 R2
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2R2
Uniprot ID:	Q712K3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH1
Reactions:
Gene Name:	MARCH1
Uniprot ID:	Q8TCQ1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase FANCL
Reactions:
Gene Name:	FANCL
Uniprot ID:	Q9NW38
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-like modifier-activating enzyme 6
Reactions:
Gene Name:	UBA6
Uniprot ID:	A0AVT1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme 16
Reactions:
Gene Name:	UBE2W
Uniprot ID:	Q96B02
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Galactosyl transferase-associated protein
Reactions:
Gene Name:	GTAP
Uniprot ID:	Q29SN7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase CHFR
Reactions:
Gene Name:	CHFR
Uniprot ID:	Q96EP1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ring finger protein 20
Reactions:
Gene Name:	RNF20
Uniprot ID:	Q5VTR2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase RAD18
Reactions:
Gene Name:	RAD18
Uniprot ID:	Q9NS91
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin ligase SMURF1
Reactions:
Gene Name:	SMURF1
Uniprot ID:	Q9HCE7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Baculoviral IAP repeat-containing protein 6
Reactions:
Gene Name:	BIRC6
Uniprot ID:	Q9NR09
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH4
Reactions:
Gene Name:	MARCH4
Uniprot ID:	Q9P2E8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase CCNB1IP1
Reactions:
Gene Name:	CCNB1IP1
Uniprot ID:	Q9NPC3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase RNF5
Reactions:
Gene Name:	RNF5
Uniprot ID:	Q99942
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 O
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2O
Uniprot ID:	Q9C0C9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Praja 1
Reactions:
Gene Name:	PJA1
Uniprot ID:	A2A322
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	RFWD2 protein
Reactions:
Gene Name:	RFWD2
Uniprot ID:	Q05CT6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase SMURF2
Reactions:
Gene Name:	SMURF2
Uniprot ID:	Q9HAU4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase SIAH1
Reactions:
Gene Name:	SIAH1
Uniprot ID:	Q8IUQ4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase SIAH2
Reactions:
Gene Name:	SIAH2
Uniprot ID:	O43255
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH7
Reactions:
Gene Name:	MARCH7
Uniprot ID:	Q9H992
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 Z
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2Z
Uniprot ID:	Q9H832
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-like modifier-activating enzyme 7
Reactions:
Gene Name:	UBA7
Uniprot ID:	P41226
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carrier protein
Reactions:
Gene Name:	UBE2H
Uniprot ID:	A4D1L5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-protein ligase E3A
Reactions:
Gene Name:	UBE3A
Uniprot ID:	Q05086
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase RNF128
Reactions:
Gene Name:	RNF128
Uniprot ID:	Q8TEB7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase TRIM11
Reactions:
Gene Name:	TRIM11
Uniprot ID:	Q96F44
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	BRCA1 associated protein variant
Reactions:
Gene Name:	Not Available
Uniprot ID:	Q59H81
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase synoviolin
Reactions:
Gene Name:	SYVN1
Uniprot ID:	Q86TM6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase TRIM63
Reactions:
Gene Name:	TRIM63
Uniprot ID:	Q969Q1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase LNX
Reactions:
Gene Name:	LNX1
Uniprot ID:	Q8TBB1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase ZNRF1
Reactions:
Gene Name:	ZNRF1
Uniprot ID:	Q8ND25
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tripartite motif-containing protein 5
Reactions:
Gene Name:	TRIM5
Uniprot ID:	Q9C035
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-protein ligase E3B
Reactions:
Gene Name:	UBE3B
Uniprot ID:	Q7Z3V4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase RNF8
Reactions:
Gene Name:	RNF8
Uniprot ID:	O76064
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase LRSAM1
Reactions:
Gene Name:	LRSAM1
Uniprot ID:	Q6UWE0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 Q2
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2Q2
Uniprot ID:	Q8WVN8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH9
Reactions:
Gene Name:	MARCH9
Uniprot ID:	Q86YJ5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable E3 ubiquitin-protein ligase TRIP12
Reactions:
Gene Name:	TRIP12
Uniprot ID:	Q14669
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase DZIP3
Reactions:
Gene Name:	DZIP3
Uniprot ID:	Q86Y13
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-protein ligase E3C
Reactions:
Gene Name:	UBE3C
Uniprot ID:	Q15386
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA-directed RNA polymerase III subunit RPC1
Reactions:	nucleoside triphosphate + RNAn = diphosphate + RNAn+1 [RN:R00444]
Gene Name:	POLR3A
Uniprot ID:	O14802
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA-directed RNA polymerase I subunit RPA1
Reactions:	nucleoside triphosphate + RNAn = diphosphate + RNAn+1 [RN:R00444]
Gene Name:	POLR1A
Uniprot ID:	O95602
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Zinc ribbon domain containing 1
Reactions:
Gene Name:	ZNRD1
Uniprot ID:	Q2L6J2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA-directed RNA polymerases I and III subunit RPAC2
Reactions:
Gene Name:	POLR1D
Uniprot ID:	Q9Y2S0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA-directed RNA polymerase
Reactions:	nucleoside triphosphate + RNAn = diphosphate + RNAn+1 [RN:R00444]
Gene Name:	DKFZp686D10173
Uniprot ID:	Q7Z3R8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA-directed RNA polymerase III subunit RPC7-like
Reactions:
Gene Name:	POLR3GL
Uniprot ID:	Q9BT43
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	POLR1C protein
Reactions:
Gene Name:	POLR1C
Uniprot ID:	Q96HT3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	tRNA isopentenyltransferase 1 variant
Reactions:
Gene Name:	TRIT1
Uniprot ID:	Q53F11
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Myb-binding protein 1A
Reactions:
Gene Name:	MYBBP1A
Uniprot ID:	Q9BQG0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase theta
Reactions:
Gene Name:	POLQ
Uniprot ID:	O75417
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Poly(A) polymerase beta (Testis specific)
Reactions:
Gene Name:	PAPOLB
Uniprot ID:	A4D1Z6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Isoleucyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle [RN:R03656]
Gene Name:	IARS2
Uniprot ID:	Q9NSE4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MIB1
Reactions:
Gene Name:	MIB1
Uniprot ID:	Q86YT6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase RNF138
Reactions:
Gene Name:	RNF138
Uniprot ID:	Q8WVD3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase RING2
Reactions:
Gene Name:	RNF2
Uniprot ID:	Q99496
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Reactions:
Gene Name:	AASDHPPT
Uniprot ID:	Q9NRN7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	SUMO-activating enzyme subunit 1
Reactions:
Gene Name:	SAE1
Uniprot ID:	Q9UBE0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 D4
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2D4
Uniprot ID:	Q9Y2X8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin conjugation factor E4 A
Reactions:
Gene Name:	UBE4A
Uniprot ID:	Q14139
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase RNF144B
Reactions:
Gene Name:	RNF144B
Uniprot ID:	Q7Z419
Protein Sequence:	FASTA
Gene Sequence:	FASTA