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Record Information
Version3.6
Creation Date2006-05-22 14:17:38 UTC
Update Date2013-04-24 17:56:44 UTC
HMDB IDHMDB02142
Secondary Accession NumbersNone
Metabolite Identification
Common NamePhosphoric acid
DescriptionPhosphoric acid, also known as orthophosphoric acid or phosphoric(V) acid, is a mineral acid with the chemical formula H3PO4. Alternatively, orthophosphoric acid molecules can combine with themselves to form a variety of compounds referred to as phosphoric acids in a more general way. For a discussion of these, see Phosphoric acids and Phosphates. Appears to exist only as a food additive and produced synthetically. --Wikipedia.
Structure
Thumb
Synonyms
  1. Acide phosphorique (FRENCH)
  2. Acido fosforico [Italian]
  3. Acidum phosphoricum
  4. Diphosphate tetrasodium
  5. Fosforzuuroplossingen [Dutch]
  6. Marphos
  7. NFB
  8. Ortho- phosphoric acid
  9. Orthophosphoric acid
  10. Phosphoric acid (ACD/Name 4.0)
  11. Phosphorsaeure
  12. Phosphorsaeureloesungen [German]
  13. Sodium Pyrophosphate
  14. Sodium pyrophosphate decahydrate
  15. Sodium pyrophosphate decahydrate BioChemica
  16. Sonac
  17. Tetra-Sodium pyrophosphate
  18. Tetrasodium pyrophosphate 10-hydrate
  19. Tetrasodium Pyrophosphate Decahydrate
  20. White phosphoric acid
Chemical FormulaH3O4P
Average Molecular Weight97.9952
Monoisotopic Molecular Weight97.976895096
IUPAC Namephosphoric acid
Traditional Namephosphoric acid
CAS Registry Number7664-38-2
SMILES
OP(O)(O)=O
InChI Identifier
InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)
InChI KeyNBIIXXVUZAFLBC-UHFFFAOYSA-N
Chemical Taxonomy
KingdomInorganic Compounds
Super ClassHomogeneous Non-metal Compounds
ClassNon-metal Oxoanionic Compounds
Sub ClassNon-metal Phosphates
Other Descriptors
  • phosphoric acids(ChEBI)
Substituents
  • N/A
Direct ParentNon-metal Phosphates
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
Biofunction
  • Osmolyte, enzyme cofactor, signalling
ApplicationNot Available
Cellular locations
  • Cytoplasm (predicted from logP)
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point42.35 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-1.436Not Available
Predicted Properties
PropertyValueSource
logP-1ChemAxon
pKa (Strongest Acidic)1.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area77.76ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity14.65ChemAxon
Polarizability5.81ChemAxon
Spectra
SpectraGC-MSMS/MS
Biological Properties
Cellular Locations
  • Cytoplasm (predicted from logP)
Biofluid Locations
  • Blood
  • Urine
Tissue LocationNot Available
PathwaysNot Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified820.4 uMAdult (>18 years old)Not SpecifiedNormal details
BloodDetected and Quantified1100.0 (810.0-1450.0) uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
UrineDetected and Quantified784 (425-1170) umol/mmol creatinineAdult (>18 years old)Both
Normal
details
UrineDetected and Quantified1000-4900 umol/mmol creatinineAdult (>18 years old)BothNormal
    • Great Plains Labo...
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB013380
KNApSAcK IDNot Available
Chemspider ID979
KEGG Compound IDC00009
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkPhosphoric acid
NuGOwiki LinkHMDB02142
Metagene LinkHMDB02142
METLIN IDNot Available
PubChem Compound1004
PDB IDNot Available
ChEBI ID26078
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Faiman C, Moorhouse JA: Diurnal variation in the levels of glucose and related substances in healthy and diabetic subjects during starvation. Clin Sci. 1967 Feb;32(1):111-26. Pubmed: 5336272

Only showing the first 50 proteins. There are 686 proteins in total.

Enzymes

General function:
Involved in hydrolase activity
Specific function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
Gene Name:
NT5E
Uniprot ID:
P21589
Molecular weight:
57948.125
Reactions
A 5'-ribonucleotide + Water → a ribonucleoside + Phosphoric aciddetails
Adenosine monophosphate + Water → Adenosine + Phosphoric aciddetails
Cytidine monophosphate + Water → Cytidine + Phosphoric aciddetails
Uridine 5'-monophosphate + Water → Uridine + Phosphoric aciddetails
Inosinic acid + Water → Inosine + Phosphoric aciddetails
Guanosine monophosphate + Water → Guanosine + Phosphoric aciddetails
5-Thymidylic acid + Water → Thymidine + Phosphoric aciddetails
dCMP + Water → Deoxycytidine + Phosphoric aciddetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphoric aciddetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphoric aciddetails
beta-nicotinamide D-ribonucleotide + Water → Nicotinamide riboside + Phosphoric aciddetails
Xanthylic acid + Water → Xanthosine + Phosphoric aciddetails
nicotinate beta-D-ribonucleotide + Water → Nicotinate D-ribonucleoside + Phosphoric aciddetails
General function:
Involved in nucleotide binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).
Gene Name:
NT5C1B
Uniprot ID:
Q96P26
Molecular weight:
68803.055
Reactions
A 5'-ribonucleotide + Water → a ribonucleoside + Phosphoric aciddetails
Adenosine monophosphate + Water → Adenosine + Phosphoric aciddetails
Cytidine monophosphate + Water → Cytidine + Phosphoric aciddetails
Uridine 5'-monophosphate + Water → Uridine + Phosphoric aciddetails
Inosinic acid + Water → Inosine + Phosphoric aciddetails
Guanosine monophosphate + Water → Guanosine + Phosphoric aciddetails
5-Thymidylic acid + Water → Thymidine + Phosphoric aciddetails
dCMP + Water → Deoxycytidine + Phosphoric aciddetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphoric aciddetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphoric aciddetails
beta-nicotinamide D-ribonucleotide + Water → Nicotinamide riboside + Phosphoric aciddetails
Xanthylic acid + Water → Xanthosine + Phosphoric aciddetails
nicotinate beta-D-ribonucleotide + Water → Nicotinate D-ribonucleoside + Phosphoric aciddetails
General function:
Involved in nucleotide binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
Gene Name:
NT5C1A
Uniprot ID:
Q9BXI3
Molecular weight:
41020.145
Reactions
A 5'-ribonucleotide + Water → a ribonucleoside + Phosphoric aciddetails
Adenosine monophosphate + Water → Adenosine + Phosphoric aciddetails
Cytidine monophosphate + Water → Cytidine + Phosphoric aciddetails
Uridine 5'-monophosphate + Water → Uridine + Phosphoric aciddetails
Inosinic acid + Water → Inosine + Phosphoric aciddetails
Guanosine monophosphate + Water → Guanosine + Phosphoric aciddetails
5-Thymidylic acid + Water → Thymidine + Phosphoric aciddetails
dCMP + Water → Deoxycytidine + Phosphoric aciddetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphoric aciddetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphoric aciddetails
beta-nicotinamide D-ribonucleotide + Water → Nicotinamide riboside + Phosphoric aciddetails
Xanthylic acid + Water → Xanthosine + Phosphoric aciddetails
nicotinate beta-D-ribonucleotide + Water → Nicotinate D-ribonucleoside + Phosphoric aciddetails
General function:
Involved in metal ion binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Gene Name:
NT5C
Uniprot ID:
Q8TCD5
Molecular weight:
Not Available
Reactions
Adenosine monophosphate + Water → Adenosine + Phosphoric aciddetails
Cytidine monophosphate + Water → Cytidine + Phosphoric aciddetails
Uridine 5'-monophosphate + Water → Uridine + Phosphoric aciddetails
Inosinic acid + Water → Inosine + Phosphoric aciddetails
Guanosine monophosphate + Water → Guanosine + Phosphoric aciddetails
5-Thymidylic acid + Water → Thymidine + Phosphoric aciddetails
dCMP + Water → Deoxycytidine + Phosphoric aciddetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphoric aciddetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphoric aciddetails
beta-nicotinamide D-ribonucleotide + Water → Nicotinamide riboside + Phosphoric aciddetails
Xanthylic acid + Water → Xanthosine + Phosphoric aciddetails
nicotinate beta-D-ribonucleotide + Water → Nicotinate D-ribonucleoside + Phosphoric aciddetails
General function:
Involved in phosphatase activity
Specific function:
Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Gene Name:
NT5M
Uniprot ID:
Q9NPB1
Molecular weight:
Not Available
Reactions
Adenosine monophosphate + Water → Adenosine + Phosphoric aciddetails
Cytidine monophosphate + Water → Cytidine + Phosphoric aciddetails
Uridine 5'-monophosphate + Water → Uridine + Phosphoric aciddetails
Inosinic acid + Water → Inosine + Phosphoric aciddetails
Guanosine monophosphate + Water → Guanosine + Phosphoric aciddetails
5-Thymidylic acid + Water → Thymidine + Phosphoric aciddetails
dCMP + Water → Deoxycytidine + Phosphoric aciddetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphoric aciddetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphoric aciddetails
beta-nicotinamide D-ribonucleotide + Water → Nicotinamide riboside + Phosphoric aciddetails
Xanthylic acid + Water → Xanthosine + Phosphoric aciddetails
nicotinate beta-D-ribonucleotide + Water → Nicotinate D-ribonucleoside + Phosphoric aciddetails
General function:
Involved in ATP citrate synthase activity
Specific function:
ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
Gene Name:
ACLY
Uniprot ID:
P53396
Molecular weight:
120838.27
Reactions
ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic acid → Adenosine triphosphate + Citric acid + Coenzyme Adetails
Adenosine triphosphate + Citric acid + Coenzyme A → ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic aciddetails
General function:
Involved in acetyl-CoA carboxylase activity
Specific function:
ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Gene Name:
ACACB
Uniprot ID:
O00763
Molecular weight:
276538.575
Reactions
Adenosine triphosphate + Acetyl-CoA + Carbonic acid → ADP + Phosphoric acid + Malonyl-CoAdetails
Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + Phosphoric acid + carboxy-biotin-[carboxyl-carrier-protein]details
Adenosine triphosphate + Holo-[carboxylase] + Carbonic acid → ADP + Phosphoric acid + Carboxybiotin-carboxyl-carrier proteindetails
General function:
Involved in catalytic activity
Specific function:
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
Gene Name:
PC
Uniprot ID:
P11498
Molecular weight:
129632.565
Reactions
Adenosine triphosphate + Pyruvic acid + Carbonic acid → ADP + Phosphoric acid + Oxalacetic aciddetails
General function:
Involved in acetate-CoA ligase activity
Specific function:
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
Gene Name:
ACSS1
Uniprot ID:
Q9NUB1
Molecular weight:
74625.88
General function:
Involved in acetyl-CoA carboxylase activity
Specific function:
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Gene Name:
ACACA
Uniprot ID:
Q13085
Molecular weight:
269997.01
Reactions
Adenosine triphosphate + Acetyl-CoA + Carbonic acid → ADP + Phosphoric acid + Malonyl-CoAdetails
Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + Phosphoric acid + carboxy-biotin-[carboxyl-carrier-protein]details
Adenosine triphosphate + Holo-[carboxylase] + Carbonic acid → ADP + Phosphoric acid + Carboxybiotin-carboxyl-carrier proteindetails
General function:
Involved in hydrolase activity
Specific function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:
ENTPD1
Uniprot ID:
P49961
Molecular weight:
58706.0
Reactions
Adenosine triphosphate + Water → Adenosine monophosphate + Phosphoric aciddetails
Adenosine triphosphate + Water → ADP + Phosphoric aciddetails
ADP + Water → Adenosine monophosphate + Phosphoric aciddetails
Uridine 5'-diphosphate + Water → Uridine 5'-monophosphate + Phosphoric aciddetails
Uridine triphosphate + Water → Uridine 5'-diphosphate + Phosphoric aciddetails
Guanosine diphosphate + Water → Guanosine monophosphate + Phosphoric aciddetails
Guanosine triphosphate + Water → Guanosine diphosphate + Phosphoric aciddetails
CDP + Water → Cytidine monophosphate + Phosphoric aciddetails
Cytidine triphosphate + Water → CDP + Phosphoric aciddetails
Inosine triphosphate + Water → IDP + Phosphoric aciddetails
IDP + Water → Inosinic acid + Phosphoric aciddetails
dTDP + Water → 5-Thymidylic acid + Phosphoric aciddetails
Thymidine 5'-triphosphate + Water → dTDP + Phosphoric aciddetails
General function:
Involved in calcium ion binding
Specific function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:
CANT1
Uniprot ID:
Q8WVQ1
Molecular weight:
44839.24
Reactions
A nucleoside diphosphate + Water → a nucleotide + Phosphoric aciddetails
Uridine 5'-diphosphate + Water → Uridine 5'-monophosphate + Phosphoric aciddetails
Guanosine diphosphate + Water → Guanosine monophosphate + Phosphoric aciddetails
IDP + Water → Inosinic acid + Phosphoric aciddetails
General function:
Involved in hydrolase activity
Specific function:
Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:
ENTPD3
Uniprot ID:
O75355
Molecular weight:
59104.76
Reactions
Adenosine triphosphate + Water → Adenosine monophosphate + Phosphoric aciddetails
Adenosine triphosphate + Water → ADP + Phosphoric aciddetails
ADP + Water → Adenosine monophosphate + Phosphoric aciddetails
Uridine 5'-diphosphate + Water → Uridine 5'-monophosphate + Phosphoric aciddetails
Uridine triphosphate + Water → Uridine 5'-diphosphate + Phosphoric aciddetails
Guanosine diphosphate + Water → Guanosine monophosphate + Phosphoric aciddetails
Guanosine triphosphate + Water → Guanosine diphosphate + Phosphoric aciddetails
CDP + Water → Cytidine monophosphate + Phosphoric aciddetails
Cytidine triphosphate + Water → CDP + Phosphoric aciddetails
Inosine triphosphate + Water → IDP + Phosphoric aciddetails
IDP + Water → Inosinic acid + Phosphoric aciddetails
dTDP + Water → 5-Thymidylic acid + Phosphoric aciddetails
Thymidine 5'-triphosphate + Water → dTDP + Phosphoric aciddetails
General function:
Involved in arylesterase activity
Specific function:
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Gene Name:
PON3
Uniprot ID:
Q15166
Molecular weight:
39607.185
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
ALPP
Uniprot ID:
P05187
Molecular weight:
57953.31
Reactions
A phosphate monoester + Water → an alcohol + Phosphoric aciddetails
4-Nitrophenyl phosphate + Water → 4-Nitrophenol + Phosphoric aciddetails
Dihydroneopterin triphosphate + Water → 7,8-Dihydroneopterin + Phosphoric aciddetails
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
ALPI
Uniprot ID:
P09923
Molecular weight:
56811.695
Reactions
A phosphate monoester + Water → an alcohol + Phosphoric aciddetails
4-Nitrophenyl phosphate + Water → 4-Nitrophenol + Phosphoric aciddetails
Dihydroneopterin triphosphate + Water → 7,8-Dihydroneopterin + Phosphoric aciddetails
General function:
Involved in acid phosphatase activity
Specific function:
Not Available
Gene Name:
ACP2
Uniprot ID:
P11117
Molecular weight:
48343.92
Reactions
A phosphate monoester + Water → an alcohol + Phosphoric aciddetails
Flavin Mononucleotide + Water → Riboflavin + Phosphoric aciddetails
General function:
Involved in acid phosphatase activity
Specific function:
Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
Gene Name:
ACP1
Uniprot ID:
P24666
Molecular weight:
18042.315
Reactions
Protein tyrosine phosphate + Water → protein tyrosine + Phosphoric aciddetails
A phosphate monoester + Water → an alcohol + Phosphoric aciddetails
Flavin Mononucleotide + Water → Riboflavin + Phosphoric aciddetails
General function:
Involved in catalytic activity
Specific function:
This isozyme may play a role in skeletal mineralization.
Gene Name:
ALPL
Uniprot ID:
P05186
Molecular weight:
57304.435
Reactions
A phosphate monoester + Water → an alcohol + Phosphoric aciddetails
4-Nitrophenyl phosphate + Water → 4-Nitrophenol + Phosphoric aciddetails
Dihydroneopterin triphosphate + Water → 7,8-Dihydroneopterin + Phosphoric aciddetails
General function:
Involved in hydrolase activity
Specific function:
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
Gene Name:
ACP5
Uniprot ID:
P13686
Molecular weight:
36598.47
Reactions
A phosphate monoester + Water → an alcohol + Phosphoric aciddetails
Flavin Mononucleotide + Water → Riboflavin + Phosphoric aciddetails
General function:
Involved in acid phosphatase activity
Specific function:
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.
Gene Name:
ACPP
Uniprot ID:
P15309
Molecular weight:
44565.715
Reactions
A phosphate monoester + Water → an alcohol + Phosphoric aciddetails
A 5'-ribonucleotide + Water → a ribonucleoside + Phosphoric aciddetails
Flavin Mononucleotide + Water → Riboflavin + Phosphoric aciddetails
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
ALPPL2
Uniprot ID:
P10696
Molecular weight:
57376.515
Reactions
A phosphate monoester + Water → an alcohol + Phosphoric aciddetails
4-Nitrophenyl phosphate + Water → 4-Nitrophenol + Phosphoric aciddetails
Dihydroneopterin triphosphate + Water → 7,8-Dihydroneopterin + Phosphoric aciddetails
General function:
Involved in catalytic activity
Specific function:
Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.
Gene Name:
PPAP2C
Uniprot ID:
O43688
Molecular weight:
32573.435
Reactions
A 1,2-diacylglycerol 3-phosphate + Water → a 1,2-diacyl-sn-glycerol + Phosphoric aciddetails
Phosphatidate + Water → 1,2-Diacyl-sn-glycerol + Phosphoric aciddetails
2-Acyl-1-alkyl-sn-glycero-3-phosphate + Water → 1-Alkyl-2-acylglycerol + Phosphoric aciddetails
Sphinganine 1-phosphate + Water → Sphinganine + Phosphoric aciddetails
Sphingosine 1-phosphate + Water → Sphingosine + Phosphoric aciddetails
Ceramide 1-phosphate + Water → N-Acylsphingosine + Phosphoric aciddetails
General function:
Involved in catalytic activity
Specific function:
Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.
Gene Name:
PPAP2A
Uniprot ID:
O14494
Molecular weight:
32155.715
Reactions
A 1,2-diacylglycerol 3-phosphate + Water → a 1,2-diacyl-sn-glycerol + Phosphoric aciddetails
Phosphatidate + Water → 1,2-Diacyl-sn-glycerol + Phosphoric aciddetails
2-Acyl-1-alkyl-sn-glycero-3-phosphate + Water → 1-Alkyl-2-acylglycerol + Phosphoric aciddetails
Sphinganine 1-phosphate + Water → Sphinganine + Phosphoric aciddetails
Sphingosine 1-phosphate + Water → Sphingosine + Phosphoric aciddetails
Ceramide 1-phosphate + Water → N-Acylsphingosine + Phosphoric aciddetails
General function:
Involved in catalytic activity
Specific function:
Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.
Gene Name:
PPAP2B
Uniprot ID:
O14495
Molecular weight:
35115.61
Reactions
A 1,2-diacylglycerol 3-phosphate + Water → a 1,2-diacyl-sn-glycerol + Phosphoric aciddetails
Phosphatidate + Water → 1,2-Diacyl-sn-glycerol + Phosphoric aciddetails
2-Acyl-1-alkyl-sn-glycero-3-phosphate + Water → 1-Alkyl-2-acylglycerol + Phosphoric aciddetails
Sphinganine 1-phosphate + Water → Sphinganine + Phosphoric aciddetails
Sphingosine 1-phosphate + Water → Sphingosine + Phosphoric aciddetails
Ceramide 1-phosphate + Water → N-Acylsphingosine + Phosphoric aciddetails
General function:
Involved in fucose-1-phosphate guanylyltransferase acti
Specific function:
Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.
Gene Name:
FPGT
Uniprot ID:
O14772
Molecular weight:
37630.405
General function:
Involved in ligase activity
Specific function:
Not Available
Gene Name:
PCCB
Uniprot ID:
P05166
Molecular weight:
58215.13
Reactions
Adenosine triphosphate + Propionyl-CoA + Carbonic acid → ADP + Phosphoric acid + S-Methylmalonyl-CoAdetails
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
PCCA
Uniprot ID:
P05165
Molecular weight:
80058.295
Reactions
Adenosine triphosphate + Propionyl-CoA + Carbonic acid → ADP + Phosphoric acid + S-Methylmalonyl-CoAdetails
General function:
Involved in transferase activity
Specific function:
Not Available
Gene Name:
FDFT1
Uniprot ID:
P37268
Molecular weight:
48114.87
General function:
Involved in catalytic activity
Specific function:
Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities.
Gene Name:
BPGM
Uniprot ID:
P07738
Molecular weight:
30004.98
Reactions
2,3-Diphosphoglyceric acid + Water → 3-Phosphoglyceric acid + Phosphoric aciddetails
General function:
Involved in catalytic activity
Specific function:
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
Gene Name:
PGAM2
Uniprot ID:
P15259
Molecular weight:
28765.96
Reactions
2,3-Diphosphoglyceric acid + Water → 3-Phosphoglyceric acid + Phosphoric aciddetails
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
PGAM4
Uniprot ID:
Q8N0Y7
Molecular weight:
28776.605
Reactions
2,3-Diphosphoglyceric acid + Water → 3-Phosphoglyceric acid + Phosphoric aciddetails
General function:
Involved in catalytic activity
Specific function:
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
Gene Name:
PGAM1
Uniprot ID:
P18669
Molecular weight:
28803.675
Reactions
2,3-Diphosphoglyceric acid + Water → 3-Phosphoglyceric acid + Phosphoric aciddetails
General function:
Involved in nucleotide binding
Specific function:
Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins.
Gene Name:
FARS2
Uniprot ID:
O95363
Molecular weight:
52356.21
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
GART
Uniprot ID:
P22102
Molecular weight:
107766.295
Reactions
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine → ADP + Phosphoric acid + Glycineamideribotidedetails
Adenosine triphosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine → ADP + Phosphoric acid + 5-Aminoimidazole ribonucleotidedetails
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine → ADP + Phosphoric acid + Glycineamideribotidedetails
Adenosine triphosphate + Phosphoribosylformylglycineamidine → ADP + Phosphoric acid + 5-Aminoimidazole ribonucleotidedetails
General function:
Involved in catalytic activity
Specific function:
Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.
Gene Name:
NANS
Uniprot ID:
Q9NR45
Molecular weight:
40307.26
Reactions
Phosphoenolpyruvic acid + N-Acetylmannosamine + Water → Phosphoric acid + N-Acetylneuraminic aciddetails
Phosphoenolpyruvic acid + N-acyl-D-mannosamine 6-phosphate + Water → N-acylneuraminate 9-phosphate + Phosphoric aciddetails
N-Acetylneuraminic acid 9-phosphate + Phosphoric acid → N-Acetyl-D-mannosamine 6-phosphate + Phosphoenolpyruvic acid + Waterdetails
General function:
Involved in nucleotidyltransferase activity
Specific function:
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults.
Gene Name:
NMNAT1
Uniprot ID:
Q9HAN9
Molecular weight:
31932.22
General function:
Involved in nucleotidyltransferase activity
Specific function:
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury.
Gene Name:
NMNAT3
Uniprot ID:
Q96T66
Molecular weight:
18255.08
General function:
Involved in catalytic activity
Specific function:
Involved in the catabolism of quinolinic acid (QA).
Gene Name:
QPRT
Uniprot ID:
Q15274
Molecular weight:
30815.28
General function:
Involved in nucleotidyltransferase activity
Specific function:
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+).
Gene Name:
NMNAT2
Uniprot ID:
Q9BZQ4
Molecular weight:
34438.38
General function:
Involved in inositol or phosphatidylinositol phosphatase activity
Specific function:
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.
Gene Name:
BPNT1
Uniprot ID:
O95861
Molecular weight:
33392.035
Reactions
Adenosine 3',5'-diphosphate + Water → Adenosine monophosphate + Phosphoric aciddetails
Phosphoadenosine phosphosulfate + Water → Adenosine phosphosulfate + Phosphoric aciddetails
General function:
Involved in ATP binding
Specific function:
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
Gene Name:
PAPSS1
Uniprot ID:
O43252
Molecular weight:
70832.725
General function:
Involved in ATP binding
Specific function:
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth (By similarity).
Gene Name:
PAPSS2
Uniprot ID:
O95340
Molecular weight:
69969.8
General function:
Involved in catalytic activity
Specific function:
Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
Gene Name:
CPS1
Uniprot ID:
P31327
Molecular weight:
165649.075
Reactions
Adenosine triphosphate + Ammonia + CO(2) + Water → ADP + Phosphoric acid + Carbamoyl phosphatedetails
Adenosine triphosphate + Ammonia + Carbon dioxide + Water → ADP + Phosphoric acid + Carbamoyl phosphatedetails
General function:
Involved in inositol or phosphatidylinositol phosphatase activity
Specific function:
Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.
Gene Name:
INPP5A
Uniprot ID:
Q14642
Molecular weight:
47819.155
Reactions
Inositol 1,4,5-trisphosphate + Water → 1D-Myo-inositol 1,4-bisphosphate + Phosphoric aciddetails
Inositol 1,3,4,5-tetraphosphate + Water → Inositol 1,3,4-trisphosphate + Phosphoric aciddetails
Inositol 1,4,5-trisphosphate + Water → 1D-Myo-inositol 1,4-bisphosphate + Phosphoric aciddetails
General function:
Involved in inositol or phosphatidylinositol phosphatase activity
Specific function:
Not Available
Gene Name:
INPP1
Uniprot ID:
P49441
Molecular weight:
43997.62
Reactions
1D-Myo-inositol 1,4-bisphosphate + Water → D-Myo-inositol 4-phosphate + Phosphoric aciddetails
Inositol 1,3,4-trisphosphate + Water → 1D-Myo-inositol 3,4-bisphosphate + Phosphoric aciddetails
General function:
Involved in inositol or phosphatidylinositol phosphatase activity
Specific function:
Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity).
Gene Name:
INPP5J
Uniprot ID:
Q15735
Molecular weight:
70238.575
Reactions
Inositol 1,4,5-trisphosphate + Water → 1D-Myo-inositol 1,4-bisphosphate + Phosphoric aciddetails
Inositol 1,3,4,5-tetraphosphate + Water → Inositol 1,3,4-trisphosphate + Phosphoric aciddetails
Inositol 1,4,5-trisphosphate + Water → 1D-Myo-inositol 1,4-bisphosphate + Phosphoric aciddetails
General function:
Involved in inositol or phosphatidylinositol phosphatase activity
Specific function:
Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton.
Gene Name:
INPP5K
Uniprot ID:
Q9BT40
Molecular weight:
42783.425
Reactions
Inositol 1,4,5-trisphosphate + Water → 1D-Myo-inositol 1,4-bisphosphate + Phosphoric aciddetails
Inositol 1,4,5-trisphosphate + Water → 1D-Myo-inositol 1,4-bisphosphate + Phosphoric aciddetails
Inositol 1,3,4,5-tetraphosphate + Water → Inositol 1,3,4-trisphosphate + Phosphoric aciddetails
General function:
Involved in phosphorylase activity
Specific function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Gene Name:
PYGL
Uniprot ID:
P06737
Molecular weight:
93133.25
Reactions
(1,4-alpha-D-glucosyl)(n) + Phosphoric acid → (1,4-alpha-D-glucosyl)(n-1) + Glucose 1-phosphatedetails
Starch + Phosphoric acid → Amylose + Glucose 1-phosphatedetails
General function:
Involved in phosphorylase activity
Specific function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Gene Name:
PYGM
Uniprot ID:
P11217
Molecular weight:
87316.355
Reactions
(1,4-alpha-D-glucosyl)(n) + Phosphoric acid → (1,4-alpha-D-glucosyl)(n-1) + Glucose 1-phosphatedetails
Starch + Phosphoric acid → Amylose + Glucose 1-phosphatedetails

Only showing the first 50 proteins. There are 686 proteins in total.