Human Metabolome Database Version 3.5

Showing metabocard for Hydrochloric acid (HMDB02306)

Record Information
Version 3.5
Creation Date 2006-05-22 08:17:47 -0600
Update Date 2013-02-08 17:11:43 -0700
HMDB ID HMDB02306
Secondary Accession Numbers
  • HMDB02162
Metabolite Identification
Common Name Hydrochloric acid
Description Hydrochloric acid constitutes the majority of gastric acid, the human digestive fluid. In a complex process and at a large energetic burden, it is secreted by parietal cells (also known as oxyntic cells). These cells contain an extensive secretory network (called canaliculi) from which the HCl is secreted into the lumen of the stomach. They are part of the epithelial fundic glands (also known as oxyntic glands) in the stomach. The chemical compound hydrochloric acid is the aqueous (water-based) solution of hydrogen chloride gas (HCl). It is a strong acid, the major component of gastric acid and of wide industrial use. Hydrochloric acid must be handled with appropriate safety precautions because it is a highly corrosive liquid. Hydrochloric acid, or muriatic acid by its historical but still occasionally used name, has been an important and frequently used chemical from early history and was discovered by the alchemist Jabir ibn Hayyan around the year 800. Hydrogen chloride, also known under the name HCl, is a highly corrosive and toxic colorless gas that forms white fumes on contact with humidity. These fumes consist of hydrochloric acid which forms when hydrogen chloride dissolves in water. The hydrogen chloride molecule HCl is a simple diatomic molecule consisting of a hydrogen atom H and a chlorine atom Cl connected with a covalent single bond. Since the chlorine atom is much more electronegative than the hydrogen atom, the covalent bond between the atoms is quite polar. Hydrogen chloride forms corrosive hydrochloric acid on contact with body tissue. Inhalation of the fumes can cause coughing, choking, inflammation of the nose, throat, and upper respiratory tract, and in severe cases, pulmonary edema, circulatory system failure, and death. Skin contact can cause redness, pain, and severe skin burns. Hydrogen chloride may cause severe burns to the eye and permanent eye damage.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. Anhydrous Hydrochloric acid
  2. Aqueous hydrogen chloride
  3. Chlorane
  4. Chlorohydric acid
  5. HCL]
  6. Hydrochloric acid (JP15/NF)
  7. Hydrochloric acid gas
  8. Hydrochloric acid [jan]
  9. Hydrogen chloric anhydrous
  10. Hydrogen chloride (acid)
  11. Hydrogen chloride (HCL)
  12. Hydrogen chloride anhydrous [UN1050] [Poison gas]
  13. Marine acid
  14. Muriatic acid
  15. Spirit of salt
  16. [HCL]
Chemical Formula ClH
Average Molecular Weight 36.461
Monoisotopic Molecular Weight 35.976677739
IUPAC Name hydrogen chloride
Traditional IUPAC Name hydrochloric acid
CAS Registry Number 7647-01-0
SMILES Cl
InChI Identifier InChI=1S/ClH/h1H
InChI Key VEXZGXHMUGYJMC-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom Inorganic Compounds
Super Class Homogeneous Non-metal Compounds
Class Halogen Organides
Sub Class Halogen Hydrides
Other Descriptors
  • Aliphatic Acyclic Compounds
  • a small molecule(Cyc)
  • chlorine molecular entity(ChEBI)
  • hydrogen halide(ChEBI)
  • mononuclear parent hydride(ChEBI)
Substituents
  • N/A
Direct Parent Halogen Hydrides
Ontology
Status Expected and Not Quantified
Origin
  • Endogenous
Biofunction
  • Osmolyte, enzyme cofactor, signalling
Application Not Available
Cellular locations Not Available
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility ALOGPS
LogP 0.61 ChemAxon
pKa (strongest acidic) -7 ChemAxon
Hydrogen Acceptor Count 0 ChemAxon
Hydrogen Donor Count 0 ChemAxon
Polar Surface Area 0 A2 ChemAxon
Rotatable Bond Count 0 ChemAxon
Refractivity 6.42 ChemAxon
Polarizability 2.65 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -1 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations Not Available
Biofluid Locations Not Available
Tissue Location Not Available
Pathways Not Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID Not Available
DrugBank Metabolite ID Not Available
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB016076
KNApSAcK ID Not Available
Chemspider ID 307 Link_out
KEGG Compound ID C01327 Link_out
BioCyc ID Not Available
BiGG ID Not Available
Wikipedia Link Hydrochloric acid Link_out
NuGOwiki Link HMDB02306 Link_out
Metagene Link HMDB02306 Link_out
METLIN ID Not Available
PubChem Compound 313 Link_out
PDB ID Not Available
ChEBI ID 17883 Link_out
References
Synthesis Reference Suzuta, Tetsuya; Mori, Yasuhiko; Abe, Tadashi. method to produce chlorine and hydrochloric acid. Jpn. Kokai Tokkyo Koho (2005), 13 pp.
Material Safety Data Sheet (MSDS) Download (PDF)
General References Not Available

Enzymes
Name: Myeloperoxidase
Reactions:
Hydrochloric acid + Hydrogen peroxide + Hydrogen Ion unknown HClO + Water details
Hydrochloric acid + Hydrogen peroxide unknown HClO + Water details
Gene Name: MPO
Uniprot ID: P05164 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase Mu 2
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTM2
Uniprot ID: P28161 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase Mu 1
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTM1
Uniprot ID: P09488 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase kappa 1
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTK1
Uniprot ID: Q9Y2Q3 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Microsomal glutathione S-transferase 3
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: MGST3
Uniprot ID: O14880 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase Mu 3
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTM3
Uniprot ID: P21266 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase A1
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTA1
Uniprot ID: P08263 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Maleylacetoacetate isomerase
Reactions: Not Available
Gene Name: GSTZ1
Uniprot ID: O43708 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Microsomal glutathione S-transferase 1
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: MGST1
Uniprot ID: P10620 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase Mu 4
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTM4
Uniprot ID: Q03013 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase Mu 5
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTM5
Uniprot ID: P46439 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Microsomal glutathione S-transferase 2
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: MGST2
Uniprot ID: Q99735 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase omega-1
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTO1
Uniprot ID: P78417 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase A5
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTA5
Uniprot ID: Q7RTV2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase A2
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTA2
Uniprot ID: P09210 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase A3
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTA3
Uniprot ID: Q16772 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase A4
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTA4
Uniprot ID: O15217 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase omega-2
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTO2
Uniprot ID: Q9H4Y5 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase theta-1
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTT1
Uniprot ID: P30711 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase P
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTP1
Uniprot ID: P09211 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase kappa 1
Reactions: Not Available
Gene Name: LOC51064
Uniprot ID: Q6FII1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase theta-2
Reactions: Not Available
Gene Name: GSTT2
Uniprot ID: P0CG29 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutathione S-transferase theta-2B
Reactions:
1,1-Dichloroethylene epoxide + Glutathione unknown 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid details
Chloroacetyl chloride + Glutathione unknown S-(2-Chloroacetyl)glutathione + Hydrochloric acid details
2-(S-Glutathionyl)acetyl chloride + Glutathione unknown 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid details
Trichloroethylene + Glutathione unknown S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid details
Gene Name: GSTT2B
Uniprot ID: P0CG30 Link_out
Protein Sequence: FASTA