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Record Information
Version4.0
StatusDetected and Quantified
Creation Date2006-05-22 14:17:55 UTC
Update Date2017-10-23 19:04:00 UTC
HMDB IDHMDB0002501
Secondary Accession Numbers
  • HMDB02501
Metabolite Identification
Common NameGermanium
DescriptionGermanium is not an essential element. Physiologically, it exists as an ion in the body. Its acute toxicity is low. Germanium-containing dietary supplements became popular in the 1970s in Japan and later in other countries, as elixirs for certain diseases (e.g., cancer and AIDS). However, at least 31 reported human cases linked prolonged intake of germanium products with renal failure and even death.
Structure
Thumb
Synonyms
ValueSource
Ge(4+)ChEBI
GeHMDB
GermideHMDB
SerocionHMDB
Chemical FormulaGe
Average Molecular Weight72.64
Monoisotopic Molecular Weight73.921178213
IUPAC Namegermanium(4+) ion
Traditional Namegermanium(4+) ion
CAS Registry Number7440-56-4
SMILES
[Ge+4]
InChI Identifier
InChI=1S/Ge/q+4
InChI KeyCULSIAXQVSZNSV-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as homogeneous metalloid compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a metalloid atom.
KingdomChemical entities
Super ClassInorganic compounds
ClassHomogeneous metal compounds
Sub ClassHomogeneous metalloid compounds
Direct ParentHomogeneous metalloid compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous metalloid
Molecular FrameworkNot Available
External Descriptors
Ontology
Disposition

Biological Location:

  Biofluid and excreta:

Source:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point938.3 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0ChemAxon
Physiological Charge4ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-9000000000-d30e86fb68c056ba94faView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-001i-9000000000-d30e86fb68c056ba94faView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-001i-9000000000-d30e86fb68c056ba94faView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-001i-9000000000-0aec2ac48ffee5c3828aView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-001i-9000000000-0aec2ac48ffee5c3828aView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-001i-9000000000-0aec2ac48ffee5c3828aView in MoNA
Biological Properties
Cellular LocationsNot Available
Biofluid Locations
  • Blood
  • Saliva
  • Urine
Tissue LocationNot Available
PathwaysNot Available
NameSMPDB/PathwhizKEGG
No entries found
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodExpected but not Quantified Not AvailableNot Available
Normal
    details
    SalivaDetected and Quantified0.006 +/- 0.003 uMAdult (>18 years old)BothNormal
      • Zerihun T. Dame, ...
    details
    UrineDetected and Quantified1.58 (0.49-2.6) umol/mmol creatinineAdult (>18 years old)BothNormal details
    Abnormal Concentrations
    Not Available
    Associated Disorders and Diseases
    Disease ReferencesNone
    Associated OMIM IDsNone
    DrugBank IDNot Available
    DrugBank Metabolite IDNot Available
    Phenol Explorer Compound IDNot Available
    Phenol Explorer Metabolite IDNot Available
    FoodDB IDFDB003630
    KNApSAcK IDNot Available
    Chemspider ID10605699
    KEGG Compound IDC15472
    BioCyc IDNot Available
    BiGG IDNot Available
    Wikipedia LinkGermanium
    METLIN IDNot Available
    PubChem CompoundNot Available
    PDB IDNot Available
    ChEBI ID30550
    References
    Synthesis ReferenceNot Available
    Material Safety Data Sheet (MSDS)Not Available
    General References
    1. Nielsen FH: How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential? J Nutr. 1996 Sep;126(9 Suppl):2377S-2385S. [PubMed:8811801 ]
    2. Tao SH, Bolger PM: Hazard assessment of germanium supplements. Regul Toxicol Pharmacol. 1997 Jun;25(3):211-9. [PubMed:9237323 ]