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Identification Taxonomy Ontology Physical properties Spectra Biological properties Concentrations Links References XML

Record Information

Version

5.0

Status

Detected and Quantified

Creation Date

2006-05-22 15:12:01 UTC

Update Date

2020-02-26 21:24:13 UTC

HMDB ID

HMDB0002659

Secondary Accession Numbers

HMDB02659

Metabolite Identification

Common Name

Silver

Description

Silver is widely distributed in the earth's crust and is found in soil, fresh and sea water, and the air. It is readily absorbed into the human body with food and drink and through inhalation, but the low levels of silver commonly present in the bloodstream (< 2.3 b.mu g/L) and in key tissues like liver and kidney have not been associated with any disease or disability. Silver is not an acknowledged trace element in the human body and fulfills no physiological or biochemical role in any tissue even though it interacts with several essential elements including zinc and calcium. Physiologically, it exists as an ion in the body. Silver has a long history in the treatment of human diseases, including epilepsy, neonatal eye disease, venereal diseases, and wound infections. It has been employed in water purification and is currently used to safeguard hospital hot water systems against Legionella infections. Principle routes of human exposure to silver nowadays are through its widespread use as an antimicrobial agent in wound care products and medical devices, including in-dwelling catheters, bone cements, cardiac valves and prostheses, orthopedic pins, and dental devices. In each case, the antimicrobial properties of silver are dependent upon release of biologically active silver ion (Ag*) from metallic silver (including nanocrystalline forms), silver nitrate, silver sulfadiazine, and other silver compounds incorporated in the various devices, and its lethal effect on pathogenic organisms. Experience has shown that a large proportion of the silver ion released from medical devices not required for antimicrobial action is disseminated into tissue fluids and exudates, where it combines with albumins and macroglobulins. These silver-protein complexes are absorbed into the systemic circulation to be deposited in key soft tissues, including the skin, liver, kidney, spleen, lungs, and brain. As a xenobiotic material, silver must be presumed to present a health risk to exposed persons under some circumstances. Unlike the well-documented neurotoxic metals including lead and mercury, silver does not appear to be a cumulative poison and is eliminated from the body through the urine and feces. Excretion of silver by these routes may be a measure of mean daily intake, but since this view is based largely on the clinical use of silver nitrate and silver sulfadiazine used in burn wound therapy, its true relevance in the metabolism of silver used in the wider context of medical devices is questionable. Argyria is the most widely publicized clinical condition associated with silver accumulation in blood and soft tissues. It commonly occurs in individuals exposed to high levels of silver occupationally (metallurgy, photography, and mining industries), or consuming or inhaling silver hygiene products (including colloidal silver products) for long periods. Silver is absorbed into the body and deposited in the perivascular regions of the skin and other soft tissues as black granules of silver sulfide or silver selenide. The resulting slate grey discoloration of the skin occasionally associated with melanogenic changes, is semipermanent and cosmetically undesirable but is not known to be life-threatening. (PMID: 17453933 ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

View in JSmol View Stereo Labels

Synonyms

Value	Source
Ag(+)	ChEBI
SILVER ion	ChEBI
Silver ion (1+)	ChEBI
AG	HMDB
Ag+	HMDB
AGN	HMDB
Algaedyn	HMDB
Amalgum	HMDB
Argent. nit.	HMDB
Argentum	HMDB
Argentum colloidale	HMDB
Argentum met.praep.d8(D10 D12 D15 D20 D30)	HMDB
Argentum metallicum	HMDB
Argentum metallicum (silver metallicum 6X)	HMDB
Argentum metallicum 4ch - 30ch	HMDB
Argentum mettallicum gtte 4ch-30ch	HMDB
Astroflake 5	HMDB
Carey lea silver	HMDB
Col sil	HMDB
Colloidal silver	HMDB
Collosol argentum	HMDB
D 25 (Metal)	HMDB
Degussa 67	HMDB
Degussa 80	HMDB
Dermazin CRM 1%	HMDB
Dotite xa 208	HMDB
Epinall	HMDB
FA 2 (metal)	HMDB
Flamazine CRM 1%	HMDB
g 12 (Metal)	HMDB
Jelcon SH 1	HMDB
KS (Metal)	HMDB
L-3 (Element)	HMDB
Lead refinery silver bullion	HMDB
Liquid silver	HMDB
Metz 25b	HMDB
Pekana - argentum metallicum	HMDB
Shell silver	HMDB
Silber	HMDB
Silflake 135	HMDB
Silpowder 130	HMDB
Silvadene	HMDB
Silver atom	HMDB
Silver atomic absorption standard solution	HMDB
Silver atomic spectroscopy standard concentrate 1.00 g ag	HMDB
Silver colloidal	HMDB
Silver elemental	HMDB
Silver ion standard solution	HMDB
Silver liquid (s#107)-liq	HMDB
Silver metal	HMDB
Silver metal and soluble compounds	HMDB
Silver nanoparticles	HMDB
Silver preparation	HMDB
Silver standard for aas	HMDB
Silver standard for icp	HMDB
Silver(0)	HMDB
Silver(II)	HMDB
SSD (1% silver sulfadiazine cream usp)	HMDB
TCG 7R	HMDB

Chemical Formula

Average Molecular Weight

107.8682

Monoisotopic Molecular Weight

106.90509302

IUPAC Name

silver(1+) ion

Traditional Name

silver(1+) ion

CAS Registry Number

7440-22-4

SMILES

[Ag+]

InChI Identifier

InChI=1S/Ag/q+1

InChI Key

FOIXSVOLVBLSDH-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.

Kingdom

Inorganic compounds

Super Class

Homogeneous metal compounds

Class

Homogeneous transition metal compounds

Sub Class

Not Available

Direct Parent

Homogeneous transition metal compounds

Alternative Parents

Not Available

Substituents

Homogeneous transition metal

Molecular Framework

Not Available

External Descriptors

monovalent inorganic cation (CHEBI:49468 )
monoatomic monocation (CHEBI:49468 )
silver cation (CHEBI:49468 )
elemental silver (CHEBI:49468 )
a cation (AG+ )

Ontology

Not Available

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	960.5 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
logP	-0.73	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	0 m³·mol⁻¹	ChemAxon
Polarizability	1.78 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
AllCCS	[M+H]+	127.0	32859911
AllCCS	[M+H-H2O]+	123.4	32859911
AllCCS	[M+NH4]+	130.3	32859911
AllCCS	[M+Na]+	131.3	32859911
AllCCS	[M-H]-	149.2	32859911
AllCCS	[M+Na-2H]-	160.9	32859911
AllCCS	[M+HCOO]-	173.6	32859911

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
Silver	[Ag+]	700.7	Standard polar	33892256
Silver	[Ag+]	205.7	Standard non polar	33892256
Silver	[Ag+]	59.6	Semi standard non polar	33892256

Spectra

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Silver 10V, Negative-QTOF	splash10-0a4i-0900000000-411976aa2a4fb62a6313	2016-08-03	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Silver 20V, Negative-QTOF	splash10-0a4i-0900000000-411976aa2a4fb62a6313	2016-08-03	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Silver 40V, Negative-QTOF	splash10-0a4i-0900000000-411976aa2a4fb62a6313	2016-08-03	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Silver 10V, Positive-QTOF	splash10-0a4i-0900000000-3126e0d9c9c0db35ef52	2016-08-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Silver 20V, Positive-QTOF	splash10-0a4i-0900000000-3126e0d9c9c0db35ef52	2016-08-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Silver 40V, Positive-QTOF	splash10-0a4i-0900000000-3126e0d9c9c0db35ef52	2016-08-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Silver 10V, Positive-QTOF	splash10-0a4i-0900000000-aae4e13838785fce7529	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Silver 20V, Positive-QTOF	splash10-0a4i-0900000000-aae4e13838785fce7529	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Silver 40V, Positive-QTOF	splash10-0a4i-0900000000-aae4e13838785fce7529	2021-09-25	Wishart Lab	View Spectrum

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Blood
Cerebrospinal Fluid (CSF)

Tissue Locations

Not Available

Pathways

Not Available

Name	SMPDB/PathBank	KEGG

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	0.0063 +/- 0.0058 uM	Adult (>18 years old)	Both	Normal	Geigy Scientific ...	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0025 (0.0005-0.0046) uM	Adult (>18 years old)	Both	Normal	1641639	details

Abnormal Concentrations

Not Available

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB004188

KNApSAcK ID

Not Available

Chemspider ID

94565

KEGG Compound ID

C06710

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Silver

METLIN ID

Not Available

PubChem Compound

104755

PDB ID

Not Available

ChEBI ID

49468

Food Biomarker Ontology

Not Available

VMH ID

Not Available

MarkerDB ID

Not Available

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Download (PDF)

General References

Lansdown AB: Critical observations on the neurotoxicity of silver. Crit Rev Toxicol. 2007 Mar;37(3):237-50. [PubMed:17453933 ]

Showing metabocard for Silver (HMDB0002659)

MOL for HMDB0002659 (Silver)

3D MOL for HMDB0002659 (Silver)

3D SDF for HMDB0002659 (Silver)

3D-SDF for HMDB0002659 (Silver)

PDB for HMDB0002659 (Silver)

3D PDB for HMDB0002659 (Silver)

SMILES for HMDB0002659 (Silver)

INCHI for HMDB0002659 (Silver)

Structure for HMDB0002659 (Silver)

3D Structure for HMDB0002659 (Silver)

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

MS/MS Spectra