Human Metabolome Database Version 3.5

Showing metabocard for Hydrogen peroxide (HMDB03125)

Record Information
Version 3.5
Creation Date 2006-05-22 09:12:34 -0600
Update Date 2013-05-29 13:37:27 -0600
HMDB ID HMDB03125
Secondary Accession Numbers
  • HMDB06491
Metabolite Identification
Common Name Hydrogen peroxide
Description Hydrogen peroxide (H2O2) is a very pale blue liquid which appears colourless in a dilute solution, slightly more viscous than water. It is a weak acid. It has strong oxidizing properties and is therefore a powerful bleaching agent that is mostly used for bleaching paper, but has also found use as a disinfectant and as an oxidizer. Hydrogen peroxide in the form of carbamide peroxide is widely used for tooth whitening (bleaching), both in professionally- and in self-administered products. Hydrogen peroxide (H2O2) is a well-documented component of living cells. It plays important roles in host defense and oxidative biosynthetic reactions. In addition there is growing evidence that at low levels, H2O2 also functions as a signaling agent, particularly in higher organisms. H2O2 has increasingly been viewed as an important cellular signaling agent in its own right, capable of modulating both contractile and growth-promoting pathways with more far-reaching effects. Due to the accumulation of hydrogen peroxide in the skin of patients with the depigmentation disorder vitiligo, the human epidermis cannot have the normal capacity for autocrine synthesis, transport and degradation of acetylcholine as well as the muscarinic (m1-m5) and nicotinic signal transduction in keratinocytes and melanocytes. Accumulating evidence suggests that hydrogen peroxide (H(2)O(2)) plays an important role in cancer development. Experimental data have shown that cancer cells produce high amounts of H(2)O(2). An increase in the cellular levels of H(2)O(2) has been linked to several key alterations in cancer, including DNA alterations, cell proliferation, apoptosis resistance, metastasis, angiogenesis and hypoxia-inducible factor 1 (HIF-1) activation. (PMID: 17150302 Link_out, 17335854 Link_out, 16677071 Link_out, 16607324 Link_out, 16514169 Link_out).
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. Adeka Super EL
  2. Albone
  3. Albone 35
  4. Albone DS
  5. Anti-Keim 50
  6. Asepticper
  7. Baquashock
  8. CIX
  9. Clarigel Gold
  10. Crestal Whitestrips
  11. Crystacide
  12. Dentasept
  13. Deslime LP
  14. Hioxyl
  15. Hipox
  16. Hybrite
  17. Hydrogen dioxide
  18. Hydrogen peroxide
  19. Inhibine
  20. Lase Peroxide
  21. Lensan A
  22. Magic Bleaching
  23. Metrokur
  24. Mirasept
  25. Nite White Excel 2
  26. Odosat D
  27. Opalescence Xtra
  28. Oxigenal
  29. Oxydol
  30. Oxyfull
  31. Oxysept
  32. Oxysept I
  33. Pegasyl
  34. Perhydrol
  35. Perone
  36. Peroxaan
  37. Peroxclean
  38. Quasar Brite
  39. Select Bleach
  40. Superoxol
  41. T-Stuff
  42. Whiteness HP
  43. Whitespeed
  44. Xtra White
Chemical Formula H2O2
Average Molecular Weight 34.0147
Monoisotopic Molecular Weight 34.005479308
IUPAC Name peroxol
Traditional IUPAC Name hydrogen peroxide
CAS Registry Number 7722-84-1
SMILES OO
InChI Identifier InChI=1S/H2O2/c1-2/h1-2H
InChI Key MHAJPDPJQMAIIY-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom Inorganic Compounds
Super Class Homogeneous Non-metal Compounds
Class Non-metal Oxoanionic Compounds
Sub Class Non-metal Superoxides
Other Descriptors
  • a small molecule(Cyc)
  • inorganic peroxide(ChEBI)
  • reactive oxygen species(ChEBI)
Substituents
  • N/A
Direct Parent Non-metal Superoxides
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction
  • Host defense, signalling
Application Not Available
Cellular locations Not Available
Physical Properties
State Liquid
Experimental Properties
Property Value Reference
Melting Point -0.43 °C Not Available
Boiling Point Not Available Not Available
Water Solubility 1000 mg/mL at 25 °C Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility ALOGPS
LogP -0.45 ChemAxon
pKa (strongest acidic) 11.52 ChemAxon
pKa (strongest basic) -4.2 ChemAxon
Hydrogen Acceptor Count 2 ChemAxon
Hydrogen Donor Count 2 ChemAxon
Polar Surface Area 40.46 A2 ChemAxon
Rotatable Bond Count 0 ChemAxon
Refractivity 5.13 ChemAxon
Polarizability 2.29 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge 0 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations Not Available
Biofluid Locations
  • Blood
Tissue Location Not Available
Pathways
Name SMPDB Link KEGG Link
Phenylalanine and Tyrosine Metabolism SMP00008 map00360 Link_out
Histidine Metabolism SMP00044 map00340 Link_out
D-Arginine and D-Ornithine Metabolism SMP00036 map00472 Link_out
Riboflavin Metabolism SMP00070 map00740 Link_out
Ethanol Degradation SMP00449 Not Available
Degradation of Superoxides SMP00468 Not Available
Plasmalogen Synthesis SMP00479 Not Available
Arachidonic Acid Metabolism SMP00075 map00590 Link_out
Glycine and Serine Metabolism SMP00004 map00260 Link_out
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
10.5 +/- 3.6 uM Adult (>18 years old) Both Normal
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified 23.5 +/- 3.0 uM Adult (>18 years old) Both Comment Coronary heart disease
Blood Detected and Quantified 21.0 +/- 2.9 uM Adult (>18 years old) Both Comment Coronary heart disease
Blood Detected and Quantified 50.3 +/- 5.4 uM Adult (>18 years old) Both Comment Coronary heart disease
Blood Detected and Quantified 30.5 +/- 4.6 uM Adult (>18 years old) Both Comment Coronary heart disease
Associated Disorders and Diseases
Disease References
Coronary heart disease
  • Kazmierczak M, Wysocki H, Wykretowicz A, Minczykowski A: Estimation of hydrogen peroxide plasma levels in patients evaluated for coronary heart disease using dipyridamole infusion followed by SPECT. Coron Artery Dis. 1995 Jan;6(1):65-9. Pubmed: 7767505 Link_out
      Associated OMIM IDs None
      DrugBank ID Not Available
      DrugBank Metabolite ID Not Available
      Phenol Explorer Compound ID Not Available
      Phenol Explorer Metabolite ID Not Available
      FoodDB ID FDB014562
      KNApSAcK ID Not Available
      Chemspider ID 763 Link_out
      KEGG Compound ID C00027 Link_out
      BioCyc ID HYDROGEN-PEROXIDE Link_out
      BiGG ID 33570 Link_out
      Wikipedia Link Hydrogen peroxide Link_out
      NuGOwiki Link HMDB03125 Link_out
      Metagene Link HMDB03125 Link_out
      METLIN ID Not Available
      PubChem Compound 784 Link_out
      PDB ID PEO Link_out
      ChEBI ID 16240 Link_out
      References
      Synthesis Reference Not Available
      Material Safety Data Sheet (MSDS) Download (PDF)
      General References
      1. Lopez-Lazaro M: Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy. Cancer Lett. 2007 Jul 8;252(1):1-8. Epub 2006 Dec 5. Pubmed: 17150302 Link_out
      2. Schallreuter KU, Elwary S: Hydrogen peroxide regulates the cholinergic signal in a concentration dependent manner. Life Sci. 2007 May 30;80(24-25):2221-6. Epub 2007 Jan 25. Pubmed: 17335854 Link_out
      3. Stone JR, Yang S: Hydrogen peroxide: a signaling messenger. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):243-70. Pubmed: 16677071 Link_out
      4. Tredwin CJ, Naik S, Lewis NJ, Scully C: Hydrogen peroxide tooth-whitening (bleaching) products: review of adverse effects and safety issues. Br Dent J. 2006 Apr 8;200(7):371-6. Pubmed: 16607324 Link_out
      5. Ardanaz N, Pagano PJ: Hydrogen peroxide as a paracrine vascular mediator: regulation and signaling leading to dysfunction. Exp Biol Med (Maywood). 2006 Mar;231(3):237-51. Pubmed: 16514169 Link_out

      Enzymes

      Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 52 enzymes in total.

      Name: Peroxisomal sarcosine oxidase
      Reactions:
      Sarcosine + Water + Oxygen unknown Glycine + Formaldehyde + Hydrogen peroxide details
      L-Pipecolic acid + Oxygen unknown (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + Hydrogen peroxide details
      Gene Name: PIPOX
      Uniprot ID: Q9P0Z9 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
      Reactions:
      N1-Acetylspermine + Oxygen + Water unknown Spermidine + Acetamidopropanal + Hydrogen peroxide details
      N1-Acetylspermidine + Oxygen + Water unknown Putrescine + Acetamidopropanal + Hydrogen peroxide details
      N1,N12-Diacetylspermine + Oxygen + Water unknown N1-Acetylspermidine + 3-Acetamidobutanal + Hydrogen peroxide details
      Gene Name: PAOX
      Uniprot ID: Q6QHF9 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Aldehyde oxidase
      Reactions:
      An aldehyde + Water + Oxygen unknown a carboxylate + Hydrogen peroxide details
      Pyridoxal + Oxygen + Water unknown 4-Pyridoxic acid + Hydrogen peroxide details
      Gentisic acid + Hydrogen peroxide unknown Gentisate aldehyde + Oxygen + Water details
      Methylmalonic acid + Hydrogen peroxide unknown (S)-Methylmalonic acid semialdehyde + Oxygen + Water details
      1-Methylnicotinamide + Oxygen + Water unknown N1-Methyl-4-pyridone-3-carboxamide + Hydrogen peroxide + Hydrogen Ion details
      5-Hydroxyindoleacetaldehyde + Oxygen + Water unknown 5-Hydroxyindoleacetic acid + Hydrogen peroxide details
      Citalopram aldehyde + Water + Oxygen unknown Citalopram propionic acid + Hydrogen peroxide details
      1-Methylnicotinamide + Oxygen + Water unknown N1-Methyl-2-pyridone-5-carboxamide + Hydrogen peroxide + Hydrogen Ion details
      Gene Name: AOX1
      Uniprot ID: Q06278 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Peroxisomal acyl-coenzyme A oxidase 1
      Reactions:
      Acyl-CoA + Oxygen unknown trans-2,3-dehydroacyl-CoA + Hydrogen peroxide details
      Gene Name: ACOX1
      Uniprot ID: Q15067 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: D-aspartate oxidase
      Reactions:
      D-Aspartic acid + Water + Oxygen unknown Oxalacetic acid + Ammonia + Hydrogen peroxide details
      Gene Name: DDO
      Uniprot ID: Q99489 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Amine oxidase [flavin-containing] B
      Reactions:
      RCH(2)NHR' + Water + Oxygen unknown RCHO + R'NH(2) + Hydrogen peroxide details
      Tryptamine + Water + Oxygen unknown Indoleacetaldehyde + Ammonia + Hydrogen peroxide details
      Tyramine + Water + Oxygen unknown 4-Hydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide details
      Aminoacetone + Water + Oxygen unknown Pyruvaldehyde + Ammonia + Hydrogen peroxide details
      Norepinephrine + Water + Oxygen unknown 3,4-Dihydroxymandelaldehyde + Ammonia + Hydrogen peroxide details
      Phenylethylamine + Oxygen + Water unknown Phenylacetaldehyde + Ammonia + Hydrogen peroxide details
      Serotonin + Water + Oxygen unknown 5-Hydroxyindoleacetaldehyde + Ammonia + Hydrogen peroxide details
      Epinephrine + Water + Oxygen unknown 3,4-Dihydroxymandelaldehyde + Methylamine + Hydrogen peroxide details
      N-Acetylputrescine + Water + Oxygen unknown N4-Acetylaminobutanal + Ammonia + Hydrogen peroxide details
      Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide details
      1-Methylhistamine + Water + Oxygen unknown Methylimidazole acetaldehyde + Ammonia + Hydrogen peroxide details
      3-Methoxytyramine + Water + Oxygen unknown Homovanillin + Hydrogen peroxide + Ammonia details
      Normetanephrine + Water + Oxygen unknown 3-Methoxy-4-hydroxyphenylglycolaldehyde + Ammonia + Hydrogen peroxide details
      Metanephrine + Water + Oxygen unknown 3-Methoxy-4-hydroxyphenylglycolaldehyde + Hydrogen peroxide + Methylamine details
      3-Hydroxykynurenamine + Oxygen unknown Quinoline-4,8-diol + Ammonia + Hydrogen peroxide details
      5-Hydroxykynurenamine + Water + Oxygen unknown 4,6-Dihydroxyquinoline + Ammonia + Hydrogen peroxide + Water details
      Citalopram + Oxygen + Water unknown Citalopram aldehyde + Dimethylamine + Hydrogen peroxide details
      N-Desmethylcitalopram + Oxygen + Water unknown Citalopram aldehyde + Methylamine + Hydrogen peroxide details
      Didemethylcitalopram + Water + Oxygen unknown Citalopram aldehyde + Ammonia + Hydrogen peroxide details
      Gene Name: MAOB
      Uniprot ID: P27338 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Amine oxidase [flavin-containing] A
      Reactions:
      RCH(2)NHR' + Water + Oxygen unknown RCHO + R'NH(2) + Hydrogen peroxide details
      Tryptamine + Water + Oxygen unknown Indoleacetaldehyde + Ammonia + Hydrogen peroxide details
      Tyramine + Water + Oxygen unknown 4-Hydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide details
      Aminoacetone + Water + Oxygen unknown Pyruvaldehyde + Ammonia + Hydrogen peroxide details
      Norepinephrine + Water + Oxygen unknown 3,4-Dihydroxymandelaldehyde + Ammonia + Hydrogen peroxide details
      Phenylethylamine + Oxygen + Water unknown Phenylacetaldehyde + Ammonia + Hydrogen peroxide details
      Serotonin + Water + Oxygen unknown 5-Hydroxyindoleacetaldehyde + Ammonia + Hydrogen peroxide details
      Epinephrine + Water + Oxygen unknown 3,4-Dihydroxymandelaldehyde + Methylamine + Hydrogen peroxide details
      N-Acetylputrescine + Water + Oxygen unknown N4-Acetylaminobutanal + Ammonia + Hydrogen peroxide details
      Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide details
      1-Methylhistamine + Water + Oxygen unknown Methylimidazole acetaldehyde + Ammonia + Hydrogen peroxide details
      3-Methoxytyramine + Water + Oxygen unknown Homovanillin + Hydrogen peroxide + Ammonia details
      Normetanephrine + Water + Oxygen unknown 3-Methoxy-4-hydroxyphenylglycolaldehyde + Ammonia + Hydrogen peroxide details
      Metanephrine + Water + Oxygen unknown 3-Methoxy-4-hydroxyphenylglycolaldehyde + Hydrogen peroxide + Methylamine details
      3-Hydroxykynurenamine + Oxygen unknown Quinoline-4,8-diol + Ammonia + Hydrogen peroxide details
      5-Hydroxykynurenamine + Water + Oxygen unknown 4,6-Dihydroxyquinoline + Ammonia + Hydrogen peroxide + Water details
      Citalopram + Oxygen + Water unknown Citalopram aldehyde + Dimethylamine + Hydrogen peroxide details
      N-Desmethylcitalopram + Oxygen + Water unknown Citalopram aldehyde + Methylamine + Hydrogen peroxide details
      Didemethylcitalopram + Water + Oxygen unknown Citalopram aldehyde + Ammonia + Hydrogen peroxide details
      Gene Name: MAOA
      Uniprot ID: P21397 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Xanthine dehydrogenase/oxidase
      Reactions:
      Xanthine + Water + Oxygen unknown Uric acid + Hydrogen peroxide details
      Hypoxanthine + Oxygen + Water unknown Xanthine + Hydrogen peroxide details
      1-Methylxanthine + Water + Oxygen unknown 1-Methyluric acid + Hydrogen peroxide details
      Paraxanthine + Oxygen + Water unknown 1,7-Dimethyluric acid + Hydrogen peroxide details
      Theobromine + Water + Oxygen unknown 3,7-Dimethyluric acid + Hydrogen peroxide details
      7-Methylxanthine + Oxygen + Water unknown 7-Methyluric acid + Hydrogen peroxide details
      Mercaptopurine + Water + Oxygen unknown 6-Thiourate + Hydrogen peroxide details
      Gene Name: XDH
      Uniprot ID: P47989 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Dihydroorotate dehydrogenase (quinone), mitochondrial
      Reactions: Not Available
      Gene Name: DHODH
      Uniprot ID: Q02127 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Peroxisomal acyl-coenzyme A oxidase 3
      Reactions:
      Acyl-CoA + Oxygen unknown trans-2,3-dehydroacyl-CoA + Hydrogen peroxide details
      Gene Name: ACOX3
      Uniprot ID: O15254 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: D-amino-acid oxidase
      Reactions:
      A D-amino acid + Water + Oxygen unknown a 2-oxo acid + Ammonia + Hydrogen peroxide details
      Glycine + Water + Oxygen unknown Glyoxylic acid + Ammonia + Hydrogen peroxide details
      D-Ornithine + Water + Oxygen unknown 5-Amino-2-oxopentanoic acid + Ammonia + Hydrogen peroxide details
      D-Proline + Oxygen unknown 1-Pyrroline-2-carboxylic acid + Hydrogen peroxide details
      cis-4-Hydroxy-D-proline + Oxygen unknown 1-Pyrroline-4-hydroxy-2-carboxylate + Hydrogen peroxide details
      Cephalosporin C + Water + Oxygen unknown (7R)-7-(5-Carboxy-5-oxopentanoyl)aminocephalosporinate + Ammonia + Hydrogen peroxide details
      Gene Name: DAO
      Uniprot ID: P14920 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Thyroid peroxidase
      Reactions:
      I(-) + Hydrogen peroxide + Hydrogen Ion unknown Iodine + Water details
      [Thyroglobulin]-L-tyrosine + I(-) + Hydrogen peroxide unknown [thyroglobulin]-3-iodo-L-tyrosine + Water details
      [Thyroglobulin]-3-iodo-L-tyrosine + I(-) + Hydrogen peroxide unknown [thyroglobulin]-3,5-diiodo-L-tyrosine + Water details
      [thyroglobulin]-3,5-diiodo-L-tyrosine + Hydrogen peroxide unknown [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + Water details
      [Thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + Hydrogen peroxide unknown [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + Water details
      3,5-Diiodo-L-tyrosine + Hydrogen peroxide unknown Thyroxine + 2-Aminoacrylic acid + Water details
      Iodotyrosine + 3,5-Diiodo-L-tyrosine + Hydrogen peroxide unknown Liothyronine + 2-Aminoacrylic acid + Water details
      Gene Name: TPO
      Uniprot ID: P07202 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Lactoperoxidase
      Reactions:
      phenolic donor + Hydrogen peroxide unknown phenoxyl radical of the donor + Water details
      Gene Name: LPO
      Uniprot ID: P22079 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Peroxiredoxin-6
      Reactions:
      Glutathione + Hydrogen peroxide unknown Oxidized glutathione + Water details
      Methanol + Hydrogen peroxide unknown Formaldehyde + Water details
      Gene Name: PRDX6
      Uniprot ID: P30041 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Myeloperoxidase
      Reactions:
      Hydrochloric acid + Hydrogen peroxide + Hydrogen Ion unknown HClO + Water details
      Hydrochloric acid + Hydrogen peroxide unknown HClO + Water details
      Gene Name: MPO
      Uniprot ID: P05164 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Eosinophil peroxidase
      Reactions:
      phenolic donor + Hydrogen peroxide unknown phenoxyl radical of the donor + Water details
      Gene Name: EPX
      Uniprot ID: P11678 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Amiloride-sensitive amine oxidase [copper-containing]
      Reactions:
      Histamine + Water + Oxygen unknown Imidazole-4-acetaldehyde + Ammonia + Hydrogen peroxide details
      Putrescine + Oxygen + Water unknown 4-Aminobutyraldehyde + Ammonia + Hydrogen peroxide details
      Tryptamine + Water + Oxygen unknown Indoleacetaldehyde + Ammonia + Hydrogen peroxide details
      Gene Name: ABP1
      Uniprot ID: P19801 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Membrane primary amine oxidase
      Reactions:
      RCH(2)NH(2) + Water + Oxygen unknown RCHO + Ammonia + Hydrogen peroxide details
      Tyramine + Water + Oxygen unknown 4-Hydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide details
      Aminoacetone + Water + Oxygen unknown Pyruvaldehyde + Ammonia + Hydrogen peroxide details
      Phenylethylamine + Oxygen + Water unknown Phenylacetaldehyde + Ammonia + Hydrogen peroxide details
      1,3-Diaminopropane + Oxygen + Water unknown 3-Aminopropionaldehyde + Ammonia + Hydrogen peroxide details
      N-Methylputrescine + Oxygen + Hydrogen Ion unknown 1-Methylpyrrolinium + Hydrogen peroxide + Ammonia details
      Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide details
      Methylamine + Oxygen + Water unknown Formaldehyde + Ammonia + Hydrogen peroxide details
      Cadaverine + Water + Oxygen unknown 5-Aminopentanal + Ammonia + Hydrogen peroxide details
      Gene Name: AOC3
      Uniprot ID: Q16853 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Retina-specific copper amine oxidase
      Reactions:
      RCH(2)NH(2) + Water + Oxygen unknown RCHO + Ammonia + Hydrogen peroxide details
      Tyramine + Water + Oxygen unknown 4-Hydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide details
      Aminoacetone + Water + Oxygen unknown Pyruvaldehyde + Ammonia + Hydrogen peroxide details
      Phenylethylamine + Oxygen + Water unknown Phenylacetaldehyde + Ammonia + Hydrogen peroxide details
      1,3-Diaminopropane + Oxygen + Water unknown 3-Aminopropionaldehyde + Ammonia + Hydrogen peroxide details
      N-Methylputrescine + Oxygen + Hydrogen Ion unknown 1-Methylpyrrolinium + Hydrogen peroxide + Ammonia details
      Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide details
      Methylamine + Oxygen + Water unknown Formaldehyde + Ammonia + Hydrogen peroxide details
      Cadaverine + Water + Oxygen unknown 5-Aminopentanal + Ammonia + Hydrogen peroxide details
      Gene Name: AOC2
      Uniprot ID: O75106 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Pyridoxine-5'-phosphate oxidase
      Reactions:
      Pyridoxamine 5'-phosphate + Water + Oxygen unknown Pyridoxal 5'-phosphate + Ammonia + Hydrogen peroxide details
      Pyridoxine 5'-phosphate + Oxygen unknown Pyridoxal 5'-phosphate + Hydrogen peroxide details
      Pyridoxamine + Water + Oxygen unknown Pyridoxal + Ammonia + Hydrogen peroxide details
      Pyridoxine + Oxygen unknown Pyridoxal + Hydrogen peroxide details
      Gene Name: PNPO
      Uniprot ID: Q9NVS9 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Protein-lysine 6-oxidase
      Reactions:
      Peptidyl-L-lysyl-peptide + Oxygen + Water unknown peptidyl-allysyl-peptide + Ammonia + Hydrogen peroxide details
      Gene Name: LOX
      Uniprot ID: P28300 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Hydroxyacid oxidase 1
      Reactions:
      (S)-2-hydroxy acid + Oxygen unknown 2-oxo acid + Hydrogen peroxide details
      Glycolic acid + Oxygen unknown Glyoxylic acid + Hydrogen peroxide details
      Gene Name: HAO1
      Uniprot ID: Q9UJM8 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Hydroxyacid oxidase 2
      Reactions:
      (S)-2-hydroxy acid + Oxygen unknown 2-oxo acid + Hydrogen peroxide details
      Glycolic acid + Oxygen unknown Glyoxylic acid + Hydrogen peroxide details
      Gene Name: HAO2
      Uniprot ID: Q9NYQ3 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Glutathione peroxidase 7
      Reactions:
      Glutathione + Hydrogen peroxide unknown Oxidized glutathione + Water details
      Gene Name: GPX7
      Uniprot ID: Q96SL4 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Epididymal secretory glutathione peroxidase
      Reactions:
      Glutathione + Hydrogen peroxide unknown Oxidized glutathione + Water details
      Gene Name: GPX5
      Uniprot ID: O75715 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Glutathione peroxidase 6
      Reactions:
      Glutathione + Hydrogen peroxide unknown Oxidized glutathione + Water details
      Gene Name: GPX6
      Uniprot ID: P59796 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Glutathione peroxidase 1
      Reactions:
      Glutathione + Hydrogen peroxide unknown Oxidized glutathione + Water details
      Gene Name: GPX1
      Uniprot ID: P07203 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
      Reactions: Not Available
      Gene Name: GPX4
      Uniprot ID: P36969 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Glutathione peroxidase 3
      Reactions:
      Glutathione + Hydrogen peroxide unknown Oxidized glutathione + Water details
      Gene Name: GPX3
      Uniprot ID: P22352 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Glutathione peroxidase 2
      Reactions:
      Glutathione + Hydrogen peroxide unknown Oxidized glutathione + Water details
      Gene Name: GPX2
      Uniprot ID: P18283 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Protoporphyrinogen oxidase
      Reactions:
      Protoporphyrinogen IX + Oxygen unknown Protoporphyrin IX + Hydrogen peroxide details
      Protoporphyrinogen IX + Oxygen unknown Protoporphyrin IX + Hydrogen peroxide details
      Gene Name: PPOX
      Uniprot ID: P50336 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Sulfite oxidase, mitochondrial
      Reactions:
      Sulfurous acid + Oxygen + Water unknown Oat gum + Hydrogen peroxide details
      Gene Name: SUOX
      Uniprot ID: P51687 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Catalase
      Reactions:
      Hydrogen peroxide unknown Oxygen + Water details
      Methanol + Hydrogen peroxide unknown Formaldehyde + Water details
      3-Hydroxyanthranilic acid + Oxygen unknown Cinnavalininate + Superoxide + Hydrogen peroxide + Hydrogen Ion details
      Gene Name: CAT
      Uniprot ID: P04040 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Superoxide dismutase [Mn], mitochondrial
      Reactions:
      Superoxide + Hydrogen Ion unknown Oxygen + Hydrogen peroxide details
      Gene Name: SOD2
      Uniprot ID: P04179 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Amyloid beta A4 protein
      Reactions: Not Available
      Gene Name: APP
      Uniprot ID: P05067 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Superoxide dismutase [Cu-Zn]
      Reactions:
      Superoxide + Hydrogen Ion unknown Oxygen + Hydrogen peroxide details
      Gene Name: SOD1
      Uniprot ID: P00441 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Peroxiredoxin-5, mitochondrial
      Reactions: Not Available
      Gene Name: PRDX5
      Uniprot ID: P30044 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Spermine oxidase
      Reactions:
      Spermine + Oxygen + Water unknown Spermidine + 3-Aminopropionaldehyde + Hydrogen peroxide details
      Gene Name: SMOX
      Uniprot ID: Q9NWM0 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Dual oxidase 2
      Reactions:
      NAD(P)H + Oxygen unknown NAD(P)(+) + Hydrogen peroxide details
      Gene Name: DUOX2
      Uniprot ID: Q9NRD8 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Extracellular superoxide dismutase [Cu-Zn]
      Reactions:
      Superoxide + Hydrogen Ion unknown Oxygen + Hydrogen peroxide details
      Gene Name: SOD3
      Uniprot ID: P08294 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Dual oxidase 1
      Reactions:
      NAD(P)H + Oxygen unknown NAD(P)(+) + Hydrogen peroxide details
      Gene Name: DUOX1
      Uniprot ID: Q9NRD9 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Peroxidasin homolog
      Reactions:
      phenolic donor + Hydrogen peroxide unknown phenoxyl radical of the donor + Water details
      Gene Name: PXDN
      Uniprot ID: Q92626 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Peroxidasin-like protein
      Reactions:
      phenolic donor + Hydrogen peroxide unknown phenoxyl radical of the donor + Water details
      Gene Name: PXDNL
      Uniprot ID: A1KZ92 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Lysyl oxidase homolog 2
      Reactions:
      Peptidyl-L-lysyl-peptide + Oxygen + Water unknown peptidyl-allysyl-peptide + Ammonia + Hydrogen peroxide details
      Gene Name: LOXL2
      Uniprot ID: Q9Y4K0 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: FAD-linked sulfhydryl oxidase ALR
      Reactions:
      R'C(R)SH + Oxygen unknown R'C(R)S-S(R)CR' + Hydrogen peroxide details
      Gene Name: GFER
      Uniprot ID: P55789 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: L-amino-acid oxidase
      Reactions:
      An L-amino acid + Water + Oxygen unknown a 2-oxo acid + Ammonia + Hydrogen peroxide details
      L-Aspartic acid + Water + Oxygen unknown Oxalacetic acid + Ammonia + Hydrogen peroxide details
      L-Methionine + Water + Oxygen unknown 2-Oxo-4-methylthiobutanoic acid + Ammonia + Hydrogen peroxide details
      L-Tryptophan + Water + Oxygen unknown Indolepyruvate + Ammonia + Hydrogen peroxide details
      L-Phenylalanine + Water + Oxygen unknown Phenylpyruvic acid + Ammonia + Hydrogen peroxide details
      L-Tyrosine + Water + Oxygen unknown 4-Hydroxyphenylpyruvic acid + Ammonia + Hydrogen peroxide details
      L-Isoleucine + Water + Oxygen unknown 3-Methyl-2-oxovaleric acid + Ammonia + Hydrogen peroxide details
      Gene Name: IL4I1
      Uniprot ID: Q96RQ9 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Prenylcysteine oxidase 1
      Reactions:
      An S-prenyl-L-cysteine + Oxygen + Water unknown a prenal + L-Cysteine + Hydrogen peroxide details
      Farnesylcysteine + Oxygen + Water unknown 2-trans,6-trans-Farnesal + L-Cysteine + Hydrogen peroxide details
      Gene Name: PCYOX1
      Uniprot ID: Q9UHG3 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Sulfhydryl oxidase 1
      Reactions:
      R'C(R)SH + Oxygen unknown R'C(R)S-S(R)CR' + Hydrogen peroxide details
      Gene Name: QSOX1
      Uniprot ID: O00391 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Sulfhydryl oxidase 2
      Reactions:
      R'C(R)SH + Oxygen unknown R'C(R)S-S(R)CR' + Hydrogen peroxide details
      Gene Name: QSOX2
      Uniprot ID: Q6ZRP7 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: NADPH oxidase activator 1
      Reactions: Not Available
      Gene Name: NOXA1
      Uniprot ID: Q86UR1 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA