Human Metabolome Database Version 3.5

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Showing metabocard for Heme (HMDB03178)

enzymes (169) transporters (1)

Blood
Urine

Record Information

Version

3.5

Creation Date

2006-05-22 09:12:38 -0600

Update Date

2013-02-08 11:22:55 -0700

HMDB ID

HMDB03178

Secondary Accession Numbers

None

Metabolite Identification

Common Name

Heme

Description

Heme is the color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins. A heme or haem is a prosthetic group that consists of an iron atom contained in the center of a large heterocyclic organic ring called a porphyrin. Not all porphyrins contain iron, but a substantial fraction of porphyrin-containing metalloproteins have heme as their prosthetic subunit; these are known as hemoproteins.

Structure

Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure

Synonyms

(protoporphyrinato)iron
Ferroheme
Ferroheme b
Ferroprotoheme
Ferroprotoporphyrin
Ferroprotoporphyrin IX
Ferrous protoheme
Ferrous protoheme IX
Haem
Hem
Heme
Iron protoporphyrin
Iron protoporphyrin IX
Iron(II) protoporphyrin IX
Protoferroheme
Protohaem
Protoheme
Protoheme IX
Reduced hematin

Chemical Formula

C₃₄H₃₂FeN₄O₄

Average Molecular Weight

616.487

Monoisotopic Molecular Weight

616.177297665

IUPAC Name

10,14-bis(2-carboxyethyl)-5,20-diethenyl-4,9,15,19-tetramethyl-2$l^{4},22$l^{4},23,25-tetraaza-1-ferraoctacyclo[11.9.1.1^{1,8}.1^{3,21}.0^{2,6}.0^{16,23}.0^{18,22}.0^{11,25}]pentacosa-2,4,6,8,10,12,14,16,18(22),19,21(24)-undecaene-1,1-bis(ylium)

Traditional IUPAC Name

CAS Registry Number

14875-96-8

SMILES

CC1=C(CCC(O)=O)C2=CC3=C(CCC(O)=O)C(C)=C4C=C5C(C=C)=C(C)C6=[N]5[Fe++]5(N2C1=CC1=[N]5C(=C6)C(C=C)=C1C)N34

InChI Identifier

InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+4/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;

InChI Key

YHLKGEDAGPGZPN-RGGAHWMASA-L

Chemical Taxonomy

Kingdom

Organic Compounds

Super Class

Aromatic Heteropolycyclic Compounds

Class

Tetrapyrroles and Derivatives

Sub Class

Metallotetrapyrroles

Other Descriptors

Organic Compounds
Porphyrins

Substituents

Carboxylic Acid
Dicarboxylic Acid Derivative
Organic Transition Metal Moeity
Organometallic Compound
Pyrrole
Quaternary Ammonium Salt

Direct Parent

Metalloporphyrins

Ontology

Status

Expected and Not Quantified

Origin

Endogenous

Biofunction

Component of Porphyrin and chlorophyll metabolism
Enzyme co-factor

Application

Not Available

Cellular locations

Cytoplasm
Extracellular
Mitochondria

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
LogP	2.00	ALOGPS
LogS	-5.75	ALOGPS
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	121.19 A²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	176.19	ChemAxon
Polarizability	70.03	ChemAxon
Formal Charge	2	ChemAxon
Physiological Charge	2	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm
Extracellular
Mitochondria

Biofluid Locations

Not Available

Tissue Location

Skin

Pathways

Name	SMPDB Link	KEGG Link
Porphyrin Metabolism	SMP00024	map00860

Normal Concentrations

Not Available

Abnormal Concentrations

Not Available

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

Phenol Explorer Metabolite ID

Not Available

FoodDB ID

FDB016272

KNApSAcK ID

Not Available

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

NuGOwiki Link

Metagene Link

METLIN ID

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

17627

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Ono F, Sharma BK, Smith CC, Burnett JW, Aurelian L: CD34+ cells in the peripheral blood transport herpes simplex virus DNA fragments to the skin of patients with erythema multiforme (HAEM). J Invest Dermatol. 2005 Jun;124(6):1215-24. Pubmed: 15955097
Allhorn M, Lundqvist K, Schmidtchen A, Akerstrom B: Heme-scavenging role of alpha1-microglobulin in chronic ulcers. J Invest Dermatol. 2003 Sep;121(3):640-6. Pubmed: 12925227
Walczyk T, von Blanckenburg F: Natural iron isotope variations in human blood. Science. 2002 Mar 15;295(5562):2065-6. Pubmed: 11896276
Kuhnel A, Gross U, Doss MO: Hereditary coproporphyria in Germany: clinical-biochemical studies in 53 patients. Clin Biochem. 2000 Aug;33(6):465-73. Pubmed: 11074238
Zhang JP, Normark S: Induction of gene expression in Escherichia coli after pilus-mediated adherence. Science. 1996 Aug 30;273(5279):1234-6. Pubmed: 8703059
Taylor TD, Litt M, Kramer P, Pandolfo M, Angelini L, Nardocci N, Davis S, Pineda M, Hattori H, Flett PJ, Cilio MR, Bertini E, Hayflick SJ: Homozygosity mapping of Hallervorden-Spatz syndrome to chromosome 20p12.3-p13. Nat Genet. 1996 Dec;14(4):479-81. Pubmed: 8944032
Park KK, Park JH, Jung YJ, Chung WY: Inhibitory effects of chlorophyllin, hemin and tetrakis(4-benzoic acid)porphyrin on oxidative DNA damage and mouse skin inflammation induced by 12-O-tetradecanoylphorbol-13-acetate as a possible anti-tumor promoting mechanism. Mutat Res. 2003 Dec 9;542(1-2):89-97. Pubmed: 14644357

Enzymes

Name:	5-aminolevulinate synthase, erythroid-specific, mitochondrial
Reactions:	succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 [RN:R00830]
Gene Name:	ALAS2
Uniprot ID:	P22557
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	5-aminolevulinate synthase, nonspecific, mitochondrial
Reactions:	succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 [RN:R00830]
Gene Name:	ALAS1
Uniprot ID:	P13196
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Reactions:	--- []
Gene Name:	SDHC
Uniprot ID:	Q99643
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde oxidase
Reactions:	an aldehyde + H2O + O2 = a carboxylic acid + H2O2 [RN:R00635]
Gene Name:	AOX1
Uniprot ID:	Q06278
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Heme oxygenase 2
Reactions:	heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O [RN:R00311]
Gene Name:	HMOX2
Uniprot ID:	P30519
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Reactions:
Gene Name:	SDHD
Uniprot ID:	O14521
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH--cytochrome P450 reductase
Reactions:	NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein
Gene Name:	POR
Uniprot ID:	P16435
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Heme oxygenase 1
Reactions:	heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O [RN:R00311]
Gene Name:	HMOX1
Uniprot ID:	P09601
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Uroporphyrinogen decarboxylase
Reactions:	uroporphyrinogen III = coproporphyrinogen III + 4 CO2 [RN:R03197]
Gene Name:	UROD
Uniprot ID:	P06132
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Coproporphyrinogen-III oxidase, mitochondrial
Reactions:	coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O [RN:R03220]
Gene Name:	CPOX
Uniprot ID:	P36551
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lanosterol 14-alpha demethylase
Reactions:	obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 3 NADP+ + 4 H2O [RN:R05731]
Gene Name:	CYP51A1
Uniprot ID:	Q16850
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Thyroid peroxidase
Reactions:	2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O [RN:R02810]
Gene Name:	TPO
Uniprot ID:	P07202
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lactoperoxidase
Reactions:	donor + H2O2 = oxidized donor + 2 H2O [RN:R03532]
Gene Name:	LPO
Uniprot ID:	P22079
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Myeloperoxidase
Reactions:	donor + H2O2 = oxidized donor + 2 H2O [RN:R03532]
Gene Name:	MPO
Uniprot ID:	P05164
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Eosinophil peroxidase
Reactions:	donor + H2O2 = oxidized donor + 2 H2O [RN:R03532]
Gene Name:	EPX
Uniprot ID:	P11678
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Uroporphyrinogen-III synthase
Reactions:	hydroxymethylbilane = uroporphyrinogen III + H2O [RN:R03165]
Gene Name:	UROS
Uniprot ID:	P10746
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Porphobilinogen deaminase
Reactions:	4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3 [RN:R00084]
Gene Name:	HMBS
Uniprot ID:	P08397
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4A11
Reactions:	octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O [RN:R02879]
Gene Name:	CYP4A11
Uniprot ID:	Q02928
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Indoleamine 2,3-dioxygenase 1
Reactions:	(1) D-tryptophan + O2 = N-formyl-D-kynurenine [RN:R07362] (2) L-tryptophan + O2 = N-formyl-L-kynurenine [RN:R00678]
Gene Name:	IDO1
Uniprot ID:	P14902
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 11B1, mitochondrial
Reactions:	a steroid + reduced adrenal ferredoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O [RN:R02726]
Gene Name:	CYP11B1
Uniprot ID:	P15538
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cholesterol 7-alpha-monooxygenase
Reactions:	cholesterol + NADPH + H+ + O2 = 7alpha-hydroxycholesterol + NADP+ + H2O [RN:R01463]
Gene Name:	CYP7A1
Uniprot ID:	P22680
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Biliverdin reductase A
Reactions:	bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+ [RN:R02391 R02393]
Gene Name:	BLVRA
Uniprot ID:	P53004
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Flavin reductase
Reactions:	reduced riboflavin + NADP+ = riboflavin + NADPH + H+ [RN:R05707]
Gene Name:	BLVRB
Uniprot ID:	P30043
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cholesterol side-chain cleavage enzyme, mitochondrial
Reactions:	cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O [RN:R02724]
Gene Name:	CYP11A1
Uniprot ID:	P05108
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cystathionine beta-synthase
Reactions:	L-serine + L-homocysteine = L-cystathionine + H2O [RN:R01290]
Gene Name:	CBS
Uniprot ID:	P35520
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nitric oxide synthase, inducible
Reactions:	L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+ [RN:R00557]
Gene Name:	NOS2
Uniprot ID:	P35228
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nitric oxide synthase, brain
Reactions:	L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+ [RN:R00557]
Gene Name:	NOS1
Uniprot ID:	P29475
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nitric oxide synthase, endothelial
Reactions:	L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+ [RN:R00557]
Gene Name:	NOS3
Uniprot ID:	P29474
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
Reactions:	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA [RN:R00405]
Gene Name:	SUCLA2
Uniprot ID:	Q9P2R7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Prostaglandin G/H synthase 2
Reactions:	arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O [RN:R01599]
Gene Name:	PTGS2
Uniprot ID:	P35354
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Prostaglandin G/H synthase 1
Reactions:	arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O [RN:R01599]
Gene Name:	PTGS1
Uniprot ID:	P23219
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b-c1 complex subunit 9
Reactions:	--- []
Gene Name:	UQCR10
Uniprot ID:	Q9UDW1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b
Reactions:
Gene Name:	MT-CYB
Uniprot ID:	P00156
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c1, heme protein, mitochondrial
Reactions:
Gene Name:	CYC1
Uniprot ID:	P08574
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b-c1 complex subunit 6, mitochondrial
Reactions:
Gene Name:	UQCRH
Uniprot ID:	P07919
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Leukotriene-B(4) omega-hydroxylase 1
Reactions:	(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14- tetraenoate + NADP+ + H2O [RN:R03866]
Gene Name:	CYP4F2
Uniprot ID:	P78329
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Leukotriene-B(4) omega-hydroxylase 2
Reactions:	(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14- tetraenoate + NADP+ + H2O [RN:R03866]
Gene Name:	CYP4F3
Uniprot ID:	Q08477
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 3A4
Reactions:	(1) taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O [RN:R07205] (2) lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O [RN:R07206]
Gene Name:	CYP3A4
Uniprot ID:	P08684
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protoporphyrinogen oxidase
Reactions:	protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2 [RN:R03222]
Gene Name:	PPOX
Uniprot ID:	P50336
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2C9
Reactions:	(R)-limonene + NADPH + H+ + O2 = (+)-trans-carveol + NADP+ + H2O [RN:R06119]
Gene Name:	CYP2C9
Uniprot ID:	P11712
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sterol 26-hydroxylase, mitochondrial
Reactions:	5beta-cholestane-3alpha,7alpha,12alpha-triol + NADPH + H+ + O2 = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + NADP+ + H2O [RN:R04807]
Gene Name:	CYP27A1
Uniprot ID:	Q02318
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2C19
Reactions:	(R)-limonene + NADPH + H+ + O2 = (+)-trans-carveol + NADP+ + H2O [RN:R06119]
Gene Name:	CYP2C19
Uniprot ID:	P33261
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Reactions:	calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O [RN:R03610]
Gene Name:	CYP27B1
Uniprot ID:	O15528
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Steroid 17-alpha-hydroxylase/17,20 lyase
Reactions:	a steroid + AH2 + O2 = a 17alpha-hydroxysteroid + A + H2O [RN:R02131]
Gene Name:	CYP17A1
Uniprot ID:	P05093
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sulfite oxidase, mitochondrial
Reactions:	sulfite + O2 + H2O = sulfate + H2O2 [RN:R00533]
Gene Name:	SUOX
Uniprot ID:	P51687
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ferrochelatase, mitochondrial
Reactions:	protoheme + 2 H+ = protoporphyrin + Fe2+ [RN:R00310]
Gene Name:	FECH
Uniprot ID:	P22830
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Delta-aminolevulinic acid dehydratase
Reactions:	2 5-aminolevulinate = porphobilinogen + 2 H2O [RN:R00036]
Gene Name:	ALAD
Uniprot ID:	P13716
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Guanylate cyclase soluble subunit beta-1
Reactions:	GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Gene Name:	GUCY1B3
Uniprot ID:	Q02153
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Guanylate cyclase soluble subunit beta-2
Reactions:	GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Gene Name:	GUCY1B2
Uniprot ID:	O75343
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Prostacyclin synthase
Reactions:	(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13- dienoate = (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13- dienoate [RN:R02267]
Gene Name:	PTGIS
Uniprot ID:	Q16647
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2E1
Reactions:	--- []
Gene Name:	CYP2E1
Uniprot ID:	P05181
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4F11
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP4F11
Uniprot ID:	Q9HBI6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 3A43
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP3A43
Uniprot ID:	Q9HB55
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 1B1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP1B1
Uniprot ID:	Q16678
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2D6
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2D6
Uniprot ID:	P10635
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2C18
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2C18
Uniprot ID:	P33260
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4F12
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP4F12
Uniprot ID:	Q9HCS2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2F1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2F1
Uniprot ID:	P24903
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4X1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP4X1
Uniprot ID:	Q8N118
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2B6
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2B6
Uniprot ID:	P20813
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 3A5
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP3A5
Uniprot ID:	P20815
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 1A1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP1A1
Uniprot ID:	P04798
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2A13
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2A13
Uniprot ID:	Q16696
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 3A7
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP3A7
Uniprot ID:	P24462
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4B1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP4B1
Uniprot ID:	P13584
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4Z1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP4Z1
Uniprot ID:	Q86W10
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 1A2
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP1A2
Uniprot ID:	P05177
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 19A1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP19A1
Uniprot ID:	P11511
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2C8
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2C8
Uniprot ID:	P10632
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2S1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2S1
Uniprot ID:	Q96SQ9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4F8
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP4F8
Uniprot ID:	P98187
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2J2
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2J2
Uniprot ID:	P51589
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2A7
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2A7
Uniprot ID:	P20853
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2A6
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2A6
Uniprot ID:	P11509
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Catalase
Reactions:	2 H2O2 = O2 + 2 H2O [RN:R00009]
Gene Name:	CAT
Uniprot ID:	P04040
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Thromboxane-A synthase
Reactions:	(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13- dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13- dienoate [RN:R02268]
Gene Name:	TBXAS1
Uniprot ID:	P24557
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hemoglobin subunit beta
Reactions:
Gene Name:	HBB
Uniprot ID:	P68871
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hemoglobin subunit alpha
Reactions:
Gene Name:	HBA1
Uniprot ID:	P69905
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hemoglobin subunit gamma-1
Reactions:
Gene Name:	HBG1
Uniprot ID:	P69891
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hemopexin
Reactions:
Gene Name:	HPX
Uniprot ID:	P02790
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	25-hydroxycholesterol 7-alpha-hydroxylase
Reactions:	(1) cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O [RN:R07209] (2) cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O [RN:R07372]
Gene Name:	CYP7B1
Uniprot ID:	O75881
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 1
Reactions:	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O [RN:R00081]
Gene Name:	MT-CO1
Uniprot ID:	P00395
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protoheme IX farnesyltransferase, mitochondrial
Reactions:
Gene Name:	COX10
Uniprot ID:	Q12887
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hereditary hemochromatosis protein
Reactions:
Gene Name:	HFE
Uniprot ID:	Q30201
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein AMBP
Reactions:
Gene Name:	AMBP
Uniprot ID:	P02760
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Calcium-activated potassium channel subunit alpha-1
Reactions:
Gene Name:	KCNMA1
Uniprot ID:	Q12791
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b561 domain-containing protein 2
Reactions:
Gene Name:	CYB561D2
Uniprot ID:	O14569
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b561
Reactions:
Gene Name:	CYB561
Uniprot ID:	P49447
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c
Reactions:
Gene Name:	CYCS
Uniprot ID:	P99999
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b-245 heavy chain
Reactions:
Gene Name:	CYBB
Uniprot ID:	P04839
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c-type heme lyase
Reactions:	holocytochrome c = apocytochrome c + heme [RN:R02480]
Gene Name:	HCCS
Uniprot ID:	P53701
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Reactions:	--- []
Gene Name:	CYP24A1
Uniprot ID:	Q07973
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	PR domain zinc finger protein 2
Reactions:	S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine [RN:R03938]
Gene Name:	PRDM2
Uniprot ID:	Q13029
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 26A1
Reactions:
Gene Name:	CYP26A1
Uniprot ID:	O43174
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serotransferrin
Reactions:
Gene Name:	TF
Uniprot ID:	P02787
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Feline leukemia virus subgroup C receptor-related protein 1
Reactions:
Gene Name:	FLVCR1
Uniprot ID:	Q9Y5Y0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Myoglobin
Reactions:
Gene Name:	MB
Uniprot ID:	P02144
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Transcription factor NF-E2 45 kDa subunit
Reactions:
Gene Name:	NFE2
Uniprot ID:	Q16621
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b-245 light chain
Reactions:
Gene Name:	CYBA
Uniprot ID:	P13498
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Fatty acid desaturase 1
Reactions:	--- []
Gene Name:	FADS1
Uniprot ID:	O60427
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Vitamin D 25-hydroxylase
Reactions:	5beta-cholestane-3alpha,7alpha,12alpha-triol + NADPH + H+ + O2 = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + NADP+ + H2O [RN:R04807]
Gene Name:	CYP2R1
Uniprot ID:	Q6VVX0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Translocator protein
Reactions:
Gene Name:	TSPO
Uniprot ID:	P30536
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Histidine-rich glycoprotein
Reactions:
Gene Name:	HRG
Uniprot ID:	P04196
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hemoglobin subunit gamma-2
Reactions:
Gene Name:	HBG2
Uniprot ID:	P69892
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b5
Reactions:
Gene Name:	CYB5A
Uniprot ID:	P00167
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Frataxin, mitochondrial
Reactions:	4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O [RN:R00078]
Gene Name:	FXN
Uniprot ID:	Q16595
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b reductase 1
Reactions:
Gene Name:	CYBRD1
Uniprot ID:	Q53TN4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase subunit 5A, mitochondrial
Reactions:	--- []
Gene Name:	COX5A
Uniprot ID:	P20674
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Fatty acid desaturase 2
Reactions:	--- []
Gene Name:	FADS2
Uniprot ID:	O95864
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cholesterol 24-hydroxylase
Reactions:	cholesterol + NADPH + H+ + O2 = (24S)-24-hydroxycholesterol + NADP+ + H2O [RN:R07207]
Gene Name:	CYP46A1
Uniprot ID:	Q9Y6A2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	24-hydroxycholesterol 7-alpha-hydroxylase
Reactions:	(24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2 = (24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O [RN:R07208]
Gene Name:	CYP39A1
Uniprot ID:	Q9NYL5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Reactions:	7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O [RN:R04826]
Gene Name:	CYP8B1
Uniprot ID:	Q9UNU6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b5 reductase 4
Reactions:	NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5 [RN:R00100]
Gene Name:	CYB5R4
Uniprot ID:	Q7L1T6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4A22
Reactions:	octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O [RN:R02879]
Gene Name:	CYP4A22
Uniprot ID:	Q5TCH4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Indoleamine 2,3-dioxygenase 2
Reactions:
Gene Name:	IDO2
Uniprot ID:	Q6ZQW0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450, family 1, subfamily A, polypeptide 1
Reactions:
Gene Name:	CYP1A1
Uniprot ID:	A0N0X8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Scavenger receptor cysteine-rich type 1 protein M130
Reactions:
Gene Name:	CD163
Uniprot ID:	Q86VB7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH oxidase 5
Reactions:
Gene Name:	NOX5
Uniprot ID:	Q96PH1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxidasin homolog
Reactions:	donor + H2O2 = oxidized donor + 2 H2O [RN:R03532]
Gene Name:	PXDN
Uniprot ID:	Q92626
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxidasin-like protein
Reactions:	donor + H2O2 = oxidized donor + 2 H2O [RN:R03532]
Gene Name:	PXDNL
Uniprot ID:	A1KZ92
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Metalloreductase STEAP3
Reactions:
Gene Name:	STEAP3
Uniprot ID:	Q658P3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH oxidase 1
Reactions:
Gene Name:	NOX1
Uniprot ID:	Q9Y5S8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH oxidase 4
Reactions:
Gene Name:	NOX4
Uniprot ID:	Q9NPH5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Metalloreductase STEAP1
Reactions:
Gene Name:	STEAP1
Uniprot ID:	Q9UHE8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Metalloreductase STEAP2
Reactions:
Gene Name:	STEAP2
Uniprot ID:	Q8NFT2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Metalloreductase STEAP4
Reactions:
Gene Name:	STEAP4
Uniprot ID:	Q687X5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP-binding cassette sub-family B member 6, mitochondrial
Reactions:
Gene Name:	ABCB6
Uniprot ID:	Q9NP58
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP-binding cassette sub-family B member 7, mitochondrial
Reactions:
Gene Name:	ABCB7
Uniprot ID:	O75027
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP-binding cassette sub-family B member 10, mitochondrial
Reactions:
Gene Name:	ABCB10
Uniprot ID:	Q9NRK6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 27C1
Reactions:
Gene Name:	CYP27C1
Uniprot ID:	Q4G0S4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b561 domain-containing protein 1
Reactions:
Gene Name:	CYB561D1
Uniprot ID:	Q8N8Q1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b5 domain-containing protein 1
Reactions:
Gene Name:	CYB5D1
Uniprot ID:	Q6P9G0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Neuferricin
Reactions:
Gene Name:	CYB5D2
Uniprot ID:	Q8WUJ1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hsp90 co-chaperone Cdc37
Reactions:
Gene Name:	CDC37
Uniprot ID:	Q16543
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome c oxidase assembly protein COX15 homolog
Reactions:
Gene Name:	COX15
Uniprot ID:	Q7KZN9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 20A1
Reactions:
Gene Name:	CYP20A1
Uniprot ID:	Q6UW02
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 26B1
Reactions:
Gene Name:	CYP26B1
Uniprot ID:	Q9NR63
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 26C1
Reactions:
Gene Name:	CYP26C1
Uniprot ID:	Q6V0L0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2U1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2U1
Uniprot ID:	Q7Z449
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2W1
Reactions:
Gene Name:	CYP2W1
Uniprot ID:	Q8TAV3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4F22
Reactions:
Gene Name:	CYP4F22
Uniprot ID:	Q6NT55
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4V2
Reactions:
Gene Name:	CYP4V2
Uniprot ID:	Q6ZWL3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b5 type B
Reactions:
Gene Name:	CYB5B
Uniprot ID:	O43169
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytoglobin
Reactions:
Gene Name:	CYGB
Uniprot ID:	Q8WWM9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Eukaryotic translation initiation factor 2-alpha kinase 1
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	EIF2AK1
Uniprot ID:	Q9BQI3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Fatty acid 2-hydroxylase
Reactions:
Gene Name:	FA2H
Uniprot ID:	Q7L5A8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Fatty acid desaturase 2-like protein
Reactions:
Gene Name:	Not Available
Uniprot ID:	A8MWK0
Protein Sequence:	FASTA

Name:	Fatty acid desaturase 3
Reactions:
Gene Name:	FADS3
Uniprot ID:	Q9Y5Q0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ferric-chelate reductase 1
Reactions:
Gene Name:	FRRS1
Uniprot ID:	Q6ZNA5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hemoglobin subunit theta-1
Reactions:
Gene Name:	HBQ1
Uniprot ID:	P09105
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hemoglobin subunit zeta
Reactions:
Gene Name:	HBZ
Uniprot ID:	P02008
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hemoglobin subunit delta
Reactions:
Gene Name:	HBD
Uniprot ID:	P02042
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hemoglobin subunit epsilon
Reactions:
Gene Name:	HBE1
Uniprot ID:	P02100
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hemoglobin subunit mu
Reactions:
Gene Name:	HBM
Uniprot ID:	Q6B0K9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Heme-binding protein 1
Reactions:
Gene Name:	HEBP1
Uniprot ID:	Q9NRV9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Heme-binding protein 2
Reactions:
Gene Name:	HEBP2
Uniprot ID:	Q9Y5Z4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase HERC2
Reactions:
Gene Name:	HERC2
Uniprot ID:	O95714
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Heme transporter HRG1
Reactions:
Gene Name:	SLC48A1
Uniprot ID:	Q6P1K1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Mitoferrin-1
Reactions:
Gene Name:	SLC25A37
Uniprot ID:	Q9NYZ2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Mitoferrin-2
Reactions:
Gene Name:	SLC25A28
Uniprot ID:	Q96A46
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Neudesin
Reactions:
Gene Name:	NENF
Uniprot ID:	Q9UMX5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nuclear factor erythroid 2-related factor 1
Reactions:
Gene Name:	NFE2L1
Uniprot ID:	Q14494
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Neuroglobin
Reactions:
Gene Name:	NGB
Uniprot ID:	Q9NPG2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nuclear respiratory factor 1
Reactions:
Gene Name:	NRF1
Uniprot ID:	Q16656
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Membrane-associated progesterone receptor component 1
Reactions:
Gene Name:	PGRMC1
Uniprot ID:	O00264
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Membrane-associated progesterone receptor component 2
Reactions:
Gene Name:	PGRMC2
Uniprot ID:	O15173
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Radical S-adenosyl methionine domain-containing protein 2
Reactions:
Gene Name:	RSAD2
Uniprot ID:	Q8WXG1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450, family 21, subfamily A, polypeptide 2
Reactions:
Gene Name:	CYP21A2
Uniprot ID:	Q08AG9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2D6
Reactions:
Gene Name:	CYP2D6
Uniprot ID:	Q6NWU0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Transporters

Name:	Proton-coupled folate transporter
Reactions:
Gene Name:	SLC46A1
Uniprot ID:	Q96NT5
Protein Sequence:	FASTA
Gene Sequence:	FASTA