We are currently updating the database - data may be missing for the next 10 minutes. We apologize for any inconvenience.

Human Metabolome Database Version 2.5

 

Showing metabocard for Chitin (HMDB03362)

Legend: metabolite field enzyme field

Version 2.5
Creation Date 2006-08-12 20:21:29
Update Date 2010-04-19 17:15:22
Accession Number HMDB03362
Secondary Accession Numbers Not Available
Common Name Chitin
Description Chitin is an unusual substance as it is a naturally occurring polymer. Its breakdown is conducted by bacteria which have receptors to simple sugars from the decomposition of chitin. If chitin is detected they then produce enzymes to digest the chitin by reducing it to simple sugars and ammonia. Chitin (IPA: [Kaitin]) is one of the main components in the cell walls of fungi, the exoskeletons of insects and other arthropods, and in some other animals. It is a polysaccharide; it is constructed from units of acetylglucosamine (more completely, N-acetyl-D-glucos-2-amine). These are linked together in beta-1,4 fashion (in a similar manner to the glucose units which form cellulose). In effect chitin may be described as cellulose with one hydroxyl group on each monomer replaced by an acetylamine group. This allows for increased hydrogen bonding between adjacent polymers, giving the polymer increased strength. A linear polysaccharide of beta-1->4 linked units of acetylglucosamine. It is the second most abundant biopolymer on earth, found especially in insects and fungi. When deacetylated it is called chitosan.
Synonyms
  1. N-acetyl-D-glucosamine
  2. Poly 2-Acetamido-2-deoxy-D-glucose
  3. [1,4-(N-Acetyl-beta-D-glucosaminyl)]n
  4. [1,4-(N-Acetyl-beta-D-glucosaminyl)]n+1
  5. beta-1,4-Poly-N-acetyl-D-glucosamine
  6. N-acetyl-delta-glucosamine
  7. Poly 2-Acetamido-2-deoxy-delta-glucose
  8. [1,4-(N-Acetyl-beta-delta-glucosaminyl)]n
  9. [1,4-(N-Acetyl-beta-delta-glucosaminyl)]n+1
  10. beta-1,4-Poly-N-acetyl-delta-glucosamine
Chemical IUPAC Name N-[(2R,4R,5S)-5-[[(2R,4S,5S)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]methoxymethyl]-2-[[(3S,4R,6R)-5-acetamido-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]methoxymethyl]-4-hydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
Chemical Formula C28H49N3O16
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Carbohydrates and Carbohydrate conjugates
Class
  • Carbohydrates
Sub Class
  • Polysaccharides
Family
  • Mammalian Metabolite
Species
  • hemiacetal
  • primary alcohol
  • secondary alcohol
  • 1,2-diol
  • dialkyl ether
  • secondary carboxylic acid amide
  • heterocyclic compound
Biofunction
  • Component of Aminosugars metabolism
Application
—
Source
  • Endogenous
Average Molecular Weight 683.699
Monoisotopic Molecular Weight 683.311279
Isomeric SMILES CC(=O)NC1[C@H](O)OC(CO)[C@@H](COC[C@@H]2OC(CO)[C@@H](COC[C@@H]3OC(CO)[C@@H](O)[C@H](O)C3NC(C)=O)[C@H](O)C2NC(C)=O)[C@@H]1O
Canonical SMILES CC(=O)NC1C(O)OC(CO)C(COCC2OC(CO)C(COCC3OC(CO)C(O)C(O)C3NC(C)=O)C(O)C2NC(C)=O)C1O
KEGG Compound ID C00461 Link Image
BioCyc ID 14-N-ACETYL-BETA-D-GLUCOSAMINYLN1 Link Image
BiGG ID 2242111 Link Image
Wikipedia Link Chitin Link Image
NuGOwiki Link HMDB03362 Link Image
Metagene Link HMDB03362 Link Image
METLIN ID 6903 Link Image
PubChem Compound 453624 Link Image
PubChem Substance 599272 Link Image
ChEBI ID 17029 Link Image
CAS Registry Number 1398-61-4
InChI Identifier InChI=1/C28H49N3O16/c1-11(35)29-21-19(9-44-8-15-17(5-33)47-28(42)23(25(15)39)31-13(3)37)45-16(4-32)14(24(21)38)7-43-10-20-22(30-12(2)36)27(41)26(40)18(6-34)46-20/h14-28,32-34,38-42H,4-10H2,1-3H3,(H,29,35)(H,30,36)(H,31,37)/t14-,15-,16?,17?,18?,19+,20+,21?,22?,23?,24+,25+,26-,27-,28-/m1/s1
Synthesis Reference Kurita, Keisuke; Koyama, Yoshiyuki; Nishimura, Shinichiro; Kamiya, Mami. Facile preparation of water-soluble chitin from chitosan. Chemistry Letters (1989), (9), 1597-8.
Melting Point (Experimental) Not Available
Experimental Water Solubility Not Available Source: PhysProp
Predicted Water Solubility 1000 mg/mL at 25 oC [MEYLAN,WM et al. (1996)]; 31.0 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge 0
State Solid
Experimental LogP/Hydrophobicity Not Available Source: PhysProp
Predicted LogP/Hydrophobicity -3.03 [Predicted by ALOGPS]; -5.5 [Predicted by PubChem via XLOGP]; -2.83 [MEYLAN,WM & HOWARD,PH (1995)] Calculated using ALOGPS
Material Safety Data Sheet (MSDS)
MOL File Show
SDF File Show
PDB File Show
2D Structure
3D Structure
Experimental PDB ID Not Available
Experimental 1H NMR Spectrum
Show Experimental Conditions Link Image
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum Not Available
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location
  • Cytoplasm (Predicted from LogP)
  • Extracellular
Biofluid Location Not Available
Tissue Location
Tissue References
Fibroblasts —
Intestine —
Spleen —
Testes —
Concentrations (Normal) Not Available
Concentrations (Abnormal) Not Available
Associated Disorders Not Available
OMIM ID Not Available
Pathways
Name SMPDB Link KEGG Link
Amino Sugar Metabolism SMP00045 Link Image map00520 Link Image
Glutamate Metabolism SMP00072 Link Image map00250 Link Image
General References
  1. Nakajima M, Atsumi K, Kifune K, Miura K, Kanamaru H: Chitin is an effective material for sutures. Jpn J Surg. 1986 Nov;16(6):418-24. [PubMed Link Image]
  2. Soule JB, Halverson AL, Becker RB, Pistole MC, Orenstein JM: A patient with acquired immunodeficiency syndrome and untreated Encephalitozoon (Septata) intestinalis microsporidiosis leading to small bowel perforation. Response to albendazole. Arch Pathol Lab Med. 1997 Aug;121(8):880-7. [PubMed Link Image]
  3. Gheri G, Sgambati E, Thyrion GD, Vichi D, Orlandini GE: The oligosaccharidic content of the glycoconjugates of the prepubertal descended and undescended testis: lectin histochemical study. Ital J Anat Embryol. 2004 Apr-Jun;109(2):69-84. [PubMed Link Image]
  4. Hatcher VB, Schwarzmann GO, Jeanloz RW, McArthur JW: Changes in the sialic acid concentration in the major cervical glycoprotein from the bonnet monkey (Macaca radiata) during a hormonally induced cycle. Fertil Steril. 1977 Jun;28(6):682-8. [PubMed Link Image]
  5. Piskun RP, Pentiuk AA, Serkova VK, Polesia TL, Savitskaia EA: [Enterosorbents in the treatment of atherosclerosis] Eksp Klin Farmakol. 1998 Mar-Apr;61(2):69-74. [PubMed Link Image]
  6. Kawashita M, Nakao M, Minoda M, Kim HM, Beppu T, Miyamoto T, Kokubo T, Nakamura T: Apatite-forming ability of carboxyl group-containing polymer gels in a simulated body fluid. Biomaterials. 2003 Jun;24(14):2477-84. [PubMed Link Image]
  7. Howling GI, Dettmar PW, Goddard PA, Hampson FC, Dornish M, Wood EJ: The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro. Biomaterials. 2001 Nov;22(22):2959-66. [PubMed Link Image]
  8. Vasstrand EN, Jensen HB: Affinity chromatography of human saliva lysozyme and effect of pH and ionic strength on lytic activity. Scand J Dent Res. 1980 Jun;88(3):219-28. [PubMed Link Image]
  9. Collard CD, Montalto MC, Reenstra WR, Buras JA, Stahl GL: Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1. Am J Pathol. 2001 Sep;159(3):1045-54. [PubMed Link Image]
  10. Shibuya N, Nakamura K, Ogoshi K, Ohta T, Hori Y, Kodama K, Yamamoto M: Modification of mutagenic activities of pro-mutagens by glyco-ursodeoxycholic acid in the Ames assay. Tohoku J Exp Med. 1999 Sep;189(1):1-9. [PubMed Link Image]
  11. Ishihara C, Yoshimatsu K, Tsuji M, Arikawa J, Saiki I, Tokura S, Azuma I: Anti-viral activity of sulfated chitin derivatives against Friend murine leukaemia and herpes simplex type-1 viruses. Vaccine. 1993;11(6):670-4. [PubMed Link Image]
  12. Zampini M, Pruzzo C, Bondre VP, Tarsi R, Cosmo M, Bacciaglia A, Chhabra A, Srivastava R, Srivastava BS: Vibrio cholerae persistence in aquatic environments and colonization of intestinal cells: involvement of a common adhesion mechanism. FEMS Microbiol Lett. 2005 Mar 15;244(2):267-73. [PubMed Link Image]
  13. Xu Y, Olman V, Xu D: Clustering gene expression data using a graph-theoretic approach: an application of minimum spanning trees. Bioinformatics. 2002 Apr;18(4):536-45. [PubMed Link Image]
  14. Sharaev PN, Strelkov NS, Sannikova AA, Zvorykin IA, Men'shikova NN, Sakhabutdinova EP, Gabdrakhmanova NK: [The method for detection of urinary lysozyme] Klin Lab Diagn. 2001 Apr;(4):52-3. [PubMed Link Image]
  15. Farnia P, Mohammadi F, Zarifi Z, Tabatabee DJ, Ganavi J, Ghazisaeedi K, Farnia PK, Gheydi M, Bahadori M, Masjedi MR, Velayati AA: Improving sensitivity of direct microscopy for detection of acid-fast bacilli in sputum: use of chitin in mucus digestion. J Clin Microbiol. 2002 Feb;40(2):508-11. [PubMed Link Image]
  16. Sano H, Matsukubo T, Shibasaki K, Itoi H, Takaesu Y: Inhibition of adsorption of oral streptococci to saliva treated hydroxyapatite by chitin derivatives. Bull Tokyo Dent Coll. 1991 Feb;32(1):9-17. [PubMed Link Image]
  17. Johnson SM, Pappagianis D: The coccidioidal complement fixation and immunodiffusion-complement fixation antigen is a chitinase. Infect Immun. 1992 Jul;60(7):2588-92. [PubMed Link Image]
  18. Wikipedia Link Image
Metabolic Enzymes
  1. N-acetylglucosamine kinase
  2. Acidic mammalian chitinase precursor
  3. Chitotriosidase-1 precursor
  4. Chitinase family protein 3
  5. Chitinase family protein V2
  6. Chitinase family protein V1
  7. cDNA FLJ76132, highly similar to Homo sapiens chitinase, acidic (CHIA), mRNA
  8. CHIA protein
  9. Chitinase, acidic
  10. Chitinase, acidic
Enzyme 1 [top]
Enzyme 1 ID 6316
Enzyme 1 Name N-acetylglucosamine kinase
Enzyme 1 Synonyms
  1. GlcNAc kinase
Enzyme 1 Gene Name NAGK
Enzyme 1 Protein Sequence >N-acetylglucosamine kinase 
MAAIYGGVEGGGTRSEVLLVSEDGKILAEADGLSTNHWLIGTDKCVERINEMVNRAKRKA
GVDPLVPLRSLGLSLSGGDQEDAGRILIEELRDRFPYLSESYLITTDAAGSIATATPDGG
VVLISGTGSNCRLINPDGSESGCGGWGHMMGDEGSAYWIAHQAVKIVFDSIDNLEAAPHD
IGYVKQAMFHYFQVPDRLGILTHLYRDFDKCRFAGFCRKIAEGAQQGDPLSRYIFRKAGE
MLGRHIVAVLPEIDPVLFQGKIGLPILCVGSVWKSWELLKEGFLLALTQGREIQAQNFFS
SFTLMKLRHSSALGGASLGARHIGHLLPMDYSANAIAFYSYTFS
Enzyme 1 Number of Residues 344
Enzyme 1 Molecular Weight 37376
Enzyme 1 Theoretical pI 6.18
Enzyme 1 GO Classification Not Available
Enzyme 1 General Function Carbohydrate transport and metabolism
Enzyme 1 Specific Function Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Also has ManNAc kinase activity
Enzyme 1 Pathways
Enzyme 1 Reactions
  • ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 6491737 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID Q9UJ70 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name NAGK_HUMAN Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >1035 bp 
ATGGCCGCGATCTATGGGGGTGTAGAGGGGGGAGGCACACGATCCGAGGTCCTTTTAGTC
TCAGAGGATGGGAAGATCCTGGCAGAAGCAGATGGACTGAGCACAAACCACTGGCTGATC
GGGACAGACAAGTGTGTGGAGAGGATCAATGAGATGGTGAACAGGGCCAAACGGAAAGCA
GGGGTGGATCCTCTGGTACCGCTGCGAATTTTGGGCCTATCTCTGAGCGGTGGGGACCAG
GAGGACGCGGGGAGGATCCTGATCGAGGAGCTGAGGGACCGATTTCCCTACCTGAGTGAA
AGCTACTTAATCACCACCGATGCCGCCGGCTCCATCGCCACAGCTACACCGGATGGTGGG
ATTGTGCTCATATCTGGAACAGGCTCCAACTGCAGGCTCATCAACCCTGATGGCTCCGAG
AGTGGCTGCGGCGGCTGGGGCCATATGATGGGTGATGAGGGTTCAGCCTACTGGATCGCA
CACCAAGCAGTGAAAATAGTGTTTGACTCCATTGACAACCTAGAGGCGGCTCCTCATGAT
ATCGGCTACGTCAAACAGGCCATGTTCCACTATTTCCAGGTGCCAGATCGGCTAGGGATA
CTCACTCACCTGTATAGGGACTTTGATAAATGCAGGTTTGCTGGGTTTTGCCGGAAAATT
GCAGAAGGTGCTCAGCAGGGAGACCCCCTTTCCCGCTATATCTTCAGGAAGGCTGGGGAG
ATGCTGGGCAGACACATCGTAGCAGTGTTGCCCGAGATTGACCCGGTCTTGTTCCAGGGC
AAGATTGGACTCCCCATCCTGTGCGTGGGCTCTGTGTGGAAGAGCTGGGAGCTGCTGAAG
GAAGGTTTTCTTTTGGCGCTGACCCAGGGCAGAGAGATCCAGGCTCAGAACTTCTTCTCC
AGCTTCACCCTGATGAAGCTGAGGCACTCCTCCGCTCTGGGTGGGGCCAGCCTAGGGGCC
AGGCACATCGGGCACCTCCTCCCCATGGACTATAGCGCCAATGCCATTGCCTTCTATTCC
TACACCTTTTCCTAG
Enzyme 1 GenBank Gene ID AJ242910 Link Image
Enzyme 1 GeneCard ID NAGK Link Image
Enzyme 1 GenAtlas ID NAGK Link Image
Enzyme 1 HGNC ID HGNC:17174 Link Image
Enzyme 1 Chromosome Location 2
Enzyme 1 Locus 2p13.3
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References
  1. Hinderlich S, Berger M, Schwarzkopf M, Effertz K, Reutter W: Molecular cloning and characterization of murine and human N-acetylglucosamine kinase. Eur J Biochem. 2000 Jun;267(11):3301-8. [PubMed Link Image]
  2. Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol. 2003 May;21(5):566-9. Epub 2003 Mar 31. [PubMed Link Image]
  3. Maguire PB, Wynne KJ, Harney DF, O'Donoghue NM, Stephens G, Fitzgerald DJ: Identification of the phosphotyrosine proteome from thrombin activated platelets. Proteomics. 2002 Jun;2(6):642-8. [PubMed Link Image]
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 6317
Enzyme 2 Name Acidic mammalian chitinase precursor
Enzyme 2 Synonyms
  1. AMCase
  2. TSA1902
Enzyme 2 Gene Name CHIA
Enzyme 2 Protein Sequence >Acidic mammalian chitinase precursor 
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG
RQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFI
TSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMV
TAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAY
LNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGI
WAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVW
AIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSS
GGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
Enzyme 2 Number of Residues 476
Enzyme 2 Molecular Weight 52271
Enzyme 2 Theoretical pI 5.63
Enzyme 2 GO Classification
Function
  • binding
  • catalytic activity
  • chitin binding
  • chitinase activity
  • hydrolase activity
  • hydrolase activity, acting on glycosyl bonds
  • hydrolase activity, hydrolyzing O-glycosyl compounds
  • pattern binding
  • polysaccharide binding
Process
  • N-acetylglucosamine metabolism
  • amine metabolism
  • amino sugar metabolism
  • carbohydrate metabolism
  • chitin catabolism
  • chitin metabolism
  • glucosamine metabolism
  • macromolecule metabolism
  • metabolism
  • nitrogen compound metabolism
  • physiological process
Component
  • extracellular region
Enzyme 2 General Function Not Available
Enzyme 2 Specific Function Degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens
Enzyme 2 Pathways
Enzyme 2 Reactions
  • Random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • 1-21
Enzyme 2 Transmembrane Regions Not Available
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 6467177 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID Q9BZP6 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name CHIA_HUMAN Link Image
Enzyme 2 PDB ID Not Available
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >1107 bp 
ATGGTTTCTACTCCTGAGAACCGCCAGACTTTCATCACCTCAGTCATCAAATTCCTGCGC
CAGTATGAGTTTGACGGGCTGGACTTTGACTGGGAGTACCCTGGCTCTCGTGGGAGCCCT
CCTCAGGACAAGCATCTCTTCACTGTCCTGGTGCAGGAAATGCGTGAAGCTTTTGAGCAG
GAGGCCAAGCAGATCAACAAGCCCAGGCTGATGGTCACTGCTGCAGTAGCTGCTGGCATC
TCCAATATCCAGTCTGGCTATGAGATCCCCCAACTGTCACAGTACCTGGACTACATCCAT
GTCATGACCTACGACCTCCATGGCTCCTGGGAGGGCTACACTGGAGAGAACAGCCCCCTC
TACAAATACCCGACTGACACCGGCAGCAACGCCTACCTCAATGTGGATTATGTCATGAAC
TACTGGAAGGACAATGGAGCACCAGCTGAGAAGCTCATCGTTGGATTCCCTACCTATGGA
CACAACTTCATCCTGAGCAACCCCTCCAACACTGGAATTGGTGCCCCCACCTCTGGTGCT
GGTCCTGCTGGGCCCTATGCCAAGGAGTCTGGGATCTGGGCTTACTACGAGATCTGTACC
TTCCTGAAAAATGGAGCCACTCAGGGATGGGATGCCCCTCAGGAAGTGCCTTATGCCTAT
CAGGGCAATGTGTGGGTTGGCTATGACAACGTCAAGAGCTTCGATATTAAGGCTCAATGG
CTTAAGCACAACAAATTTGGAGGCGCCATGGTCTGGGCCATTGATCTGGATGACTTCACT
GGCACTTTCTGCAACCAGGGCAAGTTTCCCCTAATCTCCACCCTGAAGAAGGCCCTTGGC
CTGCAGAGTGCAAGTTGCACGGCTCCAGCTCAGCCCATTGAGCCAATAACTGCTGCTCCC
AGTGGCAGCGGGAACGGGAGCGGGAGTAGCAGCTCTGGAGGCAGCTCGGGAGGCAGTGGA
TTCTGTGCTGGCAGAGCCAACGGCCTCTACCCCGTGGCAAATAACAGAAATGCCTTCTGG
CACTGCGTGAATGGAGTCACGTACCAGCAGAACTGCCAGGCCGGGCTTGTCTTCGACACC
AGCTGTGATTGCTGCAACTGGGCATAA
Enzyme 2 GenBank Gene ID AB025008 Link Image
Enzyme 2 GeneCard ID CHIA Link Image
Enzyme 2 GenAtlas ID CHIA Link Image
Enzyme 2 HGNC ID HGNC:17432 Link Image
Enzyme 2 Chromosome Location 1
Enzyme 2 Locus 1p13.1-p21.3
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References
  1. Saito A, Ozaki K, Fujiwara T, Nakamura Y, Tanigami A: Isolation and mapping of a human lung-specific gene, TSA1902, encoding a novel chitinase family member. Gene. 1999 Nov 1;239(2):325-31. [PubMed Link Image]
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 6319
Enzyme 3 Name Chitotriosidase-1 precursor
Enzyme 3 Synonyms
  1. Chitinase-1
Enzyme 3 Gene Name CHIT1
Enzyme 3 Protein Sequence >Chitotriosidase-1 precursor 
MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAG
MTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFV
NSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLL
SAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAAS
LNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGM
LAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWAL
DLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFC
QGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN
Enzyme 3 Number of Residues 466
Enzyme 3 Molecular Weight 51682
Enzyme 3 Theoretical pI 6.96
Enzyme 3 GO Classification
Function
  • binding
  • catalytic activity
  • chitin binding
  • chitinase activity
  • hydrolase activity
  • hydrolase activity, acting on glycosyl bonds
  • hydrolase activity, hydrolyzing O-glycosyl compounds
  • pattern binding
  • polysaccharide binding
Process
  • N-acetylglucosamine metabolism
  • amine metabolism
  • amino sugar metabolism
  • carbohydrate metabolism
  • chitin catabolism
  • chitin metabolism
  • glucosamine metabolism
  • macromolecule metabolism
  • metabolism
  • nitrogen compound metabolism
  • physiological process
Component
  • extracellular region
Enzyme 3 General Function Not Available
Enzyme 3 Specific Function Degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity
Enzyme 3 Pathways
Enzyme 3 Reactions
  • Random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • 1-21
Enzyme 3 Transmembrane Regions Not Available
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 1050958 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID Q13231 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name CHIT1_HUMAN Link Image
Enzyme 3 PDB ID 1WB0 Link Image
Enzyme 3 PDB File Show
Enzyme 3 3D Structure
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >1401 bp 
ATGGTGCGGTCTGTGGCCTGGGCAGGTTTCATGGTCCTGCTGATGATCCCATGGGGCTCT
GCTGCAAAACTGGTCTGCTACTTCACCAACTGGGCCCAGTACAGACAGGGGGAGGCTCGC
TTCCTGCCCAAGGACTTGGACCCCAGCCTTTGCACCCACCTCATCTACGCCTTCGCTGGC
ATGACCAACCACCAGCTGAGCACCACTGAGTGGAATGACGAGACTCTCTACCAGGAGTTC
AATGGCCTGAAGAAGATGAATCCCAAGCTGAAGACCCTGTTAGCCATCGGAGGCTGGAAT
TTCGGCACTCAGAAGTTCACAGATATGGTAGCCACGGCCAACAACCGTCAGACCTTTGTC
AACTCGGCCATCAGGTTTCTGCGCAAATACAGCTTTGACGGCCTTGACCTTGACTGGGAG
TACCCAGGAAGCCAGGGGAGCCCTGCCGTAGACAAGGAGCGCTTCACAACCCTGGTACAG
GACTTGGCCAATGCCTTCCAGCAGGAAGCCCAGACCTCAGGGAAGGAACGCCTTCTTCTG
AGTGCAGCGGTTCCAGCTGGGCAGACCTATGTGGATGCTGGATACGAGGTGGACAAAATC
GCCCAGAACCTGGATTTTGTCAACCTTATGGCCTACGACTTCCATGGCTCTTGGGAGAAG
GTCACGGGACATAACAGCCCCCTCTACAAGAGGCAAGAAGAGAGTGGTGCAGCAGCCAGC
CTCAACGTGGATGCTGCTGTGCAACAGTGGCTGCAGAAGGGGACCCCTGCCAGCAAGCTG
ATCCTTGGCATGCCTACCTACGGACGCTCCTTCACACTGGCCTCCTCATCAGACACCAGA
GTGGGGGCCCCAGCCACAGGGTCTGGCACTCCAGGCCCCTTCACCAAGGAAGGAGGGATG
CTGGCCTACTATGAAGTCTGCTCCTGGAAGGGGGCCACCAAACAGAGAATCCAGGATCAG
AAGGTGCCCTACATCTTCCGGGACAACCAGTGGGTGGGCTTTGATGATGTGGAGAGCTTC
AAAACCAAGGTCAGCTATCTGAAGCAGAAGGGACTGGGCGGGGCCATGGTCTGGGCACTG
GACTTAGATGACTTTGCCGGCTTCTCCTGCAACCAGGGCCGATACCCCCTCATCCAGACG
CTACGGCAGGAACTGAGTCTTCCATACTTGCCTTCAGGCACCCCAGAGCTTGAAGTTCCA
AAACCAGGTCAGCCCTCTGAACCTGAGCATGGCCCCAGCCCTGGACAAGACACGTTCTGC
CAGGGCAAAGCTGATGGGCTCTATCCCAATCCTCGGGAACGGTCCAGCTTCTACAGCTGT
GCAGCGGGGCGGCTGTTCCAGCAAAGCTGCCCGACAGGCCTGGTGTTCAGCAACTCCTGC
AAATGCTGCACCTGGAATTGA
Enzyme 3 GenBank Gene ID U29615 Link Image
Enzyme 3 GeneCard ID CHIT1 Link Image
Enzyme 3 GenAtlas ID CHIT1 Link Image
Enzyme 3 HGNC ID HGNC:1936 Link Image
Enzyme 3 Chromosome Location 1
Enzyme 3 Locus 1q31-q32
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References
  1. Boot RG, Renkema GH, Strijland A, van Zonneveld AJ, Aerts JM: Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages. J Biol Chem. 1995 Nov 3;270(44):26252-6. [PubMed Link Image]
  2. Renkema GH, Boot RG, Muijsers AO, Donker-Koopman WE, Aerts JM: Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteins. J Biol Chem. 1995 Feb 3;270(5):2198-202. [PubMed Link Image]
  3. Boot RG, Renkema GH, Verhoek M, Strijland A, Bliek J, de Meulemeester TM, Mannens MM, Aerts JM: The human chitotriosidase gene. Nature of inherited enzyme deficiency. J Biol Chem. 1998 Oct 2;273(40):25680-5. [PubMed Link Image]
  4. Fusetti F, von Moeller H, Houston D, Rozeboom HJ, Dijkstra BW, Boot RG, Aerts JM, van Aalten DM: Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins. J Biol Chem. 2002 Jul 12;277(28):25537-44. Epub 2002 Apr 17. [PubMed Link Image]
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 16921
Enzyme 4 Name Chitinase family protein 3
Enzyme 4 Synonyms Not Available
Enzyme 4 Gene Name Not Available
Enzyme 4 Protein Sequence >Chitinase family protein 3 
ETSSSVHEQVADSGAQAVAFQSGGESSIVWSCPYTEFAARNSQLKTLLAIGGWNFGTAPF
TAMVSTPENRQTFITSVIRFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAF
EQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENS
PLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTS
GAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKA
QWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITA
APSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVF
DTSCDCCNWA
Enzyme 4 Number of Residues 430
Enzyme 4 Molecular Weight 46616
Enzyme 4 Theoretical pI 4.81
Enzyme 4 GO Classification
Function
  • binding
  • catalytic activity
  • chitin binding
  • chitinase activity
  • hydrolase activity
  • hydrolase activity, acting on glycosyl bonds
  • hydrolase activity, hydrolyzing O-glycosyl compounds
  • pattern binding
  • polysaccharide binding
Process
  • N-acetylglucosamine metabolism
  • amine metabolism
  • amino sugar metabolism
  • carbohydrate metabolism
  • chitin catabolism
  • chitin metabolism
  • glucosamine metabolism
  • macromolecule metabolism
  • metabolism
  • nitrogen compound metabolism
  • physiological process
Component
  • extracellular region
Enzyme 4 General Function Not Available
Enzyme 4 Specific Function Not Available
Enzyme 4 Pathways Not Available
Enzyme 4 Reactions Not Available
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein Not Available
Enzyme 4 UniProtKB/Swiss-Prot ID Q2VT96 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name Q2VT96_HUMAN Link Image
Enzyme 4 PDB ID Not Available
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence Not Available
Enzyme 4 GenBank Gene ID AY825504 Link Image
Enzyme 4 GeneCard ID Q2VT96 Link Image
Enzyme 4 GenAtlas ID Not Available
Enzyme 4 HGNC ID HGNC:17432 Link Image
Enzyme 4 Chromosome Location Not Available
Enzyme 4 Locus Not Available
Enzyme 4 SNPs Not Available
Enzyme 4 General References Not Available
Enzyme 4 Metabolite References Not Available
Enzyme 5 [top]
Enzyme 5 ID 16922
Enzyme 5 Name Chitinase family protein V2
Enzyme 5 Synonyms Not Available
Enzyme 5 Gene Name Not Available
Enzyme 5 Protein Sequence >Chitinase family protein V2 
MREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGY
TGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGI
GAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNVKS
FDIKAQWLKHNKSGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPI
EPITAAPSGSGNGSGSSSSGGSSGGSGFCAGRANGLYPVASNRNAFWHCVNGVTYQQNCQ
AGLVFDTSCDCCNWA
Enzyme 5 Number of Residues 315
Enzyme 5 Molecular Weight 33763
Enzyme 5 Theoretical pI 5.26
Enzyme 5 GO Classification
Function
  • binding
  • catalytic activity
  • chitin binding
  • chitinase activity
  • hydrolase activity
  • hydrolase activity, acting on glycosyl bonds
  • hydrolase activity, hydrolyzing O-glycosyl compounds
  • pattern binding
  • polysaccharide binding
Process
  • N-acetylglucosamine metabolism
  • amine metabolism
  • amino sugar metabolism
  • carbohydrate metabolism
  • chitin catabolism
  • chitin metabolism
  • glucosamine metabolism
  • macromolecule metabolism
  • metabolism
  • nitrogen compound metabolism
  • physiological process
Component
  • extracellular region
Enzyme 5 General Function Not Available
Enzyme 5 Specific Function Not Available
Enzyme 5 Pathways Not Available
Enzyme 5 Reactions Not Available
Enzyme 5 Pfam Domain Function
Enzyme 5 Signals
  • None
Enzyme 5 Transmembrane Regions
  • None
Enzyme 5 Essentiality Not Available
Enzyme 5 GenBank ID Protein Not Available
Enzyme 5 UniProtKB/Swiss-Prot ID Q1M0P3 Link Image
Enzyme 5 UniProtKB/Swiss-Prot Entry Name Q1M0P3_HUMAN Link Image
Enzyme 5 PDB ID Not Available
Enzyme 5 Cellular Location Not Available
Enzyme 5 Gene Sequence Not Available
Enzyme 5 GenBank Gene ID AY911311 Link Image
Enzyme 5 GeneCard ID Q1M0P3 Link Image
Enzyme 5 GenAtlas ID Not Available
Enzyme 5 HGNC ID HGNC:17432 Link Image
Enzyme 5 Chromosome Location Not Available
Enzyme 5 Locus Not Available
Enzyme 5 SNPs Not Available
Enzyme 5 General References Not Available
Enzyme 5 Metabolite References Not Available
Enzyme 6 [top]
Enzyme 6 ID 16923
Enzyme 6 Name Chitinase family protein V1
Enzyme 6 Synonyms Not Available
Enzyme 6 Gene Name Not Available
Enzyme 6 Protein Sequence >Chitinase family protein V1 
MREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYVHVMTYDLHGSWEGY
TGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGI
GAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWAGYDNVKS
FDIKAQWLKHNKSGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPI
EPITAAPSGSGNGSGSSSSGGSSGGSGFCAGRANGLYPVANNRNAFWHCVNGVTYQQNCQ
AGLVFDTSCDCCNWA
Enzyme 6 Number of Residues 315
Enzyme 6 Molecular Weight 33748
Enzyme 6 Theoretical pI 5.26
Enzyme 6 GO Classification
Function
  • binding
  • catalytic activity
  • chitin binding
  • chitinase activity
  • hydrolase activity
  • hydrolase activity, acting on glycosyl bonds
  • hydrolase activity, hydrolyzing O-glycosyl compounds
  • pattern binding
  • polysaccharide binding
Process
  • N-acetylglucosamine metabolism
  • amine metabolism
  • amino sugar metabolism
  • carbohydrate metabolism
  • chitin catabolism
  • chitin metabolism
  • glucosamine metabolism
  • macromolecule metabolism
  • metabolism
  • nitrogen compound metabolism
  • physiological process
Component
  • extracellular region
Enzyme 6 General Function Not Available
Enzyme 6 Specific Function Not Available
Enzyme 6 Pathways Not Available
Enzyme 6 Reactions Not Available
Enzyme 6 Pfam Domain Function
Enzyme 6 Signals
  • None
Enzyme 6 Transmembrane Regions
  • None
Enzyme 6 Essentiality Not Available
Enzyme 6 GenBank ID Protein Not Available
Enzyme 6 UniProtKB/Swiss-Prot ID Q1M0P4 Link Image
Enzyme 6 UniProtKB/Swiss-Prot Entry Name Q1M0P4_HUMAN Link Image
Enzyme 6 PDB ID Not Available
Enzyme 6 Cellular Location Not Available
Enzyme 6 Gene Sequence Not Available
Enzyme 6 GenBank Gene ID AY911310 Link Image
Enzyme 6 GeneCard ID Q1M0P4 Link Image
Enzyme 6 GenAtlas ID Not Available
Enzyme 6 HGNC ID HGNC:17432 Link Image
Enzyme 6 Chromosome Location Not Available
Enzyme 6 Locus Not Available
Enzyme 6 SNPs Not Available
Enzyme 6 General References Not Available
Enzyme 6 Metabolite References Not Available
Enzyme 7 [top]
Enzyme 7 ID 17158
Enzyme 7 Name cDNA FLJ76132, highly similar to Homo sapiens chitinase, acidic (CHIA), mRNA
Enzyme 7 Synonyms Not Available
Enzyme 7 Gene Name Not Available
Enzyme 7 Protein Sequence >cDNA FLJ76132, highly similar to Homo sapiens chitinase, acidic (CHIA), mRNA 
MVSTPENRQTSITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQ
EAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPL
YKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGA
GPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQW
LKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAP
SGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDT
SCDCCNWA
Enzyme 7 Number of Residues 368
Enzyme 7 Molecular Weight 40079
Enzyme 7 Theoretical pI 4.97
Enzyme 7 GO Classification
Function
  • binding
  • catalytic activity
  • chitin binding
  • chitinase activity
  • hydrolase activity
  • hydrolase activity, acting on glycosyl bonds
  • hydrolase activity, hydrolyzing O-glycosyl compounds
  • pattern binding
  • polysaccharide binding
Process
  • N-acetylglucosamine metabolism
  • amine metabolism
  • amino sugar metabolism
  • carbohydrate metabolism
  • chitin catabolism
  • chitin metabolism
  • glucosamine metabolism
  • macromolecule metabolism
  • metabolism
  • nitrogen compound metabolism
  • physiological process
Component
  • extracellular region
Enzyme 7 General Function Not Available
Enzyme 7 Specific Function Not Available
Enzyme 7 Pathways Not Available
Enzyme 7 Reactions Not Available
Enzyme 7 Pfam Domain Function
Enzyme 7 Signals
  • None
Enzyme 7 Transmembrane Regions
  • None
Enzyme 7 Essentiality Not Available
Enzyme 7 GenBank ID Protein Not Available
Enzyme 7 UniProtKB/Swiss-Prot ID A8K3T7 Link Image
Enzyme 7 UniProtKB/Swiss-Prot Entry Name A8K3T7_HUMAN Link Image
Enzyme 7 PDB ID Not Available
Enzyme 7 Cellular Location Not Available
Enzyme 7 Gene Sequence Not Available
Enzyme 7 GenBank Gene ID AK290702 Link Image
Enzyme 7 GeneCard ID A8K3T7 Link Image
Enzyme 7 GenAtlas ID Not Available
Enzyme 7 HGNC ID Not Available
Enzyme 7 Chromosome Location Not Available
Enzyme 7 Locus Not Available
Enzyme 7 SNPs Not Available
Enzyme 7 General References Not Available
Enzyme 7 Metabolite References Not Available
Enzyme 8 [top]
Enzyme 8 ID 17159
Enzyme 8 Name CHIA protein
Enzyme 8 Synonyms Not Available
Enzyme 8 Gene Name CHIA
Enzyme 8 Protein Sequence >CHIA protein 
KAYSPHRSCPYTEFAARNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIRFLRQ
YEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGIS
NIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNY
WKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTF
LKNGATQGWDAPQEVPYAYQGNVWVGYDNVKSFDIKAQWLKHNKSGGAMVWAIDLDDFTG
TFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGF
CAGRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
Enzyme 8 Number of Residues 407
Enzyme 8 Molecular Weight 44307
Enzyme 8 Theoretical pI 5.90
Enzyme 8 GO Classification
Function
  • binding
  • catalytic activity
  • chitin binding
  • chitinase activity
  • hydrolase activity
  • hydrolase activity, acting on glycosyl bonds
  • hydrolase activity, hydrolyzing O-glycosyl compounds
  • pattern binding
  • polysaccharide binding
Process
  • N-acetylglucosamine metabolism
  • amine metabolism
  • amino sugar metabolism
  • carbohydrate metabolism
  • chitin catabolism
  • chitin metabolism
  • glucosamine metabolism
  • macromolecule metabolism
  • metabolism
  • nitrogen compound metabolism
  • physiological process
Component
  • extracellular region
Enzyme 8 General Function Not Available
Enzyme 8 Specific Function Not Available
Enzyme 8 Pathways Not Available
Enzyme 8 Reactions Not Available
Enzyme 8 Pfam Domain Function
Enzyme 8 Signals
  • None
Enzyme 8 Transmembrane Regions
  • None
Enzyme 8 Essentiality Not Available
Enzyme 8 GenBank ID Protein Not Available
Enzyme 8 UniProtKB/Swiss-Prot ID A5D6V7 Link Image
Enzyme 8 UniProtKB/Swiss-Prot Entry Name A5D6V7_HUMAN Link Image
Enzyme 8 PDB ID Not Available
Enzyme 8 Cellular Location Not Available
Enzyme 8 Gene Sequence Not Available
Enzyme 8 GenBank Gene ID BC139901 Link Image
Enzyme 8 GeneCard ID A5D6V7 Link Image
Enzyme 8 GenAtlas ID Not Available
Enzyme 8 HGNC ID Not Available
Enzyme 8 Chromosome Location Not Available
Enzyme 8 Locus Not Available
Enzyme 8 SNPs SNPJam Report Link Image
Enzyme 8 General References Not Available
Enzyme 8 Metabolite References Not Available
Enzyme 9 [top]
Enzyme 9 ID 17160
Enzyme 9 Name Chitinase, acidic
Enzyme 9 Synonyms Not Available
Enzyme 9 Gene Name CHIA
Enzyme 9 Protein Sequence >Chitinase, acidic 
YSPHRSCPYTEFAARNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYE
FDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNI
QSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWK
DNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLK
NGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTF
CNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCA
VRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
Enzyme 9 Number of Residues 405
Enzyme 9 Molecular Weight 44195
Enzyme 9 Theoretical pI 5.61
Enzyme 9 GO Classification
Function
  • binding
  • catalytic activity
  • chitin binding
  • chitinase activity
  • hydrolase activity
  • hydrolase activity, acting on glycosyl bonds
  • hydrolase activity, hydrolyzing O-glycosyl compounds
  • pattern binding
  • polysaccharide binding
Process
  • N-acetylglucosamine metabolism
  • amine metabolism
  • amino sugar metabolism
  • carbohydrate metabolism
  • chitin catabolism
  • chitin metabolism
  • glucosamine metabolism
  • macromolecule metabolism
  • metabolism
  • nitrogen compound metabolism
  • physiological process
Component
  • extracellular region
Enzyme 9 General Function Not Available
Enzyme 9 Specific Function Not Available
Enzyme 9 Pathways Not Available
Enzyme 9 Reactions Not Available
Enzyme 9 Pfam Domain Function
Enzyme 9 Signals
  • None
Enzyme 9 Transmembrane Regions
  • None
Enzyme 9 Essentiality Not Available
Enzyme 9 GenBank ID Protein Not Available
Enzyme 9 UniProtKB/Swiss-Prot ID Q5VUV3 Link Image
Enzyme 9 UniProtKB/Swiss-Prot Entry Name Q5VUV3_HUMAN Link Image
Enzyme 9 PDB ID Not Available
Enzyme 9 Cellular Location Not Available
Enzyme 9 Gene Sequence Not Available
Enzyme 9 GenBank Gene ID AL513202 Link Image
Enzyme 9 GeneCard ID Q5VUV3 Link Image
Enzyme 9 GenAtlas ID CHIA Link Image
Enzyme 9 HGNC ID HGNC:17432 Link Image
Enzyme 9 Chromosome Location Not Available
Enzyme 9 Locus Not Available
Enzyme 9 SNPs SNPJam Report Link Image
Enzyme 9 General References Not Available
Enzyme 9 Metabolite References Not Available
Enzyme 10 [top]
Enzyme 10 ID 17161
Enzyme 10 Name Chitinase, acidic
Enzyme 10 Synonyms Not Available
Enzyme 10 Gene Name CHIA
Enzyme 10 Protein Sequence >Chitinase, acidic 
ETSSSVHEQVADSGAQAVAFQSGGESSIVWNSQLKTLLAIGGWNFGTAPFTAMVSTPENR
QTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKP
RLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTG
SNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAK
ESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGG
AMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSG
SSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
Enzyme 10 Number of Residues 420
Enzyme 10 Molecular Weight 45462
Enzyme 10 Theoretical pI 4.79
Enzyme 10 GO Classification
Function
  • binding
  • catalytic activity
  • chitin binding
  • chitinase activity
  • hydrolase activity
  • hydrolase activity, acting on glycosyl bonds
  • hydrolase activity, hydrolyzing O-glycosyl compounds
  • pattern binding
  • polysaccharide binding
Process
  • N-acetylglucosamine metabolism
  • amine metabolism
  • amino sugar metabolism
  • carbohydrate metabolism
  • chitin catabolism
  • chitin metabolism
  • glucosamine metabolism
  • macromolecule metabolism
  • metabolism
  • nitrogen compound metabolism
  • physiological process
Component
  • extracellular region
Enzyme 10 General Function Not Available
Enzyme 10 Specific Function Not Available
Enzyme 10 Pathways Not Available
Enzyme 10 Reactions Not Available
Enzyme 10 Pfam Domain Function
Enzyme 10 Signals
  • None
Enzyme 10 Transmembrane Regions
  • None
Enzyme 10 Essentiality Not Available
Enzyme 10 GenBank ID Protein Not Available
Enzyme 10 UniProtKB/Swiss-Prot ID Q5VUV5 Link Image
Enzyme 10 UniProtKB/Swiss-Prot Entry Name Q5VUV5_HUMAN Link Image
Enzyme 10 PDB ID Not Available
Enzyme 10 Cellular Location Not Available
Enzyme 10 Gene Sequence Not Available
Enzyme 10 GenBank Gene ID AL513202 Link Image
Enzyme 10 GeneCard ID Q5VUV5 Link Image
Enzyme 10 GenAtlas ID CHIA Link Image
Enzyme 10 HGNC ID HGNC:17432 Link Image
Enzyme 10 Chromosome Location Not Available
Enzyme 10 Locus Not Available
Enzyme 10 SNPs SNPJam Report Link Image
Enzyme 10 General References Not Available
Enzyme 10 Metabolite References Not Available