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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2006-08-12 21:15:59 UTC
Update Date2023-02-21 17:16:41 UTC
HMDB IDHMDB0003450
Secondary Accession Numbers
  • HMDB0006410
  • HMDB03450
  • HMDB06410
Metabolite Identification
Common Name(-)-trans-Carveol
Description(-)-trans-Carveol, also known as (1S,5R)-carveol, belongs to the class of organic compounds known as menthane monoterpenoids. These are monoterpenoids with a structure based on the o-, m-, or p-menthane backbone. P-menthane consists of the cyclohexane ring with a methyl group and a (2-methyl)-propyl group at the 1 and 4 ring position, respectively. The o- and m- menthanes are much rarer, and presumably arise by alkyl migration of p-menthanes. Thus, (-)-trans-carveol is considered to be an isoprenoid lipid molecule (-)-trans-Carveol is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.
Structure
Data?1676999801
Synonyms
ValueSource
(-)-(4R,6S)-trans-CarveolChEBI
(1S,5R)-CarveolChEBI
CarveolHMDB
(-)-(4R,6S)-CarveolHMDB
(1S,5R)-2-Methyl-5-(1-methylethenyl)-2-cyclohexen-1-olHMDB
(e)-CarveolHMDB
(±)-trans-carveolHMDB
trans-(-)-CarveolHMDB
trans-5-(1-Methylethenyl)-2-methyl-2-cyclohexenolHMDB
trans-CarveolHMDB
trans-Mentha-1,8-dien-6-olHMDB
(-)-trans-CarveolHMDB
Chemical FormulaC10H16O
Average Molecular Weight152.2334
Monoisotopic Molecular Weight152.120115134
IUPAC Name(1S,5R)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-ol
Traditional Name(-)-trans-carveol
CAS Registry Number2102-58-1
SMILES
CC(=C)[C@@H]1CC=C(C)[C@@H](O)C1
InChI Identifier
InChI=1S/C10H16O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9-11H,1,5-6H2,2-3H3/t9-,10+/m1/s1
InChI KeyBAVONGHXFVOKBV-ZJUUUORDSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as menthane monoterpenoids. These are monoterpenoids with a structure based on the o-, m-, or p-menthane backbone. P-menthane consists of the cyclohexane ring with a methyl group and a (2-methyl)-propyl group at the 1 and 4 ring position, respectively. The o- and m- menthanes are much rarer, and presumably arise by alkyl migration of p-menthanes.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassPrenol lipids
Sub ClassMonoterpenoids
Direct ParentMenthane monoterpenoids
Alternative Parents
Substituents
  • P-menthane monoterpenoid
  • Monocyclic monoterpenoid
  • Secondary alcohol
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Alcohol
  • Aliphatic homomonocyclic compound
Molecular FrameworkAliphatic homomonocyclic compounds
External Descriptors
Ontology
Physiological effect
Disposition
Process
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP3.12GRIFFIN,S ET AL. (1999)
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility2.82 g/LALOGPS
logP2.41ALOGPS
logP1.99ChemAxon
logS-1.7ALOGPS
pKa (Strongest Acidic)18.21ChemAxon
pKa (Strongest Basic)-1.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area20.23 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity48 m³·mol⁻¹ChemAxon
Polarizability18 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+138.08231661259
DarkChem[M-H]-133.76831661259
DeepCCS[M+H]+142.66430932474
DeepCCS[M-H]-140.26930932474
DeepCCS[M-2H]-174.2430932474
DeepCCS[M+Na]+148.74330932474
AllCCS[M+H]+133.632859911
AllCCS[M+H-H2O]+129.132859911
AllCCS[M+NH4]+137.732859911
AllCCS[M+Na]+138.932859911
AllCCS[M-H]-136.232859911
AllCCS[M+Na-2H]-137.732859911
AllCCS[M+HCOO]-139.532859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
(-)-trans-CarveolCC(=C)[C@@H]1CC=C(C)[C@@H](O)C11803.9Standard polar33892256
(-)-trans-CarveolCC(=C)[C@@H]1CC=C(C)[C@@H](O)C11198.7Standard non polar33892256
(-)-trans-CarveolCC(=C)[C@@H]1CC=C(C)[C@@H](O)C11214.8Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
(-)-trans-Carveol,1TMS,isomer #1C=C(C)[C@@H]1CC=C(C)[C@@H](O[Si](C)(C)C)C11295.1Semi standard non polar33892256
(-)-trans-Carveol,1TBDMS,isomer #1C=C(C)[C@@H]1CC=C(C)[C@@H](O[Si](C)(C)C(C)(C)C)C11538.8Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - (-)-trans-Carveol EI-B (Non-derivatized)splash10-05nf-9700000000-a75055e28480ba00b8202017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - (-)-trans-Carveol EI-B (Non-derivatized)splash10-0a5c-9300000000-0497c064b7fcb0223af52017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - (-)-trans-Carveol EI-B (Non-derivatized)splash10-05nf-9700000000-a75055e28480ba00b8202018-05-18HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - (-)-trans-Carveol EI-B (Non-derivatized)splash10-0a5c-9300000000-0497c064b7fcb0223af52018-05-18HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - (-)-trans-Carveol EI-B (Non-derivatized)splash10-05nf-9700000000-a75055e28480ba00b8202018-05-18HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - (-)-trans-Carveol EI-B (Non-derivatized)splash10-0a5c-9300000000-0497c064b7fcb0223af52018-05-18HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - (-)-trans-Carveol EI-B (Non-derivatized)splash10-05nf-9700000000-a75055e28480ba00b8202018-05-18HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - (-)-trans-Carveol EI-B (Non-derivatized)splash10-0a5c-9300000000-0497c064b7fcb0223af52018-05-18HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - (-)-trans-Carveol GC-MS (Non-derivatized) - 70eV, Positivesplash10-0040-9300000000-900d20824e13ff7b371a2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - (-)-trans-Carveol GC-MS (1 TMS) - 70eV, Positivesplash10-059l-9420000000-c8fe9a59dae7a88e5d862017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - (-)-trans-Carveol GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - (-)-trans-Carveol 10V, Positive-QTOFsplash10-0f79-1900000000-6cbdaa00e43b6a5f14662015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - (-)-trans-Carveol 20V, Positive-QTOFsplash10-0f79-7900000000-b55dc6268bf1d9facfab2015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - (-)-trans-Carveol 40V, Positive-QTOFsplash10-1000-9200000000-82efaa1d3034c0a127ad2015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - (-)-trans-Carveol 10V, Negative-QTOFsplash10-0udi-0900000000-63662b96265d54ab95ac2015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - (-)-trans-Carveol 20V, Negative-QTOFsplash10-0udi-0900000000-fb53bb25a46fab88d48a2015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - (-)-trans-Carveol 40V, Negative-QTOFsplash10-0frl-6900000000-b30096dc2484f9341f672015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - (-)-trans-Carveol 10V, Negative-QTOFsplash10-0udi-0900000000-c751b1e6b18ebbd8226b2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - (-)-trans-Carveol 20V, Negative-QTOFsplash10-0ue9-0900000000-ff7b348d24f4a9fae7682021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - (-)-trans-Carveol 40V, Negative-QTOFsplash10-0159-5900000000-32379e3babd1cfac9d582021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - (-)-trans-Carveol 10V, Positive-QTOFsplash10-000l-7900000000-14152f364bee2002ab862021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - (-)-trans-Carveol 20V, Positive-QTOFsplash10-002f-9100000000-c417dcb5d6ff023a5c442021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - (-)-trans-Carveol 40V, Positive-QTOFsplash10-0006-9000000000-33b66b0d611b3c8dca5f2021-09-25Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB013717
KNApSAcK IDC00000814
Chemspider ID85031
KEGG Compound IDC00964
BioCyc IDNot Available
BiGG ID36494
Wikipedia LinkCarveol
METLIN ID6934
PubChem Compound94221
PDB IDNot Available
ChEBI ID15389
Food Biomarker OntologyNot Available
VMH IDCARVEOL
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceWouter, Adrian Duetz; Witholt, Bernard; Jourdat, Catherine. Process for the preparation of trans-carveol. Eur. Pat. Appl. (2002), 12 pp.
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular weight:
55627.365
Reactions
(+)-Limonene + NADPH + Oxygen → (-)-trans-Carveol + NADP + Waterdetails
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55944.565
Reactions
(+)-Limonene + NADPH + Oxygen → (-)-trans-Carveol + NADP + Waterdetails