Human Metabolome Database Version 3.5

Showing metabocard for Carbonic acid (HMDB03538)

Record Information
Version 3.5
Creation Date 2006-08-12 17:21:59 -0600
Update Date 2013-02-08 17:12:37 -0700
HMDB ID HMDB03538
Secondary Accession Numbers None
Metabolite Identification
Common Name Carbonic acid
Description Carbonic acid (ancient name acid of air or aerial acid) is the only inorganic carbon acid, and has the formula H2CO3. It is also a name sometimes given to solutions of carbon dioxide in water, which contain small amounts of H2CO3. The salts of carbonic acids are called bicarbonates (or hydrogencarbonates) and carbonates. (wikipedia).
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. Acid of air
  2. Aerial acid
  3. Bisodium carbonate
  4. Calcined
  5. Carbonic acid sodium salt
  6. Consal
  7. Crystol carbonate
  8. Dihydrogen carbonate
  9. Disodium carbonate
  10. Mild alkali
  11. Na-X
  12. Oxyper
  13. Sal soda
  14. Salt of soda
  15. Scotch soda
  16. Soda
  17. Soda ash
  18. Sodium carbonate
  19. Sodium carbonate anhydrous
  20. Sodium carbonate hydrated
  21. Sodium carbonate peroxyhydrate
  22. Solvay soda
  23. Trona soda ash
  24. Tronalight light soda ash
Chemical Formula CH2O3
Average Molecular Weight 62.0248
Monoisotopic Molecular Weight 62.00039393
IUPAC Name carbonic acid
Traditional IUPAC Name carbonic acid
CAS Registry Number 463-79-6
SMILES OC(O)=O
InChI Identifier InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)
InChI Key BVKZGUZCCUSVTD-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Organic Acids and Derivatives
Class Organic Carbonic Acids and Derivatives
Sub Class Organic Carbonic Acids
Other Descriptors
  • Aliphatic Acyclic Compounds
  • Organic Carbonic Acids and Derivatives
  • a small molecule(Cyc)
  • carbon oxoacid(ChEBI)
  • chalcocarbonic acid(ChEBI)
Substituents
  • N/A
Direct Parent Organic Carbonic Acids
Ontology
Status Expected and Not Quantified
Origin
  • Endogenous
Biofunction
  • Osmolyte, enzyme cofactor, signalling
Application Not Available
Cellular locations
  • Mitochondria
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility 231 g/L ALOGPS
LogP 0.60 ALOGPS
LogP 0.25 ChemAxon
LogS 0.57 ALOGPS
pKa (strongest acidic) 6.05 ChemAxon
Hydrogen Acceptor Count 3 ChemAxon
Hydrogen Donor Count 2 ChemAxon
Polar Surface Area 57.53 A2 ChemAxon
Rotatable Bond Count 0 ChemAxon
Refractivity 9.5 ChemAxon
Polarizability 4.23 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -1 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations
  • Mitochondria
Biofluid Locations Not Available
Tissue Location
  • Skeletal Muscle
  • Bladder
  • Intestine
  • Pancreas
  • Placenta
  • Testes
  • Kidney
  • Epidermis
  • Thyroid Gland
  • Nerve Cells
  • Platelet
Pathways Not Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID Not Available
DrugBank Metabolite ID Not Available
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB023191
KNApSAcK ID Not Available
Chemspider ID 747 Link_out
KEGG Compound ID C01353 Link_out
BioCyc ID CARBON-DIOXIDE Link_out
BiGG ID 1436647 Link_out
Wikipedia Link Carbonic acid Link_out
NuGOwiki Link HMDB03538 Link_out
Metagene Link HMDB03538 Link_out
METLIN ID 6944 Link_out
PubChem Compound 767 Link_out
PDB ID Not Available
ChEBI ID 28976 Link_out
References
Synthesis Reference Govdyak, R. M. Liquid carbonic acid production at gas industry facilities. Ekotekhnologii i Resursosberezhenie (2005), (3), 41-48.
Material Safety Data Sheet (MSDS) Download (PDF)
General References
  1. Sepai O, Anderson D, Street B, Bird I, Farmer PB, Bailey E: Monitoring of exposure to styrene oxide by GC-MS analysis of phenylhydroxyethyl esters in hemoglobin. Arch Toxicol. 1993;67(1):28-33. Pubmed: 8452476 Link_out
  2. Gross E, Fedotoff O, Pushkin A, Abuladze N, Newman D, Kurtz I: Phosphorylation-induced modulation of pNBC1 function: distinct roles for the amino- and carboxy-termini. J Physiol. 2003 Jun 15;549(Pt 3):673-82. Epub 2003 May 2. Pubmed: 12730338 Link_out
  3. DiGiovanna JJ, Aoyagi T, Taylor JR, Halprin KM: Inhibition of epidermal adenyl cyclase by lithium carbonate. J Invest Dermatol. 1981 Apr;76(4):259-63. Pubmed: 6259263 Link_out
  4. Thakur SC, Thakur SS, Chaube SK, Singh SP: Subchronic supplementation of lithium carbonate induces reproductive system toxicity in male rat. Reprod Toxicol. 2003 Nov-Dec;17(6):683-90. Pubmed: 14613820 Link_out
  5. Faravelli C, Di Bernardo M, Ricca V, Benvenuti P, Bartelli M, Ronchi O: Effects of chronic lithium treatment on the peripheral nervous system. J Clin Psychiatry. 1999 May;60(5):306-10. Pubmed: 10362438 Link_out
  6. Siegel L, Walker SI, Robin NI: Total hydrolyzable glycerol in amniotic fluid, and its relationship to fetal lung maturity. Clin Chem. 1984 Sep;30(9):1546-8. Pubmed: 6467568 Link_out
  7. Bartsch I, Zschaler I, Haseloff M, Steinberg P: Establishment of a long-term culture system for rat colon epithelial cells. In Vitro Cell Dev Biol Anim. 2004 Sep-Oct;40(8-9):278-84. Pubmed: 15723563 Link_out
  8. Kristensen JM, Kristensen M, Juel C: Expression of Na+/HCO3- co-transporter proteins (NBCs) in rat and human skeletal muscle. Acta Physiol Scand. 2004 Sep;182(1):69-76. Pubmed: 15329059 Link_out
  9. Matousek P, Novotny J, Rudajev V, Svoboda P: Prolonged agonist stimulation does not alter the protein composition of membrane domains in spite of dramatic changes induced in a specific signaling cascade. Cell Biochem Biophys. 2005;42(1):21-40. Pubmed: 15673926 Link_out
  10. Xu W, Yoon SI, Huang P, Wang Y, Chen C, Chong PL, Liu-Chen LY: Localization of the kappa opioid receptor in lipid rafts. J Pharmacol Exp Ther. 2006 Jun;317(3):1295-306. Epub 2006 Feb 27. Pubmed: 16505160 Link_out
  11. Perrild H, Hegedus L, Arnung K: Sex related goitrogenic effect of lithium carbonate in healthy young subjects. Acta Endocrinol (Copenh). 1984 Jun;106(2):203-8. Pubmed: 6428121 Link_out
  12. Sack DA, Sack RB, Nair GB, Siddique AK: Cholera. Lancet. 2004 Jan 17;363(9404):223-33. Pubmed: 14738797 Link_out
  13. Bomhard EM, Brendler-Schwaab SY, Freyberger A, Herbold BA, Leser KH, Richter M: O-phenylphenol and its sodium and potassium salts: a toxicological assessment. Crit Rev Toxicol. 2002;32(6):551-625. Pubmed: 12487365 Link_out
  14. Severina IS, Pyatakova NV, Shchegolev AY, Ponomarev GV: YC-1-like potentiation of NO-dependent activation of soluble guanylate cyclase by derivatives of protoporphyrin IX. Biochemistry (Mosc). 2006 Mar;71(3):340-4. Pubmed: 16545073 Link_out
  15. Loiselle FB, Jaschke P, Casey JR: Structural and functional characterization of the human NBC3 sodium/bicarbonate co-transporter carboxyl-terminal cytoplasmic domain. Mol Membr Biol. 2003 Oct-Dec;20(4):307-17. Pubmed: 14578046 Link_out
  16. Antonijevic N, Terzic T, Jovanovic V, Suvajdzic N, Milosevic R, Basara N, Elezovic I: [Acquired amegakaryocytic thrombocytopenia: three case reports and a literature review] Med Pregl. 2004 May-Jun;57(5-6):292-7. Pubmed: 15503803 Link_out
  17. Chang TC: Influence of lithium carbonate on the thyrotropin receptor in vitro. Taiwan Yi Xue Hui Za Zhi. 1989 Jan;88(1):13-7. Pubmed: 2547015 Link_out

Enzymes
Name: Acetyl-CoA carboxylase 2
Reactions:
Adenosine triphosphate + Acetyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + Malonyl-CoA details
Adenosine triphosphate + Holo-[carboxylase] + Carbonic acid unknown ADP + Phosphoric acid + Carboxybiotin-carboxyl-carrier protein details
Gene Name: ACACB
Uniprot ID: O00763 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyruvate carboxylase, mitochondrial
Reactions:
Adenosine triphosphate + Pyruvic acid + Carbonic acid unknown ADP + Phosphoric acid + Oxalacetic acid details
Gene Name: PC
Uniprot ID: P11498 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-CoA carboxylase 1
Reactions:
Adenosine triphosphate + Acetyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + Malonyl-CoA details
Adenosine triphosphate + Holo-[carboxylase] + Carbonic acid unknown ADP + Phosphoric acid + Carboxybiotin-carboxyl-carrier protein details
Gene Name: ACACA
Uniprot ID: Q13085 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Reactions:
2-Methyl-3-oxopropanoic acid + Coenzyme A + Water + NAD unknown Propionyl-CoA + Carbonic acid + NADH details
Gene Name: ALDH6A1
Uniprot ID: Q02252 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Propionyl-CoA carboxylase beta chain, mitochondrial
Reactions:
Adenosine triphosphate + Propionyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + S-Methylmalonyl-CoA details
Gene Name: PCCB
Uniprot ID: P05166 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Propionyl-CoA carboxylase alpha chain, mitochondrial
Reactions:
Adenosine triphosphate + Propionyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + S-Methylmalonyl-CoA details
Gene Name: PCCA
Uniprot ID: P05165 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
Reactions:
Adenosine triphosphate + 3-Methylcrotonyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + 3-Methylglutaconyl-CoA details
Gene Name: MCCC2
Uniprot ID: Q9HCC0 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Reactions:
Adenosine triphosphate + 3-Methylcrotonyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + 3-Methylglutaconyl-CoA details
Gene Name: MCCC1
Uniprot ID: Q96RQ3 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carbonic anhydrase 1
Reactions:
Carbonic acid unknown CO(2) + Water details
Carbonic acid unknown Carbon dioxide + Water details
Gene Name: CA1
Uniprot ID: P00915 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carbonic anhydrase 2
Reactions:
Carbonic acid unknown CO(2) + Water details
Carbonic acid unknown Carbon dioxide + Water details
Gene Name: CA2
Uniprot ID: P00918 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carbonic anhydrase 5A, mitochondrial
Reactions:
Carbonic acid unknown CO(2) + Water details
Carbonic acid unknown Carbon dioxide + Water details
Gene Name: CA5A
Uniprot ID: P35218 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carbonic anhydrase 3
Reactions:
Carbonic acid unknown CO(2) + Water details
Carbonic acid unknown Carbon dioxide + Water details
Gene Name: CA3
Uniprot ID: P07451 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carbonic anhydrase 5B, mitochondrial
Reactions:
Carbonic acid unknown CO(2) + Water details
Carbonic acid unknown Carbon dioxide + Water details
Gene Name: CA5B
Uniprot ID: Q9Y2D0 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carbonic anhydrase 12
Reactions:
Carbonic acid unknown CO(2) + Water details
Carbonic acid unknown Carbon dioxide + Water details
Gene Name: CA12
Uniprot ID: O43570 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carbonic anhydrase 4
Reactions:
Carbonic acid unknown CO(2) + Water details
Carbonic acid unknown Carbon dioxide + Water details
Gene Name: CA4
Uniprot ID: P22748 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carbonic anhydrase 9
Reactions:
Carbonic acid unknown CO(2) + Water details
Carbonic acid unknown Carbon dioxide + Water details
Gene Name: CA9
Uniprot ID: Q16790 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carbonic anhydrase 13
Reactions:
Carbonic acid unknown CO(2) + Water details
Carbonic acid unknown Carbon dioxide + Water details
Gene Name: CA13
Uniprot ID: Q8N1Q1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: CAD protein
Reactions:
Adenosine triphosphate + L-Glutamine + Carbonic acid + Water unknown ADP + Phosphoric acid + L-Glutamic acid + Carbamoyl phosphate details
Gene Name: CAD
Uniprot ID: P27708 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carbonic anhydrase 14
Reactions:
Carbonic acid unknown CO(2) + Water details
Carbonic acid unknown Carbon dioxide + Water details
Gene Name: CA14
Uniprot ID: Q9ULX7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carbonic anhydrase 7
Reactions:
Carbonic acid unknown CO(2) + Water details
Carbonic acid unknown Carbon dioxide + Water details
Gene Name: CA7
Uniprot ID: P43166 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carbonic anhydrase 6
Reactions:
Carbonic acid unknown CO(2) + Water details
Carbonic acid unknown Carbon dioxide + Water details
Gene Name: CA6
Uniprot ID: P23280 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carbonic anhydrase-related protein
Reactions:
Carbonic acid unknown Carbon dioxide + Water details
Gene Name: CA8
Uniprot ID: P35219 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA