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Human Metabolome Database Version 2.5

 

Showing metabocard for 3'-AMP (HMDB03540)

Legend: metabolite field enzyme field

Version 2.5
Creation Date 2006-08-13 00:23:28
Update Date 2009-05-22 15:23:59
Accession Number HMDB03540
Secondary Accession Numbers HMDB06550
Common Name 3'-AMP
Description Adenylic acid. Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
Synonyms
  1. 3'-Adenylic acid
  2. 3'-Adenosine monophosphate
  3. Adenosine-3'-monophosphate
  4. Adenosine 3'-phosphate
  5. AMP 3'-phosphate
  6. Adenosine-3'-phosphate
  7. Adenosine-3'-monophosphoric acid
  8. Synadenylic acid
  9. Adenosine 3'-monophosphate
  10. Yeast adenylic acid
Chemical IUPAC Name [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]dihydrogen phosphate
Chemical Formula C10H14N5O7P
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Nucleosides and Nucleoside conjugates
Class
  • Nucleotides
Sub Class
  • Nucleotide monophosphates
Family
  • Microbial Metabolite
Species
  • primary alcohol
  • secondary alcohol
  • primary amine
  • primary aromatic amine
  • phosphoric acid ester
  • aromatic compound
  • heterocyclic compound
Biofunction
  • Enzyme cofactor
Application
—
Source
  • Endogenous
Average Molecular Weight 347.221
Monoisotopic Molecular Weight 347.063080
Isomeric SMILES NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]3O)C2=NC=N1
Canonical SMILES NC1=C2N=CN(C3OC(CO)C(OP(O)(O)=O)C3O)C2=NC=N1
KEGG Compound ID C01367 Link Image
BioCyc ID Not Available
BiGG ID 2224997 Link Image
Wikipedia Link Not Available
NuGOwiki Link HMDB03540 Link Image
Metagene Link HMDB03540 Link Image
METLIN ID Not Available
PubChem Compound 41211 Link Image
PubChem Substance 11533209 Link Image
ChEBI ID 28931 Link Image
CAS Registry Number 84-21-9
InChI Identifier InChI=1/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(17)7(4(1-16)21-10)22-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
Synthesis Reference Not Available
Melting Point (Experimental) 197 oC
Experimental Water Solubility 500 mg/L at 15 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)] Source: PhysProp
Predicted Water Solubility 3.48 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge -2
State Solid
Experimental LogP/Hydrophobicity -1.453 Source: PhysProp
Predicted LogP/Hydrophobicity -3.14 [Predicted by ALOGPS] Calculated using ALOGPS
Material Safety Data Sheet (MSDS)
MOL File Show Link Image
SDF File Show Link Image
PDB File Show Link Image
2D Structure
3D Structure
Experimental PDB ID Not Available
Experimental 1H NMR Spectrum Not Available
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum Not Available
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location Not Available
Biofluid Location Not Available
Tissue Location Not Available
Concentrations (Normal) Not Available
Concentrations (Abnormal) Not Available
Associated Disorders Not Available
OMIM ID Not Available
Pathways Not Available
General References Not Available
Metabolic Enzymes
  1. 5'-nucleotidase family protein/Ser/Thr protein phosphatase family protein
  2. Putative 2', 3'-cyclic nucleotide 2'-phosphodiesterase
  3. 2',3'-cyclic-nucleotide 2'-phosphodiesterase
  4. 2`,3`-cyclic-nucleotide 2`-phosphodiesterase
  5. Ser/Thr protein phosphatase family protein
  6. 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
Enzyme 1 [top]
Enzyme 1 ID 16287
Enzyme 1 Name 5'-nucleotidase family protein/Ser/Thr protein phosphatase family protein
Enzyme 1 Synonyms Not Available
Enzyme 1 Gene Name Not Available
Enzyme 1 Protein Sequence >5'-nucleotidase family protein/Ser/Thr protein phosphatase family protein 
MLKKVRDKKFTALAVATSMIFGIATPLTTVKATENLAPENLEKKGEEASLEKEGDVTIQI
LGTSDLHGRFMNYEYARNQKSDGGLNQISTLVNEARNENPNTIVVDNGDTIQGNFNHLFK
NGPNPMVMGMNAIGYDVFSLGNHEFNYGMDNLNDVVSQANDNLDVLCANLYKDGKRVYEG
YTTREIEGVEVALIGVVSPHIMKWDSENLKGYEAKNPAEEVGFVIDEIENRPEGGADVYA
VVSHVGLESEYGNGDSARAIAEMNPEVSAIVAGHSHTNVPEEKINNAVISQPTSNGQMVS
KIELTVRKNGEKVEVVDKKSKLLSTKGVAEDQKINDLLSDFHNTAIADATAPVGEMVGGD
LADKNEIKEIPQSLVEDQGITDFINEVQLYNSRKHLESKNINPDEVYMVSGAALFSASSN
LYEGNISKADISNIYRYDNKLYTIKTNGKQLKKYMEKNAEYYNTYKDGDLTVSFNEDVRM
YLYDMFDGVSYEINISKEPGQRIENLKFEKDGKPVEDSDVVYLTVNDYRYNSGLAAGIMD
QGEHEKIYDTNNDQISDMRDLIVDYIQNVKGGKITKNIDNNWKITGNDWDSEQRELAVKL
INEGKIKIPVSEDGRTPNVKAVTWNDVLEALGTKEVEIPIVTFNDFHGSLAESKSDVGAA
KLVGEIKRVKEENPNTVVVTGGDIYQGSAMSNLLKGEPVTAMLKEMGLEFSAVGNHEFDW
GYEYIPDWAKAGEFDFLASNIYEKETGKPVEWAKPYGVVEREGKKVGFIGLATPETAYKT
KPDNVAHLEFKDPVEATKTWVDYLENKENVDAVVVLSHLGSEQNRETGEITGEIVEVAEV
PGVDAIISAHSHQKVEGKVNGVPVIQAYKNGRNLGYVNLKFDYKDELVVTTKLDDISKRK
DTLPVDKNMEDILAKFEADLAPIMNEKVADLSVDLPHDRDTGVSPMGATVAETMRRIVDA
DIAITNGGGVRAPLMAGTVTVGDMYTILPFDNTLVTMEMKGSDIIKVLEHGIEPDNFGWG
QHAGVKLWYTPGAERGEKITSVRLADGTKLENDKYYTVVTNDFMAVGGDSYDFSAAKNVV
DTNLVIRDEMANYWRENGIDPITDLSTLLEAGEDTTVDSEKPENPENPGNPETPQNPENP
DNGENLPNTGMPFGTGAVAAMGTVLTIGGLAVLRKKKNNAA
Enzyme 1 Number of Residues 1181
Enzyme 1 Molecular Weight 129963.6
Enzyme 1 Theoretical pI 4.42
Enzyme 1 GO Classification
Function
  • binding
  • catalytic activity
  • cation binding
  • hydrolase activity
  • hydrolase activity, acting on ester bonds
  • ion binding
  • metal ion binding
  • nucleotide binding
Process
  • cellular nitrogen compound metabolic process
  • metabolic process
  • nitrogen compound metabolic process
  • nucleobase, nucleoside and nucleotide metabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • nucleoside phosphate metabolic process
  • nucleotide catabolic process
  • nucleotide metabolic process
Component
—
Enzyme 1 General Function Involved in hydrolase activity
Enzyme 1 Specific Function Not Available
Enzyme 1 Pathways Not Available
Enzyme 1 Reactions Not Available
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 110673959 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID Q0TP10 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name Q0TP10_CLOP1 Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >3546 bp 
ATGCTTAAAAAAGTAAGGGATAAGAAATTTACAGCATTAGCAGTTGCTACTTCAATGATC
TTTGGAATTGCAACACCGTTAACTACTGTAAAGGCTACTGAAAATTTAGCACCGGAAAAC
CTAGAGAAAAAAGGAGAAGAAGCTAGTTTAGAAAAAGAAGGAGATGTAACTATTCAGATT
TTAGGTACATCAGACCTTCATGGTAGATTTATGAATTATGAGTATGCTCGTAATCAAAAA
TCTGATGGTGGATTAAATCAAATATCCACATTAGTTAATGAAGCTAGAAATGAAAATCCT
AATACAATAGTGGTTGATAATGGAGATACTATACAAGGAAATTTCAATCACTTATTTAAA
AATGGTCCTAATCCTATGGTTATGGGAATGAATGCTATAGGATATGATGTTTTCTCTTTA
GGAAATCATGAATTTAACTATGGAATGGACAACCTTAATGATGTTGTAAGTCAAGCTAAT
GATAATTTAGATGTATTATGTGCAAATCTTTATAAAGATGGTAAGAGGGTTTATGAAGGA
TATACAACTAGGGAAATAGAAGGCGTTGAAGTTGCTCTAATTGGAGTTGTAAGTCCTCAT
ATAATGAAATGGGATTCAGAAAATTTAAAAGGATATGAGGCTAAAAATCCTGCAGAAGAA
GTTGGATTTGTAATAGATGAAATAGAAAATAGACCTGAGGGTGGCGCTGATGTTTATGCA
GTAGTTTCACATGTGGGATTAGAAAGTGAATATGGTAATGGAGATAGTGCTAGAGCCATA
GCTGAAATGAACCCAGAGGTATCTGCCATAGTTGCAGGACATAGTCATACTAATGTACCA
GAAGAAAAAATAAACAATGCAGTTATAAGCCAACCTACAAGTAATGGTCAAATGGTTTCT
AAAATAGAATTAACTGTTAGAAAAAATGGAGAAAAAGTAGAAGTTGTAGATAAAAAGTCT
AAATTATTAAGCACAAAGGGTGTAGCAGAGGATCAAAAAATAAATGATTTACTTTCTGAT
TTTCATAACACAGCAATTGCTGATGCAACAGCACCTGTTGGCGAAATGGTTGGAGGAGAT
CTTGCTGATAAAAATGAAATAAAAGAAATTCCACAATCATTAGTTGAAGATCAAGGTATA
ACTGACTTTATAAATGAAGTTCAATTATATAATAGTAGAAAGCATTTAGAATCAAAGAAT
ATAAATCCAGATGAGGTTTATATGGTTTCTGGAGCAGCTTTATTTAGTGCTTCATCAAAC
TTATATGAAGGAAATATAAGCAAAGCAGATATTTCAAATATTTATAGATATGATAATAAA
TTATATACTATAAAAACAAATGGAAAGCAACTTAAAAAGTATATGGAAAAAAATGCTGAG
TATTATAATACTTATAAAGATGGGGATTTAACAGTATCTTTCAATGAAGATGTTAGAATG
TATTTATATGATATGTTTGATGGAGTAAGTTATGAAATAAATATATCTAAAGAGCCAGGT
CAAAGAATTGAAAACTTAAAGTTTGAAAAAGATGGTAAGCCAGTTGAAGACTCAGATGTA
GTTTATTTAACAGTAAATGATTATAGATATAATTCTGGCTTAGCTGCTGGAATAATGGAC
CAAGGTGAGCATGAGAAAATATATGATACAAATAATGATCAAATATCAGATATGAGAGAT
TTAATAGTTGATTATATTCAAAATGTAAAAGGTGGAAAAATTACTAAAAACATTGATAAT
AACTGGAAGATAACAGGTAATGATTGGGATTCAGAACAAAGAGAATTAGCTGTTAAACTT
ATAAATGAAGGTAAAATAAAAATACCTGTATCAGAAGATGGAAGAACTCCAAATGTAAAA
GCTGTAACTTGGAATGATGTTTTAGAAGCTTTAGGAACTAAGGAAGTTGAAATACCAATA
GTTACTTTCAACGATTTCCATGGATCTTTAGCAGAATCTAAGAGTGATGTTGGAGCAGCT
AAGTTAGTTGGAGAAATAAAGAGAGTAAAAGAAGAAAATCCAAATACTGTAGTTGTTACA
GGTGGAGATATATATCAAGGAAGTGCTATGTCAAATCTTTTAAAAGGTGAGCCAGTTACT
GCTATGCTTAAGGAAATGGGCTTAGAATTTTCAGCAGTTGGTAACCATGAGTTTGACTGG
GGATATGAATATATACCAGACTGGGCTAAAGCTGGAGAATTTGATTTCTTAGCATCAAAT
ATATATGAAAAAGAAACTGGAAAACCAGTTGAATGGGCTAAGCCTTATGGCGTTGTTGAA
AGAGAAGGAAAGAAAGTTGGATTTATAGGACTTGCTACTCCTGAAACTGCATACAAGACA
AAACCAGATAACGTTGCTCATTTAGAATTTAAAGATCCTGTAGAAGCAACTAAGACTTGG
GTAGATTATTTAGAAAATAAAGAAAATGTAGATGCCGTTGTTGTTTTAAGTCATTTAGGA
AGTGAACAAAATAGAGAGACTGGAGAAATAACTGGTGAGATTGTTGAAGTTGCTGAAGTA
CCAGGAGTTGATGCTATAATATCAGCTCATAGTCACCAAAAAGTTGAAGGAAAAGTTAAT
GGAGTACCAGTTATACAAGCGTATAAAAATGGTAGAAATTTAGGATATGTTAACTTAAAA
TTTGACTATAAAGATGAATTAGTAGTTACAACTAAACTTGACGATATTTCTAAGAGAAAA
GATACTCTTCCAGTTGATAAGAATATGGAAGATATATTAGCAAAATTTGAAGCTGATTTA
GCTCCTATAATGAATGAAAAAGTTGCTGATTTATCAGTAGATTTACCACATGATAGAGAT
ACTGGAGTAAGTCCTATGGGGGCTACTGTAGCTGAAACTATGAGAAGAATAGTTGATGCT
GATATAGCAATAACTAATGGTGGAGGAGTAAGAGCCCCATTAATGGCTGGAACAGTTACT
GTTGGAGATATGTACACAATACTTCCATTTGACAATACTTTAGTTACAATGGAAATGAAA
GGTTCAGATATAATAAAAGTTTTAGAGCATGGAATAGAACCAGATAACTTTGGATGGGGA
CAACATGCTGGTGTTAAACTTTGGTACACTCCAGGAGCTGAAAGAGGAGAAAAGATAACT
TCTGTTAGATTAGCTGATGGAACTAAATTAGAAAATGACAAGTATTATACAGTAGTTACT
AATGATTTCATGGCTGTAGGTGGAGATTCTTATGATTTCTCAGCTGCTAAAAATGTAGTG
GATACAAACTTAGTTATAAGAGATGAAATGGCAAATTATTGGAGAGAAAATGGAATAGAT
CCTATAACTGATTTATCTACTTTATTAGAAGCTGGTGAAGATACAACTGTTGATTCAGAA
AAACCTGAAAATCCAGAAAATCCAGGTAACCCAGAAACACCACAAAATCCAGAAAATCCT
GATAATGGTGAAAACTTACCTAACACAGGTATGCCATTTGGAACTGGAGCAGTGGCTGCT
ATGGGTACAGTATTAACAATTGGTGGACTAGCTGTATTAAGAAAGAAAAAGAATAATGCT
GCATAG
Enzyme 1 GenBank Gene ID CP000246 Link Image
Enzyme 1 GeneCard ID Not Available
Enzyme 1 GenAtlas ID Not Available
Enzyme 1 HGNC ID Not Available
Enzyme 1 Chromosome Location Not Available
Enzyme 1 Locus CPF_2206
Enzyme 1 SNPs Not Available
Enzyme 1 General References
  1. Myers GS, Rasko DA, Cheung JK, Ravel J, Seshadri R, DeBoy RT, Ren Q, Varga J, Awad MM, Brinkac LM, Daugherty SC, Haft DH, Dodson RJ, Madupu R, Nelson WC, Rosovitz MJ, Sullivan SA, Khouri H, Dimitrov GI, Watkins KL, Mulligan S, Benton J, Radune D, Fisher DJ, Atkins HS, Hiscox T, Jost BH, Billington SJ, Songer JG, McClane BA, Titball RW, Rood JI, Melville SB, Paulsen IT: Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Res. 2006 Aug;16(8):1031-40. Epub 2006 Jul 6. [PubMed Link Image]
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 16288
Enzyme 2 Name Putative 2', 3'-cyclic nucleotide 2'-phosphodiesterase
Enzyme 2 Synonyms Not Available
Enzyme 2 Gene Name Not Available
Enzyme 2 Protein Sequence >Putative 2', 3'-cyclic nucleotide 2'-phosphodiesterase 
MIMMKRLICMYAFLLCLVCVLPAQEREVKLKIVQTSDVHGNYFPYNFITQKEWGGSLARV
YALVQKNREVYKENLILLDNGDILQGQPSAYYYNYIDTVAPHVCAEMMNFMGYDAGNMGN
HDVETGRAVFDRWIGECNFPVLGANIVETATGETHLPPYRVLERDGVKIVVLGMITPAIP
AWLSENLWQGLRFDDMEETARKWMKVIREKENPDLVIGLFHAGQDAFVMSGKYNENASLN
VAKNVPGFDMVLMGHDHARECKKVVNVAGDSVLVIDPASNGIVVSDIDVTLKLKDGKVVS
KQIDGVLTDTKEYGVSESFMRHFALQYGAVEKFVSKKIGVFTEDLSTRPAYFGSSAFIDF
IHSLQLDISGADISFAAPLSFDAEIKKGDIRVSDMFNLYKYENMLYVMKLSGKEIKDFLE
ESYYMWTNRMKSPEDHLLWLKEKRRAGAEDRASFQNFSFNFDSAAGIIYTVDVTRPKGEK
VTIVSMADGSPFRMDHIYKVALNSYRGNGGGELLTKGSGIPQEKLKERIIFSTDKDLRFY
LMQYIEKKGTLDPRALNQWKFVPEEWVKPAAERDYEYLFGGK
Enzyme 2 Number of Residues 582
Enzyme 2 Molecular Weight 66027.4
Enzyme 2 Theoretical pI 6.02
Enzyme 2 GO Classification
Function
  • catalytic activity
  • hydrolase activity
Process
  • cellular nitrogen compound metabolic process
  • metabolic process
  • nitrogen compound metabolic process
  • nucleobase, nucleoside and nucleotide metabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • nucleoside phosphate metabolic process
  • nucleotide catabolic process
  • nucleotide metabolic process
Component
—
Enzyme 2 General Function Involved in hydrolase activity
Enzyme 2 Specific Function Not Available
Enzyme 2 Pathways Not Available
Enzyme 2 Reactions Not Available
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • None
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 60492798 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID Q5LE80 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name Q5LE80_BACFN Link Image
Enzyme 2 PDB ID Not Available
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >1749 bp 
ATGATTATGATGAAAAGATTGATTTGTATGTATGCTTTCTTGCTCTGCCTGGTATGTGTG
TTGCCGGCACAAGAGAGAGAGGTGAAACTGAAAATTGTGCAGACCAGTGATGTACATGGT
AATTACTTTCCATATAACTTCATTACACAAAAGGAGTGGGGCGGAAGTCTTGCACGTGTA
TATGCATTGGTGCAAAAGAACCGGGAGGTGTATAAGGAAAACCTTATATTGCTGGATAAC
GGAGATATTCTGCAAGGACAGCCTTCGGCGTACTATTATAATTATATAGATACAGTGGCG
CCTCACGTATGTGCCGAGATGATGAATTTTATGGGATACGACGCCGGGAACATGGGAAAT
CATGATGTGGAAACAGGACGCGCTGTATTCGACCGCTGGATTGGTGAGTGCAATTTCCCG
GTGCTGGGGGCAAACATCGTTGAAACGGCTACGGGAGAGACCCATCTTCCTCCTTATCGG
GTGTTGGAGCGCGACGGAGTGAAGATTGTGGTGCTGGGAATGATTACGCCGGCTATTCCC
GCGTGGTTGTCAGAGAATCTGTGGCAGGGACTGCGGTTTGACGATATGGAAGAGACAGCA
CGGAAGTGGATGAAAGTCATTCGTGAGAAAGAAAATCCGGATCTGGTGATCGGGTTGTTT
CATGCCGGACAAGATGCTTTTGTGATGTCAGGCAAGTATAACGAGAATGCTTCGCTGAAT
GTGGCGAAGAATGTACCGGGATTTGATATGGTGCTGATGGGGCACGACCATGCGCGGGAG
TGCAAGAAGGTGGTGAATGTGGCAGGCGACTCCGTACTGGTGATCGATCCGGCAAGCAAC
GGAATCGTAGTGTCGGACATTGACGTGACTTTAAAGTTGAAAGACGGTAAAGTGGTGAGC
AAACAGATAGACGGTGTGCTGACGGATACAAAAGAATACGGAGTCAGCGAGTCCTTTATG
AGACATTTCGCATTGCAATACGGGGCGGTTGAGAAGTTTGTATCTAAGAAGATCGGGGTA
TTTACAGAAGATCTGTCTACCCGTCCCGCCTATTTCGGTTCGTCGGCATTTATTGATTTT
ATCCATTCGTTGCAACTCGATATTTCGGGAGCGGATATTTCGTTTGCCGCTCCGTTATCT
TTCGATGCAGAGATAAAGAAAGGAGATATTCGTGTGAGCGACATGTTCAATCTGTATAAG
TACGAAAATATGCTTTATGTGATGAAGTTGTCGGGCAAAGAGATTAAAGACTTCCTGGAA
GAGTCCTATTATATGTGGACGAACCGGATGAAATCTCCCGAAGACCACTTGTTGTGGCTG
AAAGAAAAACGTAGGGCAGGTGCCGAAGACCGGGCTTCGTTCCAGAATTTTAGTTTTAAT
TTCGATTCGGCTGCGGGAATTATCTACACAGTGGATGTGACCCGACCGAAGGGAGAAAAA
GTGACTATTGTCAGTATGGCGGACGGTTCTCCGTTCCGGATGGATCATATCTACAAAGTG
GCGCTGAACTCTTATCGTGGCAACGGCGGGGGAGAACTGCTGACAAAAGGATCGGGAATC
CCGCAGGAGAAACTGAAAGAGCGTATTATCTTCTCTACGGACAAGGACCTCCGTTTCTAT
CTGATGCAGTATATCGAGAAGAAAGGTACGCTTGATCCGCGTGCGCTGAACCAATGGAAA
TTTGTACCAGAAGAGTGGGTGAAACCTGCCGCAGAGAGAGATTATGAATATCTGTTTGGT
GGAAAATAA
Enzyme 2 GenBank Gene ID CR626927 Link Image
Enzyme 2 GeneCard ID Not Available
Enzyme 2 GenAtlas ID Not Available
Enzyme 2 HGNC ID Not Available
Enzyme 2 Chromosome Location Not Available
Enzyme 2 Locus BF1873
Enzyme 2 SNPs Not Available
Enzyme 2 General References
  1. Cerdeno-Tarraga AM, Patrick S, Crossman LC, Blakely G, Abratt V, Lennard N, Poxton I, Duerden B, Harris B, Quail MA, Barron A, Clark L, Corton C, Doggett J, Holden MT, Larke N, Line A, Lord A, Norbertczak H, Ormond D, Price C, Rabbinowitsch E, Woodward J, Barrell B, Parkhill J: Extensive DNA inversions in the B. fragilis genome control variable gene expression. Science. 2005 Mar 4;307(5714):1463-5. [PubMed Link Image]
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 16289
Enzyme 3 Name 2',3'-cyclic-nucleotide 2'-phosphodiesterase
Enzyme 3 Synonyms Not Available
Enzyme 3 Gene Name Not Available
Enzyme 3 Protein Sequence >2',3'-cyclic-nucleotide 2'-phosphodiesterase 
MKRLICMYAFLLCLVCVLPAQEREVKLKIVQTSDVHGNYFPYNFITQKEWGGSLARVYAL
VQKNREVYKGNLILLDNGDILQGQPSAYYYNYIDTVAPHVCAEMMNFMGYDAGNMGNHDV
ETGRAVFDRWIGECNFPVLGANIVETATGETHLPPYRVLERDGVKIVVLGMITPAIPAWL
SENLWQGLRFDDMEETARKWMKVIREKENPDLVIGLFHAGQDAFVMSGKYNENASLNVAK
NVPGFDMVLMGHDHARECKKVVNVAGDSVLVIDPASNGIVVSDIDVTLKLKDGKVVSKQI
DGVLTDTKEYGVSESFMRHFALQYGAVEKFVSKKIGVFTEDLSTRPAYFGSSAFIDFIHS
LQLDISGADISFAAPLSFDAEIKKGDIRVSDMFNLYKYENMLYVMKLSGKEIKDFLEESY
YMWTNQMKSPEDHLLWLKEKRRAGAEDRASFQNFSFNFDSAAGIIYTVDVTRPKGEKVTI
VSMADGSPFRMDHIYKVALNSYRGNGGGELLTKGSGIPQEKLKERIIFSTDKDLRFYLMQ
YIEKKGTLDPRALNQWKFVPEEWVKPAAERDYEYLFGGK
Enzyme 3 Number of Residues 579
Enzyme 3 Molecular Weight 65551.7
Enzyme 3 Theoretical pI 6.02
Enzyme 3 GO Classification
Function
  • catalytic activity
  • hydrolase activity
Process
  • cellular nitrogen compound metabolic process
  • metabolic process
  • nitrogen compound metabolic process
  • nucleobase, nucleoside and nucleotide metabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • nucleoside phosphate metabolic process
  • nucleotide catabolic process
  • nucleotide metabolic process
Component
—
Enzyme 3 General Function Involved in hydrolase activity
Enzyme 3 Specific Function Not Available
Enzyme 3 Pathways Not Available
Enzyme 3 Reactions Not Available
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • None
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 52215462 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID Q64VC3 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name Q64VC3_BACFR Link Image
Enzyme 3 PDB ID Not Available
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >1740 bp 
ATGAAAAAGACATCTTTGTTTTTGTCGTTTTTTATTGCTCTCTTTTTGTTTTCGGCTTGT
ACTGACGATACTGAGCAATGTCTATATTCCCCTAAAGTTTTTGATACGGGTAATCTATTG
AGCAATAGAGTGAAAGAAGAATTTCTTAATTTTGATTATCCTGCCGGGATTGTTCCAATT
CTTTTTGCCGTAGATAGTATCGAGGCCATCCAAATGGGGGCTTATGCTGATGAATGTTTT
AATGATCTTGTAGATTCGATATCCGAGTCAAGAGATTTTAAGCATAGAGGGATGTTGGTG
CTTGTTTCGAAAAATCCGAAACTCATTCAAATACGTTTGGGTAATCGATATAGGGTTTAT
TGCAATATGACAGGAGCAACTTCCGGACTGAATTATTTAGATTTGCAAAAGCAAATACAG
GAGAGAGGTGTAGAAGAAACTCTTCCATTGTTTCTGCAAAACACTTCAGTTCGTATTCAG
GAGTTGAATGAATTACCTTCATATAAAAAATATCGAATCAACTCTGCAATATCAGTAATT
TCTACCTGTTTGGAATACATAGGAACTCCTTCGGAGAACTTTTACGGAAAGTGTGTTTTA
ACCCCCATTTTAAAAATAACATCATTTGGGTATTATATTTTTAAATCATGGTTGTTGACC
TTCATGTTTGTATGTCTGATAATGCTTTTATGCCGTTGGATGATGTTTCTGCTAGTGAAG
CGTTTATTGGGAGAGAATGTTATAGCCCTTATGTGGACTCAAAAGATCATTAATTGGGGA
CTTGGTTTATTGTTTTCAATTTCTGCAGCAGCTTCGGCTATTATTTTGTCCAGTGGACGA
ATGGAAGATGCGATAGCGTTGCAGGCTATTGGAATTCCTTTTATGGAGAATTTTCAGATT
GCCGCTGCAGATTATGTTTTGAAAACATCGTTTGTTGCCGCTTTCTTTTTTGTTTTAATG
TATGCATTGAAACGAAATATCGTATCAGATATCTTTTTAATGAGTCTTTTGGAACCAGCC
AAGCAGCAGGAAGTTTATCGTAGTTTGAGCGATGCTCAAAAGACTGCTTTGGTTATAGGA
CACGAAGCGGATCTCAATGAAGTTGAAACAAGTTCCGAACCATATTCCGAATTGTTCACT
TCGCGTGTATCTAAACAGGAAACCGTGACTATTGTTTCATTGGCAATAGCGGCTTTATTT
TTGATTCCGCGGCCTTTGATTATAATGGGTATTGCTTTAACCATTTACCCGCTGGTCGGG
CAATGTGTGAAGATTTATCATGTGGTGAGTAATCATACGCTTCCGGCACAAATAAAGGGA
GATAGAAGAAGGGCATTAATAACCAATTTACTTATCATTTTTGCAATAGCTTTTATAACT
GTTCTGATAGGACTGTTTTTTAATCCCATGCCGGATAAAAAAGAAATTGATCGGAATGAA
ATAAAGATGGAATTGATTGCTCCGGATAGACTGGAAGGAAATTATACTGTTAGTAAATCT
ATTGTGGGGCAGATCCAAGTATCCAGTGGTATTATAAAAAAGGTGAAAGATGGAACGTTT
CAACTTTTGATAACCGGTAAATCTTCTCCTAAAGTGTATAAGTTGGATTTTAATTCTGAT
AAAATGATATTTGTTTCAGGAGAACTGGGTAATGGAGCAATCCACTATGATAAAGATTTG
GATAAAATTAAAATAGTATTTAATATAAATGAACAAACGACATGGACAATTTCAAAGTGA
Enzyme 3 GenBank Gene ID AP006841 Link Image
Enzyme 3 GeneCard ID Not Available
Enzyme 3 GenAtlas ID Not Available
Enzyme 3 HGNC ID Not Available
Enzyme 3 Chromosome Location Not Available
Enzyme 3 Locus BF1808
Enzyme 3 SNPs Not Available
Enzyme 3 General References
  1. Kuwahara T, Yamashita A, Hirakawa H, Nakayama H, Toh H, Okada N, Kuhara S, Hattori M, Hayashi T, Ohnishi Y: Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14919-24. Epub 2004 Oct 4. [PubMed Link Image]
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 16290
Enzyme 4 Name 2`,3`-cyclic-nucleotide 2`-phosphodiesterase
Enzyme 4 Synonyms Not Available
Enzyme 4 Gene Name cpdC
Enzyme 4 Protein Sequence >2`,3`-cyclic-nucleotide 2`-phosphodiesterase 
MRKLIKPLSVATMMFLSLNLCFFNGKIVKGEEISNETKVTILGTSDIHGRFVPWEYSSDT
ENKSGSLSQISTIVKKERNENPNLILVDAGDSIQDNFVETFNKGPHQPMVLGMNKMKYDV
WEMGNHEFNFGLDVLKHVTSQFEGKVLAGNIYNDDGTRFMDGYTIIERDGIKIGIIGMDT
PMIKEFEKPYNIKGIEFRDPVKETKKIIKELDGKVDAMIGVMHMGLDNENAISNTGVTDI
ANQCPELTAIVGGHMHKLVKNEVVNGVIITEPGKYGQAVSKIDLTFKKENGKNVLKNKNA
DTISVANVESDKEIEDLLKPFHEELRKDANSVIGRLEGVNMVDEDYIKGIPTIHIEDTPL
IDFFHEVGKYYSKADVIALSIDNDKAKLNVGDIKKKDIAYNYRYTGGEISVYEVTGKDLK
KYMEWAAGYFNTLNPGDITPSFNPKRRASKYSTNDMFGGITYKIDLREKEGNRIKDVKYK
DGRELKDTDVLKLGMNSYRLGQLQGKGGIFEGKEFKKLWDSKTAYGEEEGTIRNLAIDYI
KNVKNGLINTKKQNNWCLLGIDPNSENYKKVRDLVNSGELKIPTSEDGKYTNIASINEKD
LPSDNNTSKENEENINLDSINNKNNNKDQEVNEESKKDVPKVEENIEKQKNNKENNSNGD
NTLVKEDSKSKEVNEKNNEQNNIEEVSKKENKLPNTGSPIGAEAMSQIGMLLLGAGVILK
KKNKK
Enzyme 4 Number of Residues 725
Enzyme 4 Molecular Weight 81510.8
Enzyme 4 Theoretical pI 5.97
Enzyme 4 GO Classification
Function
  • binding
  • catalytic activity
  • cation binding
  • hydrolase activity
  • hydrolase activity, acting on ester bonds
  • ion binding
  • metal ion binding
  • nucleotide binding
Process
  • cellular nitrogen compound metabolic process
  • metabolic process
  • nitrogen compound metabolic process
  • nucleobase, nucleoside and nucleotide metabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • nucleoside phosphate metabolic process
  • nucleotide catabolic process
  • nucleotide metabolic process
Component
—
Enzyme 4 General Function Involved in hydrolase activity
Enzyme 4 Specific Function Not Available
Enzyme 4 Pathways Not Available
Enzyme 4 Reactions Not Available
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein 18145827 Link Image
Enzyme 4 UniProtKB/Swiss-Prot ID Q8XIF9 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name Q8XIF9_CLOPE Link Image
Enzyme 4 PDB ID Not Available
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence >2178 bp 
GTGAGAAAACTAATTAAACCATTAAGTGTAGCTACAATGATGTTCTTATCATTAAATTTA
TGTTTTTTTAATGGTAAGATTGTTAAGGGGGAAGAGATTTCTAATGAAACTAAGGTTACC
ATCTTAGGAACCTCAGATATACATGGAAGATTTGTTCCTTGGGAATATTCATCAGATACT
GAAAATAAATCAGGAAGTTTATCACAAATATCAACAATTGTTAAAAAGGAGAGAAATGAA
AATCCAAATTTAATTCTTGTAGATGCAGGTGATTCAATTCAAGATAACTTTGTTGAAACT
TTTAATAAAGGACCTCACCAACCTATGGTTTTAGGTATGAATAAGATGAAATATGATGTT
TGGGAAATGGGAAACCATGAATTTAATTTTGGATTAGATGTGCTTAAACATGTAACAAGT
CAATTTGAAGGAAAGGTCTTAGCTGGTAATATCTATAATGATGATGGAACAAGATTTATG
GATGGATATACTATTATAGAAAGAGATGGTATAAAGATAGGTATTATAGGTATGGATACT
CCAATGATAAAAGAGTTTGAAAAACCATATAATATAAAAGGAATTGAATTTAGAGATCCA
GTTAAAGAAACAAAAAAGATTATAAAAGAATTAGATGGAAAAGTTGATGCCATGATTGGA
GTTATGCATATGGGATTAGATAATGAAAATGCTATTTCTAATACAGGTGTTACAGATATT
GCCAATCAGTGCCCAGAGCTTACAGCAATTGTAGGGGGACACATGCATAAGTTAGTTAAA
AATGAGGTTGTAAATGGAGTTATTATAACTGAGCCAGGAAAGTATGGACAAGCTGTATCA
AAAATAGATTTAACATTTAAAAAAGAAAATGGAAAAAATGTACTTAAAAATAAAAATGCA
GATACTATTTCAGTAGCTAATGTAGAATCAGATAAAGAAATAGAAGATTTATTAAAACCT
TTCCATGAGGAATTGCGTAAAGATGCTAACTCAGTTATTGGAAGACTTGAAGGGGTTAAC
ATGGTAGATGAAGATTACATAAAAGGAATACCTACTATACATATAGAAGATACTCCATTA
ATTGATTTCTTTCATGAAGTAGGAAAATATTATAGTAAAGCAGATGTAATAGCTTTATCT
ATAGATAATGATAAGGCTAAGTTAAATGTAGGAGATATAAAAAAGAAAGATATAGCTTAT
AACTATAGATATACTGGTGGAGAAATAAGCGTTTATGAAGTAACTGGAAAAGACTTAAAA
AAATATATGGAATGGGCAGCTGGCTATTTTAATACATTAAATCCAGGAGATATTACTCCA
AGTTTTAATCCTAAAAGAAGAGCGTCAAAGTATAGTACTAATGATATGTTTGGAGGAATA
ACTTACAAAATTGATTTACGAGAAAAAGAAGGTAATAGGATTAAAGATGTTAAGTATAAA
GATGGAAGAGAACTTAAGGATACAGATGTTTTAAAGTTAGGAATGAATTCATATAGACTT
GGACAATTACAAGGAAAAGGAGGAATCTTTGAAGGAAAAGAATTTAAAAAACTTTGGGAT
TCTAAGACAGCTTATGGAGAAGAAGAAGGAACAATAAGAAATTTAGCTATAGACTATATT
AAAAATGTTAAAAATGGCCTTATAAATACAAAAAAACAAAATAATTGGTGTCTATTAGGA
ATAGATCCAAATTCAGAAAACTATAAAAAGGTTAGAGATTTAGTTAATTCAGGAGAATTA
AAAATACCTACATCAGAAGACGGAAAATATACTAATATAGCATCAATAAATGAAAAAGAT
TTACCTTCAGATAATAATACATCTAAAGAAAATGAGGAAAATATAAACTTAGATTCTATT
AATAATAAAAATAATAATAAGGATCAAGAAGTTAATGAAGAAAGTAAAAAAGATGTGCCT
AAAGTAGAGGAAAACATAGAAAAACAAAAAAATAATAAAGAAAATAATTCAAATGGAGAT
AATACTTTAGTTAAAGAAGATAGTAAATCTAAAGAAGTGAATGAAAAAAATAATGAACAA
AATAACATTGAGGAAGTTTCTAAAAAAGAAAATAAACTTCCTAACACAGGATCTCCTATA
GGTGCAGAAGCTATGTCACAAATAGGTATGTTATTATTAGGTGCAGGTGTAATATTAAAA
AAGAAAAATAAAAAATAG
Enzyme 4 GenBank Gene ID BA000016 Link Image
Enzyme 4 GeneCard ID cpdC Link Image
Enzyme 4 GenAtlas ID Not Available
Enzyme 4 HGNC ID Not Available
Enzyme 4 Chromosome Location Not Available
Enzyme 4 Locus CPE2162
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References
  1. Shimizu T, Ohtani K, Hirakawa H, Ohshima K, Yamashita A, Shiba T, Ogasawara N, Hattori M, Kuhara S, Hayashi H: Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):996-1001. Epub 2002 Jan 15. [PubMed Link Image]
Enzyme 4 Metabolite References Not Available
Enzyme 5 [top]
Enzyme 5 ID 16291
Enzyme 5 Name Ser/Thr protein phosphatase family protein
Enzyme 5 Synonyms Not Available
Enzyme 5 Gene Name Not Available
Enzyme 5 Protein Sequence >Ser/Thr protein phosphatase family protein 
MLKKFSNKKITALMVVLAMVFSFILPIPVKAAEISETKNSNVTEKTDKKTVNIQILATSD
LHGKFMDYDYAQGEESVGGLNQIATVVKEAKKENPNTLVLDNGDTIQGNYNHLFMNKENP
MILAMNTIGYDVFSLGNHEFNFGMDKLHNIIGQANPNLHVLCGNLYRNGERVFNPYTIKD
VDGIKVAIIGVVTPHIMQWDSQNLKGYEAKNPTEEVKKIIGEIKANGGADVYVVTSHASL
NGEYGDGDSAAGIAEANPEVSVVVAGHSHDTVKSELRGNAIISEPASRAKYVSKFNLTVE
KDESGIKVLDKNADLISLKGVQGDPELTEKLKPFHEAAINDATAKIGELKGGDLAKPDEV
KGIPQSIVEDQGVTDFINEVQLYNSKKFLQTKGIDSNNVYMVSSAALFSPKANLKEGPIS
KADVSNIYKFDNKLYVIKTNGKQLKKYMEENSKFFNKYKDGDLTISFDENVRMYKYDMFE
GVNYEINIAKDPGERIENLKFSKDGKPVEDSDVVYLSVNDYRYNSGLAAGIMDPGEHEKI
YDTVNDDISAIRDLISDYIINVKHGVINRNVDGNWKITGNNWNPEQRALAVKLINEGKIK
LPTSSNGRTPNVKSVTWDEVSKFAEALPEEKKEVEIPILTFNDFHGSLKESGGNPGAAKF
VGELKKVKEKNPNTIVVSGGDMYQGSALSNLLKGKPVSDMNKALGVQFSSVGNHEFDWGY
DLIPGWAKDGGFEFLASNIYEKSTGEPVKWAKPYGVVEKGGKKIGFIGLATPETAYKTNP
DNVKDLEFRDPNTEAEKWVKHLREVEKVDAVIALTHIGSQQDRKTGEITGEVVNLTKVTG
LDAIVSAHSHMPVKGTVNGVPIVQAYKNGRAIGLIDLKFDKDGKLSVEAQRMDISKNIKD
LPVDKEMEETLGKYEKELSPILDVKVADLSEDLPHNRDAGVSPMGATVTETMRKIVDADI
AINNGGGVRAPLKKGVITVGDMYTILPFDNTIVTMDMKGSDIIKVLEHGIAPKDFGWGQH
AGLKFWYNPDAEPGNRITSVRLLDGSKLDPNKYYKLATNDFMAAGGDGYDFSAAKNIKDT
NKVLREGISDYWKNHGINPITNLATLIEPGEDKGEAVKPVEPENPSVDSNKPVEQEKPSI
DTNKPMDPTIDDINTDKPEISNPDNNSNNEENKKDDLIKLPNTGNPFGSEVFAAMGVLAT
IGGSIILKKKHNDAA
Enzyme 5 Number of Residues 1215
Enzyme 5 Molecular Weight 133324.9
Enzyme 5 Theoretical pI 5.31
Enzyme 5 GO Classification
Function
  • binding
  • catalytic activity
  • cation binding
  • hydrolase activity
  • hydrolase activity, acting on ester bonds
  • ion binding
  • metal ion binding
  • nucleotide binding
Process
  • cellular nitrogen compound metabolic process
  • metabolic process
  • nitrogen compound metabolic process
  • nucleobase, nucleoside and nucleotide metabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • nucleoside phosphate metabolic process
  • nucleotide catabolic process
  • nucleotide metabolic process
Component
  • cell part
  • cell surface
Enzyme 5 General Function Involved in hydrolase activity
Enzyme 5 Specific Function Not Available
Enzyme 5 Pathways Not Available
Enzyme 5 Reactions Not Available
Enzyme 5 Pfam Domain Function
Enzyme 5 Signals
  • None
Enzyme 5 Transmembrane Regions
  • None
Enzyme 5 Essentiality Not Available
Enzyme 5 GenBank ID Protein 110675944 Link Image
Enzyme 5 UniProtKB/Swiss-Prot ID Q0TP09 Link Image
Enzyme 5 UniProtKB/Swiss-Prot Entry Name Q0TP09_CLOP1 Link Image
Enzyme 5 PDB ID Not Available
Enzyme 5 Cellular Location Not Available
Enzyme 5 Gene Sequence >3648 bp 
ATGTTAAAGAAGTTTAGTAACAAAAAAATTACTGCTTTAATGGTTGTATTAGCAATGGTC
TTTAGCTTTATACTACCAATACCAGTTAAAGCTGCTGAAATTTCTGAAACAAAAAATTCA
AATGTAACAGAAAAGACAGATAAAAAAACTGTCAATATTCAAATACTTGCCACTTCTGAT
TTGCATGGTAAGTTTATGGATTATGATTATGCACAGGGAGAGGAATCTGTTGGTGGATTA
AATCAAATAGCTACTGTGGTTAAAGAAGCTAAAAAGGAAAATCCTAATACTCTAGTGCTA
GATAATGGTGATACTATTCAAGGAAATTACAATCACCTATTTATGAATAAAGAAAATCCT
ATGATACTTGCTATGAACACAATAGGATATGATGTTTTTTCATTAGGAAATCATGAATTT
AATTTTGGAATGGACAAACTTCATAATATTATTGGTCAAGCAAATCCAAATCTTCATGTC
TTATGTGGAAACCTTTACAGAAATGGAGAGAGAGTTTTTAATCCTTATACAATTAAAGAT
GTAGATGGAATAAAGGTTGCAATAATAGGAGTAGTTACTCCACATATAATGCAATGGGAT
TCTCAAAACTTAAAAGGTTATGAAGCTAAGAATCCGACAGAAGAAGTAAAGAAAATAATA
GGAGAAATAAAGGCAAATGGAGGCGCTGATGTCTATGTAGTAACTTCTCATGCAAGTTTA
AATGGAGAATATGGTGATGGAGATAGTGCTGCTGGAATAGCTGAAGCAAATCCAGAAGTA
AGTGTAGTAGTTGCTGGACATAGTCATGATACAGTTAAATCAGAATTAAGAGGAAACGCT
ATAATTAGTGAACCTGCAAGTAGAGCAAAATATGTTTCTAAATTCAATTTAACTGTTGAA
AAAGATGAAAGTGGAATAAAAGTTCTTGATAAGAATGCAGATCTTATAAGCCTTAAAGGG
GTACAAGGAGATCCTGAATTAACTGAGAAACTTAAGCCTTTCCATGAAGCTGCTATAAAT
GATGCAACAGCTAAGATTGGAGAATTAAAAGGTGGAGATTTAGCAAAACCTGATGAAGTA
AAAGGTATTCCACAATCAATAGTTGAAGACCAAGGGGTTACTGATTTTATAAATGAAGTA
CAATTATATAATAGTAAAAAGTTTTTACAAACTAAAGGAATAGATTCAAATAATGTGTAC
ATGGTTTCATCAGCAGCTTTATTTAGTCCTAAGGCTAATCTTAAAGAAGGTCCTATAAGC
AAGGCTGATGTTTCAAATATATATAAATTTGATAATAAATTATATGTTATAAAAACTAAT
GGAAAACAATTAAAGAAATACATGGAAGAAAACTCTAAGTTCTTTAATAAATATAAAGAT
GGAGATTTAACTATATCTTTTGATGAAAATGTAAGAATGTATAAGTATGATATGTTTGAA
GGCGTTAATTACGAAATAAATATAGCTAAAGATCCAGGTGAAAGAATAGAAAACTTAAAA
TTCTCTAAAGATGGTAAACCAGTTGAAGATTCAGATGTAGTGTACCTATCAGTAAATGAT
TATAGATATAATTCAGGGTTAGCTGCAGGAATAATGGATCCAGGTGAACATGAAAAAATA
TATGATACAGTAAATGATGATATATCAGCAATAAGAGATTTAATAAGTGATTATATAATT
AATGTTAAACATGGAGTAATAAATAGAAATGTAGATGGAAACTGGAAAATAACAGGTAAC
AATTGGAATCCAGAACAAAGAGCTTTAGCAGTTAAACTTATTAATGAAGGAAAAATAAAG
CTACCAACTTCATCAAATGGAAGAACTCCAAATGTTAAATCTGTTACTTGGGATGAAGTA
TCAAAATTTGCAGAGGCTTTACCAGAAGAAAAGAAAGAAGTTGAGATTCCTATTTTAACA
TTCAATGATTTTCATGGTTCTTTAAAAGAATCAGGAGGAAATCCTGGAGCTGCTAAATTT
GTTGGGGAATTAAAGAAAGTAAAAGAAAAAAATCCTAACACAATAGTAGTAAGTGGTGGA
GATATGTATCAAGGAAGTGCATTATCTAACCTTTTAAAAGGAAAGCCAGTTAGTGATATG
AATAAAGCTTTAGGTGTTCAATTTTCATCTGTAGGAAATCATGAATTTGACTGGGGTTAT
GATTTAATTCCAGGATGGGCTAAAGATGGTGGATTTGAATTCTTAGCTTCTAATATATAT
GAAAAATCTACAGGAGAACCTGTAAAATGGGCTAAACCTTATGGAGTTGTTGAAAAAGGT
GGAAAGAAAATAGGATTTATAGGCCTTGCAACACCTGAAACAGCATATAAAACAAATCCT
GATAATGTAAAAGATTTAGAATTTAGAGACCCTAACACTGAAGCAGAAAAATGGGTTAAA
CATTTAAGAGAAGTTGAAAAAGTTGATGCAGTAATTGCTTTAACACACATTGGAAGTCAA
CAAGATAGAAAAACTGGAGAAATAACAGGTGAAGTAGTTAATCTTACAAAGGTTACAGGC
TTAGATGCAATTGTATCAGCTCATAGTCATATGCCTGTTAAAGGAACTGTTAACGGAGTT
CCAATAGTACAAGCTTATAAAAATGGACGTGCTATTGGTCTTATAGATTTAAAATTTGAT
AAAGATGGAAAATTATCTGTTGAAGCTCAACGTATGGATATTTCTAAAAATATTAAAGAT
TTACCTGTAGATAAAGAAATGGAAGAAACATTAGGAAAATATGAAAAAGAATTATCACCT
ATCTTAGATGTTAAGGTGGCTGATTTAAGTGAAGATCTTCCACATAATAGAGATGCAGGG
GTAAGCCCAATGGGAGCAACTGTTACAGAAACTATGAGAAAAATAGTAGATGCAGATATA
GCTATAAACAATGGTGGTGGAGTAAGAGCTCCATTAAAGAAAGGAGTAATAACAGTAGGA
GATATGTACACTATACTTCCTTTTGATAATACTATAGTAACAATGGATATGAAAGGTTCA
GATATTATTAAAGTATTAGAACATGGAATTGCTCCTAAAGATTTTGGATGGGGACAACAT
GCTGGTCTTAAGTTCTGGTATAATCCAGATGCTGAACCTGGAAATAGAATAACGTCTGTA
AGATTATTAGATGGAAGTAAGCTAGATCCAAATAAATATTATAAATTAGCAACTAATGAT
TTTATGGCCGCTGGTGGAGATGGATATGATTTCTCAGCAGCTAAGAATATTAAAGATACT
AATAAAGTTTTAAGAGAAGGAATAAGTGATTATTGGAAAAATCATGGTATAAATCCTATA
ACTAACTTAGCAACTCTTATTGAACCTGGAGAAGATAAGGGAGAAGCTGTTAAACCAGTA
GAACCAGAAAATCCATCTGTAGATTCAAACAAACCAGTTGAACAAGAAAAACCATCTATA
GATACAAATAAGCCAATGGATCCAACTATAGATGATATTAATACAGATAAGCCTGAAATA
TCTAATCCAGATAATAATTCAAATAATGAAGAAAATAAAAAGGATGATTTAATTAAATTA
CCTAACACAGGAAATCCTTTTGGATCTGAAGTTTTTGCAGCAATGGGAGTTTTAGCTACT
ATAGGCGGTAGCATAATTCTAAAAAAGAAACATAATGATGCAGCTTAA
Enzyme 5 GenBank Gene ID CP000246 Link Image
Enzyme 5 GeneCard ID Not Available
Enzyme 5 GenAtlas ID Not Available
Enzyme 5 HGNC ID Not Available
Enzyme 5 Chromosome Location Not Available
Enzyme 5 Locus CPF_2207
Enzyme 5 SNPs Not Available
Enzyme 5 General References
  1. Myers GS, Rasko DA, Cheung JK, Ravel J, Seshadri R, DeBoy RT, Ren Q, Varga J, Awad MM, Brinkac LM, Daugherty SC, Haft DH, Dodson RJ, Madupu R, Nelson WC, Rosovitz MJ, Sullivan SA, Khouri H, Dimitrov GI, Watkins KL, Mulligan S, Benton J, Radune D, Fisher DJ, Atkins HS, Hiscox T, Jost BH, Billington SJ, Songer JG, McClane BA, Titball RW, Rood JI, Melville SB, Paulsen IT: Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Res. 2006 Aug;16(8):1031-40. Epub 2006 Jul 6. [PubMed Link Image]
Enzyme 5 Metabolite References Not Available
Enzyme 6 [top]
Enzyme 6 ID 16292
Enzyme 6 Name 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
Enzyme 6 Synonyms Not Available
Enzyme 6 Gene Name cpdB
Enzyme 6 Protein Sequence >2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase 
MIKFSATLLATLIAASVNAATVDLRIMETTDLHSNMMDFDYYKDTATEKFGLVRTASLIN
DARNEVKNSVLVDNGDLIQGSPLADYMSAKGLKAGDIHPVYKALNTLDYTVGTLGNHEFN
YGLDYLKNALAGAKFPYVNANVIDARTKQPMFTPYLIKDTEVVDKDGKKQTLKIGYIGVV
PPQIMGWDKANLSGKVTVNDITETVRKYVPEMREKGADVVVVLAHSGLSADPYKVMAENS
VYYLSEIPGVNAIMFGHAHAVFPGKDFADIEGADIAKGTLNGVPAVMPGMWGDHLGVVDL
QLSNDSGKWQVTQAKAEARPIYDIANKKSLAAEDSKLVETLKADHDATRQFVSKPIGKSA
DNMYSYLALVQDDPTVQVVNNAQKAYVEHYIQGDPDLAKLPVLSAAAPFKVGGRKNDPAS
YVEVEKGQLTFRNAADLYLYPNTLIVVKASGKEVKEWLECSAGQFNQIDPNSTKPQSLIN
WDGFRTYNFDVIDGVNYQIDVTQPARYDGECQMINANAERIKNLTFNGKPIDPNAMFLVA
TNNYRAYGGKFAGTGDSHIAFASPDENRSVLAAWIADESKRAGEIHPAADNNWRLAPIAG
DKKLDIRFETSPSDKAAAFIKEKGQYPMNKVATDDIGFAIYQVDLSK
Enzyme 6 Number of Residues 647
Enzyme 6 Molecular Weight 70831.6
Enzyme 6 Theoretical pI 5.42
Enzyme 6 GO Classification
Function
  • 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
  • binding
  • catalytic activity
  • cation binding
  • cyclic-nucleotide phosphodiesterase activity
  • hydrolase activity
  • hydrolase activity, acting on ester bonds
  • ion binding
  • metal ion binding
  • nucleotide binding
  • phosphoric diester hydrolase activity
  • phosphoric ester hydrolase activity
Process
  • cellular nitrogen compound metabolic process
  • metabolic process
  • nitrogen compound metabolic process
  • nucleobase, nucleoside and nucleotide metabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • nucleoside phosphate metabolic process
  • nucleotide catabolic process
  • nucleotide metabolic process
Component
—
Enzyme 6 General Function Involved in hydrolase activity
Enzyme 6 Specific Function This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate
Enzyme 6 Pathways Not Available
Enzyme 6 Reactions
  • nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate [RN:R03423]
Enzyme 6 Pfam Domain Function
Enzyme 6 Signals
  • 1-19
Enzyme 6 Transmembrane Regions
  • None
Enzyme 6 Essentiality Not Available
Enzyme 6 GenBank ID Protein 85676964 Link Image
Enzyme 6 UniProtKB/Swiss-Prot ID P08331 Link Image
Enzyme 6 UniProtKB/Swiss-Prot Entry Name CPDB_ECOLI Link Image
Enzyme 6 PDB ID Not Available
Enzyme 6 Cellular Location Not Available
Enzyme 6 Gene Sequence >1944 bp 
ATGATTAAGTTTAGCGCAACGCTCCTGGCCACGCTGATTGCCGCCAGTGTGAATGCAGCG
ACGGTCGATCTGCGTATCATGGAAACCACTGATCTGCATAGCAACATGATGGATTTCGAT
TATTACAAAGACACCGCCACGGAAAAATTCGGACTGGTACGTACGGCAAGCCTGATTAAC
GATGCCCGCAATGAAGTGAAAAACAGCGTACTGGTTGATAACGGCGATTTGATTCAGGGG
AGTCCGCTGGCCGATTACATGTCGGCGAAAGGATTAAAAGCAGGTGATATTCACCCGGTC
TATAAGGCATTAAATACGCTGGACTATACCGTCGGAACGCTTGGCAACCACGAGTTTAAC
TACGGTCTGGATTACCTGAAAAATGCGCTGGCAGGAGCGAAATTCCCTTATGTAAATGCC
AACGTCATTGACGCCAGAACCAAACAGCCAATGTTTACACCGTATTTAATTAAAGACACC
GAAGTGGTCGATAAAGACGGAAAAAAACAGACGCTGAAGATTGGCTATATTGGCGTCGTG
CCACCACAAATCATGGGCTGGGATAAAGCTAATTTATCCGGGAAAGTGACGGTGAATGAT
ATTACCGAAACCGTGCGCAAATACGTGCCTGAAATGCGCGAGAAAGGTGCCGATGTTGTT
GTCGTTCTGGCACATTCCGGGCTATCTGCCGATCCGTATAAAGTGATGGCGGAAAACTCA
GTTTATTACCTCAGTGAAATTCCGGGCGTTAACGCCATTATGTTTGGCCATGCTCACGCC
GTTTTCCCAGGTAAAGATTTTGCTGATATCGAAGGGGCTGATATCGCCAAAGGCACGCTG
AATGGTGTTCCGGCGGTAATGCCAGGCATGTGGGGCGATCATCTTGGTGTGGTCGACTTA
CAACTCAGTAATGACAGCGGTAAATGGCAGGTGACGCAGGCGAAAGCGGAAGCACGACCG
ATTTACGACATCGCTAATAAAAAATCCCTCGCGGCGGAAGACAGCAAGCTGGTAGAAACA
CTCAAAGCCGATCACGATGCCACACGCCAGTTCGTCAGCAAGCCAATCGGTAAATCTGCC
GACAATATGTATAGCTATCTGGCGCTGGTGCAGGACGATCCGACCGTGCAGGTGGTGAAC
AACGCGCAAAAAGCGTATGTCGAGCATTACATTCAGGGCGATCCGGATCTGGCAAAACTG
CCGGTGCTTTCAGCTGCCGCACCGTTTAAAGTCGGTGGTCGCAAAAATGACCCGGCAAGC
TATGTGGAGGTGGAAAAAGGCCAGTTGACCTTCCGTAATGCCGCCGATCTTTATCTCTAT
CCCAATACGCTGATTGTGGTGAAAGCCAGCGGTAAAGAGGTGAAAGAGTGGCTGGAGTGC
TCCGCGGGACAGTTTAACCAGATTGATCCCAACAGCACGAAACCACAGTCACTCATCAAC
TGGGATGGTTTCCGCACTTATAACTTTGATGTTATTGATGGTGTGAATTATCAGATTGAT
GTTACCCAGCCCGCCCGTTATGACGGCGAGTGCCAGATGATTAATGCCAATGCGGAAAGG
ATTAAGAACCTGACCTTTAATGGCAAGCCGATTGATCCGAACGCCATGTTCCTGGTTGCC
ACCAATAACTATCGCGCTTACGGCGGCAAATTTGCCGGTACGGGCGACAGCCATATCGCT
TTTGCTTCACCGGATGAGAACCGCTCGGTGCTGGCAGCGTGGATTGCTGATGAGTCGAAA
CGTGCGGGGGAAATTCACCCGGCGGCAGATAACAACTGGCGTTTAGCACCGATAGCTGGC
GATAAGAAACTGGATATCCGTTTCGAAACCTCTCCGTCAGATAAAGCCGCAGCGTTTATT
AAAGAGAAAGGGCAGTATCCGATGAATAAAGTCGCGACCGATGATATCGGGTTTGCGATT
TATCAGGTGGATTTGAGTAAGTAA
Enzyme 6 GenBank Gene ID AP009048 Link Image
Enzyme 6 GeneCard ID cpdB Link Image
Enzyme 6 GenAtlas ID Not Available
Enzyme 6 HGNC ID Not Available
Enzyme 6 Chromosome Location Not Available
Enzyme 6 Locus b4213
Enzyme 6 SNPs SNPJam Report Link Image
Enzyme 6 General References
  1. Liu J, Burns DM, Beacham IR: Isolation and sequence analysis of the gene (cpdB) encoding periplasmic 2',3'-cyclic phosphodiesterase. J Bacteriol. 1986 Mar;165(3):1002-10. [PubMed Link Image]
  2. Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 1995 Jun 25;23(12):2105-19. [PubMed Link Image]
  3. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-74. [PubMed Link Image]
  4. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [PubMed Link Image]
  5. Liu J, Beacham IR: Transcription and regulation of the cpdB gene in Escherichia coli K12 and Salmonella typhimurium LT2: evidence for modulation of constitutive promoters by cyclic AMP-CRP complex. Mol Gen Genet. 1990 Jun;222(1):161-5. [PubMed Link Image]
  6. Link AJ, Robison K, Church GM: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12. Electrophoresis. 1997 Aug;18(8):1259-313. [PubMed Link Image]
Enzyme 6 Metabolite References Not Available