We are currently updating the database - data may be missing for the next 10 minutes. We apologize for any inconvenience.

Human Metabolome Database Version 2.5

 

Showing metabocard for 3'-AMP (HMDB03540)

Legend: metabolite field enzyme field

Version 2.5
Creation Date 2006-08-13 00:23:28
Update Date 2009-05-22 15:23:59
Accession Number HMDB03540
Secondary Accession Numbers HMDB06550
Common Name 3'-AMP
Description Adenylic acid. Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
Synonyms
  1. 3'-Adenylic acid
  2. 3'-Adenosine monophosphate
  3. Adenosine-3'-monophosphate
  4. Adenosine 3'-phosphate
  5. AMP 3'-phosphate
  6. Adenosine-3'-phosphate
  7. Adenosine-3'-monophosphoric acid
  8. Synadenylic acid
  9. Adenosine 3'-monophosphate
  10. Yeast adenylic acid
Chemical IUPAC Name [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]dihydrogen phosphate
Chemical Formula C10H14N5O7P
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Nucleosides and Nucleoside conjugates
Class
  • Nucleotides
Sub Class
  • Nucleotide monophosphates
Family
  • Microbial Metabolite
Species
  • primary alcohol
  • secondary alcohol
  • primary amine
  • primary aromatic amine
  • phosphoric acid ester
  • aromatic compound
  • heterocyclic compound
Biofunction
  • Enzyme cofactor
Application
—
Source
  • Endogenous
Average Molecular Weight 347.221
Monoisotopic Molecular Weight 347.063080
Isomeric SMILES NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]3O)C2=NC=N1
Canonical SMILES NC1=C2N=CN(C3OC(CO)C(OP(O)(O)=O)C3O)C2=NC=N1
KEGG Compound ID C01367 Link Image
BioCyc ID Not Available
BiGG ID 2224997 Link Image
Wikipedia Link Not Available
NuGOwiki Link HMDB03540 Link Image
Metagene Link HMDB03540 Link Image
METLIN ID Not Available
PubChem Compound 41211 Link Image
PubChem Substance 11533209 Link Image
ChEBI ID 28931 Link Image
CAS Registry Number 84-21-9
InChI Identifier InChI=1/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(17)7(4(1-16)21-10)22-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
Synthesis Reference Not Available
Melting Point (Experimental) 197 oC
Experimental Water Solubility 500 mg/L at 15 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)] Source: PhysProp
Predicted Water Solubility 3.48 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge -2
State Solid
Experimental LogP/Hydrophobicity -1.453 Source: PhysProp
Predicted LogP/Hydrophobicity -3.14 [Predicted by ALOGPS] Calculated using ALOGPS
Material Safety Data Sheet (MSDS)
MOL File Show
SDF File Show
PDB File Show
2D Structure
3D Structure
Experimental PDB ID Not Available
Experimental 1H NMR Spectrum Not Available
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum Not Available
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location Not Available
Biofluid Location Not Available
Tissue Location Not Available
Concentrations (Normal) Not Available
Concentrations (Abnormal) Not Available
Associated Disorders Not Available
OMIM ID Not Available
Pathways Not Available
General References Not Available
Metabolic Enzymes
  1. 5'-nucleotidase family protein/Ser/Thr protein phosphatase family protein
  2. Putative 2', 3'-cyclic nucleotide 2'-phosphodiesterase
  3. 2',3'-cyclic-nucleotide 2'-phosphodiesterase
  4. 2`,3`-cyclic-nucleotide 2`-phosphodiesterase
  5. Ser/Thr protein phosphatase family protein
  6. 2',3'-cyclic-nucleotide 2'-phosphodiesterase
Enzyme 1 [top]
Enzyme 1 ID 16287
Enzyme 1 Name 5'-nucleotidase family protein/Ser/Thr protein phosphatase family protein
Enzyme 1 Synonyms Not Available
Enzyme 1 Gene Name Not Available
Enzyme 1 Protein Sequence >5'-nucleotidase family protein/Ser/Thr protein phosphatase family protein 
MLKKVRDKKFTALAVATSMIFGIATPLTTVKATENLAPENLEKKGEEASLEKEGDVTIQI
LGTSDLHGRFMNYEYARNQKSDGGLNQISTLVNEARNENPNTIVVDNGDTIQGNFNHLFK
NGPNPMVMGMNAIGYDVFSLGNHEFNYGMDNLNDVVSQANDNLDVLCANLYKDGKRVYEG
YTTREIEGVEVALIGVVSPHIMKWDSENLKGYEAKNPAEEVGFVIDEIENRPEGGADVYA
VVSHVGLESEYGNGDSARAIAEMNPEVSAIVAGHSHTNVPEEKINNAVISQPTSNGQMVS
KIELTVRKNGEKVEVVDKKSKLLSTKGVAEDQKINDLLSDFHNTAIADATAPVGEMVGGD
LADKNEIKEIPQSLVEDQGITDFINEVQLYNSRKHLESKNINPDEVYMVSGAALFSASSN
LYEGNISKADISNIYRYDNKLYTIKTNGKQLKKYMEKNAEYYNTYKDGDLTVSFNEDVRM
YLYDMFDGVSYEINISKEPGQRIENLKFEKDGKPVEDSDVVYLTVNDYRYNSGLAAGIMD
QGEHEKIYDTNNDQISDMRDLIVDYIQNVKGGKITKNIDNNWKITGNDWDSEQRELAVKL
INEGKIKIPVSEDGRTPNVKAVTWNDVLEALGTKEVEIPIVTFNDFHGSLAESKSDVGAA
KLVGEIKRVKEENPNTVVVTGGDIYQGSAMSNLLKGEPVTAMLKEMGLEFSAVGNHEFDW
GYEYIPDWAKAGEFDFLASNIYEKETGKPVEWAKPYGVVEREGKKVGFIGLATPETAYKT
KPDNVAHLEFKDPVEATKTWVDYLENKENVDAVVVLSHLGSEQNRETGEITGEIVEVAEV
PGVDAIISAHSHQKVEGKVNGVPVIQAYKNGRNLGYVNLKFDYKDELVVTTKLDDISKRK
DTLPVDKNMEDILAKFEADLAPIMNEKVADLSVDLPHDRDTGVSPMGATVAETMRRIVDA
DIAITNGGGVRAPLMAGTVTVGDMYTILPFDNTLVTMEMKGSDIIKVLEHGIEPDNFGWG
QHAGVKLWYTPGAERGEKITSVRLADGTKLENDKYYTVVTNDFMAVGGDSYDFSAAKNVV
DTNLVIRDEMANYWRENGIDPITDLSTLLEAGEDTTVDSEKPENPENPGNPETPQNPENP
DNGENLPNTGMPFGTGAVAAMGTVLTIGGLAVLRKKKNNAA
Enzyme 1 Number of Residues 1181
Enzyme 1 Molecular Weight 129966
Enzyme 1 Theoretical pI 4.42
Enzyme 1 GO Classification
Function
  • catalytic activity
  • hydrolase activity
  • hydrolase activity, acting on ester bonds
Process
  • cellular metabolism
  • metabolism
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolism
  • nucleotide catabolism
  • nucleotide metabolism
  • physiological process
Component
  • cell
  • cell surface
Enzyme 1 General Function Nucleotide transport and metabolism
Enzyme 1 Specific Function Not Available
Enzyme 1 Pathways Not Available
Enzyme 1 Reactions Not Available
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein Not Available
Enzyme 1 UniProtKB/Swiss-Prot ID Q0TP10 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name Q0TP10_CLOP1 Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence Not Available
Enzyme 1 GenBank Gene ID CP000246 Link Image
Enzyme 1 GeneCard ID Not Available
Enzyme 1 GenAtlas ID Not Available
Enzyme 1 HGNC ID Not Available
Enzyme 1 Chromosome Location Not Available
Enzyme 1 Locus Not Available
Enzyme 1 SNPs Not Available
Enzyme 1 General References Not Available
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 16288
Enzyme 2 Name Putative 2', 3'-cyclic nucleotide 2'-phosphodiesterase
Enzyme 2 Synonyms Not Available
Enzyme 2 Gene Name Not Available
Enzyme 2 Protein Sequence >Putative 2', 3'-cyclic nucleotide 2'-phosphodiesterase 
MIMMKRLICMYAFLLCLVCVLPAQEREVKLKIVQTSDVHGNYFPYNFITQKEWGGSLARV
YALVQKNREVYKENLILLDNGDILQGQPSAYYYNYIDTVAPHVCAEMMNFMGYDAGNMGN
HDVETGRAVFDRWIGECNFPVLGANIVETATGETHLPPYRVLERDGVKIVVLGMITPAIP
AWLSENLWQGLRFDDMEETARKWMKVIREKENPDLVIGLFHAGQDAFVMSGKYNENASLN
VAKNVPGFDMVLMGHDHARECKKVVNVAGDSVLVIDPASNGIVVSDIDVTLKLKDGKVVS
KQIDGVLTDTKEYGVSESFMRHFALQYGAVEKFVSKKIGVFTEDLSTRPAYFGSSAFIDF
IHSLQLDISGADISFAAPLSFDAEIKKGDIRVSDMFNLYKYENMLYVMKLSGKEIKDFLE
ESYYMWTNRMKSPEDHLLWLKEKRRAGAEDRASFQNFSFNFDSAAGIIYTVDVTRPKGEK
VTIVSMADGSPFRMDHIYKVALNSYRGNGGGELLTKGSGIPQEKLKERIIFSTDKDLRFY
LMQYIEKKGTLDPRALNQWKFVPEEWVKPAAERDYEYLFGGK
Enzyme 2 Number of Residues 582
Enzyme 2 Molecular Weight 66029
Enzyme 2 Theoretical pI 6.02
Enzyme 2 GO Classification
Function
  • catalytic activity
  • hydrolase activity
Process
  • cellular metabolism
  • metabolism
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolism
  • nucleotide catabolism
  • nucleotide metabolism
  • physiological process
Component
—
Enzyme 2 General Function Nucleotide transport and metabolism
Enzyme 2 Specific Function Not Available
Enzyme 2 Pathways Not Available
Enzyme 2 Reactions Not Available
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • None
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein Not Available
Enzyme 2 UniProtKB/Swiss-Prot ID Q5LE80 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name Q5LE80_BACFN Link Image
Enzyme 2 PDB ID Not Available
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence Not Available
Enzyme 2 GenBank Gene ID CR626927 Link Image
Enzyme 2 GeneCard ID Not Available
Enzyme 2 GenAtlas ID Not Available
Enzyme 2 HGNC ID Not Available
Enzyme 2 Chromosome Location Not Available
Enzyme 2 Locus Not Available
Enzyme 2 SNPs Not Available
Enzyme 2 General References Not Available
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 16289
Enzyme 3 Name 2',3'-cyclic-nucleotide 2'-phosphodiesterase
Enzyme 3 Synonyms Not Available
Enzyme 3 Gene Name Not Available
Enzyme 3 Protein Sequence >2',3'-cyclic-nucleotide 2'-phosphodiesterase 
MKRLICMYAFLLCLVCVLPAQEREVKLKIVQTSDVHGNYFPYNFITQKEWGGSLARVYAL
VQKNREVYKGNLILLDNGDILQGQPSAYYYNYIDTVAPHVCAEMMNFMGYDAGNMGNHDV
ETGRAVFDRWIGECNFPVLGANIVETATGETHLPPYRVLERDGVKIVVLGMITPAIPAWL
SENLWQGLRFDDMEETARKWMKVIREKENPDLVIGLFHAGQDAFVMSGKYNENASLNVAK
NVPGFDMVLMGHDHARECKKVVNVAGDSVLVIDPASNGIVVSDIDVTLKLKDGKVVSKQI
DGVLTDTKEYGVSESFMRHFALQYGAVEKFVSKKIGVFTEDLSTRPAYFGSSAFIDFIHS
LQLDISGADISFAAPLSFDAEIKKGDIRVSDMFNLYKYENMLYVMKLSGKEIKDFLEESY
YMWTNQMKSPEDHLLWLKEKRRAGAEDRASFQNFSFNFDSAAGIIYTVDVTRPKGEKVTI
VSMADGSPFRMDHIYKVALNSYRGNGGGELLTKGSGIPQEKLKERIIFSTDKDLRFYLMQ
YIEKKGTLDPRALNQWKFVPEEWVKPAAERDYEYLFGGK
Enzyme 3 Number of Residues 579
Enzyme 3 Molecular Weight 65553
Enzyme 3 Theoretical pI 6.02
Enzyme 3 GO Classification
Function
  • catalytic activity
  • hydrolase activity
Process
  • cellular metabolism
  • metabolism
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolism
  • nucleotide catabolism
  • nucleotide metabolism
  • physiological process
Component
—
Enzyme 3 General Function Nucleotide transport and metabolism
Enzyme 3 Specific Function Not Available
Enzyme 3 Pathways Not Available
Enzyme 3 Reactions Not Available
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • None
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein Not Available
Enzyme 3 UniProtKB/Swiss-Prot ID Q64VC3 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name Q64VC3_BACFR Link Image
Enzyme 3 PDB ID Not Available
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence Not Available
Enzyme 3 GenBank Gene ID AP006841 Link Image
Enzyme 3 GeneCard ID Not Available
Enzyme 3 GenAtlas ID Not Available
Enzyme 3 HGNC ID Not Available
Enzyme 3 Chromosome Location Not Available
Enzyme 3 Locus Not Available
Enzyme 3 SNPs Not Available
Enzyme 3 General References Not Available
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 16290
Enzyme 4 Name 2`,3`-cyclic-nucleotide 2`-phosphodiesterase
Enzyme 4 Synonyms Not Available
Enzyme 4 Gene Name cpdC
Enzyme 4 Protein Sequence >2`,3`-cyclic-nucleotide 2`-phosphodiesterase 
MRKLIKPLSVATMMFLSLNLCFFNGKIVKGEEISNETKVTILGTSDIHGRFVPWEYSSDT
ENKSGSLSQISTIVKKERNENPNLILVDAGDSIQDNFVETFNKGPHQPMVLGMNKMKYDV
WEMGNHEFNFGLDVLKHVTSQFEGKVLAGNIYNDDGTRFMDGYTIIERDGIKIGIIGMDT
PMIKEFEKPYNIKGIEFRDPVKETKKIIKELDGKVDAMIGVMHMGLDNENAISNTGVTDI
ANQCPELTAIVGGHMHKLVKNEVVNGVIITEPGKYGQAVSKIDLTFKKENGKNVLKNKNA
DTISVANVESDKEIEDLLKPFHEELRKDANSVIGRLEGVNMVDEDYIKGIPTIHIEDTPL
IDFFHEVGKYYSKADVIALSIDNDKAKLNVGDIKKKDIAYNYRYTGGEISVYEVTGKDLK
KYMEWAAGYFNTLNPGDITPSFNPKRRASKYSTNDMFGGITYKIDLREKEGNRIKDVKYK
DGRELKDTDVLKLGMNSYRLGQLQGKGGIFEGKEFKKLWDSKTAYGEEEGTIRNLAIDYI
KNVKNGLINTKKQNNWCLLGIDPNSENYKKVRDLVNSGELKIPTSEDGKYTNIASINEKD
LPSDNNTSKENEENINLDSINNKNNNKDQEVNEESKKDVPKVEENIEKQKNNKENNSNGD
NTLVKEDSKSKEVNEKNNEQNNIEEVSKKENKLPNTGSPIGAEAMSQIGMLLLGAGVILK
KKNKK
Enzyme 4 Number of Residues 725
Enzyme 4 Molecular Weight 81512
Enzyme 4 Theoretical pI 5.97
Enzyme 4 GO Classification
Function
  • catalytic activity
  • hydrolase activity
  • hydrolase activity, acting on ester bonds
Process
  • cellular metabolism
  • metabolism
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolism
  • nucleotide catabolism
  • nucleotide metabolism
  • physiological process
Component
  • cell
  • cell surface
Enzyme 4 General Function Nucleotide transport and metabolism
Enzyme 4 Specific Function Not Available
Enzyme 4 Pathways Not Available
Enzyme 4 Reactions Not Available
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein Not Available
Enzyme 4 UniProtKB/Swiss-Prot ID Q8XIF9 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name Q8XIF9_CLOPE Link Image
Enzyme 4 PDB ID Not Available
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence Not Available
Enzyme 4 GenBank Gene ID BA000016 Link Image
Enzyme 4 GeneCard ID Not Available
Enzyme 4 GenAtlas ID Not Available
Enzyme 4 HGNC ID Not Available
Enzyme 4 Chromosome Location Not Available
Enzyme 4 Locus Not Available
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References
  1. Shimizu T, Ohtani K, Hirakawa H, Ohshima K, Yamashita A, Shiba T, Ogasawara N, Hattori M, Kuhara S, Hayashi H: Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):996-1001. Epub 2002 Jan 15. [PubMed Link Image]
Enzyme 4 Metabolite References Not Available
Enzyme 5 [top]
Enzyme 5 ID 16291
Enzyme 5 Name Ser/Thr protein phosphatase family protein
Enzyme 5 Synonyms Not Available
Enzyme 5 Gene Name Not Available
Enzyme 5 Protein Sequence >Ser/Thr protein phosphatase family protein 
MLKKFSNKKITALMVVLAMVFSFILPIPVKAAEISETKNSNVTEKTDKKTVNIQILATSD
LHGKFMDYDYAQGEESVGGLNQIATVVKEAKKENPNTLVLDNGDTIQGNYNHLFMNKENP
MILAMNTIGYDVFSLGNHEFNFGMDKLHNIIGQANPNLHVLCGNLYRNGERVFNPYTIKD
VDGIKVAIIGVVTPHIMQWDSQNLKGYEAKNPTEEVKKIIGEIKANGGADVYVVTSHASL
NGEYGDGDSAAGIAEANPEVSVVVAGHSHDTVKSELRGNAIISEPASRAKYVSKFNLTVE
KDESGIKVLDKNADLISLKGVQGDPELTEKLKPFHEAAINDATAKIGELKGGDLAKPDEV
KGIPQSIVEDQGVTDFINEVQLYNSKKFLQTKGIDSNNVYMVSSAALFSPKANLKEGPIS
KADVSNIYKFDNKLYVIKTNGKQLKKYMEENSKFFNKYKDGDLTISFDENVRMYKYDMFE
GVNYEINIAKDPGERIENLKFSKDGKPVEDSDVVYLSVNDYRYNSGLAAGIMDPGEHEKI
YDTVNDDISAIRDLISDYIINVKHGVINRNVDGNWKITGNNWNPEQRALAVKLINEGKIK
LPTSSNGRTPNVKSVTWDEVSKFAEALPEEKKEVEIPILTFNDFHGSLKESGGNPGAAKF
VGELKKVKEKNPNTIVVSGGDMYQGSALSNLLKGKPVSDMNKALGVQFSSVGNHEFDWGY
DLIPGWAKDGGFEFLASNIYEKSTGEPVKWAKPYGVVEKGGKKIGFIGLATPETAYKTNP
DNVKDLEFRDPNTEAEKWVKHLREVEKVDAVIALTHIGSQQDRKTGEITGEVVNLTKVTG
LDAIVSAHSHMPVKGTVNGVPIVQAYKNGRAIGLIDLKFDKDGKLSVEAQRMDISKNIKD
LPVDKEMEETLGKYEKELSPILDVKVADLSEDLPHNRDAGVSPMGATVTETMRKIVDADI
AINNGGGVRAPLKKGVITVGDMYTILPFDNTIVTMDMKGSDIIKVLEHGIAPKDFGWGQH
AGLKFWYNPDAEPGNRITSVRLLDGSKLDPNKYYKLATNDFMAAGGDGYDFSAAKNIKDT
NKVLREGISDYWKNHGINPITNLATLIEPGEDKGEAVKPVEPENPSVDSNKPVEQEKPSI
DTNKPMDPTIDDINTDKPEISNPDNNSNNEENKKDDLIKLPNTGNPFGSEVFAAMGVLAT
IGGSIILKKKHNDAA
Enzyme 5 Number of Residues 1215
Enzyme 5 Molecular Weight 133327
Enzyme 5 Theoretical pI 5.31
Enzyme 5 GO Classification
Function
  • catalytic activity
  • hydrolase activity
  • hydrolase activity, acting on ester bonds
Process
  • cellular metabolism
  • metabolism
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolism
  • nucleotide catabolism
  • nucleotide metabolism
  • physiological process
Component
  • cell
  • cell surface
Enzyme 5 General Function Nucleotide transport and metabolism
Enzyme 5 Specific Function Not Available
Enzyme 5 Pathways Not Available
Enzyme 5 Reactions Not Available
Enzyme 5 Pfam Domain Function
Enzyme 5 Signals
  • None
Enzyme 5 Transmembrane Regions
  • None
Enzyme 5 Essentiality Not Available
Enzyme 5 GenBank ID Protein Not Available
Enzyme 5 UniProtKB/Swiss-Prot ID Q0TP09 Link Image
Enzyme 5 UniProtKB/Swiss-Prot Entry Name Q0TP09_CLOP1 Link Image
Enzyme 5 PDB ID Not Available
Enzyme 5 Cellular Location Not Available
Enzyme 5 Gene Sequence Not Available
Enzyme 5 GenBank Gene ID CP000246 Link Image
Enzyme 5 GeneCard ID Not Available
Enzyme 5 GenAtlas ID Not Available
Enzyme 5 HGNC ID Not Available
Enzyme 5 Chromosome Location Not Available
Enzyme 5 Locus Not Available
Enzyme 5 SNPs Not Available
Enzyme 5 General References Not Available
Enzyme 5 Metabolite References Not Available
Enzyme 6 [top]
Enzyme 6 ID 16292
Enzyme 6 Name 2',3'-cyclic-nucleotide 2'-phosphodiesterase
Enzyme 6 Synonyms Not Available
Enzyme 6 Gene Name cpdB
Enzyme 6 Protein Sequence >2',3'-cyclic-nucleotide 2'-phosphodiesterase 
MIKFSATLLATLIAASVNAATVDLRIMETTDLHSNMMDFDYYKDTATEKFGLVRTASLIN
DARNEVKNSVLVDNGDLIQGSPLADYMSAKGLKAGDIHPVYKALNTLDYTVGTLGNHEFN
YGLDYLKNALAGAKFPYVNANVIDARTKQPMFTPYLIKDTEVVDKDGKKQTLKIGYIGVV
PPQIMGWDKANLSGKVTVNDITETVRKYVPEMREKGADVVVVLAHSGLSADPYKVMAENS
VYYLSEIPGVNAIMFGHAHAVFPGKDFADIEGADIAKGTLNGVPAVMPGMWGDHLGVVDL
QLSNDSGKWQVTQAKAEARPIYDIANKKSLAAEDSKLVETLKADHDATRQFVSKPIGKSA
DNMYSYLALVQDDPTVQVVNNAQKAYVEHYIQGDPDLAKLPVLSAAAPFKVGGRKNDPAS
YVEVEKGQLTFRNAADLYLYPNTLIVVKASGKEVKEWLECSAGQFNQIDPNSTKPQSLIN
WDGFRTYNFDVIDGVNYQIDVTQPARYDGECQMINANAERIKNLTFNGKPIDPNAMFLVA
TNNYRAYGGKFAGTGDSHIAFASPDENRSVLAAWIADESKRAGEIHPAADNNWRLAPIAG
DKKLDIRFETSPSDKAAAFIKEKGQYPMNKVATDDIGFAIYQVDLSK
Enzyme 6 Number of Residues 647
Enzyme 6 Molecular Weight 70833
Enzyme 6 Theoretical pI 5.42
Enzyme 6 GO Classification
Function
  • 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
  • catalytic activity
  • cyclic-nucleotide phosphodiesterase activity
  • hydrolase activity
  • hydrolase activity, acting on ester bonds
  • phosphoric diester hydrolase activity
  • phosphoric ester hydrolase activity
Process
  • cellular metabolism
  • metabolism
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolism
  • nucleotide catabolism
  • nucleotide metabolism
  • physiological process
Component
—
Enzyme 6 General Function Nucleotide transport and metabolism
Enzyme 6 Specific Function This bifunctional enzyme catalyzes two consecutive reactions converting 2',3'-cyclic-nucleotide to 3'-nucleotide and then 3'-nucleotide to nucleic acid and phosphate
Enzyme 6 Pathways Not Available
Enzyme 6 Reactions Not Available
Enzyme 6 Pfam Domain Function
Enzyme 6 Signals
  • 1-19
Enzyme 6 Transmembrane Regions
  • None
Enzyme 6 Essentiality Not Available
Enzyme 6 GenBank ID Protein Not Available
Enzyme 6 UniProtKB/Swiss-Prot ID P08331 Link Image
Enzyme 6 UniProtKB/Swiss-Prot Entry Name CN16_ECOLI Link Image
Enzyme 6 PDB ID Not Available
Enzyme 6 Cellular Location Not Available
Enzyme 6 Gene Sequence Not Available
Enzyme 6 GenBank Gene ID M13464 Link Image
Enzyme 6 GeneCard ID Not Available
Enzyme 6 GenAtlas ID Not Available
Enzyme 6 HGNC ID Not Available
Enzyme 6 Chromosome Location Not Available
Enzyme 6 Locus Not Available
Enzyme 6 SNPs SNPJam Report Link Image
Enzyme 6 General References
  1. Liu J, Burns DM, Beacham IR: Isolation and sequence analysis of the gene (cpdB) encoding periplasmic 2',3'-cyclic phosphodiesterase. J Bacteriol. 1986 Mar;165(3):1002-10. [PubMed Link Image]
  2. Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 1995 Jun 25;23(12):2105-19. [PubMed Link Image]
  3. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-74. [PubMed Link Image]
  4. Liu J, Beacham IR: Transcription and regulation of the cpdB gene in Escherichia coli K12 and Salmonella typhimurium LT2: evidence for modulation of constitutive promoters by cyclic AMP-CRP complex. Mol Gen Genet. 1990 Jun;222(1):161-5. [PubMed Link Image]
  5. Link AJ, Robison K, Church GM: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12. Electrophoresis. 1997 Aug;18(8):1259-313. [PubMed Link Image]
Enzyme 6 Metabolite References Not Available