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Record Information
Creation Date2006-08-13 11:32:55 UTC
Update Date2017-08-16 04:15:20 UTC
Secondary Accession Numbers
  • HMDB04118
Metabolite Identification
Common NameAntimony
DescriptionAntimony metal and many of its compounds have been known since ancient times, and its toxicity has periodically been a matter of comment. Antimony (stibium) is an element and a metalloid, with atomic number 51 and atomic weight 121.75. It is in Group Va of the Periodic Table along with arsenic, bismuth, nitrogen and phosphorus. Contact with antimony occurs in a variety of ways, and as it is a common element in the surface of the earth it may accompany exposures to many different materials. Antimony has been identified in at least 114 different ores, and has even been found in meteorites. A recurrent problem in assessing its toxicity industrially is that arsenic and lead are often found with it, and other toxic materials, for example sulfur dioxide, may also be produced in the course of the process, and separation of exposures may be difficult or impossible. Contact with antimony has also occurred from is use as a medicinal substance, from natural exposures, and from domestic sources. Antimony has been a constituent not only of printing-metal but also of lead acid batteries, pigments, an opacifier under glazes and enamels (the white oxide), and in the present day it has been used widely as a flame retardant in fabrics and in brake linings of motor cars. Large scale industrial production, largely of antimony oxide, began in the early 19th century. Physiologically, this metal/element exists as an ion in the body. The toxicology of antimony and its compounds is known from three sources: its medicinal use over centuries, studies of process workers in more recent times, and more recent still, studies of its presence in modern city environments and in domestic environments. Gross exposure to antimony compounds over long periods, usually the sulfide (SbS3) or the oxide (Sb2O3) has occurred in antimony miners and in antimony process workers. There have been relatively few of these, and few studies of possible symptoms have been made. Antimony sulfide imported from, at different times, China, South Africa, and South America was processed in the North-East of England from about 1870 to 2003. The process workers in North-East England have been studied at different times, notably by Sir Thomas Oliver in 1933, and by the Newcastle upon Tyne University Department of Occupational Medicine on later occasions. Studies which have been made of the working environment, and in particular of the risk of lung cancer in process workers, have underlined the high levels of exposure to antimony compounds and to other toxic materials. However, the working conditions in antimony processing have improved markedly over the last 30 years, and the workforce had been much reduced in numbers following automation of the process. Prior to the cessation of the industry in the UK it had become a white coat operation with relatively few people exposed to high concentrations of antimony. Antimony, which is normally present in domestic environments, has also been studied as a possible cause of cot death syndrome (SIDS) but extensive investigations have not confirmed this. The full importance of environmental antimony has still to be determined, and evidence of specific effects has not yet been presented. (PMID: 16307078 ).
Antimony, ion (SB(3+))ChEBI
Antimony blackHMDB
Antimony elementHMDB
Chemical FormulaSb
Average Molecular Weight121.76
Monoisotopic Molecular Weight120.903818044
IUPAC Nameantimony(3+) ion
Traditional Nameantimony(3+) ion
CAS Registry Number7440-36-0
InChI Identifier
Chemical Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as homogeneous metalloid compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a metalloid atom.
KingdomChemical entities
Super ClassInorganic compounds
ClassHomogeneous metal compounds
Sub ClassHomogeneous metalloid compounds
Direct ParentHomogeneous metalloid compounds
Alternative ParentsNot Available
  • Homogeneous metalloid
Molecular FrameworkNot Available
External Descriptors
StatusDetected and Quantified
  • Cosmetic
  • Drug
  • Toxin/Pollutant
BiofunctionNot Available
ApplicationNot Available
Cellular locationsNot Available
Physical Properties
Experimental Properties
Melting Point630 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
Physiological Charge3ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Biological Properties
Cellular LocationsNot Available
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue LocationNot Available
PathwaysNot Available
Normal Concentrations
BloodDetected and Quantified0.0050-0.030 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.0038 +/- 0.002 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.0038 +/- 0.002 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified0-0.049 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.005-0.016 uMAdult (>18 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.002+/-0.009 (0.0007-0.003) uMAdult (>18 years old)BothNormal details
UrineDetected and Quantified0.0000529 (0.0000492-0.0000557) umol/mmol creatinineAdult (>18 years old)Not SpecifiedNormal details
UrineDetected and Quantified0.00008728 (0.0000780-0.0000975) umol/mmol creatinineChildren (1-13 years old)Not SpecifiedNormal details
UrineDetected and Quantified0.00005 +/- 0.00002 umol/mmol creatinineAdult (>18 years old)BothNormal details
UrineDetected and Quantified0-0.008 umol/mmol creatinineAdult (>18 years old)BothNormal details
UrineDetected and Quantified0.00007 (0.00005-0.00009) umol/mmol creatinineNot AvailableBothNormal
    • Report on Human B...
UrineDetected and Quantified0.00007 (0.00005-0.00010) umol/mmol creatinineAdult (>18 years old)BothNormal
    • Report on Human B...
Abnormal Concentrations
BloodDetected and Quantified0.0055 +/- 0.0038 uMAdult (>18 years old)BothMultiple Sclerosis details
BloodDetected and Quantified0.0055 +/- 0.0039 uMAdult (>18 years old)Bothmultiple sclerosis details
BloodDetected and Quantified0.030 - 0.082 uMAdult (>18 years old)Not SpecifiedAntimony Exposure details
Associated Disorders and Diseases
Disease References
Multiple sclerosis
  1. Forte G, Visconti A, Santucci S, Ghazaryan A, Figa-Talamanca L, Cannoni S, Bocca B, Pino A, Violante N, Alimonti A, Salvetti M, Ristori G: Quantification of chemical elements in blood of patients affected by multiple sclerosis. Ann Ist Super Sanita. 2005;41(2):213-6. [PubMed:16244395 ]
Associated OMIM IDs
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB003762
KNApSAcK IDNot Available
Chemspider ID94667
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
NuGOwiki LinkHMDB0004118
METLIN IDNot Available
PubChem Compound104894
ChEBI ID49867
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. McCallum RI: Occupational exposure to antimony compounds. J Environ Monit. 2005 Dec;7(12):1245-50. Epub 2005 Oct 26. [PubMed:16307078 ]