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Record Information
Version4.0
Creation Date2006-08-13 12:56:35 UTC
Update Date2017-09-27 08:24:27 UTC
HMDB IDHMDB0004143
Secondary Accession Numbers
  • HMDB04143
Metabolite Identification
Common NameTantalum
DescriptionTantalum is a transition metal (atomic number 73; atomic weight 180.05) that remains relatively inert in vivo. Dating back to the mid-1900s multiple medical devices have been fabricated that utilize this material, including: pacemaker electrodes, foil and mesh for nerve repair, radiopaque markers, and cranioplasty plates. Tantalum-based implants have displayed an exceptional biocompatibility and safety record in orthopedic, cranio-facial, and dentistry literature. The basic structure of this porous tantalum metal yields a high volumetric porosity, a low modulus of elasticity, and relatively high frictional characteristics. Tantalum is known to be relatively inert in vivo and is now used as plates, sutures, radio-markers, and prostheses covering a wide variety of medical subspecialties and procedures. Dental implants have yielded excellent 8-year follow-up with tantalum-based components used for osseous anchorage. The oxide formed on the surface of tantalum implants (self-passivation) in vivo has been found to be quite stable over a wide range of pH and potential ranges. On high-resolution examination, titanium was found to have no multi-nucleated macrophages in the tissue surrounding the metallic implant, while tantalum implants displayed an occasional peri-implant macrophage. Physiologically, it exists as an ion in the body. Overall porous tantalum is corrosion resistant, may be associated with less peri-implant stress shielding, and has the potential to allow for immediate weight bearing (given its high frictional characteristics). These inherent properties and proven biocompatibility make porous tantalum an intriguing metal for the design and manufacture of: press-fit or cementless components for total joint arthroplasty, bone graft substitute, or a scaffold for potential cartilage resurfacing. (PMID: 16737737 ).
Structure
Thumb
Synonyms
ValueSource
TAHMDB
TantalHMDB
Tantalum elementalHMDB
Tantalum metalHMDB
Tantalum metal and oxide dustHMDB
Tantalum-181HMDB
Chemical FormulaTa
Average Molecular Weight180.9479
Monoisotopic Molecular Weight180.947996346
IUPAC Nametantalum(5+) ion
Traditional Nametantalum(5+) ion
CAS Registry Number7440-25-7
SMILES
[Ta+5]
InChI Identifier
InChI=1S/Ta/q+5
InChI KeyWTKKCYNZRWIVKL-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
KingdomChemical entities
Super ClassInorganic compounds
ClassHomogeneous metal compounds
Sub ClassHomogeneous transition metal compounds
Direct ParentHomogeneous transition metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous transition metal
Molecular FrameworkNot Available
External DescriptorsNot Available
Ontology
Disposition

Biological Location:

  Biofluid and excreta:

Source:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0ChemAxon
Physiological Charge5ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular LocationsNot Available
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue LocationNot Available
PathwaysNot Available
NameSMPDB/PathwhizKEGG
No entries found
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodExpected but not Quantified Not AvailableNot Available
Normal
    details
    Cerebrospinal Fluid (CSF)Detected and Quantified0.002 +/- 0.0009 uMAdult (>18 years old)Not SpecifiedNormal details
    Cerebrospinal Fluid (CSF)Detected and Quantified0.0005 +/- 0.0004 uMAdult (>18 years old)BothNormal details
    UrineDetected and Quantified0.00020 (0.00004-0.00074) umol/mmol creatinineAdult (>18 years old)Both
    Normal
    details
    UrineDetected and Quantified0.00008 ± 0.00006 umol/mmol creatinineAdult (>18 years old)BothNormal details
    Abnormal Concentrations
    Not Available
    Associated Disorders and Diseases
    Disease ReferencesNone
    Associated OMIM IDsNone
    DrugBank IDNot Available
    DrugBank Metabolite IDNot Available
    Phenol Explorer Compound IDNot Available
    Phenol Explorer Metabolite IDNot Available
    FoodDB IDFDB003787
    KNApSAcK IDNot Available
    Chemspider ID3726905
    KEGG Compound IDNot Available
    BioCyc IDNot Available
    BiGG IDNot Available
    Wikipedia LinkNot Available
    METLIN IDNot Available
    PubChem Compound4532223
    PDB IDNot Available
    ChEBI ID33348
    References
    Synthesis ReferenceNot Available
    Material Safety Data Sheet (MSDS)Download (PDF)
    General References
    1. Levine BR, Sporer S, Poggie RA, Della Valle CJ, Jacobs JJ: Experimental and clinical performance of porous tantalum in orthopedic surgery. Biomaterials. 2006 Sep;27(27):4671-81. Epub 2006 Jun 5. [PubMed:16737737 ]