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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2006-08-14 00:42:32 UTC
Update Date2022-03-07 02:49:21 UTC
HMDB IDHMDB0004694
Secondary Accession Numbers
  • HMDB04694
Metabolite Identification
Common Name11,14,15-THETA
Description11,14,15-trihydroxyeicosatrienoic acid (11,14,15-THETA) is a metabolite of the 15-lipoxygenase (15-LO) pathway of arachidonic acid (AA). Increased amounts of 11,14,15-THETA are synthesized in subacute hypoxia. Prolonged exposure to reduced PO2 activates 15-LO in small pulmonary arteries (PA); activation of 15-LO is associated with translocation of the enzyme from the cytosol to membrane. 11,14,15-THETA is an endothelium-derived relaxing factor. (PMID: 12690037 , 9812980 , 15388505 , 14622984 ).
Structure
Data?1582752312
Synonyms
ValueSource
(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acidChEBI
(5Z,8Z,12E)-11,14,15-Trihydroxyeicosatrienoic acidChEBI
(5Z,8Z,12E)-11,14,15-Trihydroxyicosatrienoic acidChEBI
11,14,15-Trihydroxy-(5Z,8Z,12E)-eicosatrienoic acidChEBI
11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoic acidChEBI
11,14,15-Trihydroxyicosatrienoic acidChEBI
(5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acidKegg
(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoateGenerator
(5Z,8Z,12E)-11,14,15-TrihydroxyeicosatrienoateGenerator
(5Z,8Z,12E)-11,14,15-TrihydroxyicosatrienoateGenerator
11,14,15-Trihydroxy-(5Z,8Z,12E)-eicosatrienoateGenerator
11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoateGenerator
11,14,15-TrihydroxyicosatrienoateGenerator
(5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoateGenerator
11,14,15-THETHMDB
11,14,15-Trihydroxyeicosa-5,8,12-trienoic acidHMDB
11,14,15-Trihydroxyeicosatetraenoic acidHMDB
Chemical FormulaC20H34O5
Average Molecular Weight354.481
Monoisotopic Molecular Weight354.240624198
IUPAC Name(5Z,8Z,12E)-11,14,15-trihydroxyicosa-5,8,12-trienoic acid
Traditional Name(5Z,8Z,12E)-11,14,15-trihydroxyicosa-5,8,12-trienoic acid
CAS Registry NumberNot Available
SMILES
CCCCCC(O)C(O)\C=C\C(O)C\C=C/C\C=C/CCCC(O)=O
InChI Identifier
InChI=1S/C20H34O5/c1-2-3-9-13-18(22)19(23)16-15-17(21)12-10-7-5-4-6-8-11-14-20(24)25/h4,6-7,10,15-19,21-23H,2-3,5,8-9,11-14H2,1H3,(H,24,25)/b6-4-,10-7-,16-15+
InChI KeyYCFPVUKKIWMCJK-LTCHCNGXSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as hydroxyeicosatrienoic acids. These are eicosanoic acids with an attached hydroxyl group and three CC double bonds.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassFatty Acyls
Sub ClassEicosanoids
Direct ParentHydroxyeicosatrienoic acids
Alternative Parents
Substituents
  • Hydroxyeicosatrienoic acid
  • Long-chain fatty acid
  • Hydroxy fatty acid
  • Fatty acid
  • Unsaturated fatty acid
  • Secondary alcohol
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Polyol
  • Organic oxide
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Carbonyl group
  • Organooxygen compound
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Process
Naturally occurring process
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.053 g/LALOGPS
logP4.47ALOGPS
logP3.41ChemAxon
logS-3.8ALOGPS
pKa (Strongest Acidic)4.82ChemAxon
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area97.99 ŲChemAxon
Rotatable Bond Count15ChemAxon
Refractivity103.23 m³·mol⁻¹ChemAxon
Polarizability41.29 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+193.70331661259
DarkChem[M-H]-193.26631661259
DeepCCS[M+H]+198.92630932474
DeepCCS[M-H]-196.56830932474
DeepCCS[M-2H]-229.45430932474
DeepCCS[M+Na]+205.01930932474
AllCCS[M+H]+195.932859911
AllCCS[M+H-H2O]+193.232859911
AllCCS[M+NH4]+198.332859911
AllCCS[M+Na]+199.032859911
AllCCS[M-H]-191.332859911
AllCCS[M+Na-2H]-193.332859911
AllCCS[M+HCOO]-195.732859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
11,14,15-THETACCCCCC(O)C(O)\C=C\C(O)C\C=C/C\C=C/CCCC(O)=O4565.0Standard polar33892256
11,14,15-THETACCCCCC(O)C(O)\C=C\C(O)C\C=C/C\C=C/CCCC(O)=O2512.6Standard non polar33892256
11,14,15-THETACCCCCC(O)C(O)\C=C\C(O)C\C=C/C\C=C/CCCC(O)=O2762.0Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
11,14,15-THETA,1TMS,isomer #1CCCCCC(O[Si](C)(C)C)C(O)/C=C/C(O)C/C=C\C/C=C\CCCC(=O)O2990.2Semi standard non polar33892256
11,14,15-THETA,1TMS,isomer #2CCCCCC(O)C(/C=C/C(O)C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C3005.6Semi standard non polar33892256
11,14,15-THETA,1TMS,isomer #3CCCCCC(O)C(O)/C=C/C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C3042.1Semi standard non polar33892256
11,14,15-THETA,1TMS,isomer #4CCCCCC(O)C(O)/C=C/C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C2921.2Semi standard non polar33892256
11,14,15-THETA,2TMS,isomer #1CCCCCC(O[Si](C)(C)C)C(/C=C/C(O)C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C2973.0Semi standard non polar33892256
11,14,15-THETA,2TMS,isomer #2CCCCCC(O[Si](C)(C)C)C(O)/C=C/C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C2996.1Semi standard non polar33892256
11,14,15-THETA,2TMS,isomer #3CCCCCC(O[Si](C)(C)C)C(O)/C=C/C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C2897.9Semi standard non polar33892256
11,14,15-THETA,2TMS,isomer #4CCCCCC(O)C(/C=C/C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C)O[Si](C)(C)C3002.5Semi standard non polar33892256
11,14,15-THETA,2TMS,isomer #5CCCCCC(O)C(/C=C/C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C2922.1Semi standard non polar33892256
11,14,15-THETA,2TMS,isomer #6CCCCCC(O)C(O)/C=C/C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C2943.2Semi standard non polar33892256
11,14,15-THETA,3TMS,isomer #1CCCCCC(O[Si](C)(C)C)C(/C=C/C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C)O[Si](C)(C)C2944.0Semi standard non polar33892256
11,14,15-THETA,3TMS,isomer #2CCCCCC(O[Si](C)(C)C)C(/C=C/C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C2880.7Semi standard non polar33892256
11,14,15-THETA,3TMS,isomer #3CCCCCC(O[Si](C)(C)C)C(O)/C=C/C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C2876.8Semi standard non polar33892256
11,14,15-THETA,3TMS,isomer #4CCCCCC(O)C(/C=C/C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C2892.3Semi standard non polar33892256
11,14,15-THETA,4TMS,isomer #1CCCCCC(O[Si](C)(C)C)C(/C=C/C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C2828.2Semi standard non polar33892256
11,14,15-THETA,1TBDMS,isomer #1CCCCCC(O[Si](C)(C)C(C)(C)C)C(O)/C=C/C(O)C/C=C\C/C=C\CCCC(=O)O3240.2Semi standard non polar33892256
11,14,15-THETA,1TBDMS,isomer #2CCCCCC(O)C(/C=C/C(O)C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C3250.5Semi standard non polar33892256
11,14,15-THETA,1TBDMS,isomer #3CCCCCC(O)C(O)/C=C/C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C3277.1Semi standard non polar33892256
11,14,15-THETA,1TBDMS,isomer #4CCCCCC(O)C(O)/C=C/C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C3165.1Semi standard non polar33892256
11,14,15-THETA,2TBDMS,isomer #1CCCCCC(O[Si](C)(C)C(C)(C)C)C(/C=C/C(O)C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C3441.5Semi standard non polar33892256
11,14,15-THETA,2TBDMS,isomer #2CCCCCC(O[Si](C)(C)C(C)(C)C)C(O)/C=C/C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C3451.3Semi standard non polar33892256
11,14,15-THETA,2TBDMS,isomer #3CCCCCC(O[Si](C)(C)C(C)(C)C)C(O)/C=C/C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C3392.1Semi standard non polar33892256
11,14,15-THETA,2TBDMS,isomer #4CCCCCC(O)C(/C=C/C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3463.2Semi standard non polar33892256
11,14,15-THETA,2TBDMS,isomer #5CCCCCC(O)C(/C=C/C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3416.4Semi standard non polar33892256
11,14,15-THETA,2TBDMS,isomer #6CCCCCC(O)C(O)/C=C/C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3429.9Semi standard non polar33892256
11,14,15-THETA,3TBDMS,isomer #1CCCCCC(O[Si](C)(C)C(C)(C)C)C(/C=C/C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3589.9Semi standard non polar33892256
11,14,15-THETA,3TBDMS,isomer #2CCCCCC(O[Si](C)(C)C(C)(C)C)C(/C=C/C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3571.3Semi standard non polar33892256
11,14,15-THETA,3TBDMS,isomer #3CCCCCC(O[Si](C)(C)C(C)(C)C)C(O)/C=C/C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3606.8Semi standard non polar33892256
11,14,15-THETA,3TBDMS,isomer #4CCCCCC(O)C(/C=C/C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3619.0Semi standard non polar33892256
11,14,15-THETA,4TBDMS,isomer #1CCCCCC(O[Si](C)(C)C(C)(C)C)C(/C=C/C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3740.0Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 11,14,15-THETA GC-MS (Non-derivatized) - 70eV, Positivesplash10-0udr-5593000000-b44c164b1afc4290e62a2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 11,14,15-THETA GC-MS (4 TMS) - 70eV, Positivesplash10-00b9-8310987000-e42844df87dbeaaac7b72017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 11,14,15-THETA GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,14,15-THETA 10V, Positive-QTOFsplash10-00kr-0019000000-5d98b30fc798f154e3cd2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,14,15-THETA 20V, Positive-QTOFsplash10-0600-8697000000-f2898f6e9aa37eb197012017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,14,15-THETA 40V, Positive-QTOFsplash10-05tf-9420000000-4b2f1a462946904efa652017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,14,15-THETA 10V, Negative-QTOFsplash10-0udi-0009000000-81208c2a7c484c87062f2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,14,15-THETA 20V, Negative-QTOFsplash10-0f79-4389000000-3a054cf28c217520eeed2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,14,15-THETA 40V, Negative-QTOFsplash10-0a4i-9340000000-315051dfef85d54b3de62017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,14,15-THETA 10V, Positive-QTOFsplash10-00kr-0119000000-54253aeda6e4903c01bc2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,14,15-THETA 20V, Positive-QTOFsplash10-014r-4339000000-fe248a9e503f326b01812021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,14,15-THETA 40V, Positive-QTOFsplash10-05nf-9400000000-b63770838f1639e0172e2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,14,15-THETA 10V, Negative-QTOFsplash10-0udi-0019000000-26292874068f05134a762021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,14,15-THETA 20V, Negative-QTOFsplash10-0kbs-3967000000-5212de307caf1623f8312021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,14,15-THETA 40V, Negative-QTOFsplash10-0002-9530000000-88a46328b37a9b5888f52021-09-23Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB023410
KNApSAcK IDNot Available
Chemspider ID10128354
KEGG Compound IDC14814
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound11954059
PDB IDNot Available
ChEBI ID34131
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Zhang DX, Gauthier KM, Chawengsub Y, Holmes BB, Campbell WB: Cyclooxygenase- and lipoxygenase-dependent relaxation to arachidonic acid in rabbit small mesenteric arteries. Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H302-9. Epub 2004 Sep 23. [PubMed:15388505 ]
  2. Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB: Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450. Arch Biochem Biophys. 2003 Dec 1;420(1):142-52. [PubMed:14622984 ]
  3. Zhu D, Medhora M, Campbell WB, Spitzbarth N, Baker JE, Jacobs ER: Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries. Circ Res. 2003 May 16;92(9):992-1000. Epub 2003 Apr 10. [PubMed:12690037 ]
  4. Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB: Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta. J Biol Chem. 1998 Nov 20;273(47):30879-87. [PubMed:9812980 ]

Only showing the first 10 proteins. There are 24 proteins in total.

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular weight:
55627.365
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55944.565
General function:
Involved in monooxygenase activity
Specific function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular weight:
56848.42
General function:
Involved in monooxygenase activity
Specific function:
Exhibits low testosterone 6-beta-hydroxylase activity.
Gene Name:
CYP3A43
Uniprot ID:
Q9HB55
Molecular weight:
57756.285
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development.
Gene Name:
CYP1B1
Uniprot ID:
Q16678
Molecular weight:
60845.33
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP2C18
Uniprot ID:
P33260
Molecular weight:
55710.075
General function:
Secondary metabolites biosynthesis, transport and catabolism
Specific function:
May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.
Gene Name:
CYP2F1
Uniprot ID:
P24903
Molecular weight:
55500.64
General function:
Involved in monooxygenase activity
Specific function:
Not Available
Gene Name:
CYP4X1
Uniprot ID:
Q8N118
Molecular weight:
58874.62
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular weight:
56277.81

Only showing the first 10 proteins. There are 24 proteins in total.