Hmp_logo

Human Metabolome Database Version 3.5

HMDB has recently undergone some major changes, if you are experiencing problems please click here to provide us with feedback.

Showing metabocard for Ganglioside GM1 (18:1/16:0) (HMDB04855)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:13:26 -0700
HMDB ID HMDB04855
Secondary Accession Numbers None
Metabolite Identification
Common Name Ganglioside GM1 (18:1/16:0)
Description Ganglioside GM1 (18:1/16:0) is a glycosphingolipid (ceramide and oligosaccharide)or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. It is a component the cell plasma membrane which modulates cell signal transduction events. Gangliosides have been found to be highly important in immunology. Ganglioside GM1 carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6% of the weight of lipids from brain, but they are found at low levels in all animal tissues. Gangliosides are glycosphingolipids. There are four types of glycosphingolipids, the cerebrosides, sulfatides, globosides and gangliosides. Gangliosides are very similar to globosides except that they also contain N-acetyl neuraminic acid (NANA) in varying amounts. The specific names for the gangliosides provide information about their structure. The letter G refers to ganglioside, and the subscripts M, D, T and Q indicate that the molecule contains mono-, di-, tri and quatra-sialic acid. The numbered subscripts 1, 2 and 3 refer to the carbohydrate sequence that is attached to the ceramide. In particular, 1 stands for GalGalNAcGalGlc-ceramide, 2 stands for GalNAcGalGlc-ceramide and 3 stands for GalGlc-ceramide. Deficiencies in lysosomal enzymes that degrade the carbohydrate portions of various gangliosides are responsible for a number of lysosomal storage diseases such as Tay-Sachs disease, Sandhoff disease, and GM1 gangliosidosis. The carbohydrate portion of the ganglioside GM1 is the site of attachment of cholera toxin, the protein secreted by Vibrio cholerae.
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
  2. 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-Ceramide
  3. 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-Ceramide
  4. 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-Ceramide
  5. D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-Nacylsphingosine
  6. D-Galactosyl-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
  7. delta-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-delta-galactosyl-delta-glucosyl-Nacylsphingosine
  8. delta-Galactosyl-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-delta-galactosyl-delta-glucosylceramide
  9. Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2->3)Gal-beta1->4Glc-beta1->1'Cer
  10. Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2>3)Gal-beta1->4Glc-beta1->1'Cer
  11. Ganglioside GM1
  12. GM1
  13. GM1a
  14. II3NeuAcGgOse4Cer
  15. N-Acetyl-Ganglioside GM1
  16. N-Acetylganglioside GM1
  17. NeuAc-GM1a
Chemical Formula C71H127N3O31
Average Molecular Weight 1518.7696
Monoisotopic Molecular Weight 1517.845354361
IUPAC Name (2S,4S,5R)-5-acetamido-2-{[(2R,3S,4R,5R,6S)-3-{[(2S,3R,4R,5R,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-{[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-{[(2R,3S,4R,6R)-6-{[(2S,3R,4E)-2-hexadecanamido-3-hydroxyoctadec-4-en-1-yl]oxy}-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy}-5-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-6-[(1S,2S)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
Traditional IUPAC Name (2S,4S,5R)-5-acetamido-2-{[(2R,3S,4R,5R,6S)-3-{[(2S,3R,4R,5R,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-{[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-{[(2R,3S,4R,6R)-6-{[(2S,3R,4E)-2-hexadecanamido-3-hydroxyoctadec
CAS Registry Number 104443-62-1
SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O)[C@H]3NC(C)=O)[C@H](O[C@@]3(C[C@H](O)[C@@H](NC(C)=O)C(O3)[C@@H](O)[C@@H](O)CO)C(O)=O)[C@H]2O)[C@H](O)C1O)[C@H](O)\C=C\CCCCCCCCCCCCC
InChI Identifier InChI=1S/C71H127N3O31/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-43(82)42(74-50(85)32-30-28-26-24-22-20-18-16-14-12-10-8-6-2)39-96-67-59(92)57(90)61(48(37-78)99-67)101-69-60(93)65(105-71(70(94)95)33-44(83)51(72-40(3)80)64(104-71)53(86)45(84)34-75)62(49(38-79)100-69)102-66-52(73-41(4)81)63(55(88)47(36-77)97-66)103-68-58(91)56(89)54(87)46(35-76)98-68/h29,31,42-49,51-69,75-79,82-84,86-93H,5-28,30,32-39H2,1-4H3,(H,72,80)(H,73,81)(H,74,85)(H,94,95)/b31-29+/t42-,43+,44-,45-,46+,47+,48+,49+,51+,52+,53-,54-,55-,56-,57+,58+,59?,60+,61+,62-,63+,64?,65+,66-,67+,68-,69-,71-/m0/s1
InChI Key BWZAKDPPVXHOTB-TWDSFERASA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Lipids
Class Sphingolipids
Sub Class Neutral Glycosphingolipids
Other Descriptors
  • Aliphatic Heteropolycyclic Compounds
  • Gangliosides
  • Hexose Oligosaccharides
Substituents
  • 1,2 Diol
  • 1,3 Aminoalcohol
  • Acetal
  • Alkyl Glycoside
  • Allyl Alcohol
  • Carboxamide Group
  • Carboxylic Acid
  • Ceramide
  • Fatty Acyl Glycoside
  • Glucosamine
  • Glyco Amino Acid
  • Glycosyl Compound
  • Mannosamine
  • N Acetylneuraminic Acid
  • N Acyl Amine
  • Neuraminic Acid
  • O Glycosyl Compound
  • Oxane
  • Primary Alcohol
  • Pyranoid Amino Acid
  • Saccharide
  • Secondary Alcohol
  • Secondary Carboxylic Acid Amide
  • Sugar Acid
Direct Parent Arthro and Ganglio series
Ontology
Status Expected and Not Quantified
Origin
  • Endogenous
  • Food
Biofunction
  • Cell signaling
  • Fuel and energy storage
  • Fuel or energy source
  • Membrane integrity/stability
Application
  • Nutrients
  • Stabilizers
  • Surfactants and Emulsifiers
Cellular locations
  • Extracellular
  • Membrane
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility Insoluble Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility 0.28 g/L ALOGPS
LogP 1.73 ALOGPS
LogP 1.09 ChemAxon
LogS -3.74 ALOGPS
pKa (strongest acidic) 2.8 ChemAxon
pKa (strongest basic) -3.7 ChemAxon
Hydrogen Acceptor Count 31 ChemAxon
Hydrogen Donor Count 20 ChemAxon
Polar Surface Area 540.58 A2 ChemAxon
Rotatable Bond Count 50 ChemAxon
Refractivity 366.8 ChemAxon
Polarizability 165.5 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -1 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biofluid Locations Not Available
Tissue Location
  • Fibroblasts
  • Brain
  • Myelin
  • Nerve Cells
Pathways Not Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID Not Available
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB023456
KNApSAcK ID Not Available
Chemspider ID 16744872 Link_out
KEGG Compound ID C04911 Link_out
BioCyc ID Not Available
BiGG ID Not Available
Wikipedia Link GM1 Link_out
NuGOwiki Link HMDB04855 Link_out
Metagene Link HMDB04855 Link_out
METLIN ID Not Available
PubChem Compound 20057296 Link_out
PDB ID Not Available
ChEBI ID Not Available
References
Synthesis Reference Mikhalyov, I. I.; Molotkovsky, Jul. G. Synthesis and characteristics of fluorescent BODIPY-labeled gangliosides. Russian Journal of Bioorganic Chemistry (Translation of Bioorganicheskaya Khimiya) (2003), 29(2), 168-174.
Material Safety Data Sheet (MSDS) Not Available
General References
  1. Rost KL, Brockmoller J, Weber W, Roots I: Multiple-dose pharmacokinetics of ganglioside GM1 after intravenous and intramuscular administration to healthy volunteers. Clin Pharmacol Ther. 1991 Aug;50(2):141-9. Pubmed: 1868675 Link_out
  2. Sadeghlar F, Remmel N, Breiden B, Klingenstein R, Schwarzmann G, Sandhoff K: Physiological relevance of sphingolipid activator proteins in cultured human fibroblasts. Biochimie. 2003 Mar-Apr;85(3-4):439-48. Pubmed: 12770782 Link_out
  3. Vogel A, Furst W, Abo-Hashish MA, Lee-Vaupel M, Conzelmann E, Sandhoff K: Identity of the activator proteins for the enzymatic hydrolysis of sulfatide, ganglioside GM1, and globotriaosylceramide. Arch Biochem Biophys. 1987 Dec;259(2):627-38. Pubmed: 3426245 Link_out
  4. Gregson NA, Koblar S, Hughes RA: Antibodies to gangliosides in Guillain-Barre syndrome: specificity and relationship to clinical features. Q J Med. 1993 Feb;86(2):111-7. Pubmed: 8464986 Link_out
  5. Avrova NF, Zakharova IO, Tyurin VA, Tyurina YY, Gamaley IA, Schepetkin IA: Different metabolic effects of ganglioside GM1 in brain synaptosomes and phagocytic cells. Neurochem Res. 2002 Aug;27(7-8):751-9. Pubmed: 12374210 Link_out
  6. Shoemaker JD, Elliott WH: Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. J Chromatogr. 1991 Jan 2;562(1-2):125-38. Pubmed: 2026685 Link_out
  7. Takaura N, Yagi T, Maeda M, Nanba E, Oshima A, Suzuki Y, Yamano T, Tanaka A: Attenuation of ganglioside GM1 accumulation in the brain of GM1 gangliosidosis mice by neonatal intravenous gene transfer. Gene Ther. 2003 Aug;10(17):1487-93. Pubmed: 12900764 Link_out
  8. Cacic M: Gangliosides of anencephalic and fetal brain--immunostaining on thin-layer chromatograms. Neuroreport. 1995 Jan 26;6(2):389-93. Pubmed: 7538811 Link_out
  9. Mellgren SI: [Peripheral neuropathies] Tidsskr Nor Laegeforen. 1995 May 30;115(14):1735-8. Pubmed: 7785034 Link_out
  10. Blennow K, Wallin A: Clinical heterogeneity of probable Alzheimer's disease. J Geriatr Psychiatry Neurol. 1992 Apr-Jun;5(2):106-13. Pubmed: 1590911 Link_out
  11. Matsuda J, Suzuki O, Oshima A, Ogura A, Noguchi Y, Yamamoto Y, Asano T, Takimoto K, Sukegawa K, Suzuki Y, Naiki M: Beta-galactosidase-deficient mouse as an animal model for GM1-gangliosidosis. Glycoconj J. 1997 Sep;14(6):729-36. Pubmed: 9337086 Link_out
Enzymes
Name: Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
Reactions:
  • CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)- beta-D-galactosyl-R [RN:R04564]
Gene Name: ST8SIA1
Uniprot ID: Q92185 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sialidase-2
Reactions:
  • Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates ALL_REAC (other) R03491 R04018 R04634 R04650 R05115 R05117 R05996(G) R05998(G) R05999(G) R06012(G) R06147(G) R06253(G) INHIBITOR 2-Deoxy-2,3-dehydro-N-acetylneuraminic acid [CPD:C04580]
Gene Name: NEU2
Uniprot ID: Q9Y3R4 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sialidase-3
Reactions:
  • Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates ALL_REAC (other) R03491 R04018 R04634 R04650 R05115 R05117 R05996(G) R05998(G) R05999(G) R06012(G) R06147(G) R06253(G) INHIBITOR 2-Deoxy-2,3-dehydro-N-acetylneuraminic acid [CPD:C04580]
Gene Name: NEU3
Uniprot ID: Q9UQ49 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sialidase-4
Reactions:
  • Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates ALL_REAC (other) R03491 R04018 R04634 R04650 R05115 R05117 R05996(G) R05998(G) R05999(G) R06012(G) R06147(G) R06253(G) INHIBITOR 2-Deoxy-2,3-dehydro-N-acetylneuraminic acid [CPD:C04580]
Gene Name: NEU4
Uniprot ID: Q8WWR8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Lactase-phlorizin hydrolase
Reactions:
  • lactose + H2O = D-galactose + D-glucose [RN:R01100 R06114]
Gene Name: LCT
Uniprot ID: P09848 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Reactions:
    Gene Name: GBGT1
    Uniprot ID: Q8N5D6 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
    Reactions:
    • 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate [RN:R03482 R05917]
    Gene Name: PIGL
    Uniprot ID: Q9Y2B2 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Lactosylceramide alpha-2,3-sialyltransferase
    Reactions:
    • CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D- glucosyl-(11)-ceramide [RN:R03488 R05937]
    Gene Name: ST3GAL5
    Uniprot ID: Q9UNP4 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Beta-galactosidase
    Reactions:
    • Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides ALL_REAC (other) R01100 R01105 R01678 R03355 R04633 R04783 R05112 R05994(G) R06010(G) R06098(G) R06099(G) R06114(G) R06144(G) R06202(G) R07807(G)
    Gene Name: GLB1
    Uniprot ID: P16278 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
    Reactions:
    • UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [RN:R02654 R05916]
    Gene Name: PIGQ
    Uniprot ID: Q9BRB3 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
    Reactions:
    • UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [RN:R02654 R05916]
    Gene Name: PIGA
    Uniprot ID: P37287 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
    Reactions:
    • UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [RN:R02654 R05916]
    Gene Name: PIGH
    Uniprot ID: Q14442 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
    Reactions:
    • UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [RN:R02654 R05916]
    Gene Name: PIGP
    Uniprot ID: P57054 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
    Reactions:
    • UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [RN:R02654 R05916]
    Gene Name: PIGC
    Uniprot ID: Q92535 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Beta-1,3-galactosyltransferase 4
    Reactions:
    • UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1->4)- beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-(1->3)-beta-N-acetyl-D-galactosaminyl-(N- acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine [RN:R04631 R05941]
    Gene Name: B3GALT4
    Uniprot ID: O96024 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Ganglioside GM2 activator
    Reactions:
      Gene Name: GM2A
      Uniprot ID: P17900 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
      Reactions:
      • CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl- alpha-D-galactosaminyl-R [RN:R04590 R05913]
      Gene Name: ST3GAL1
      Uniprot ID: Q11201 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: T-cell surface glycoprotein CD1e, membrane-associated
      Reactions:
        Gene Name: CD1E
        Uniprot ID: P15812 Link_out
        Protein Sequence: FASTA
        Gene Sequence: FASTA
        Name: Epididymal secretory protein E1
        Reactions:
          Gene Name: NPC2
          Uniprot ID: P61916 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Antigen-presenting glycoprotein CD1d
          Reactions:
            Gene Name: CD1D
            Uniprot ID: P15813 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: GPI mannosyltransferase 1
            Reactions:
              Gene Name: PIGM
              Uniprot ID: Q9H3S5 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Phosphatidylinositol-glycan biosynthesis class W protein
              Reactions:
                Gene Name: PIGW
                Uniprot ID: Q7Z7B1 Link_out
                Protein Sequence: FASTA
                Gene Sequence: FASTA
                Name: Phosphatidylinositol-glycan biosynthesis class X protein
                Reactions:
                  Gene Name: PIGX
                  Uniprot ID: Q8TBF5 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: GPI mannosyltransferase 4
                  Reactions:
                    Gene Name: PIGZ
                    Uniprot ID: Q86VD9 Link_out
                    Protein Sequence: FASTA
                    Gene Sequence: FASTA
                    Name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
                    Reactions:
                      Gene Name: ST3GAL4
                      Uniprot ID: Q11206 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
                      Reactions:
                        Gene Name: B3GNT5
                        Uniprot ID: Q9BYG0 Link_out
                        Protein Sequence: FASTA
                        Gene Sequence: FASTA
                        Name: Beta-1,3-galactosyltransferase 5
                        Reactions:
                          Gene Name: B3GALT5
                          Uniprot ID: Q9Y2C3 Link_out
                          Protein Sequence: FASTA
                          Gene Sequence: FASTA
                          Name: GPI mannosyltransferase 3
                          Reactions:
                            Gene Name: PIGB
                            Uniprot ID: Q92521 Link_out
                            Protein Sequence: FASTA
                            Gene Sequence: FASTA
                            Name: Phosphatidylinositol-glycan biosynthesis class F protein
                            Reactions:
                              Gene Name: PIGF
                              Uniprot ID: Q07326 Link_out
                              Protein Sequence: FASTA
                              Gene Sequence: FASTA
                              Name: GPI ethanolamine phosphate transferase 2
                              Reactions:
                                Gene Name: PIGG
                                Uniprot ID: Q5H8A4 Link_out
                                Protein Sequence: FASTA
                                Gene Sequence: FASTA
                                Name: GPI ethanolamine phosphate transferase 1
                                Reactions:
                                  Gene Name: PIGN
                                  Uniprot ID: O95427 Link_out
                                  Protein Sequence: FASTA
                                  Gene Sequence: FASTA
                                  Name: GPI ethanolamine phosphate transferase 3
                                  Reactions:
                                    Gene Name: PIGO
                                    Uniprot ID: Q8TEQ8 Link_out
                                    Protein Sequence: FASTA
                                    Gene Sequence: FASTA
                                    Name: GPI transamidase component PIG-S
                                    Reactions:
                                      Gene Name: PIGS
                                      Uniprot ID: Q96S52 Link_out
                                      Protein Sequence: FASTA
                                      Gene Sequence: FASTA
                                      Name: GPI transamidase component PIG-T
                                      Reactions:
                                        Gene Name: PIGT
                                        Uniprot ID: Q969N2 Link_out
                                        Protein Sequence: FASTA
                                        Gene Sequence: FASTA
                                        Name: Phosphatidylinositol glycan anchor biosynthesis class U protein
                                        Reactions:
                                          Gene Name: PIGU
                                          Uniprot ID: Q9H490 Link_out
                                          Protein Sequence: FASTA
                                          Gene Sequence: FASTA
                                          Name: GPI mannosyltransferase 2
                                          Reactions:
                                            Gene Name: PIGV
                                            Uniprot ID: Q9NUD9 Link_out
                                            Protein Sequence: FASTA
                                            Gene Sequence: FASTA
                                            Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
                                            Reactions:
                                              Gene Name: PIGY
                                              Uniprot ID: Q3MUY2 Link_out
                                              Protein Sequence: FASTA
                                              Gene Sequence: FASTA
                                              Name: Pleckstrin homology domain-containing family A member 8
                                              Reactions:
                                                Gene Name: PLEKHA8
                                                Uniprot ID: Q96JA3 Link_out
                                                Protein Sequence: FASTA
                                                Gene Sequence: FASTA
                                                Name: Non-lysosomal glucosylceramidase
                                                Reactions:
                                                • D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine [RN:R01498]
                                                Gene Name: GBA2
                                                Uniprot ID: Q9HCG7 Link_out
                                                Protein Sequence: FASTA
                                                Gene Sequence: FASTA
                                                Name: NEU1 protein
                                                Reactions:
                                                  Gene Name: NEU1
                                                  Uniprot ID: Q5JQI0 Link_out
                                                  Protein Sequence: FASTA
                                                  Gene Sequence: FASTA
                                                  Name: GPI-anchor transamidase
                                                  Reactions:
                                                    Gene Name: PIGK
                                                    Uniprot ID: Q92643 Link_out
                                                    Protein Sequence: FASTA
                                                    Gene Sequence: FASTA
                                                    Name: Glycosylphosphatidylinositol anchor attachment 1 protein
                                                    Reactions:
                                                      Gene Name: GPAA1
                                                      Uniprot ID: O43292 Link_out
                                                      Protein Sequence: FASTA
                                                      Gene Sequence: FASTA
                                                      Name: Protein PLEKHA9
                                                      Reactions:
                                                        Gene Name: PLEKHA9
                                                        Uniprot ID: O95397 Link_out
                                                        Protein Sequence: FASTA
                                                        Gene Sequence: FASTA
                                                        Name: Glycolipid transfer protein domain-containing protein 2
                                                        Reactions:
                                                          Gene Name: GLTPD2
                                                          Uniprot ID: A6NH11 Link_out
                                                          Protein Sequence: FASTA
                                                          Gene Sequence: FASTA
                                                          Name: Putative uncharacterized protein PLEKHA8
                                                          Reactions:
                                                            Gene Name: PLEKHA8
                                                            Uniprot ID: B5MDU3 Link_out
                                                            Protein Sequence: FASTA
                                                            Gene Sequence: FASTA
                                                            Name: T-cell surface glycoprotein CD1a
                                                            Reactions:
                                                              Gene Name: CD1A
                                                              Uniprot ID: P06126 Link_out
                                                              Protein Sequence: FASTA
                                                              Gene Sequence: FASTA
                                                              Name: Glycolipid transfer protein domain-containing protein 1
                                                              Reactions:
                                                                Gene Name: GLTPD1
                                                                Uniprot ID: Q5TA50 Link_out
                                                                Protein Sequence: FASTA
                                                                Gene Sequence: FASTA
                                                                Name: T-cell surface glycoprotein CD1c
                                                                Reactions:
                                                                  Gene Name: CD1C
                                                                  Uniprot ID: P29017 Link_out
                                                                  Protein Sequence: FASTA
                                                                  Gene Sequence: FASTA
                                                                  Name: Lipopolysaccharide-binding protein
                                                                  Reactions:
                                                                    Gene Name: LBP
                                                                    Uniprot ID: P18428 Link_out
                                                                    Protein Sequence: FASTA
                                                                    Gene Sequence: FASTA
                                                                    Name: Putative uncharacterized protein DKFZp434L0435
                                                                    Reactions:
                                                                      Gene Name: DKFZp434L0435
                                                                      Uniprot ID: Q9UFH6 Link_out
                                                                      Protein Sequence: FASTA
                                                                      Gene Sequence: FASTA
                                                                      Name: T-cell surface glycoprotein CD1b
                                                                      Reactions:
                                                                        Gene Name: CD1B
                                                                        Uniprot ID: P29016 Link_out
                                                                        Protein Sequence: FASTA
                                                                        Gene Sequence: FASTA
                                                                        Name: Glycolipid transfer protein
                                                                        Reactions:
                                                                          Gene Name: GLTP
                                                                          Uniprot ID: Q9NZD2 Link_out
                                                                          Protein Sequence: FASTA
                                                                          Gene Sequence: FASTA