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Record Information

Version

5.0

Status

Detected and Quantified

Creation Date

2006-10-25 12:50:12 UTC

Update Date

2022-09-22 17:43:53 UTC

HMDB ID

HMDB0005087

Secondary Accession Numbers

HMDB0010218
HMDB05087
HMDB10218

Metabolite Identification

Common Name

6-trans-Leukotriene B4

Description

6-trans-Leukotriene B4 is an enzymatic metabolite of leukotriene B4(LTB4). A greater increase in LTB4 and 6-trans-LTB4 (one of its hydroxylated 5-lipoxygenase metabolic derivatives) occurs after stimulation with calcium-ionophore in asthma patients compared to healthy controls. LTB4 is the major metabolite in neutrophil polymorphonuclear leukocytes. Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO is LTA4 (leukotriene A4), which is enzymatically converted into either LTB4 (leukotriene B4) by LTA4 hydrolase or LTC4 (leukotriene C4) by LTC4 synthase. The regulation of leukotriene production occurs at various levels, including expression of 5-LO, translocation of 5-LO to the perinuclear region, and phosphorylation to either enhance or inhibit the activity of 5-LO. Biologically active LTB4 is metabolized by omega-oxidation carried out by specific cytochrome P450s (CYP4F) followed by beta-oxidation from the w-carboxy position and after CoA ester formation (PMID: 17623009 , 2176862 , 7649996 , 9667737 , 2125732 ). Leukotrienes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HMDB0005087
     RDKit          3D
6-trans-Leukotriene B4
 56 55  0  0  0  0  0  0  0  0999 V2000
    5.9881    2.0227    0.5789 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9152    1.6317    1.5618 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9589    0.2288    1.9905 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8763   -0.8820    1.0617 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7197   -1.1134    0.1822 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4798   -0.0454   -0.7938 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5159   -0.2313   -2.0888 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7952   -1.5027   -2.7350 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5652   -1.8629   -3.5895 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8981   -3.0997   -4.1877 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3732   -2.0609   -2.7593 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6026   -1.0875   -2.3007 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5731   -1.3779   -1.4749 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3419   -0.4059   -1.0177 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5115   -0.6251   -0.2011 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2518    0.3788    0.2340 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4568    0.1824    1.0733 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.0742   -0.6095    2.1567 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9868    1.5176    1.4889 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2099    1.4210    2.3446 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3715    0.7350    1.7086 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8434    1.3971    0.4818 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8140    0.9319   -0.2032 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2829    2.5601   -0.0220 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5312    1.9728   -0.4425 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9056    1.4233    0.6593 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.2721    3.0864    0.7170 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2202    2.2314    2.5124 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9807    2.0942    1.2933 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2021    0.0506    2.8246 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9404    0.1042    2.5693 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0576   -1.8424    1.6606 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7979   -0.8657    0.3969 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8068   -2.1373   -0.2664 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7541   -1.2584    0.8071 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2348    0.9906   -0.4965 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3251    0.6167   -2.7964 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6131   -1.3945   -3.5220 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0012   -2.3730   -2.1439 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4667   -1.1386   -4.3960 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8653   -3.8343   -3.5117 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0552   -3.0754   -2.4696 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8418   -0.0821   -2.5359 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8550   -2.3854   -1.2102 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0456    0.6044   -1.2926 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8149   -1.6191    0.0781 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9577    1.3610   -0.0384 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1787   -0.3978    0.4603 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0854   -1.5474    1.8552 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0829    2.1415    0.5959 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1988    2.0011    2.1244 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5308    2.4658    2.5789 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9299    0.8651    3.2642 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2066    0.7479    2.4423 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1787   -0.3414    1.4914 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7772    3.4330    0.1182 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 17 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 22 24  1  0
  1 25  1  0
  1 26  1  0
  1 27  1  0
  2 28  1  0
  2 29  1  0
  3 30  1  0
  3 31  1  0
  4 32  1  0
  4 33  1  0
  5 34  1  0
  5 35  1  0
  6 36  1  0
  7 37  1  0
  8 38  1  0
  8 39  1  0
  9 40  1  6
 10 41  1  0
 11 42  1  0
 12 43  1  0
 13 44  1  0
 14 45  1  0
 15 46  1  0
 16 47  1  0
 17 48  1  6
 18 49  1  0
 19 50  1  0
 19 51  1  0
 20 52  1  0
 20 53  1  0
 21 54  1  0
 21 55  1  0
 24 56  1  0
M  END


  Mrv1652306171918142D          

 24 23  0  0  0  0            999 V2000
 9995.0047 9997.7078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9995.7193 9998.1199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9996.4339 9997.7078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.1487 9998.1199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.8633 9997.7078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.5783 9998.1199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.2917 9997.7078    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10000.0071 9998.1199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10000.7225 9997.7078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.5472 9997.7078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.2626 9998.1199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.9759 9997.7078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10003.6914 9998.1199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10004.4068 9997.7078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10005.1223 9998.1199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.2917 9996.8826    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9994.2900 9998.1199    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
 9993.5753 9997.7078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9992.8606 9998.1199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9992.1461 9997.7078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9991.4294 9998.1199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9990.7148 9997.7078    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9991.4294 9998.9445    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9994.2900 9998.9445    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1 17  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7 16  1  1  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 17 24  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0005087

> <DATABASE_NAME>
hmdb

> <SMILES>
CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C\[C@@H](O)CCCC(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11+/t18-,19-/m1/s1

> <INCHI_KEY>
VNYSSYRCGWBHLG-UKNWISKWSA-N

> <FORMULA>
C20H32O4

> <MOLECULAR_WEIGHT>
336.4657

> <EXACT_MASS>
336.230059512

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
56

> <JCHEM_AVERAGE_POLARIZABILITY>
40.58769316464145

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(5S,6E,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid

> <ALOGPS_LOGP>
5.46

> <JCHEM_LOGP>
4.125548676999999

> <ALOGPS_LOGS>
-4.34

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
17.720820347637158

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.6463449725928205

> <JCHEM_PKA_STRONGEST_BASIC>
-1.2749373349576958

> <JCHEM_POLAR_SURFACE_AREA>
77.76

> <JCHEM_REFRACTIVITY>
102.985

> <JCHEM_ROTATABLE_BOND_COUNT>
14

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.52e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
6-trans-LTB4

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0005087
     RDKit          3D
6-trans-Leukotriene B4
 56 55  0  0  0  0  0  0  0  0999 V2000
    5.9881    2.0227    0.5789 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9152    1.6317    1.5618 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9589    0.2288    1.9905 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8763   -0.8820    1.0617 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7197   -1.1134    0.1822 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4798   -0.0454   -0.7938 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5159   -0.2313   -2.0888 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7952   -1.5027   -2.7350 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5652   -1.8629   -3.5895 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8981   -3.0997   -4.1877 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3732   -2.0609   -2.7593 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6026   -1.0875   -2.3007 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5731   -1.3779   -1.4749 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3419   -0.4059   -1.0177 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5115   -0.6251   -0.2011 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2518    0.3788    0.2340 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4568    0.1824    1.0733 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.0742   -0.6095    2.1567 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9868    1.5176    1.4889 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2099    1.4210    2.3446 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3715    0.7350    1.7086 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8434    1.3971    0.4818 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8140    0.9319   -0.2032 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2829    2.5601   -0.0220 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5312    1.9728   -0.4425 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9056    1.4233    0.6593 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.2721    3.0864    0.7170 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2202    2.2314    2.5124 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9807    2.0942    1.2933 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2021    0.0506    2.8246 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9404    0.1042    2.5693 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0576   -1.8424    1.6606 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7979   -0.8657    0.3969 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8068   -2.1373   -0.2664 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7541   -1.2584    0.8071 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2348    0.9906   -0.4965 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3251    0.6167   -2.7964 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6131   -1.3945   -3.5220 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0012   -2.3730   -2.1439 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4667   -1.1386   -4.3960 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8653   -3.8343   -3.5117 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0552   -3.0754   -2.4696 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8418   -0.0821   -2.5359 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8550   -2.3854   -1.2102 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0456    0.6044   -1.2926 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8149   -1.6191    0.0781 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9577    1.3610   -0.0384 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1787   -0.3978    0.4603 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0854   -1.5474    1.8552 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0829    2.1415    0.5959 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1988    2.0011    2.1244 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5308    2.4658    2.5789 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9299    0.8651    3.2642 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2066    0.7479    2.4423 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1787   -0.3414    1.4914 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7772    3.4330    0.1182 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 17 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 22 24  1  0
  1 25  1  0
  1 26  1  0
  1 27  1  0
  2 28  1  0
  2 29  1  0
  3 30  1  0
  3 31  1  0
  4 32  1  0
  4 33  1  0
  5 34  1  0
  5 35  1  0
  6 36  1  0
  7 37  1  0
  8 38  1  0
  8 39  1  0
  9 40  1  6
 10 41  1  0
 11 42  1  0
 12 43  1  0
 13 44  1  0
 14 45  1  0
 15 46  1  0
 16 47  1  0
 17 48  1  6
 18 49  1  0
 19 50  1  0
 19 51  1  0
 20 52  1  0
 20 53  1  0
 21 54  1  0
 21 55  1  0
 24 56  1  0
M  END

HEADER    PROTEIN                                 17-JUN-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-JUN-19         0                                  
HETATM    1  C   UNK     0    8657.3428662.388   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0    8658.6768663.157   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0    8660.0108662.388   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0    8661.3448663.157   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0    8662.6788662.388   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0    8664.0138663.157   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0    8665.3458662.388   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0    8666.6808663.157   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0    8668.0158662.388   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0    8669.5558662.388   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0    8670.8908663.157   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0    8672.2228662.388   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0    8673.5578663.157   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0    8674.8938662.388   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0    8676.2288663.157   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0    8665.3458660.848   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0    8656.0088663.157   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0    8654.6748662.388   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0    8653.3408663.157   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0    8652.0068662.388   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0    8650.6688663.157   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0    8649.3348662.388   0.000  0.00  0.00           O+0
HETATM   23  O   UNK     0    8650.6688664.696   0.000  0.00  0.00           O+0
HETATM   24  O   UNK     0    8656.0088664.696   0.000  0.00  0.00           O+0
CONECT    1    2   17                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8   16                                                  
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14                                                            
CONECT   16    7                                                            
CONECT   17    1   18   24                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   22   23                                                  
CONECT   22   21                                                            
CONECT   23   21                                                            
CONECT   24   17                                                            
MASTER        0    0    0    0    0    0    0    0   24    0   46    0
END

COMPND    HMDB0005087
HETATM    1  C1  UNL     1       5.988   2.023   0.579  1.00  0.00           C  
HETATM    2  C2  UNL     1       4.915   1.632   1.562  1.00  0.00           C  
HETATM    3  C3  UNL     1       4.959   0.229   1.991  1.00  0.00           C  
HETATM    4  C4  UNL     1       4.876  -0.882   1.062  1.00  0.00           C  
HETATM    5  C5  UNL     1       3.720  -1.113   0.182  1.00  0.00           C  
HETATM    6  C6  UNL     1       3.480  -0.045  -0.794  1.00  0.00           C  
HETATM    7  C7  UNL     1       3.516  -0.231  -2.089  1.00  0.00           C  
HETATM    8  C8  UNL     1       3.795  -1.503  -2.735  1.00  0.00           C  
HETATM    9  C9  UNL     1       2.565  -1.863  -3.589  1.00  0.00           C  
HETATM   10  O1  UNL     1       2.898  -3.100  -4.188  1.00  0.00           O  
HETATM   11  C10 UNL     1       1.373  -2.061  -2.759  1.00  0.00           C  
HETATM   12  C11 UNL     1       0.603  -1.087  -2.301  1.00  0.00           C  
HETATM   13  C12 UNL     1      -0.573  -1.378  -1.475  1.00  0.00           C  
HETATM   14  C13 UNL     1      -1.342  -0.406  -1.018  1.00  0.00           C  
HETATM   15  C14 UNL     1      -2.511  -0.625  -0.201  1.00  0.00           C  
HETATM   16  C15 UNL     1      -3.252   0.379   0.234  1.00  0.00           C  
HETATM   17  C16 UNL     1      -4.457   0.182   1.073  1.00  0.00           C  
HETATM   18  O2  UNL     1      -4.074  -0.609   2.157  1.00  0.00           O  
HETATM   19  C17 UNL     1      -4.987   1.518   1.489  1.00  0.00           C  
HETATM   20  C18 UNL     1      -6.210   1.421   2.345  1.00  0.00           C  
HETATM   21  C19 UNL     1      -7.371   0.735   1.709  1.00  0.00           C  
HETATM   22  C20 UNL     1      -7.843   1.397   0.482  1.00  0.00           C  
HETATM   23  O3  UNL     1      -8.814   0.932  -0.203  1.00  0.00           O  
HETATM   24  O4  UNL     1      -7.283   2.560  -0.022  1.00  0.00           O  
HETATM   25  H1  UNL     1       5.531   1.973  -0.442  1.00  0.00           H  
HETATM   26  H2  UNL     1       6.906   1.423   0.659  1.00  0.00           H  
HETATM   27  H3  UNL     1       6.272   3.086   0.717  1.00  0.00           H  
HETATM   28  H4  UNL     1       5.220   2.231   2.512  1.00  0.00           H  
HETATM   29  H5  UNL     1       3.981   2.094   1.293  1.00  0.00           H  
HETATM   30  H6  UNL     1       4.202   0.051   2.825  1.00  0.00           H  
HETATM   31  H7  UNL     1       5.940   0.104   2.569  1.00  0.00           H  
HETATM   32  H8  UNL     1       5.058  -1.842   1.661  1.00  0.00           H  
HETATM   33  H9  UNL     1       5.798  -0.866   0.397  1.00  0.00           H  
HETATM   34  H10 UNL     1       3.807  -2.137  -0.266  1.00  0.00           H  
HETATM   35  H11 UNL     1       2.754  -1.258   0.807  1.00  0.00           H  
HETATM   36  H12 UNL     1       3.235   0.991  -0.496  1.00  0.00           H  
HETATM   37  H13 UNL     1       3.325   0.617  -2.796  1.00  0.00           H  
HETATM   38  H14 UNL     1       4.613  -1.394  -3.522  1.00  0.00           H  
HETATM   39  H15 UNL     1       4.001  -2.373  -2.144  1.00  0.00           H  
HETATM   40  H16 UNL     1       2.467  -1.139  -4.396  1.00  0.00           H  
HETATM   41  H17 UNL     1       2.865  -3.834  -3.512  1.00  0.00           H  
HETATM   42  H18 UNL     1       1.055  -3.075  -2.470  1.00  0.00           H  
HETATM   43  H19 UNL     1       0.842  -0.082  -2.536  1.00  0.00           H  
HETATM   44  H20 UNL     1      -0.855  -2.385  -1.210  1.00  0.00           H  
HETATM   45  H21 UNL     1      -1.046   0.604  -1.293  1.00  0.00           H  
HETATM   46  H22 UNL     1      -2.815  -1.619   0.078  1.00  0.00           H  
HETATM   47  H23 UNL     1      -2.958   1.361  -0.038  1.00  0.00           H  
HETATM   48  H24 UNL     1      -5.179  -0.398   0.460  1.00  0.00           H  
HETATM   49  H25 UNL     1      -4.085  -1.547   1.855  1.00  0.00           H  
HETATM   50  H26 UNL     1      -5.083   2.141   0.596  1.00  0.00           H  
HETATM   51  H27 UNL     1      -4.199   2.001   2.124  1.00  0.00           H  
HETATM   52  H28 UNL     1      -6.531   2.466   2.579  1.00  0.00           H  
HETATM   53  H29 UNL     1      -5.930   0.865   3.264  1.00  0.00           H  
HETATM   54  H30 UNL     1      -8.207   0.748   2.442  1.00  0.00           H  
HETATM   55  H31 UNL     1      -7.179  -0.341   1.491  1.00  0.00           H  
HETATM   56  H32 UNL     1      -7.777   3.433   0.118  1.00  0.00           H  
CONECT    1    2   25   26   27
CONECT    2    3   28   29
CONECT    3    4   30   31
CONECT    4    5   32   33
CONECT    5    6   34   35
CONECT    6    7    7   36
CONECT    7    8   37
CONECT    8    9   38   39
CONECT    9   10   11   40
CONECT   10   41
CONECT   11   12   12   42
CONECT   12   13   43
CONECT   13   14   14   44
CONECT   14   15   45
CONECT   15   16   16   46
CONECT   16   17   47
CONECT   17   18   19   48
CONECT   18   49
CONECT   19   20   50   51
CONECT   20   21   52   53
CONECT   21   22   54   55
CONECT   22   23   23   24
CONECT   24   56
END

HMDB0005087
     RDKit          3D
6-trans-Leukotriene B4
 56 55  0  0  0  0  0  0  0  0999 V2000
    5.9881    2.0227    0.5789 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9152    1.6317    1.5618 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9589    0.2288    1.9905 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8763   -0.8820    1.0617 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7197   -1.1134    0.1822 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4798   -0.0454   -0.7938 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5159   -0.2313   -2.0888 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7952   -1.5027   -2.7350 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5652   -1.8629   -3.5895 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8981   -3.0997   -4.1877 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3732   -2.0609   -2.7593 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6026   -1.0875   -2.3007 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5731   -1.3779   -1.4749 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3419   -0.4059   -1.0177 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5115   -0.6251   -0.2011 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2518    0.3788    0.2340 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4568    0.1824    1.0733 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.0742   -0.6095    2.1567 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9868    1.5176    1.4889 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2099    1.4210    2.3446 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3715    0.7350    1.7086 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8434    1.3971    0.4818 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8140    0.9319   -0.2032 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2829    2.5601   -0.0220 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5312    1.9728   -0.4425 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9056    1.4233    0.6593 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.2721    3.0864    0.7170 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2202    2.2314    2.5124 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9807    2.0942    1.2933 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2021    0.0506    2.8246 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9404    0.1042    2.5693 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0576   -1.8424    1.6606 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7979   -0.8657    0.3969 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8068   -2.1373   -0.2664 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7541   -1.2584    0.8071 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2348    0.9906   -0.4965 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3251    0.6167   -2.7964 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6131   -1.3945   -3.5220 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0012   -2.3730   -2.1439 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4667   -1.1386   -4.3960 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8653   -3.8343   -3.5117 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0552   -3.0754   -2.4696 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8418   -0.0821   -2.5359 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8550   -2.3854   -1.2102 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0456    0.6044   -1.2926 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8149   -1.6191    0.0781 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9577    1.3610   -0.0384 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1787   -0.3978    0.4603 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0854   -1.5474    1.8552 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0829    2.1415    0.5959 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1988    2.0011    2.1244 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5308    2.4658    2.5789 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9299    0.8651    3.2642 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2066    0.7479    2.4423 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1787   -0.3414    1.4914 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7772    3.4330    0.1182 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 17 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 22 24  1  0
  1 25  1  0
  1 26  1  0
  1 27  1  0
  2 28  1  0
  2 29  1  0
  3 30  1  0
  3 31  1  0
  4 32  1  0
  4 33  1  0
  5 34  1  0
  5 35  1  0
  6 36  1  0
  7 37  1  0
  8 38  1  0
  8 39  1  0
  9 40  1  6
 10 41  1  0
 11 42  1  0
 12 43  1  0
 13 44  1  0
 14 45  1  0
 15 46  1  0
 16 47  1  0
 17 48  1  6
 18 49  1  0
 19 50  1  0
 19 51  1  0
 20 52  1  0
 20 53  1  0
 21 54  1  0
 21 55  1  0
 24 56  1  0
M  END

View in JSmol View Stereo Labels

Synonyms

Value	Source
(5S,6E,8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoic acid	ChEBI
(6E,5S,12R)-Leukotriene b4	ChEBI
5(S),12(R)-Dihydroxy-6,8,10,14-(trans,trans,trans,cis)-eicosatetraenoic acid	ChEBI
5S,12R-Dihydroxy-6E,8E,10E,14Z-eicosatetraenoic acid	ChEBI
5S,12R-Dihydroxy-6E,8E,10E,14Z-icosatetraenoic acid	ChEBI
6-trans-LTB4	ChEBI
Delta(6)-trans-Leukotriene b4	ChEBI
Delta(6)-trans-LT b4	ChEBI
(5S,6E,8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate	Generator
5(S),12(R)-Dihydroxy-6,8,10,14-(trans,trans,trans,cis)-eicosatetraenoate	Generator
5S,12R-Dihydroxy-6E,8E,10E,14Z-eicosatetraenoate	Generator
5S,12R-Dihydroxy-6E,8E,10E,14Z-icosatetraenoate	Generator
Δ(6)-trans-leukotriene b4	Generator
Δ(6)-trans-LT b4	Generator
D6-trans-Leukotriene b4	HMDB
D6-trans-LTB4	HMDB
[S-[R,s-(e,e,e,Z)]]-5,12-dihydroxy-6,8,10,14-eicosatetraenoate	HMDB
[S-[R,s-(e,e,e,Z)]]-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid	HMDB
delta6-trans-LTB4	HMDB
delta6-trans-Leukotriene b4	HMDB
Δ6-trans-LTB4	HMDB
Δ6-trans-leukotriene b4	HMDB
5,12-HETE	MeSH
5,12-DiHETE	MeSH
Leukotriene b-4	MeSH
Leukotriene b4	MeSH
5,12 HETE	MeSH
5,12 DiHETE	MeSH
b-4, Leukotriene	MeSH
Leukotrienes b	MeSH
LTB4	MeSH
Leukotriene b	MeSH
Leukotriene b 4	MeSH
6-trans-Leukotriene B4	HMDB

Chemical Formula

C₂₀H₃₂O₄

Average Molecular Weight

336.4657

Monoisotopic Molecular Weight

336.230059512

IUPAC Name

(5S,6E,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid

Traditional Name

6-trans-LTB4

CAS Registry Number

71652-82-9

SMILES

CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C\[C@@H](O)CCCC(O)=O

InChI Identifier

InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11+/t18-,19-/m1/s1

InChI Key

VNYSSYRCGWBHLG-UKNWISKWSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as leukotrienes. These are eicosanoids containing a hydroxyl group attached to the aliphatic chain of an arachidonic acid. Leukotrienes have four double bonds, three (and only three) of which are conjugated.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Eicosanoids

Direct Parent

Leukotrienes

Alternative Parents

Substituents

Leukotriene
Hydroxyeicosatetraenoic acid
Long-chain fatty acid
Hydroxy fatty acid
Fatty acid
Unsaturated fatty acid
Secondary alcohol
Monocarboxylic acid or derivatives
Carboxylic acid
Carboxylic acid derivative
Organooxygen compound
Alcohol
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Carbonyl group
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

long-chain fatty acid (CHEBI:63981 )
leukotriene (CHEBI:63981 )
dihydroxy monocarboxylic acid (CHEBI:63981 )
polyunsaturated fatty acid (CHEBI:63981 )
hydroxy fatty acid (CHEBI:63981 )
Leukotrienes (LMFA03020013 )

Ontology

Physiological effect

Not Available

Disposition

Biological location

Non-excretory biofluid

Biofluid or Excreta

Blood (PMID: 18953024)

Cellular substructure

Extracellular (HMDB: HMDB0005087)
Membrane (HMDB: HMDB0005087)

Greylag goose (FooDB: FOOD00368)
Guinea hen (FooDB: FOOD00373)
Ostrich (FooDB: FOOD00422)
Velvet duck (FooDB: FOOD00427)
Pheasant (FooDB: FOOD00430)
Squab (FooDB: FOOD00481)
Turkey (FooDB: FOOD00494)
Quail (FooDB: FOOD00541)
Anatidae (FooDB: FOOD00576)
Rock ptarmigan (FooDB: FOOD00597)
Columbidae (Dove, Pigeon) (FooDB: FOOD00610)
Chicken (FooDB: FOOD00329)
Mallard duck (FooDB: FOOD00353)
Emu (FooDB: FOOD00360)

Equine

Horse (FooDB: FOOD00378)

Lagomorph

Ovis

Sheep (Mutton, Lamb) (FooDB: FOOD00473)

Bovine

Venison

Deer (FooDB: FOOD00524)
Mule deer (FooDB: FOOD00348)
Elk (FooDB: FOOD00359)

Caprae

Domestic goat (FooDB: FOOD00529)

Swine

Domestic pig (FooDB: FOOD00536)
Wild boar (FooDB: FOOD00307)

Process

Not Available

Role

Not Available

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	3.58	Not Available

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
Water Solubility	0.015 g/L	ALOGPS
logP	5.46	ALOGPS
logP	4.13	ChemAxon
logS	-4.3	ALOGPS
pKa (Strongest Acidic)	4.65	ChemAxon
pKa (Strongest Basic)	-1.3	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	77.76 Å²	ChemAxon
Rotatable Bond Count	14	ChemAxon
Refractivity	102.98 m³·mol⁻¹	ChemAxon
Polarizability	40.59 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DarkChem	[M+H]+	193.916	31661259
DarkChem	[M-H]-	189.801	31661259
DeepCCS	[M+H]+	196.151	30932474
DeepCCS	[M-H]-	193.577	30932474
DeepCCS	[M-2H]-	228.084	30932474
DeepCCS	[M+Na]+	203.555	30932474
AllCCS	[M+H]+	190.8	32859911
AllCCS	[M+H-H2O]+	188.0	32859911
AllCCS	[M+NH4]+	193.4	32859911
AllCCS	[M+Na]+	194.1	32859911
AllCCS	[M-H]-	187.9	32859911
AllCCS	[M+Na-2H]-	189.7	32859911
AllCCS	[M+HCOO]-	191.9	32859911

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
6-trans-Leukotriene B4	CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C\[C@@H](O)CCCC(O)=O	4605.7	Standard polar	33892256
6-trans-Leukotriene B4	CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C\[C@@H](O)CCCC(O)=O	2645.4	Standard non polar	33892256
6-trans-Leukotriene B4	CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C\[C@@H](O)CCCC(O)=O	2873.2	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
6-trans-Leukotriene B4,1TMS,isomer #1	CCCCC/C=C\C[C@H](/C=C/C=C/C=C/[C@@H](O)CCCC(=O)O)O[Si](C)(C)C	3003.9	Semi standard non polar	33892256
6-trans-Leukotriene B4,1TMS,isomer #2	CCCCC/C=C\C[C@@H](O)/C=C/C=C/C=C/[C@H](CCCC(=O)O)O[Si](C)(C)C	2997.2	Semi standard non polar	33892256
6-trans-Leukotriene B4,1TMS,isomer #3	CCCCC/C=C\C[C@@H](O)/C=C/C=C/C=C/[C@@H](O)CCCC(=O)O[Si](C)(C)C	2902.7	Semi standard non polar	33892256
6-trans-Leukotriene B4,2TMS,isomer #1	CCCCC/C=C\C[C@H](/C=C/C=C/C=C/[C@H](CCCC(=O)O)O[Si](C)(C)C)O[Si](C)(C)C	3062.5	Semi standard non polar	33892256
6-trans-Leukotriene B4,2TMS,isomer #2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C/[C@@H](O)CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C	2960.7	Semi standard non polar	33892256
6-trans-Leukotriene B4,2TMS,isomer #3	CCCCC/C=C\C[C@@H](O)/C=C/C=C/C=C/[C@H](CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C	2958.3	Semi standard non polar	33892256
6-trans-Leukotriene B4,3TMS,isomer #1	CCCCC/C=C\C[C@H](/C=C/C=C/C=C/[C@H](CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C	3003.4	Semi standard non polar	33892256
6-trans-Leukotriene B4,1TBDMS,isomer #1	CCCCC/C=C\C[C@H](/C=C/C=C/C=C/[C@@H](O)CCCC(=O)O)O[Si](C)(C)C(C)(C)C	3251.3	Semi standard non polar	33892256
6-trans-Leukotriene B4,1TBDMS,isomer #2	CCCCC/C=C\C[C@@H](O)/C=C/C=C/C=C/[C@H](CCCC(=O)O)O[Si](C)(C)C(C)(C)C	3244.7	Semi standard non polar	33892256
6-trans-Leukotriene B4,1TBDMS,isomer #3	CCCCC/C=C\C[C@@H](O)/C=C/C=C/C=C/[C@@H](O)CCCC(=O)O[Si](C)(C)C(C)(C)C	3148.3	Semi standard non polar	33892256
6-trans-Leukotriene B4,2TBDMS,isomer #1	CCCCC/C=C\C[C@H](/C=C/C=C/C=C/[C@H](CCCC(=O)O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	3518.0	Semi standard non polar	33892256
6-trans-Leukotriene B4,2TBDMS,isomer #2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C/[C@@H](O)CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	3449.6	Semi standard non polar	33892256
6-trans-Leukotriene B4,2TBDMS,isomer #3	CCCCC/C=C\C[C@@H](O)/C=C/C=C/C=C/[C@H](CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	3444.0	Semi standard non polar	33892256
6-trans-Leukotriene B4,3TBDMS,isomer #1	CCCCC/C=C\C[C@H](/C=C/C=C/C=C/[C@H](CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	3735.9	Semi standard non polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted GC-MS	Predicted GC-MS Spectrum - 6-trans-Leukotriene B4 GC-MS (Non-derivatized) - 70eV, Positive	splash10-066r-7896000000-782d01776a33cc451555	2017-09-01	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - 6-trans-Leukotriene B4 GC-MS (3 TMS) - 70eV, Positive	splash10-01rl-9113530000-205b0d713aeb42a9afc2	2017-10-06	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - 6-trans-Leukotriene B4 GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - 6-trans-Leukotriene B4 GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Experimental LC-MS/MS	LC-MS/MS Spectrum - 6-trans-Leukotriene B4 LC-ESI-QIT , negative-QTOF	splash10-000i-0419000000-061132d646cd5dd85a1b	2018-05-25	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - 6-trans-Leukotriene B4 LC-ESI-QIT , negative-QTOF	splash10-00ks-0829000000-7da7ab59ee0d4812767b	2018-05-25	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - 6-trans-Leukotriene B4 LC-ESI-QIT , negative-QTOF	splash10-0002-0933000000-3fb381ce0f3609a90222	2018-05-25	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - 6-trans-Leukotriene B4 LC-ESI-QIT , negative-QTOF	splash10-0udj-0931000000-ccfdaa3226146fe9edc3	2018-05-25	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - 6-trans-Leukotriene B4 LC-ESI-QIT , negative-QTOF	splash10-0udj-1940000000-ef988be204f5c54f4b21	2018-05-25	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - 6-trans-Leukotriene B4 LC-ESI-QIT , negative-QTOF	splash10-0r00-1910000000-e16cc958487f06dc4287	2018-05-25	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - 6-trans-Leukotriene B4 LC-ESI-QIT , negative-QTOF	splash10-0006-6900000000-a356f0334bf220eb54cc	2018-05-25	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - 6-trans-Leukotriene B4 LC-ESI-QIT , negative-QTOF	splash10-052f-9700000000-66a6a217eba63b4874d1	2018-05-25	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - 6-trans-Leukotriene B4 LC-ESI-QIT , negative-QTOF	splash10-0a4l-7900000000-aeb350579ea4a84117d0	2018-05-25	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - 6-trans-Leukotriene B4 LC-ESI-QQ , negative-QTOF	splash10-000i-0619000000-dc49d3f4ab097db18f18	2018-05-25	HMDB team, MONA	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 6-trans-Leukotriene B4 10V, Positive-QTOF	splash10-0gb9-0019000000-69c64ad7b55da6a633e1	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 6-trans-Leukotriene B4 20V, Positive-QTOF	splash10-0v4i-5598000000-0a1483f60114546ce2c7	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 6-trans-Leukotriene B4 40V, Positive-QTOF	splash10-052f-9550000000-0ad5f1d400a5ff275f25	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 6-trans-Leukotriene B4 10V, Negative-QTOF	splash10-00kr-0029000000-0164a507a03180713a2e	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 6-trans-Leukotriene B4 20V, Negative-QTOF	splash10-014r-2269000000-52f6b9d4ecc4e26ff1fe	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 6-trans-Leukotriene B4 40V, Negative-QTOF	splash10-0a4l-9340000000-c2e72464c072384447e0	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 6-trans-Leukotriene B4 10V, Positive-QTOF	splash10-0uxr-0019000000-bbfb0bde6a04ea9b05bc	2021-09-23	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 6-trans-Leukotriene B4 20V, Positive-QTOF	splash10-0udi-3439000000-d8140c418a63ad2159a3	2021-09-23	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 6-trans-Leukotriene B4 40V, Positive-QTOF	splash10-0ar0-9320000000-afb563cb7a2b51e02836	2021-09-23	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 6-trans-Leukotriene B4 10V, Negative-QTOF	splash10-000i-0009000000-74962f74765b30de04ac	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 6-trans-Leukotriene B4 20V, Negative-QTOF	splash10-00kr-3659000000-98607094f1fa036e16e2	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 6-trans-Leukotriene B4 40V, Negative-QTOF	splash10-052f-5191000000-91a6c7d4dfff9bd70967	2021-09-25	Wishart Lab	View Spectrum

Biological Properties

Cellular Locations

Extracellular
Membrane

Biospecimen Locations

Blood
Urine

Tissue Locations

Not Available

Pathways

Not Available

Name	SMPDB/PathBank	KEGG

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	0.00011 +/- 0.00003 uM	Adult (>18 years old)	Both	Normal	20671299	details
Blood	Detected and Quantified	0.000223 +/- 0.000042 uM	Adult (>18 years old)	Not Specified	Normal	18953024	details
Blood	Detected and Quantified	0.000223 +/- 0.000042 uM	Adult (>18 years old)	Both	Normal	21359215	details
Blood	Detected and Quantified	<0.0001 uM	Adult (>18 years old)	Both	Normal	21359215	details

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Urine	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Cancer patients undergoing total body irradiation	31424920	details

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB022416

KNApSAcK ID

Not Available

Chemspider ID

4446252

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Leukotriene B4

METLIN ID

Not Available

PubChem Compound

5283128

PDB ID

Not Available

ChEBI ID

63981

Food Biomarker Ontology

Not Available

VMH ID

CE2445

MarkerDB ID

Not Available

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Wheelan P, Murphy RC: Metabolism of 6-trans-isomers of leukotriene B4 in cultured hepatoma cells and in human polymorphonuclear leukocytes. Identification of a delta 6-reductase metabolic pathway. J Biol Chem. 1995 Aug 25;270(34):19845-52. [PubMed:7649996 ]
Primiano T, Li Y, Kensler TW, Trush MA, Sutter TR: Identification of dithiolethione-inducible gene-1 as a leukotriene B4 12-hydroxydehydrogenase: implications for chemoprevention. Carcinogenesis. 1998 Jun;19(6):999-1005. [PubMed:9667737 ]
Murphy RC, Gijon MA: Biosynthesis and metabolism of leukotrienes. Biochem J. 2007 Aug 1;405(3):379-95. [PubMed:17623009 ]
Wainwright S, Falck JR, Yadagiri P, Powell WS: Metabolism of 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid and other hydroxylated fatty acids by the reductase pathway in porcine polymorphonuclear leukocytes. Biochemistry. 1990 Oct 30;29(43):10126-35. [PubMed:2176862 ]
Radeau T, Chavis C, Damon M, Michel FB, Crastes de Paulet A, Godard PH: Enhanced arachidonic acid metabolism and human neutrophil migration in asthma. Prostaglandins Leukot Essent Fatty Acids. 1990 Oct;41(2):131-8. [PubMed:2125732 ]

Showing metabocard for 6-trans-Leukotriene B4 (HMDB0005087)

MOL for HMDB0005087 (6-trans-Leukotriene B4)

3D MOL for HMDB0005087 (6-trans-Leukotriene B4)

3D SDF for HMDB0005087 (6-trans-Leukotriene B4)

3D-SDF for HMDB0005087 (6-trans-Leukotriene B4)

PDB for HMDB0005087 (6-trans-Leukotriene B4)

3D PDB for HMDB0005087 (6-trans-Leukotriene B4)

SMILES for HMDB0005087 (6-trans-Leukotriene B4)

INCHI for HMDB0005087 (6-trans-Leukotriene B4)

Structure for HMDB0005087 (6-trans-Leukotriene B4)

3D Structure for HMDB0005087 (6-trans-Leukotriene B4)

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra