Showing metabocard for 3a,7a-Dihydroxy-5b-cholestan-26-al (HMDB06894)

General function:

Involved in oxidoreductase activity

Specific function:

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.

Gene Name:

ALDH9A1

Uniprot ID:

P49189

Molecular weight:

56291.485

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.

Gene Name:

ALDH7A1

Uniprot ID:

P49419

Molecular weight:

58486.74

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).

Gene Name:

ALDH1A3

Uniprot ID:

P47895

Molecular weight:

56107.995

General function:

Involved in oxidoreductase activity

Specific function:

Not Available

Gene Name:

ALDH2

Uniprot ID:

P05091

Molecular weight:

56380.93

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.

Gene Name:

ALDH3A2

Uniprot ID:

P51648

Molecular weight:

54847.36

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.

Gene Name:

ALDH1B1

Uniprot ID:

P30837

Molecular weight:

57248.96

Reactions

General function:

Involved in zinc ion binding

Specific function:

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Gene Name:

ADH5

Uniprot ID:

P11766

Molecular weight:

39723.945

General function:

Involved in zinc ion binding

Specific function:

Not Available

Gene Name:

ADH1B

Uniprot ID:

P00325

Molecular weight:

39835.17

General function:

Involved in zinc ion binding

Specific function:

Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.

Gene Name:

ADH7

Uniprot ID:

P40394

Molecular weight:

41480.985

General function:

Involved in zinc ion binding

Specific function:

Not Available

Gene Name:

ADH1A

Uniprot ID:

P07327

Molecular weight:

39858.37

General function:

Involved in zinc ion binding

Specific function:

Not Available

Gene Name:

ADH6

Uniprot ID:

P28332

Molecular weight:

39072.275

General function:

Involved in zinc ion binding

Specific function:

Not Available

Gene Name:

ADH1C

Uniprot ID:

P00326

Molecular weight:

39867.27

General function:

Involved in monooxygenase activity

Specific function:

Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity.

Gene Name:

CYP27A1

Uniprot ID:

Q02318

Molecular weight:

60234.28

Reactions