Human Metabolome Database Version 3.5

Showing metabocard for Ferrocytochrome (HMDB12947)

Record Information
Version 3.5
Creation Date 2009-07-24 18:10:23 -0600
Update Date 2013-02-08 11:40:29 -0700
Secondary Accession Numbers None
Metabolite Identification
Common Name Ferrocytochrome
Description Ferricytochrome is a cytochrome containing reduced (ferrous) iron. Cytochrome c is an electron-carrying protein found in mitochondria of all aerobic organisms. It is part of the terminal oxidation chain, which completes the breakdown of foods to COZ and HzO, storing the liberated chemical energy in molecules of ATP. Like myoglobin, it is an iron porphyrin protein, made up of one heme group and one polypeptide chain. The iron atomalternates between the +2 and +3 oxidation state as the molecule interacts in turn with cytochrome reductase and cytochrome oxidase, each a large multimolecular complex (l-3). One of the goals of the present x-ray analysis is to understand how electron. transfer occurs into and out of cytochrome c, which will ultimately require a knowledge of the molecular structure in both the ferric and ferrous states.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
  1. 553-12-8 (FREE ACID)
  2. Ferrocytochrome b-561
  3. H2ppIX
  4. HEM
  5. Kammerer'S porphyrin
  6. Kammerer'S prophyrin
  7. Lopac-P-8293
  8. NSC2632 (FREE ACID)
  9. Ooporphyrin
  10. Porphyrinogen ix
  11. PP-ix
  12. Protoporhyrin ix
  13. Protoporphyrin
  14. Protoporphyrin (PP)
  15. Protoporphyrin ix
  16. Protoporphyrin IX (6CI)
  17. Protoporphyrin IX (van)
  18. Protoporphyrin IX disodium
  19. Protoporphyrin-1x
  20. Protoporpyrin ix
Chemical Formula C33H32FeN4O4
Average Molecular Weight 604.477
Monoisotopic Molecular Weight 604.177297665
IUPAC Name 4,20-bis(2-carboxyethyl)-10-ethenyl-5,9,14,15,19-pentamethyl-2$l^{4},22,23$l^{4},25-tetraaza-1-ferraoctacyclo[^{1,8}.1^{3,21}.0^{2,6}.0^{16,23}.0^{18,22}.0^{11,25}]pentacosa-2,4,6,8,10,12,14,16(23),17,19,21(24)-undecaene-1,1-diuide
Traditional IUPAC Name 4,20-bis(2-carboxyethyl)-10-ethenyl-5,9,14,15,19-pentamethyl-2$l^{4},22,23$l^{4},25-tetraaza-1-ferraoctacyclo[^{1,8}.1^{3,21}.0^{2,6}.0^{16,23}.0^{18,22}.0^{11,25}]pentacosa-2,4,6,8,10,12,14,16(23),17,19,21(24)-undecaene-1,1-diuide
CAS Registry Number 1818-68-4
SMILES CC1=C(CCC(O)=O)C2=CC3=[N]4C(=CC5=C(C)C(C=C)=C6C=C7C(C)=C(C)C8=[N]7[Fe--]4(N2C1=C8)N56)C(C)=C3CCC(O)=O
InChI Identifier InChI=1S/C33H34N4O4.Fe/c1-7-21-18(4)26-13-28-20(6)23(9-11-33(40)41)31(37-28)15-30-22(8-10-32(38)39)19(5)27(36-30)12-24-16(2)17(3)25(34-24)14-29(21)35-26;/h7,12-15H,1,8-11H2,2-6H3,(H4,34,35,36,37,38,39,40,41);/p-2/b24-12-,25-14?,26-13-,27-12-,28-13-,29-14?,30-15-,31-15-;
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Aromatic Heteropolycyclic Compounds
Class Tetrapyrroles and Derivatives
Sub Class Metallotetrapyrroles
Other Descriptors
  • Organic Compounds
  • Porphyrins
  • Carboxylic Acid
  • Dicarboxylic Acid Derivative
  • Organic Transition Metal Moeity
  • Organometallic Compound
  • Pyrrole
  • Quaternary Ammonium Salt
Direct Parent Metalloporphyrins
Status Expected and Not Quantified
  • Endogenous
Biofunction Not Available
Application Not Available
Cellular locations Not Available
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
LogP 1.19 ALOGPS
LogS -3.64 ALOGPS
Hydrogen Acceptor Count 0 ChemAxon
Hydrogen Donor Count 0 ChemAxon
Polar Surface Area 121.19 A2 ChemAxon
Rotatable Bond Count 7 ChemAxon
Refractivity 171.54 ChemAxon
Polarizability 68.6 ChemAxon
Formal Charge -2 ChemAxon
Physiological Charge -2 ChemAxon
Not Available
Biological Properties
Cellular Locations Not Available
Biofluid Locations Not Available
Tissue Location Not Available
Pathways Not Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID Not Available
DrugBank Metabolite ID Not Available
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB029223
KNApSAcK ID Not Available
Chemspider ID Not Available
KEGG Compound ID C05183 Link_out
BioCyc ID Not Available
BiGG ID Not Available
Wikipedia Link Not Available
NuGOwiki Link HMDB12947 Link_out
Metagene Link HMDB12947 Link_out
METLIN ID Not Available
PubChem Compound Not Available
PDB ID Not Available
ChEBI ID 15910 Link_out
Synthesis Reference Not Available
Material Safety Data Sheet (MSDS) Not Available
General References
  1. Gederaas OA, Berg K, Romslo I: A comparative study of normal and reverse phase high pressure liquid chromatography for analysis of porphyrins accumulated after 5-aminolaevulinic acid treatment of colon adenocarcinoma cells. Cancer Lett. 2000 Mar 31;150(2):205-13. Pubmed: 10704744 Link_out
  2. Desuzinges-Mandon E, Arnaud O, Martinez L, Huche F, Di Pietro A, Falson P: ABCG2 transports and transfers heme to albumin through its large extracellular loop. J Biol Chem. 2010 Oct 22;285(43):33123-33. doi: 10.1074/jbc.M110.139170. Epub 2010 Aug 12. Pubmed: 20705604 Link_out
  3. Han I, Jun MS, Kim SK, Kim M, Kim JC: Expression pattern and intensity of protoporphyrin IX induced by liposomal 5-aminolevulinic acid in rat pilosebaceous unit throughout hair cycle. Arch Dermatol Res. 2005 Nov;297(5):210-7. Epub 2005 Nov 11. Pubmed: 16231146 Link_out
  4. Schumacher A, Wafula PO, Teles A, El-Mousleh T, Linzke N, Zenclussen ML, Langwisch S, Heinze K, Wollenberg I, Casalis PA, Volk HD, Fest S, Zenclussen AC: Blockage of heme oxygenase-1 abrogates the protective effect of regulatory T cells on murine pregnancy and promotes the maturation of dendritic cells. PLoS One. 2012;7(8):e42301. doi: 10.1371/journal.pone.0042301. Epub 2012 Aug 10. Pubmed: 22900010 Link_out

Name: NADH-cytochrome b5 reductase 3
Reactions: Not Available
Gene Name: CYB5R3
Uniprot ID: P00387 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Squalene monooxygenase
Reactions: Not Available
Gene Name: SQLE
Uniprot ID: Q14534 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NADPH--cytochrome P450 reductase
Reactions: Not Available
Gene Name: POR
Uniprot ID: P16435 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA