Record Information
Version3.6
Creation Date2012-09-06 15:16:50 UTC
Update Date2013-02-09 00:32:18 UTC
HMDB IDHMDB14781
Secondary Accession NumbersNone
Metabolite Identification
Common NameMebendazole
DescriptionMebendazole is only found in individuals that have used or taken this drug. It is a benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem]Mebendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.
Structure
Thumb
SynonymsNot Available
Chemical FormulaC16H13N3O3
Average Molecular Weight295.2927
Monoisotopic Molecular Weight295.095691297
IUPAC Namemethyl N-(6-benzoyl-1H-1,3-benzodiazol-2-yl)carbamate
Traditional IUPAC Namemebendazole
CAS Registry Number31431-39-7
SMILES
COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C1=CC=CC=C1
InChI Identifier
InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21)
InChI KeyOPXLLQIJSORQAM-UHFFFAOYSA-N
Chemical Taxonomy
KingdomOrganic Compounds
Super ClassAromatic Heteropolycyclic Compounds
ClassDiphenylmethanes
Sub ClassN/A
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
  • benzimidazoles(ChEBI)
Substituents
  • Aminoimidazole
  • Benzimidazole
  • Benzoyl
  • Carbamic Acid Ester (Urethane)
  • Imidazole
  • Ketone
Direct ParentDiphenylmethanes
Ontology
StatusExpected and Not Quantified
Origin
  • Drug
Biofunction
  • Antinematodal Agents
  • Tubulin Modulators
Application
  • Pharmaceutical
Cellular locations
  • Cytoplasm
  • Membrane
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point288.5 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility3.87e-02 g/LNot Available
LogP2.8Not Available
Predicted Properties
PropertyValueSource
water solubility0.039 g/LALOGPS
logP2.95ALOGPS
logP3.26ChemAxon
logS-3.9ALOGPS
pKa (strongest acidic)8.44ChemAxon
pKa (strongest basic)3.93ChemAxon
physiological charge0ChemAxon
hydrogen acceptor count4ChemAxon
hydrogen donor count2ChemAxon
polar surface area84.08ChemAxon
rotatable bond count4ChemAxon
refractivity81.5ChemAxon
polarizability31.1ChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular Locations
  • Cytoplasm
  • Membrane
Biofluid Locations
  • Blood
  • Urine
Tissue LocationNot Available
PathwaysNot Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodExpected but not QuantifiedNot ApplicableNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00643
  • Not Applicable
UrineExpected but not QuantifiedNot ApplicableNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00643
  • Not Applicable
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00643
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID3890
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkMebendazole
NuGOwiki LinkHMDB14781
Metagene LinkHMDB14781
METLIN IDNot Available
PubChem Compound4030
PDB IDNot Available
ChEBI ID6704
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Wikipedia

Enzymes

Gene Name:
CYP3A4
Uniprot ID:
P08684
Gene Name:
CYP1A1
Uniprot ID:
P04798
Gene Name:
TUBB2C
Uniprot ID:
P68371
Gene Name:
TUBA1A
Uniprot ID:
Q71U36

Transporters

Gene Name:
ABCB1
Uniprot ID:
P08183