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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:50 UTC
Update Date2023-02-21 17:18:20 UTC
HMDB IDHMDB0014935
Secondary Accession Numbers
  • HMDB14935
Metabolite Identification
Common NameTolazoline
DescriptionTolazoline, also known as priscoline or divascol, belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene. Tolazoline is a drug which is used for the treatment of pulmonary artery anomalies. Tolazoline is a very strong basic compound (based on its pKa). It is however most commonly used in veterinary medicine, to reverse xylazine-induced sedation. It is a vasodilator that is used to treat spasms of peripheral blood vessels (as in acrocyanosis). It has also been used (in conjunction with sodium nitroprusside) successfully as an antidote to reverse the severe peripheral vasoconstriction which can occur as a result of overdose with certain 5-HT2A agonist drugs such as 25I-NBOMe, DOB and Bromodragonfly (prolonged severe vasoconstriction can lead to gangrene if untreated). Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.
Structure
Data?1676999899
Synonyms
ValueSource
2-Benzyl-2-imidazolineChEBI
2-Benzyl-4,5-imidazolineChEBI
2-BenzylimidazolineChEBI
4,5-Dihydro-2-(phenylmethyl)-1H-imidazoleChEBI
TolazineKegg
DivascolHMDB
Tolazoline hydrochlorideHMDB
PridazoleHMDB
Tolazoline monohydrochlorideHMDB
BenzalolinHMDB
Novartis brand OF tolazoline hydrochlorideHMDB
PriscolineHMDB
Ciba vision brand OF tolazoline hydrochlorideHMDB
PriscolHMDB
Chemical FormulaC10H12N2
Average Molecular Weight160.2157
Monoisotopic Molecular Weight160.100048394
IUPAC Name2-benzyl-4,5-dihydro-1H-imidazole
Traditional Nametolazoline
CAS Registry Number59-98-3
SMILES
C(C1=NCCN1)C1=CC=CC=C1
InChI Identifier
InChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12)
InChI KeyJIVZKJJQOZQXQB-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassNot Available
Direct ParentBenzene and substituted derivatives
Alternative Parents
Substituents
  • Imidolactam
  • Monocyclic benzene moiety
  • 2-imidazoline
  • Azacycle
  • Organoheterocyclic compound
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Carboximidamide
  • Carboxylic acid amidine
  • Amidine
  • Organic nitrogen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point174 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility1.36 g/LNot Available
LogP1.5Not Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+Not Available135.083http://allccs.zhulab.cn/database/detail?ID=AllCCS00000830
Predicted Molecular Properties
PropertyValueSource
Water Solubility1.36 g/LALOGPS
logP2.05ALOGPS
logP1.2ChemAxon
logS-2.1ALOGPS
pKa (Strongest Basic)10.25ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area24.39 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity49.07 m³·mol⁻¹ChemAxon
Polarizability17.94 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+134.58431661259
DarkChem[M-H]-132.47531661259
DeepCCS[M+H]+133.23330932474
DeepCCS[M-H]-130.39630932474
DeepCCS[M-2H]-166.68230932474
DeepCCS[M+Na]+142.09730932474
AllCCS[M+H]+134.532859911
AllCCS[M+H-H2O]+129.932859911
AllCCS[M+NH4]+138.932859911
AllCCS[M+Na]+140.132859911
AllCCS[M-H]-137.732859911
AllCCS[M+Na-2H]-138.432859911
AllCCS[M+HCOO]-139.332859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
TolazolineC(C1=NCCN1)C1=CC=CC=C12461.3Standard polar33892256
TolazolineC(C1=NCCN1)C1=CC=CC=C11516.8Standard non polar33892256
TolazolineC(C1=NCCN1)C1=CC=CC=C11575.6Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Tolazoline,1TMS,isomer #1C[Si](C)(C)N1CCN=C1CC1=CC=CC=C11731.1Semi standard non polar33892256
Tolazoline,1TMS,isomer #1C[Si](C)(C)N1CCN=C1CC1=CC=CC=C11653.9Standard non polar33892256
Tolazoline,1TMS,isomer #1C[Si](C)(C)N1CCN=C1CC1=CC=CC=C12343.5Standard polar33892256
Tolazoline,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)N1CCN=C1CC1=CC=CC=C11952.6Semi standard non polar33892256
Tolazoline,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)N1CCN=C1CC1=CC=CC=C11901.7Standard non polar33892256
Tolazoline,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)N1CCN=C1CC1=CC=CC=C12492.4Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Tolazoline EI-B (Non-derivatized)splash10-0006-9400000000-7b6f1c4b249d1fba89272017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Tolazoline EI-B (Non-derivatized)splash10-0006-9400000000-7b6f1c4b249d1fba89272018-05-18HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Tolazoline GC-MS (Non-derivatized) - 70eV, Positivesplash10-0006-9300000000-2b6650aa08c5113fe2952017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Tolazoline GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Tolazoline LC-ESI-QQ , positive-QTOFsplash10-03di-0900000000-692cb3b89bff443fa65f2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Tolazoline LC-ESI-QQ , positive-QTOFsplash10-03di-0900000000-03a59847388e2e7417092017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Tolazoline LC-ESI-QQ , positive-QTOFsplash10-03di-4900000000-54d799a1c61663a2e5132017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Tolazoline LC-ESI-QQ , positive-QTOFsplash10-0006-9100000000-c36b35a2866405756d0a2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Tolazoline LC-ESI-QQ , positive-QTOFsplash10-0006-9000000000-c543ee9f104cc9558d702017-09-14HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tolazoline 10V, Positive-QTOFsplash10-03di-0900000000-47a6c1a5a2d279ab4f922016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tolazoline 20V, Positive-QTOFsplash10-03di-3900000000-aecd123663a1693e35242016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tolazoline 40V, Positive-QTOFsplash10-0006-9300000000-ebfb2f09103e6beeeb322016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tolazoline 10V, Negative-QTOFsplash10-0a4i-0900000000-6468e33c9df294b387c92016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tolazoline 20V, Negative-QTOFsplash10-0a4i-2900000000-770e7f8c4b1e0ae798682016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tolazoline 40V, Negative-QTOFsplash10-004l-9600000000-6bb3d6dbc9100efc43682016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tolazoline 10V, Positive-QTOFsplash10-03di-0900000000-ec9dd3a4861a20c6f98c2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tolazoline 20V, Positive-QTOFsplash10-03xu-3900000000-01b9796933a01ad40ccf2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tolazoline 40V, Positive-QTOFsplash10-00kf-9300000000-a6d07f8a048c587a6dd52021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tolazoline 10V, Negative-QTOFsplash10-0a4i-1900000000-1590a4c64e5f2e58a0d32021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tolazoline 20V, Negative-QTOFsplash10-0a4i-4900000000-1f5ee5c9b4a25f0e1faa2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tolazoline 40V, Negative-QTOFsplash10-00mo-9300000000-bbec6eccba8e917e3e292021-10-11Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00797 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00797 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00797
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID5303
KEGG Compound IDC07147
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkTolazoline
METLIN IDNot Available
PubChem Compound5504
PDB IDNot Available
ChEBI ID28502
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol
Gene Name:
ADRA2A
Uniprot ID:
P08913
Molecular weight:
48956.3
References
  1. Song W, Zhang Y, Xia L, Liu G: [Effects of some mexiletine derivatives on alpha 1-adrenoceptors]. Yao Xue Xue Bao. 1998;33(2):102-5. [PubMed:11938943 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular weight:
55783.6
References
  1. Roll C, Hanssler L: [Interaction of tolazoline and cimetidine in persistent fetal circulation of the newborn infant]. Monatsschr Kinderheilkd. 1993 Apr;141(4):297-9. [PubMed:8487790 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins
Gene Name:
ADRA1A
Uniprot ID:
P35348
Molecular weight:
51486.0
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Teskin O, Uydes-Dogan BS, Enc Y, Alp FI, Kaleli D, Keser S, Iyigun T, Bilgen F, Dagsali S, Ozdemir O: Comparative effects of tolazoline and nitroprusside on human isolated radial artery. Ann Thorac Surg. 2006 Jan;81(1):125-31. [PubMed:16368348 ]
  4. Song W, Zhang Y, Xia L, Liu G: [Effects of some mexiletine derivatives on alpha 1-adrenoceptors]. Yao Xue Xue Bao. 1998;33(2):102-5. [PubMed:11938943 ]