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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:51 UTC
Update Date2023-02-21 17:18:27 UTC
HMDB IDHMDB0015212
Secondary Accession Numbers
  • HMDB15212
Metabolite Identification
Common NameVigabatrin
DescriptionVigabatrin is only found in individuals that have used or taken this drug. It is an analogue of gamma-aminobutyric acid. It is an irreversible inhibitor of 4-aminobutyrate transaminase, the enzyme responsible for the catabolism of gamma-aminobutyric acid. (From Martindale The Extra Pharmacopoeia, 31st ed)It is believed that vigabatrin increases brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by irreversibly inhibiting enzymes that catabolize GABA (gamma-aminobutyric acid transaminase GABA-T) or block the reuptake of GABA into glia and nerve endings. Vigabatrin may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.
Structure
Data?1676999907
Synonyms
ValueSource
4-Amino-5-hexenoic acidChEBI
gamma-Vinyl gabaChEBI
gamma-Vinyl-gamma-aminobutyric acidChEBI
GVGChEBI
VigabatrinaChEBI
VigabatrineChEBI
VigabatrinumChEBI
SabrilKegg
4-Amino-5-hexenoateGenerator
g-Vinyl gabaGenerator
Γ-vinyl gabaGenerator
g-Vinyl-g-aminobutyrateGenerator
g-Vinyl-g-aminobutyric acidGenerator
gamma-Vinyl-gamma-aminobutyrateGenerator
Γ-vinyl-γ-aminobutyrateGenerator
Γ-vinyl-γ-aminobutyric acidGenerator
Acid, gamma-vinyl-gamma-aminobutyricHMDB
Yamanouchi brand OF vigabatrinHMDB
gamma Vinyl gabaHMDB
gamma-Vinyl-gabaHMDB
SabrilexHMDB
Vigabatrin aventis brandHMDB
Hoechst brand OF vigabatrinHMDB
Vigabatrin hoechst brandHMDB
gamma Vinyl gamma aminobutyric acidHMDB
Aventis brand OF vigabatrinHMDB
Vigabatrin yamanouchi brandHMDB
Chemical FormulaC6H11NO2
Average Molecular Weight129.157
Monoisotopic Molecular Weight129.078978601
IUPAC Name4-aminohex-5-enoic acid
Traditional Namevigabatrin
CAS Registry Number60643-86-9
SMILES
NC(CCC(O)=O)C=C
InChI Identifier
InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)
InChI KeyPJDFLNIOAUIZSL-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as gamma amino acids and derivatives. These are amino acids having a (-NH2) group attached to the gamma carbon atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentGamma amino acids and derivatives
Alternative Parents
Substituents
  • Gamma amino acid or derivatives
  • Medium-chain fatty acid
  • Amino fatty acid
  • Unsaturated fatty acid
  • Fatty acyl
  • Fatty acid
  • Amino acid
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Amine
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxide
  • Primary aliphatic amine
  • Organopnictogen compound
  • Organic oxygen compound
  • Carbonyl group
  • Organic nitrogen compound
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility96.6 g/LNot Available
LogP0.1Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility96.6 g/LALOGPS
logP-2.6ALOGPS
logP-2.1ChemAxon
logS-0.13ALOGPS
pKa (Strongest Acidic)4.61ChemAxon
pKa (Strongest Basic)9.91ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area63.32 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity34.29 m³·mol⁻¹ChemAxon
Polarizability13.64 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+128.81831661259
DarkChem[M-H]-123.38731661259
DeepCCS[M+H]+125.88930932474
DeepCCS[M-H]-122.9430932474
DeepCCS[M-2H]-159.83830932474
DeepCCS[M+Na]+134.58630932474
AllCCS[M+H]+132.232859911
AllCCS[M+H-H2O]+128.032859911
AllCCS[M+NH4]+136.132859911
AllCCS[M+Na]+137.332859911
AllCCS[M-H]-128.332859911
AllCCS[M+Na-2H]-131.032859911
AllCCS[M+HCOO]-134.032859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
VigabatrinNC(CCC(O)=O)C=C2193.5Standard polar33892256
VigabatrinNC(CCC(O)=O)C=C1078.6Standard non polar33892256
VigabatrinNC(CCC(O)=O)C=C1186.6Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Vigabatrin,1TMS,isomer #1C=CC(N)CCC(=O)O[Si](C)(C)C1226.2Semi standard non polar33892256
Vigabatrin,1TMS,isomer #2C=CC(CCC(=O)O)N[Si](C)(C)C1365.7Semi standard non polar33892256
Vigabatrin,2TMS,isomer #1C=CC(CCC(=O)O[Si](C)(C)C)N[Si](C)(C)C1378.7Semi standard non polar33892256
Vigabatrin,2TMS,isomer #1C=CC(CCC(=O)O[Si](C)(C)C)N[Si](C)(C)C1424.2Standard non polar33892256
Vigabatrin,2TMS,isomer #1C=CC(CCC(=O)O[Si](C)(C)C)N[Si](C)(C)C1553.5Standard polar33892256
Vigabatrin,2TMS,isomer #2C=CC(CCC(=O)O)N([Si](C)(C)C)[Si](C)(C)C1557.9Semi standard non polar33892256
Vigabatrin,2TMS,isomer #2C=CC(CCC(=O)O)N([Si](C)(C)C)[Si](C)(C)C1461.2Standard non polar33892256
Vigabatrin,2TMS,isomer #2C=CC(CCC(=O)O)N([Si](C)(C)C)[Si](C)(C)C1801.4Standard polar33892256
Vigabatrin,3TMS,isomer #1C=CC(CCC(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C1560.1Semi standard non polar33892256
Vigabatrin,3TMS,isomer #1C=CC(CCC(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C1544.3Standard non polar33892256
Vigabatrin,3TMS,isomer #1C=CC(CCC(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C1565.9Standard polar33892256
Vigabatrin,1TBDMS,isomer #1C=CC(N)CCC(=O)O[Si](C)(C)C(C)(C)C1466.0Semi standard non polar33892256
Vigabatrin,1TBDMS,isomer #2C=CC(CCC(=O)O)N[Si](C)(C)C(C)(C)C1612.0Semi standard non polar33892256
Vigabatrin,2TBDMS,isomer #1C=CC(CCC(=O)O[Si](C)(C)C(C)(C)C)N[Si](C)(C)C(C)(C)C1833.8Semi standard non polar33892256
Vigabatrin,2TBDMS,isomer #1C=CC(CCC(=O)O[Si](C)(C)C(C)(C)C)N[Si](C)(C)C(C)(C)C1832.2Standard non polar33892256
Vigabatrin,2TBDMS,isomer #1C=CC(CCC(=O)O[Si](C)(C)C(C)(C)C)N[Si](C)(C)C(C)(C)C1827.6Standard polar33892256
Vigabatrin,2TBDMS,isomer #2C=CC(CCC(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C1997.9Semi standard non polar33892256
Vigabatrin,2TBDMS,isomer #2C=CC(CCC(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C1888.4Standard non polar33892256
Vigabatrin,2TBDMS,isomer #2C=CC(CCC(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C1959.4Standard polar33892256
Vigabatrin,3TBDMS,isomer #1C=CC(CCC(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2231.3Semi standard non polar33892256
Vigabatrin,3TBDMS,isomer #1C=CC(CCC(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2163.4Standard non polar33892256
Vigabatrin,3TBDMS,isomer #1C=CC(CCC(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C1926.0Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Vigabatrin GC-MS (Non-derivatized) - 70eV, Positivesplash10-0a6r-9000000000-ed9483c326234125f4ad2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Vigabatrin GC-MS (1 TMS) - 70eV, Positivesplash10-004i-3900000000-6c317e49ab8cc532a5582017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Vigabatrin GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Vigabatrin GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Vigabatrin GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Vigabatrin GC-MS (TMS_1_2) - 70eV, PositiveNot Available2021-11-03Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Vigabatrin GC-MS (TBDMS_1_1) - 70eV, PositiveNot Available2021-11-03Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Vigabatrin GC-MS (TBDMS_1_2) - 70eV, PositiveNot Available2021-11-03Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin LC-ESI-QFT , positive-QTOFsplash10-00di-9400000000-0215823a9ba364cc48cb2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin LC-ESI-QFT , positive-QTOFsplash10-00di-9400000000-c7d21d36dfb8e7079ee22017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin LC-ESI-QFT , positive-QTOFsplash10-00di-9200000000-e0c504f980ef5bbc05012017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin LC-ESI-QFT , positive-QTOFsplash10-00di-9000000000-e1b2ea8d5a2da84a5a642017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin LC-ESI-QFT , positive-QTOFsplash10-00di-9000000000-52958176067fd9bae9162017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin LC-ESI-QFT , positive-QTOFsplash10-00di-9000000000-263da4b132ca669869672017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin LC-ESI-QFT , positive-QTOFsplash10-01b9-9000000000-1f8826cc32ef269c1a7c2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin LC-ESI-QFT , positive-QTOFsplash10-014i-9000000000-32306e2f90cd529accc72017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin LC-ESI-QFT , positive-QTOFsplash10-0gb9-9000000000-aefa9f2682087c7b78ed2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin 90V, Positive-QTOFsplash10-00di-9000000000-2e8122bd9fa086c48c812021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin 60V, Positive-QTOFsplash10-00di-9000000000-c89fa23e4a66cb1fda0e2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin 75V, Positive-QTOFsplash10-00di-9000000000-ee55e365ddd88597a4242021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin 120V, Positive-QTOFsplash10-01b9-9000000000-59ee75afd49600cf95952021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin 150V, Positive-QTOFsplash10-014i-9000000000-32306e2f90cd529accc72021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin 45V, Positive-QTOFsplash10-00di-9200000000-6c0ed7a9357b20c8ddec2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin 30V, Positive-QTOFsplash10-00di-9400000000-67f3710d9b1a8968c5282021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Vigabatrin 180V, Positive-QTOFsplash10-0gb9-9000000000-aefa9f2682087c7b78ed2021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Vigabatrin 10V, Positive-QTOFsplash10-01q9-3900000000-5bf6d0079fa19a719d282016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Vigabatrin 20V, Positive-QTOFsplash10-01q9-9400000000-1d89cce66d591018b8b62016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Vigabatrin 40V, Positive-QTOFsplash10-0gb9-9000000000-25ce972a542597293a602016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Vigabatrin 10V, Negative-QTOFsplash10-004i-2900000000-14e6a479b3001860431b2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Vigabatrin 20V, Negative-QTOFsplash10-004i-7900000000-fd7f3b3f074734314a872016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Vigabatrin 40V, Negative-QTOFsplash10-0a4l-9100000000-db0d4ab6ed018a7e6a3f2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Vigabatrin 10V, Positive-QTOFsplash10-001i-9400000000-6179584a37d7e78d72342021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Vigabatrin 20V, Positive-QTOFsplash10-014i-9000000000-ff84f320ba47dd80531b2021-10-11Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01080 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01080 details
Abnormal Concentrations
Not Available
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood0.000 uMAdult (>18 years old)BothNormalPredicted based on drug qualities
Blood0.000 umol/mmol creatinineAdult (>18 years old)BothNormalPredicted based on drug qualities
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB01080
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID5463
KEGG Compound IDC07500
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkVigabatrin
METLIN IDNot Available
PubChem Compound5665
PDB IDNot Available
ChEBI ID63638
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Lindberger M, Luhr O, Johannessen SI, Larsson S, Tomson T: Serum concentrations and effects of gabapentin and vigabatrin: observations from a dose titration study. Ther Drug Monit. 2003 Aug;25(4):457-62. [PubMed:12883229 ]
  2. Gram L, Larsson OM, Johnsen A, Schousboe A: Experimental studies of the influence of vigabatrin on the GABA system. Br J Clin Pharmacol. 1989;27 Suppl 1:13S-17S. [PubMed:2757904 ]
  3. Browne TR: Pharmacokinetics of antiepileptic drugs. Neurology. 1998 Nov;51(5 Suppl 4):S2-7. [PubMed:9818917 ]
  4. Zwanzger P, Baghai TC, Schuele C, Strohle A, Padberg F, Kathmann N, Schwarz M, Moller HJ, Rupprecht R: Vigabatrin decreases cholecystokinin-tetrapeptide (CCK-4) induced panic in healthy volunteers. Neuropsychopharmacology. 2001 Nov;25(5):699-703. [PubMed:11682253 ]
  5. Hawker DD, Silverman RB: Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase. Bioorg Med Chem. 2012 Oct 1;20(19):5763-73. doi: 10.1016/j.bmc.2012.08.009. Epub 2012 Aug 16. [PubMed:22944334 ]
  6. Tulloch JK, Carr RR, Ensom MH: A systematic review of the pharmacokinetics of antiepileptic drugs in neonates with refractory seizures. J Pediatr Pharmacol Ther. 2012 Jan;17(1):31-44. doi: 10.5863/1551-6776-17.1.31. [PubMed:23118657 ]
  7. Clayton LM, Stern WM, Newman WD, Sander JW, Acheson J, Sisodiya SM: Evolution of visual field loss over ten years in individuals taking vigabatrin. Epilepsy Res. 2013 Aug;105(3):262-71. doi: 10.1016/j.eplepsyres.2013.02.014. Epub 2013 Mar 28. [PubMed:23541931 ]

Enzymes

General function:
Involved in 4-aminobutyrate transaminase activity
Specific function:
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Gene Name:
ABAT
Uniprot ID:
P80404
Molecular weight:
56438.405
References
  1. Weber OM, Verhagen A, Duc CO, Meier D, Leenders KL, Boesiger P: Effects of vigabatrin intake on brain GABA activity as monitored by spectrally edited magnetic resonance spectroscopy and positron emission tomography. Magn Reson Imaging. 1999 Apr;17(3):417-25. [PubMed:10195585 ]
  2. Valdizan EM, Garcia AP, Armijo JA: Effects of increasing doses of vigabatrin on platelet gamma-aminobutyric acid-transaminase and brain gamma-aminobutyric acid in rats. Eur J Pharmacol. 1999 Mar 19;369(2):169-73. [PubMed:10206175 ]
  3. Arndt CF, Derambure P, Defoort-Dhellemmes S, Hache JC: Outer retinal dysfunction in patients treated with vigabatrin. Neurology. 1999 Apr 12;52(6):1201-5. [PubMed:10214744 ]
  4. Molina PE, Ahmed N, Ajmal M, Dewey S, Volkow N, Fowler J, Abumrad N: Co-administration of gamma-vinyl GABA and cocaine: preclinical assessment of safety. Life Sci. 1999;65(11):1175-82. [PubMed:10503933 ]
  5. French JA: Vigabatrin. Epilepsia. 1999;40 Suppl 5:S11-6. [PubMed:10530689 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
General function:
Involved in G-protein coupled receptor activity
Specific function:
Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites
Gene Name:
GABBR1
Uniprot ID:
Q9UBS5
Molecular weight:
108319.4
References
  1. Tyacke RJ, Lingford-Hughes A, Reed LJ, Nutt DJ: GABAB receptors in addiction and its treatment. Adv Pharmacol. 2010;58:373-96. doi: 10.1016/S1054-3589(10)58014-1. [PubMed:20655489 ]