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Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2012-09-11 17:48:37 UTC
Update Date2023-02-21 17:21:46 UTC
HMDB IDHMDB0032231
Secondary Accession Numbers
  • HMDB32231
Metabolite Identification
Common NameDimethylethanolamine
DescriptionDimethylethanolamine, also known as 2-dimethylaminoethanol or DMEA, belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom. Dimethylethanolamine is naturally produced in the human body and can also be found in fatty fish. It is also used as a food additive ("EAFUS: Everything Added to Food in the United States. "). Dimethylethanolamine is a potentially toxic compound. Dimethylethanolamine has been used in the treatment of attention deficit-hyperactivity disorder (ADHD), Alzheimer's disease, autism, and tardive dyskinesia. Dimethylethanolamine is commonly referred to as 2-(dimethylamino)ethanol, Dimethylethanolamine (DMAE) or dimethylethanolamine (DMEA). These are organic compounds containing an alkylamine group. It holds tertiary amine and primary alcohol groups as functional groups. It has been also used as an ingredient in skin care, and in cognitive function- and mood-enhancing products.
Structure
Data?1677000106
Synonyms
ValueSource
(2-Hydroxyethyl)dimethylamineChEBI
2-(Dimethylamino)-1-ethanolChEBI
2-(N,N-Dimethylamino)ethanolChEBI
2-DimethylaminoethanolChEBI
beta-Dimethylaminoethyl alcoholChEBI
beta-HydroxyethyldimethylamineChEBI
DeanolChEBI
Dimethyl(2-hydroxyethyl)amineChEBI
Dimethyl(hydroxyethyl)amineChEBI
DimethylaminoaethanolChEBI
DimethylaethanolaminChEBI
DimethylmonoethanolamineChEBI
DMAEChEBI
DMEAChEBI
N,N-Dimethyl-2-aminoethanolChEBI
N,N-Dimethyl-2-hydroxyethylamineChEBI
N,N-Dimethyl-N-(2-hydroxyethyl)amineChEBI
N,N-Dimethyl-N-(beta-hydroxyethyl)amineChEBI
N,N-DimethylaminoethanolChEBI
N-(2-Hydroxyethyl)dimethylamineChEBI
N-DimethylaminoethanolChEBI
NorcholineChEBI
Propamine aChEBI
DimethylaminoethanolKegg
b-Dimethylaminoethyl alcoholGenerator
Β-dimethylaminoethyl alcoholGenerator
b-HydroxyethyldimethylamineGenerator
Β-hydroxyethyldimethylamineGenerator
N,N-Dimethyl-N-(b-hydroxyethyl)amineGenerator
N,N-Dimethyl-N-(β-hydroxyethyl)amineGenerator
(CH3)2nch2ch2ohHMDB
(Dimethylamino)ethanolHMDB
2-(Dimethylamino) ethanolHMDB
2-(Dimethylamino)-ethanolHMDB
2-(Dimethylamino)ethanolHMDB
2-DimethylaminoHMDB
2-Dimethylamino-ethanolHMDB
2-DwumetyloaminoetanoluHMDB
Amietol m 21HMDB
beta -(Dimethylamino)ethanolHMDB
beta -(Dimethylamino)ethyl alcoholHMDB
beta -Dimethylaminoethyl alcoholHMDB
beta -HydroxyethyldimethylamineHMDB
BimanolHMDB
Dabco dmeaHMDB
DemanolHMDB
DemanylHMDB
DimethylethanoiamineHMDB
Kalpur pHMDB
LiparonHMDB
N, N-Dimethyl(2-hydroxyethyl)amineHMDB
N, N-Dimethyl-N-(2-hydroxyethyl)amineHMDB
N, N-Dimethyl-N-(beta -hydroxyethyl)amineHMDB
N,N'-dimethylethanolamineHMDB
N,N-Dimethyl(2-hydroxyethyl)amineHMDB
N,N-Dimethyl-beta -hydroxyethylamineHMDB
N,N-Dimethyl-N-(beta -hydroxyethyl)amineHMDB
N,N-Dimethyl-N-ethanolamineHMDB
N,N-Dimethylaminoethanol (dmae)HMDB
N,N-DimethylethanolamineHMDB
N-(Dimethylamino)ethanolHMDB
N-Benzyloxycarbonyl-L-tyrosineHMDB
N-CBZ-L-TyrosineHMDB
Phosphatidyl-N-dimethylethanolamineHMDB
Tegoamin dmeaHMDB
Texacat dmeHMDB
TonibralHMDB
Toyocat -dmaHMDB
VaresalHMDB
DimethylethanolamineChEBI
Chemical FormulaC4H11NO
Average Molecular Weight89.1362
Monoisotopic Molecular Weight89.084063979
IUPAC Name2-(dimethylamino)ethan-1-ol
Traditional Namedimethylaminoethanol
CAS Registry Number108-01-0
SMILES
CN(C)CCO
InChI Identifier
InChI=1S/C4H11NO/c1-5(2)3-4-6/h6H,3-4H2,1-2H3
InChI KeyUEEJHVSXFDXPFK-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom.
KingdomOrganic compounds
Super ClassOrganic nitrogen compounds
ClassOrganonitrogen compounds
Sub ClassAmines
Direct Parent1,2-aminoalcohols
Alternative Parents
Substituents
  • Tertiary aliphatic amine
  • Tertiary amine
  • 1,2-aminoalcohol
  • Organic oxygen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Primary alcohol
  • Organooxygen compound
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Process
Naturally occurring process
Role
Physical Properties
StateLiquid
Experimental Molecular Properties
PropertyValueReference
Melting Point-59 °CNot Available
Boiling Point134.00 °C. @ 760.00 mm HgThe Good Scents Company Information System
Water Solubility1000 mg/mLNot Available
LogP-0.328 (est)The Good Scents Company Information System
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility1400 g/LALOGPS
logP-0.46ALOGPS
logP-0.5ChemAxon
logS1.2ALOGPS
pKa (Strongest Acidic)15.59ChemAxon
pKa (Strongest Basic)9.03ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area23.47 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity26.28 m³·mol⁻¹ChemAxon
Polarizability10.5 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+116.57631661259
DarkChem[M-H]-110.31731661259
DeepCCS[M+H]+122.1530932474
DeepCCS[M-H]-119.9130932474
DeepCCS[M-2H]-155.78830932474
DeepCCS[M+Na]+130.45230932474
AllCCS[M+H]+123.332859911
AllCCS[M+H-H2O]+119.032859911
AllCCS[M+NH4]+127.432859911
AllCCS[M+Na]+128.632859911
AllCCS[M-H]-129.232859911
AllCCS[M+Na-2H]-134.132859911
AllCCS[M+HCOO]-139.432859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
DimethylethanolamineCN(C)CCO1388.1Standard polar33892256
DimethylethanolamineCN(C)CCO716.3Standard non polar33892256
DimethylethanolamineCN(C)CCO777.5Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Dimethylethanolamine,1TMS,isomer #1CN(C)CCO[Si](C)(C)C907.6Semi standard non polar33892256
Dimethylethanolamine,1TBDMS,isomer #1CN(C)CCO[Si](C)(C)C(C)(C)C1119.7Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Dimethylethanolamine EI-B (Non-derivatized)splash10-0a4i-9000000000-5592e4a7e549a923226d2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Dimethylethanolamine CI-B (Non-derivatized)splash10-0006-9000000000-e3c643ae324aae74c4da2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Dimethylethanolamine EI-B (Non-derivatized)splash10-0a4i-9000000000-2732583805565c0992822017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Dimethylethanolamine EI-B (Non-derivatized)splash10-0a4i-9000000000-3e9a264650444af400c52017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Dimethylethanolamine EI-B (Non-derivatized)splash10-0a4i-9000000000-5592e4a7e549a923226d2018-05-18HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Dimethylethanolamine CI-B (Non-derivatized)splash10-0006-9000000000-e3c643ae324aae74c4da2018-05-18HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Dimethylethanolamine EI-B (Non-derivatized)splash10-0a4i-9000000000-2732583805565c0992822018-05-18HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Dimethylethanolamine EI-B (Non-derivatized)splash10-0a4i-9000000000-3e9a264650444af400c52018-05-18HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Dimethylethanolamine GC-MS (Non-derivatized) - 70eV, Positivesplash10-0a4i-9000000000-130bd570c14409d6e2642017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Dimethylethanolamine GC-MS (1 TMS) - 70eV, Positivesplash10-0a4i-9100000000-7e3751ce5da091343c182017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Dimethylethanolamine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
MSMass Spectrum (Electron Ionization)splash10-0a4i-9000000000-7dbd6cd421741814dc202014-09-20Not AvailableView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dimethylethanolamine 10V, Positive-QTOFsplash10-0006-9000000000-7869c8d8628610e5b56b2015-04-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dimethylethanolamine 20V, Positive-QTOFsplash10-00dl-9000000000-36e6ea5d94dc5dee8e9a2015-04-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dimethylethanolamine 40V, Positive-QTOFsplash10-00di-9000000000-bf4edbb76b100480dfc42015-04-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dimethylethanolamine 10V, Negative-QTOFsplash10-000i-9000000000-c34f99de18e22765dca82015-04-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dimethylethanolamine 20V, Negative-QTOFsplash10-000i-9000000000-2b3e58a037c39956223b2015-04-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dimethylethanolamine 40V, Negative-QTOFsplash10-0006-9000000000-198ecf458b2bd0ac56d02015-04-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dimethylethanolamine 10V, Positive-QTOFsplash10-00dl-9000000000-b1dc54e1eeb2f8609cb82021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dimethylethanolamine 20V, Positive-QTOFsplash10-00di-9000000000-c286143495e50fa10a8d2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dimethylethanolamine 40V, Positive-QTOFsplash10-00di-9000000000-446a7821af02582da1ec2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dimethylethanolamine 10V, Negative-QTOFsplash10-000i-9000000000-5497bbbd3763043445ed2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dimethylethanolamine 20V, Negative-QTOFsplash10-00dr-9000000000-e714180acbb7d1c77dce2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dimethylethanolamine 40V, Negative-QTOFsplash10-0006-9000000000-61c8f1f79345316d74212021-09-23Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-04FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-04FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-04FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedCancer patients undergoing total body irradiation details
UrineDetected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedCancer patients undergoing total body irradiation details
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB13352
Phenol Explorer Compound IDNot Available
FooDB IDFDB009311
KNApSAcK IDNot Available
Chemspider ID13854944
KEGG Compound IDC04308
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkDimethylethanolamine
METLIN IDNot Available
PubChem Compound7902
PDB IDNot Available
ChEBI ID271436
Food Biomarker OntologyNot Available
VMH IDM02758
MarkerDB IDNot Available
Good Scents IDrw1263531
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Su X, Cunningham MF, Jessop PG: Switchable viscosity triggered by CO2 using smart worm-like micelles. Chem Commun (Camb). 2013 Apr 4;49(26):2655-7. doi: 10.1039/c3cc37816k. [PubMed:23435477 ]
  2. (). EAFUS: Everything Added to Food in the United States.. .

Enzymes

General function:
Involved in sulfotransferase activity
Specific function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.
Gene Name:
SULT2B1
Uniprot ID:
O00204
Molecular weight:
39598.595
Reactions
Dimethylethanolamine → [2-(dimethylamino)ethoxy]sulfonic aciddetails
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular weight:
59590.91
Reactions
Dimethylethanolamine → 6-[2-(dimethylamino)ethoxy]-3,4,5-trihydroxyoxane-2-carboxylic aciddetails