You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.
Record Information
Version3.6
Creation Date2012-09-13 11:39:50 UTC
Update Date2016-02-11 03:55:37 UTC
HMDB IDHMDB41797
Secondary Accession NumbersNone
Metabolite Identification
Common Name2,4-Dichlorophenoxyacetic acid
Description2,4-D is a member of the phenoxy family of herbicides, which include:; 2,4-D is a synthetic auxin, which is a class of plant hormones. It is absorbed through the leaves and is translocated to the meristems of the plant. Uncontrolled, unsustainable growth ensues, causing stem curl-over, leaf withering, and eventual plant death. 2,4-D is typically applied as an amine salt, but more potent ester versions exist as well. 2,4-Dichlorophenoxyacetic acid (usually referred to by its abbreviation, 2,4-D) is a common systemic pesticide/herbicide used in the control of broadleaf weeds. It is one of the most widely used herbicide in the world, and the third most commonly used in North America. 2,4-D is a synthetic auxin (plant hormone), and as such it is often used in laboratories for plant research and as a supplement in plant cell culture media such as MS medium. It was a major ingredient in Agent Orange alongside its chemically similar relative, 2,4,5-T (2,4,5-trichlorophenoxyacetic acid).
Structure
Thumb
Synonyms
ValueSource
(2,4-Dichlorphenoxy)essigsaeureChEBI
2,4-D acidChEBI
2,4-DichlorophenoxyacetateChEBI
2,4-DichlorphenoxyessigsaeureChEBI
Acide 2,4-dichloro phenoxyacetiqueChEBI
HedonalChEBI
TrinoxolChEBI
(2, 4-Dichlorophenoxy)acetic acidHMDB
(2,4-Dichloor-fenoxy)-azijnzuurHMDB
(2,4-Dichlor-phenoxy)-essigsaeureHMDB
(2,4-Dichlorophenoxy)-acetic acidHMDB
(2,4-Dichlorophenoxy)acetic acidHMDB
(2,4-Dichlorophenoxy)acetic acid (acd/name 4.0)HMDB
(2,4-Dichlorophenyloxy)acetic acidHMDB
(2,4-Dichlorphenoxy)acetic acidHMDB
(2,4-Dichlorphenoxy)essigsaureHMDB
(Dichlorophenoxy)acetic acidHMDB
2,4-DHMDB
2,4-D MecopropHMDB
2,4-Dichlorophenoxyethanoic acidHMDB
2,4-DichlorphenoxyessigsaureHMDB
2,4-Dwuchlorofenoksyoctowy kwasHMDB
acido(2,4-dicloro-Fenossi)-aceticoHMDB
Acme amine 4HMDB
Acme butyl ester 4HMDB
Acme LV 4HMDB
AgrotectHMDB
AmidoxHMDB
Aminopielik 50SlHMDB
AmoxoneHMDB
Aqua-kleenHMDB
Atlas DHMDB
b-SelektononHMDB
Barrage HFHMDB
Brush-rhapHMDB
chipco Turf herbicide DHMDB
chipco Turf herbicide quot dquotHMDB
ChloroxoneHMDB
Crop riderHMDB
CrotilinHMDB
DacamineHMDB
Debroussaillant 600HMDB
DecamineHMDB
Ded-weedHMDB
Ded-weed LV-69HMDB
DesormoneHMDB
DezormonHMDB
DiclordonHMDB
DicopurHMDB
DicotoxHMDB
DinoxolHMDB
DMA-4HMDB
DormoneHMDB
Emulsamine BKHMDB
Emulsamine e-3HMDB
Envert 171HMDB
Envert DTHMDB
EsteronHMDB
Esteron 44 weed killerHMDB
Esteron 76 beHMDB
Esteron 99HMDB
Esteron 99 concentrateHMDB
Esteron brush killerHMDB
EsteroneHMDB
Esterone fourHMDB
EstoneHMDB
FarmcoHMDB
FernestaHMDB
FernimineHMDB
FernoxoneHMDB
FerxoneHMDB
Foredex 75HMDB
Formula 40HMDB
Hedonal (the herbicide)HMDB
Hedonal, herbicideHMDB
HerbidalHMDB
HuraganHMDB
IpanerHMDB
KrotilineHMDB
Kwas 2,4-dwuchlorofenoksyoctowyHMDB
Kwasu 2,4-dwuchlorofenoksyoctowegoHMDB
Kyselina 2,4-dichlorfenoxyoctovaHMDB
Lawn-keepHMDB
MacrondrayHMDB
MiracleHMDB
MonosanHMDB
Mota maskrosHMDB
MoxoneHMDB
NetagroneHMDB
Netagrone 600HMDB
PennamineHMDB
Pennamine DHMDB
PhenoxHMDB
PielikHMDB
PlanotoxHMDB
PlantgardHMDB
RCRA waste number u240HMDB
RhodiaHMDB
SalvoHMDB
SpontoxHMDB
Spritz-hormin/2,4-DHMDB
Spritz-hormit/2,4-DHMDB
Super D weedoneHMDB
Superormone concentreHMDB
Tiller SHMDB
TransamineHMDB
TributonHMDB
UnisoHMDB
VergemasterHMDB
VertonHMDB
Verton 2-DHMDB
Verton 2DHMDB
Verton DHMDB
Vertron 2DHMDB
Vidon 638HMDB
visko-RhapHMDB
visko-Rhap low drift herbicidesHMDB
visko-Rhap low volatile 4lHMDB
Weed toxHMDB
Weed-ag-barHMDB
Weed-b-gonHMDB
Weed-rhapHMDB
WeedarHMDB
Weedar-64HMDB
WeedatulHMDB
Weedez wonder barHMDB
WeedoneHMDB
Weedone LV4HMDB
WeedtrolHMDB
Chemical FormulaC8H6Cl2O3
Average Molecular Weight221.037
Monoisotopic Molecular Weight219.969399472
IUPAC Name2-(2,4-dichlorophenoxy)acetic acid
Traditional Namerhodia
CAS Registry Number94-75-7
SMILES
OC(=O)COC1=C(Cl)C=C(Cl)C=C1
InChI Identifier
InChI=1S/C8H6Cl2O3/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2,(H,11,12)
InChI KeyInChIKey=OVSKIKFHRZPJSS-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenoxyacetic acid derivatives. These are compounds containing an anisole where the methane group is linked to an acetic acid or a derivative.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenoxyacetic acid derivatives
Direct ParentPhenoxyacetic acid derivatives
Alternative Parents
Substituents
  • Phenoxyacetate
  • Phenol ether
  • 1,3-dichlorobenzene
  • Halobenzene
  • Chlorobenzene
  • Alkyl aryl ether
  • Aryl halide
  • Aryl chloride
  • Monocarboxylic acid or derivatives
  • Ether
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organochloride
  • Organohalogen compound
  • Carbonyl group
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
Biofunction
  • Nutrient
ApplicationNot Available
Cellular locations
  • Membrane (predicted from logP)
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point140.5 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.677 mg/mL at 25 °CNot Available
LogP2.81Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.55 mg/mLALOGPS
logP2.82ALOGPS
logP2.5ChemAxon
logS-2.6ALOGPS
pKa (Strongest Acidic)2.81ChemAxon
pKa (Strongest Basic)-4.9ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area46.53 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity48.22 m3·mol-1ChemAxon
Polarizability19.28 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-03di-2920000000-124d727a3888770108bfView in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
Biological Properties
Cellular Locations
  • Membrane (predicted from logP)
Biofluid Locations
  • Urine
Tissue LocationNot Available
PathwaysNot Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
UrineDetected and Quantified0.000116 (0.0000962-0.000140) umol/mmol creatinineAdult (>18 years old)Not SpecifiedNormal
    • National Health a...
details
UrineDetected and Quantified0.000165 (0.000127-0.000215) umol/mmol creatinineChildren (1-13 years old)Not SpecifiedNormal
    • National Health a...
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID1441
KEGG Compound IDC03664
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia Link2,4-dichlorophenoxyacetic_acid
NuGOwiki LinkHMDB41797
Metagene LinkHMDB41797
METLIN IDNot Available
PubChem Compound1486
PDB IDCFA
ChEBI ID28854
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General ReferencesNot Available