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Identification
HMDB Protein ID HMDBP00003
Secondary Accession Numbers
  • 5231
  • HMDBP03350
Name UMP-CMP kinase
Synonyms
  1. Cytidine monophosphate kinase
  2. Cytidylate kinase
  3. Deoxycytidylate kinase
  4. UMP/CMP kinase
  5. UMP/CMPK
  6. Uridine monophosphate kinase
  7. Uridine monophosphate/cytidine monophosphate kinase
Gene Name CMPK1
Protein Type Unknown
Biological Properties
General Function Involved in ATP binding
Specific Function Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.
Pathways
  • Congenital disorder of glycosylation CDG-IId
  • Gemcitabine Action Pathway
  • Gemcitabine Metabolism Pathway
  • GLUT-1 deficiency syndrome
  • Lactose Synthesis
  • Lamivudine Metabolism Pathway
  • Pyrimidine metabolism
Reactions
Adenosine triphosphate + (d)CMP → ADP + (d)CDP details
Adenosine triphosphate + Uridine 5'-monophosphate → ADP + Uridine 5'-diphosphate details
Adenosine triphosphate + Cytidine monophosphate → ADP + CDP details
Adenosine triphosphate + dCMP → ADP + dCDP details
GO Classification
Biological Process
nucleobase-containing small molecule interconversion
Cellular Component
cytosol
nucleus
Function
binding
catalytic activity
nucleotide kinase activity
phosphotransferase activity, phosphate group as acceptor
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleobase, nucleoside, nucleotide kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
Molecular Function
ATP binding
cytidylate kinase activity
phosphotransferase activity, phosphate group as acceptor
uridine kinase activity
Process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Cellular Location
  1. Nucleus
  2. Cytoplasm
Gene Properties
Chromosome Location 1
Locus 1p32
SNPs CMPK1
Gene Sequence
>591 bp
ATGAAGCCGCTGGTCGTGTTCGTCCTCGGCGGCCCCGGCGCCGGCAAGGGGACCCAGTGC
GCCCGCATCGTCGAGAAATATGGCTACACACACCTTTCTGCAGGAGAGCTGCTTCGTGAT
GAAAGGAAGAACCCAGATTCACAGTATGGTGAACTTATTGAAAAGTACATTAAAGAAGGA
AAGATTGTACCAGTTGAGATAACCATCAGTTTATTAAAGAGGGAAATGGATCAGACAATG
GCTGCCAATGCTCAGAAGAATAAATTCTTGATTGATGGGTTTCCAAGAAATCAAGACAAC
CTTCAAGGATGGAACAAGACCATGGATGGGAAGGCAGATGTATCTTTCGTTCTCTTTTTT
GACTGTAATAATGAGATTTGTATTGAACGATGTCTTGAGAGGGGAAAGAGTAGTGGTAGG
AGTGATGACAACAGAGAGAGCTTGGAAAAGAGAATTCAGACCTACCTTCAGTCAACAAAG
CCAATTATTGACTTATATGAAGAAATGGGGAAAGTCAAGAAAATAGATGCTTCTAAATCT
GTTGATGAAGTTTTTGATGAAGTTGTGCAGATTTTTGACAAGGAAGGCTAA
Protein Properties
Number of Residues 196
Molecular Weight 20180.12
Theoretical pI 7.631
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>UMP-CMP kinase
MKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEG
KIVPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFF
DCNNEICIERCLERGKSSGRSDDNRESLEKRIQTYLQSTKPIIDLYEEMGKVKKIDASKS
VDEVFDEVVQIFDKEG
GenBank ID Protein 33150592
UniProtKB/Swiss-Prot ID P30085
UniProtKB/Swiss-Prot Entry Name KCY_HUMAN
PDB IDs
GenBank Gene ID AF087865
GeneCard ID CMPK1
GenAtlas ID CMPK1
HGNC ID HGNC:18170
References
General References
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  2. Van Rompay AR, Johansson M, Karlsson A: Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme. Mol Pharmacol. 1999 Sep;56(3):562-9. [PubMed:10462544 ]
  3. Pearman AT, Castro-Faria-Neto HC, McIntyre TM, Prescott SM, Stafforini DM: Characterization of human UMP-CMP kinase enzymatic activity and 5' untranslated region. Life Sci. 2001 Oct 5;69(20):2361-70. [PubMed:11681623 ]
  4. Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC: Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res. 2002 Mar 15;62(6):1624-31. [PubMed:11912132 ]
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  7. Hughes GJ, Frutiger S, Paquet N, Pasquali C, Sanchez JC, Tissot JD, Bairoch A, Appel RD, Hochstrasser DF: Human liver protein map: update 1993. Electrophoresis. 1993 Nov;14(11):1216-22. [PubMed:8313870 ]
  8. Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R, et al.: Human liver protein map: a reference database established by microsequencing and gel comparison. Electrophoresis. 1992 Dec;13(12):992-1001. [PubMed:1286669 ]
  9. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  10. Segura-Pena D, Sekulic N, Ort S, Konrad M, Lavie A: Substrate-induced conformational changes in human UMP/CMP kinase. J Biol Chem. 2004 Aug 6;279(32):33882-9. Epub 2004 May 26. [PubMed:15163660 ]