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Identification
HMDB Protein ID HMDBP00101
Secondary Accession Numbers
  • 5333
  • HMDBP05597
Name Acetylserotonin O-methyltransferase
Synonyms
  1. ASMT
  2. Acetylserotonin O-methyltransferase
  3. HIOMT
  4. Hydroxyindole O-methyltransferase
Gene Name ASMT
Protein Type Unknown
Biological Properties
General Function Involved in O-methyltransferase activity
Specific Function Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.
Pathways
  • melatonin biosynthesis
  • Tryptophan metabolism
  • Tryptophan metabolism
Reactions
S-Adenosylmethionine + N-Acetylserotonin → S-Adenosylhomocysteine + Melatonin details
S-Adenosylmethionine + 5-Hydroxyindoleacetic acid → S-Adenosylhomocysteine + 5-Methoxyindoleacetate details
GO Classification
Biological Process
small molecule metabolic process
indolalkylamine biosynthetic process
melatonin biosynthetic process
translation
Cellular Component
cytosol
Function
o-methyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
Molecular Function
acetylserotonin O-methyltransferase activity
O-methyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location X, Y
Locus Xp22.3 or Yp11.3
SNPs ASMT
Gene Sequence
>1038 bp
ATGGGATCCTCAGAGGACCAGGCCTATCGCCTCCTTAATGACTACGCCAACGGCTTCATG
GTGTCCCAGGTTCTCTTCGCCGCCTGCGAGCTGGGCGTGTTTGACCTTCTCGCCGAGGCC
CCAGGGCCCCTGGACGTGGCGGCAGTGGCTGCAGGTGTGAGGGCCAGCGCCCATGGGACA
GAGCTCCTGCTGGACATCTGTGTGTCCCTGAAGCTGCTGAAAGTGGAGACGAGGGGAGGA
AAAGCTTTCTATCGAAACACAGAGCTGTCCAGCGACTACCTGACCACGGTCAGCCCGACG
TCACAATGCAGCATGCTGAAGTACATGGGCAGGACCAGCTACCGGTGCTGGGGCCACCTG
GCAGACGCCGTGAGAGAAGGAAGGAACCAGTACCTGGAGACGTTTGGCGTTCCCGCTGAA
GAGCTTTTTACGGCCATCTACAGGTCCGAGGGCGAGCGGCTACAGTTCATGCAAGCTCTG
CAGGAGGTCTGGAGCGTCAACGGGAGAAGCGTGCTGACCGCCTTTGACCTGTCAGTGTTC
CCACTTATGTGTGACCTTGGTGGTGGGGCTGGAGCTCTGGCTAAGGAATGCATGTCTCTG
TACCCTGGATGTAAGATCACCGTTTTTGACATCCCAGAAGTGGTGTGGACGGCAAAGCAG
CACTTCTCATTCCAGGAGGAAGAACAGATTGACTTCCAGGAAGGGGATTTCTTCAAAGAC
CCTCTTCCGGAAGCTGATCTGTACATCCTGGCCAGGGTCCTCCATGACTGGGCAGACGGA
AAGTGCTCACACCTGCTGGAGAGGATCTACCACACTTGCAAGCCAGGTGGTGGCATTCTG
GTAATTGAAAGCCTCCTGGATGAAGACAGGCGAGGTCCTCTGCTCACGCAGCTCTACTCT
CTGAACATGCTTGTGCAGACGGAAGGGCAGGAGAGGACCCCCACCCACTACCACATGCTC
CTCTCTTCTGCTGGCTTCAGAGACTTCCAGTTTAAGAAAACAGGAGCCATTTATGATGCC
ATTTTAGCCAGGAAATAA
Protein Properties
Number of Residues 345
Molecular Weight 41660.34
Theoretical pI 5.693
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Hydroxyindole O-methyltransferase
MGSSEDQAYRLLNDYANGFMVSQVLFAACELGVFDLLAEAPGPLDVAAVAAGVRASAHGT
ELLLDICVSLKLLKVETRGGKAFYRNTELSSDYLTTVSPTSQCSMLKYMGRTSYRCWGHL
ADAVREGRNQYLETFGVPAEELFTAIYRSEGERLQFMQALQEVWSVNGRSVLTAFDLSVF
PLMCDLGGGAGALAKECMSLYPGCKITVFDIPEVVWTAKQHFSFQEEEQIDFQEGDFFKD
PLPEADLYILARVLHDWADGKCSHLLERIYHTCKPGGGILVIESLLDEDRRGPLLTQLYS
LNMLVQTEGQERTPTHYHMLLSSAGFRDFQFKKTGAIYDAILARK
GenBank ID Protein 57209912
UniProtKB/Swiss-Prot ID P46597
UniProtKB/Swiss-Prot Entry Name HIOM_HUMAN
PDB IDs
GenBank Gene ID AL683807
GeneCard ID ASMT
GenAtlas ID ASMT
HGNC ID HGNC:750
References
General References
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  4. Rodriguez IR, Mazuruk K, Schoen TJ, Chader GJ: Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters. J Biol Chem. 1994 Dec 16;269(50):31969-77. [PubMed:7989373 ]
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