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Identification
HMDB Protein ID HMDBP00405
Secondary Accession Numbers
  • 5642
  • HMDBP03963
Name S-adenosylmethionine synthase isoform type-2
Synonyms
  1. AdoMet synthase 2
  2. MAT 2
  3. MAT-II
  4. Methionine adenosyltransferase 2
  5. Methionine adenosyltransferase II
Gene Name MAT2A
Protein Type Unknown
Biological Properties
General Function Involved in methionine adenosyltransferase activity
Specific Function Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Pathways
  • Betaine Metabolism
  • Cystathionine Beta-Synthase Deficiency
  • Cysteine and methionine metabolism
  • Glycine N-methyltransferase Deficiency
  • Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type
  • Hypermethioninemia
  • Methionine Adenosyltransferase Deficiency
  • Methionine Metabolism
  • Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
  • S-adenosyl-L-methionine biosynthesis
  • S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
  • Sarcosine Oncometabolite Pathway
  • Selenoamino Acid Metabolism
  • Spermidine and Spermine Biosynthesis
Reactions
Adenosine triphosphate + L-Methionine + Water → Phosphoric acid + Pyrophosphate + S-Adenosylmethionine details
Phosphoric acid + Pyrophosphate + S-Adenosylmethionine → Adenosine triphosphate + L-Methionine + Water details
Adenosine triphosphate + Selenomethionine + Water → Phosphoric acid + Pyrophosphate + Se-Adenosylselenomethionine details
GO Classification
Biological Process
cellular nitrogen compound metabolic process
response to hormone stimulus
response to light stimulus
response to drug
sulfur amino acid metabolic process
xenobiotic metabolic process
S-adenosylmethionine biosynthetic process
methanogenesis
methylation
one-carbon metabolic process
response to cAMP
circadian rhythm
Cellular Component
cytosol
Function
binding
catalytic activity
transferase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
methionine adenosyltransferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
Molecular Function
metal ion binding
ATP binding
methionine adenosyltransferase activity
Process
metabolic process
cellular metabolic process
one-carbon metabolic process
Cellular Location Not Available
Gene Properties
Chromosome Location 2
Locus 2p11.2
SNPs MAT2A
Gene Sequence
>1188 bp
ATGAACGGACAGCTCAACGGCTTCCACGAGGCGTTCATCGAGGAGGGCACATTCCTTTTC
ACCTCAGAGTCGGTCGGGGAAGGCCACCCAGATAAGATTTGTGACCAAATCAGTGATGCT
GTCCTTGATGCCCACCTTCAGCAGGATCCTGATGCCAAAGTAGCTTGTGAAACTGTTGCT
AAAACTGGAATGATCCTTCTTGCTGGGGAAATTACATCCAGAGCTGCTGTTGACTACCAG
AAAGTGGTTCGTGAAGCTGTTAAACACATTGGATATGATGATTCTTCCAAAGGTTTTGAC
TACAAGACTTGTAACGTGCTGGTAGCCTTGGAGCAACAGTCACCAGATATTGCTCAAGGT
GTTCATCTTGACAGAAATGAAGAAGACATTGGTGCTGGAGACCAGGGCTTAATGTTTGGC
TATGCCACTGATGAAACTGAGGAGTGTATGCCTTTAACCATTGTCTTGGCACACAAGCTA
AATGCCAAACTGGCAGAACTACGCCGTAATGGCACTTTGCCTTGGTTACGCCCTGATTCT
AAAACTCAAGTTACTGTGCAGTATATGCAGGATCGAGGTGCTGTGCTTCCCATCAGAGTC
CACACAATTGTTATATCTGTTCAGCATGATGAAGAGGTTTGTCTTGATGAAATGAGGGAT
GCCCTAAAGGAGAAAGTCATCAAAGCAGTTGTGCCTGCGAAATACCTTGATGAGGATACA
ATCTACCACCTACAGCCAAGTGGCAGATTTGTTATTGGTGGGCCTCAGGGTGATGCTGGT
TTGACTGGACGGAAAATCATTGTGGACACTTATGGCGGTTGGGGTGCTCATGGAGGAGGT
GCCTTTTCAGGAAAGGATTATACCAAGGTCGACCGTTCAGCTGCTTATGCTGCTCGTTGG
GTGGCAAAATCCCTTGTTAAAGGAGGTCTGTGCCGGAGGGTTCTTGTTCAGGTCTCTTAT
GCTATTGGAGTTTCTCATCCATTATCTATCTCCATTTTCCATTATGGTACCTCTCAGAAG
AGTGAGAGAGAGCTATTAGAGATTGTGAAGAAGAATTTCGATCTCCGCCCTGGGGTCATT
GTCAGGGATCTGGATCTGAAGAAGCCAATTTATCAGAGGACTGCAGCCTATGGCCACTTT
GGTAGGGACAGCTTCCCATGGGAAGTGCCCAAAAAGCTTAAATATTGA
Protein Properties
Number of Residues 395
Molecular Weight 43660.37
Theoretical pI 6.48
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>S-adenosylmethionine synthase isoform type-2
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
GenBank ID Protein 36327
UniProtKB/Swiss-Prot ID P31153
UniProtKB/Swiss-Prot Entry Name METK2_HUMAN
PDB IDs
GenBank Gene ID X68836
GeneCard ID MAT2A
GenAtlas ID MAT2A
HGNC ID HGNC:6904
References
General References
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