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Identification
HMDB Protein ID HMDBP00934
Secondary Accession Numbers
  • 6222
Name Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
Synonyms
  1. Beta-1,3-glucuronyltransferase 2
  2. GlcAT-D
  3. GlcAT-S
  4. Glucuronosyltransferase S
  5. UDP-glucuronosyltransferase S
Gene Name B3GAT2
Protein Type Unknown
Biological Properties
General Function Involved in galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
Specific Function Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins (By similarity).
Pathways
  • Other types of O-glycan biosynthesis
  • protein glycosylation
Reactions
Uridine diphosphate glucuronic acid + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein → Uridine 5'-diphosphate + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein details
GO Classification
Biological Process
protein glycosylation
carbohydrate metabolic process
chondroitin sulfate metabolic process
Cellular Component
integral to membrane
Golgi membrane
Component
membrane
cell part
Function
catalytic activity
transferase activity
glucuronosyltransferase activity
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
udp-glycosyltransferase activity
transferase activity, transferring glycosyl groups
Molecular Function
metal ion binding
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
Cellular Location
  1. Golgi apparatus membrane
  2. Single-pass type II membrane protein
Gene Properties
Chromosome Location 6
Locus 6q13
SNPs B3GAT2
Gene Sequence
>972 bp
ATGAAGTCCGCGCTTTTCACCCGCTTCTTTATCCTCCTGCCCTGGATCCTAATTGTCATC
ATCATGCTCGACGTGGACACGCGCAGGCCAGTGCCCCCGCTCACCCCGCGCCCCTACTTC
TCTCCCTACGCGGTGGGCCGCGGGGGCGCCCGACTCCCGCTCCGCAGGGGCGGCCCGGCT
CACGGGACCCAAAAGCGCAACCAGTCTCGGCCGCAGCCACAGCCGGAGCCGCAGCTGCCC
ACCATCTATGCCATCACGCCCACCTACAGCCGCCCGGTGCAGAAAGCGGAGCTGACCCGC
CTGGCCAACACGTTCCGCCAGGTGGCGCAGCTGCACTGGATCCTGGTGGAGGACGCGGCG
GCGCGCAGCGAGCTGGTGAGCCGCTTCCTGGCGCGGGCCGGGCTGCCCAGCACTCACCTG
CACGTGCCCACGCCGCGGCGCTACAAGCGGCCCGGGCTGCCGCGCGCCACTGAGCAGCGC
AACGCGGGCCTCGCCTGGCTGCGCCAGAGGCACCAGCACCAGCGCGCGCAGCCCGGCGTG
CTCTTCTTCGCTGACGACGACAACACCTATAGTCTGGAGCTCTTCCAGGAGATGCGAACC
ACCCGCAAGGTCTCCGTCTGGCCTGTGGGCCTGGTTGGTGGGCGGCGCTACGAACGTCCG
CTGGTGGAAAACGGCAAAGTTGTTGGCTGGTACACCGGCTGGAGAGCAGACAGGCCTTTT
GCCATCGACATGGCAGGATTTGCTGTAAGTCTTCAAGTCATTTTGTCCAATCCAAAAGCT
GTATTTAAGCGTCGTGGATCCCAGCCAGGGATGCAAGAATCTGACTTTCTCAAACAGATA
ACAACAGTCGAAGAACTGGAACCGAAAGCAAATAACTGCACTAAGGTTCTCGTGTGGCAC
ACTCGGACAGAGAAGGTTAATCTAGCCAACGAGCCAAAGTACCACCTGGACACAGTGAAA
ATTGAGGTATAA
Protein Properties
Number of Residues 323
Molecular Weight 36918.42
Theoretical pI 10.629
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
MKSALFTRFFILLPWILIVIIMLDVDTRRPVPPLTPRPYFSPYAVGRGGARLPLRRGGPA
HGTQKRNQSRPQPQPEPQLPTIYAITPTYSRPVQKAELTRLANTFRQVAQLHWILVEDAA
ARSELVSRFLARAGLPSTHLHVPTPRRYKRPGLPRATEQRNAGLAWLRQRHQHQRAQPGV
LFFADDDNTYSLELFQEMRTTRKVSVWPVGLVGGRRYERPLVENGKVVGWYTGWRADRPF
AIDMAGFAVSLQVILSNPKAVFKRRGSQPGMQESDFLKQITTVEELEPKANNCTKVLVWH
TRTEKVNLANEPKYHLDTVKIEV
GenBank ID Protein 18152775
UniProtKB/Swiss-Prot ID Q9NPZ5
UniProtKB/Swiss-Prot Entry Name B3GA2_HUMAN
PDB IDs
GenBank Gene ID NM_080742.2
GeneCard ID B3GAT2
GenAtlas ID B3GAT2
HGNC ID HGNC:922
References
General References
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  3. Marcos I, Galan JJ, Borrego S, Antinolo G: Cloning, characterization, and chromosome mapping of the human GlcAT-S gene. J Hum Genet. 2002;47(12):677-80. [PubMed:12522689 ]
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