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Identification
HMDB Protein ID HMDBP01088
Secondary Accession Numbers
  • 6377
Name Ribokinase
Synonyms Not Available
Gene Name RBKS
Protein Type Enzyme
Biological Properties
General Function Involved in ribokinase activity
Specific Function Not Available
Pathways
  • D-ribose degradation
  • Glucose-6-phosphate dehydrogenase deficiency
  • Pentose Phosphate Pathway
  • Pentose phosphate pathway
  • Ribose-5-phosphate isomerase deficiency
  • Transaldolase deficiency
Reactions
Adenosine triphosphate + D-Ribose → ADP + D-Ribose 5-phosphate details
Deoxyribose 5-monophosphate + ADP → Deoxyribose + Adenosine triphosphate details
GO Classification
Biological Process
D-ribose catabolic process
Function
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
ribokinase activity
Molecular Function
ATP binding
ribokinase activity
Process
metabolic process
small molecule metabolic process
alcohol metabolic process
monosaccharide metabolic process
pentose metabolic process
d-ribose metabolic process
Cellular Location Not Available
Gene Properties
Chromosome Location 2
Locus 2p23.3
SNPs RBKS
Gene Sequence
>969 bp
ATGGCGGCGTCTGGGGAACCCCAGAGGCAGTGGCAAGAGGAGGTGGCGGCGGTGGTAGTG
GTGGGCTCCTGCATGACCGACCTGGTCAGTCTTACTTCTCGTTTGCCAAAAACTGGAGAA
ACCATCCATGGACATAAGTTTTTTATTGGCTTTGGAGGGAAAGGTGCCAACCAGTGTGTC
CAAGCTGCTCGGCTTGGAGCAATGACGTCCATGGTGTGTAAGGTTGGCAAAGATTCTTTT
GGCAATGATTATATAGAAAACTTAAAACAGAATGATATTTCTACAGAATTTACATATCAG
ACTAAAGATGCTGCTACAGGAACTGCTTCTATAATTGTCAATAATGAAGGCCAGAATATC
ATTGTCATAGTGGCTGGAGCAAATTTACTTTTGAATACGGAGGATCTGAGGGCAGCAGCC
AATGTCATTAGCAGAGCCAAAGTCATGGTCTGCCAGCTCGAAATAACTCCAGCAACTTCT
TTGGAAGCCCTAACAATGGCCCGCAGGAGTGGAGTGAAAACCTTGTTCAATCCAGCCCCT
GCCATTGCTGACCTGGATCCCCAGTTCTACACCCTCTCAGATGTGTTCTGCTGCAATGAA
AGTGAGGCTGAGATTTTAACTGGCCTCACGGTGGGCAGCGCTGCAGATGCTGGGGAGGCT
GCATTAGTGCTCTTGAAAAGGGGCTGCCAGGTGGTAATCATTACCTTAGGGGCTGAAGGA
TGTGTGGTGCTGTCACAGACAGAACCTGAGCCAAAGCACATTCCCACAGAGAAAGTCAAG
GCTGTGGATACCACGGGTGCTGGTGACAGCTTTGTGGGAGCTCTGGCCTTCTACCTGGCT
TACTATCCAAATCTGTCCTTGGAAGACATGCTCAACAGATCCAATTTCATTGCAGCAGTC
AGTGTCCAGGCTGCAGGAACACAGTCATCTTACCCTTACAAAAAAGACCTTCCGCTTACT
CTGTTTTGA
Protein Properties
Number of Residues 322
Molecular Weight 34142.685
Theoretical pI 5.045
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Ribokinase
MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV
QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI
IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAP
AIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG
CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV
SVQAAGTQSSYPYKKDLPLTLF
GenBank ID Protein 10799803
UniProtKB/Swiss-Prot ID Q9H477
UniProtKB/Swiss-Prot Entry Name RBSK_HUMAN
PDB IDs
GenBank Gene ID AJ404857
GeneCard ID RBKS
GenAtlas ID RBKS
HGNC ID HGNC:30325
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Park J, van Koeverden P, Singh B, Gupta RS: Identification and characterization of human ribokinase and comparison of its properties with E. coli ribokinase and human adenosine kinase. FEBS Lett. 2007 Jul 10;581(17):3211-6. Epub 2007 Jun 15. [PubMed:17585908 ]