Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP01110
Secondary Accession Numbers
  • 6403
Name Monocarboxylate transporter 7
Synonyms
  1. MCT 6
  2. MCT 7
  3. Monocarboxylate transporter 6
  4. Solute carrier family 16 member 6
Gene Name SLC16A6
Protein Type Enzyme
Biological Properties
General Function Involved in transmembrane transport
Specific Function Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate
Pathways Not Available
Reactions Not Available
GO Classification
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 17q24.2
SNPs SLC16A6
Gene Sequence
>1572 bp
ATGACCCAAAATAAATTAAAGCTTTGTTCCAAAGCCAATGTGTATACTGAAGTGCCTGAT
GGAGGATGGGGCTGGGCGGTAGCTGTTTCATTTTTCTTCGTTGAAGTCTTCACCTACGGC
ATCATCAAGACATTTGGTGTCTTCTTTAATGACTTAATGGACAGTTTTAATGAATCCAAT
AGCAGGATCTCATGGATAATCTCAATCTGTGTGTTTGTCTTAACATTTTCAGCTCCCCTC
GCCACAGTCCTGAGCAATCGTTTCGGACACCGTCTGGTAGTGATGTTGGGGGGGCTACTT
GTCAGCACCGGGATGGTGGCCGCCTCCTTCTCACAAGAGGTTTCTCATATGTACGTCGCC
ATCGGCATCATCTCTGGTCTGGGATACTGCTTTAGTTTTCTCCCAACTGTAACCATCCTA
TCACAATATTTTGGCAAAAGACGTTCCATAGTCACTGCAGTTGCTTCCACAGGAGAATGT
TTCGCTGTGTTTGCTTTCGCACCAGCAATCATGGCTCTGAAGGAGCGCATTGGCTGGAGA
TACAGCCTCCTCTTCGTGGGCCTACTACAGTTAAACATTGTCATCTTCGGAGCACTGCTC
AGACCCATCTTTATCAGAGGACCAGCGTCACCGAAAATAGTCATCCAGGAAAATCGGAAA
GAAGCGCAGTATATGCTTGAAAATGAGAAAACACGAACCTCAATAGACTCCATTGACTCA
GGAGTAGAACTAACTACCTCACCTAAAAATGTGCCTACTCACACTAACCTGGAACTGGAG
CCGAAGGCCGACATGCAGCAGGTCCTGGTGAAGACCAGCCCCAGGCCAAGCGAAAAGAAA
GCCCCGCTATTAGACTTCTCCATTTTGAAAGAGAAAAGTTTTATTTGTTATGCATTATTT
GGTCTCTTTGCAACACTGGGATTCTTTGCACCTTCCTTGTACATCATTCCTCTGGGCATT
AGTCTGGGCATTGACCAGGACCGCGCTGCTTTTTTATTATCTACGATGGCCATTGCAGAA
GTTTTCGGAAGGATCGGAGCTGGTTTTGTCCTCAACAGGGAGCCCATTCGTAAGATTTAC
ATTGAGCTCATCTGCGTCATCTTATTGACTGTGTCTCTGTTTGCCTTTACTTTTGCTACT
GAATTCTGGGGTCTAATGTCATGCAGCATATTTTTTGGGTTTATGGTTGGAACAATAGGA
GGGACTCACATTCCACTGCTTGCTGAGGATGATGTCGTGGGCATTGAGAAGATGTCTTCT
GCAGCTGGGGTCTACATCTTCATTCAGAGCATAGCAGGACTGGCTGGACCGCCCCTTGCA
GGTTTGTTGGTGGACCAAAGTAAGATCTACAGCAGGGCCTTCTACTCCTGCGCAGCTGGC
ATGGCCCTGGCTGCTGTGTGCCTCGCCCTGGTGAGACCGTGTAAGATGGGACTGTGCCAG
CATCATCACTCAGGTGAAACAAAGGTAGTGAGCCATCGTGGGAAGACTTTACAGGACATA
CCTGAAGACTTTCTGGAAATGGATCTTGCAAAAAATGAGCACAGAGTTCACGTGCAAATG
GAGCCGGTATGA
Protein Properties
Number of Residues 523
Molecular Weight 57392.8
Theoretical pI 7.88
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 22-42
  • 63-83
  • 92-112
  • 119-139
  • 150-170
  • 185-205
  • 300-320
  • 331-351
  • 359-379
  • 382-402
  • 424-444
  • 453-473
Protein Sequence
>Monocarboxylate transporter 7
MTQNKLKLCSKANVYTEVPDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESN
SRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVA
IGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWR
YSLLFVGLLQLNIVIFGALLRPIFIRGPASPKIVIQENRKEAQYMLENEKTRTSIDSIDS
GVELTTSPKNVPTHTNLELEPKADMQQVLVKTSPRPSEKKAPLLDFSILKEKSFICYALF
GLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIY
IELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSS
AAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVRPCKMGLCQ
HHHSGETKVVSHRGKTLQDIPEDFLEMDLAKNEHRVHVQMEPV
GenBank ID Protein 40675572
UniProtKB/Swiss-Prot ID O15403
UniProtKB/Swiss-Prot Entry Name MOT7_HUMAN
PDB IDs Not Available
GenBank Gene ID BC064832
GeneCard ID SLC16A6
GenAtlas ID SLC16A6
HGNC ID HGNC:10927
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  3. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
  4. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
  5. Price NT, Jackson VN, Halestrap AP: Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem J. 1998 Jan 15;329 ( Pt 2):321-8. [PubMed:9425115 ]