Human Metabolome Database: Showing Protein Mitogen-activated protein kinase kinase kinase 10 (HMDBP01371)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 metabolites

Identification

HMDB Protein ID

HMDBP01371

Secondary Accession Numbers

6667

Name

Mitogen-activated protein kinase kinase kinase 10

Synonyms

Mixed lineage kinase 2
Protein kinase MST

Gene Name

MAP3K10

Protein Type

Unknown

Biological Properties

General Function

Involved in protein kinase activity

Specific Function

Activates the JUN N-terminal pathway

Pathways

Not Available

Reactions

Not Available

GO Classification

Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation

Cellular Location

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

19q13.2

SNPs

MAP3K10

Gene Sequence

>2865 bp
ATGGAGGAGGAGGAGGGGGCGGTGGCCAAGGAGTGGGGCACGACCCCCGCGGGGCCCGTC
TGGACCGCGGTGTTCGACTACGAGGCGGCGGGCGACGAGGAGCTGACCCTGCGGAGGGGC
GATCGCGTCCAGGTGCTTTCCCAAGACTGTGCGGTGTCCGGCGACGAGGGCTGGTGGACC
GGGCAGCTCCCCAGCGGCCGCGTGGGCGTCTTCCCCAGCAACTACGTGGCCCCCGGCGCC
CCCGCTGCACCCGCGGGCCTCCAGCTGCCCCAGGAGATCCCCTTCCACGAGCTGCAGCTA
GAGGAGATCATCGGTGTGGGGGGCTTTGGCAAGGTCTATCGGGCCCTGTGGCGTGGCGAG
GAGGTGGCAGTCAAGGCCGCCCGGCTGGACCCTGAGAAGGACCCGGCAGTGACAGCGGAG
CAGGTGTGCCAGGAAGCCCGGCTCTTTGGAGCCCTGCAGCACCCCAACATAATTGCCCTT
AGGGGCGCCTGCCTCAACCCCCCACACCTCTGCCTAGTGATGGAGTATGCCCGGGGTGGT
GCACTGAGCAGGGTGCTGGCAGGTCGCCGGGTGCCACCTCACGTGCTGGTCAACTGGGCT
GTGCAGGTGGCCCGGGGCATGAACTACCTACACAATGATGCCCCTGTGCCCATCATCCAC
CGGGACCTCAAGTCCATCAACATCCTGATCCTGGAGGCCATCGAGAACCACAACCTCGCA
GACACGGTGCTCAAGATCACGGACTTCGGCCTCGCCCGCGAGTGGCACAAGACCACCAAG
ATGAGCGCTGCGGGGACCTACGCCTGGATGGCGCCGGAGGTTATCCGTCTCTCCCTCTTC
TCCAAAAGCAGTGATGTCTGGAGCTTCGGGGTGCTGCTGTGGGAGCTGCTGACGGGGGAG
GTCCCCTACCGTGAGATCGACGCCTTGGCCGTGGCGTATGGCGTGGCTATGAATAAGCTG
ACGCTGCCCATTCCCTCCACGTGCCCCGAGCCCTTTGCCCGCCTCCTGGAGGAATGCTGG
GACCCAGACCCCCACGGGCGGCCAGATTTCGGTAGCATCTTGAAGCGGCTTGAAGTCATC
GAACAGTCAGCCCTGTTCCAGATGCCACTGGAGTCCTTCCACTCGCTGCAGGAAGACTGG
AAGCTGGAGATTCAGCACATGTTTGATGACCTTCGGACCAAGGAGAAGGAGCTTCGGAGC
CGTGAGGAGGAGCTGCTGCGGGCGGCACAGGAGCAGCGCTTCCAGGAGGAGCAGCTGCGG
CGGCGGGAGCAGGAGCTGGCAGAACGTGAGATGGACATCGTGGAACGGGAGCTGCACCTG
CTCATGTGCCAGCTGAGCCAGGAGAAGCCCCGGGTCCGCAAGCGCAAGGGCAACTTCAAG
CGCAGCCGCCTGCTCAAGCTGCGGGAAGGCGGCAGCCACATCAGCCTGCCCTCTGGCTTT
GAGCATAAGATCACAGTCCAGGCCTCTCCAACTCTGGATAAGCGGAAAGGATCCGATGGG
GCCAGCCCCCCTGCAAGCCCCAGCATCATCCCCCGGCTGAGGGCCATTCGCCTGACTCCC
GTGGACTGTGGTGGCAGCAGCAGTGGCAGCAGCAGTGGAGGAAGTGGGACATGGAGCCGC
GGTGGGCCCCCAAAGAAGGAAGAACTGGTCGGGGGCAAGAAGAAGGGACGAACGTGGGGG
CCCAGCTCCACCCTGCAGAAGGAGCGGGTGGGAGGAGAGGAGAGGCTGAAGGGGCTGGGG
GAAGGAAGCAAACAGTGGTCATCAAGTGCCCCCAACCTGGGCAAGTCCCCCAAACACACA
CCCATCGCCCCTGGCTTCGCCAGCCTCAATGAGATGGAGGAGTTCGCGGAGGCAGAGGAT
GGAGGCAGCAGCGTGCCCCCTTCCCCCTACTCGACCCCGTCCTACCTCTCAGTGCCACTG
CCTGCCGAGCCCTCCCCGGGGGCGCGGGCGCCGTGGGAGCCGACGCCGTCCGCGCCCCCC
GCTCGGTGGGGACACGGCGCCCGGCGGCGCTGCGACCTGGCGCTGCTAGGCTGCGCCACG
CTGCTGGGGGCTGTGGGCCTGGGCGCCGACGTGGCCGAGGCGCGCGCGGCCGACGGTGAG
GAGCAGCGGCGCTGGCTCGACGGCCTCTTCTTTCCCCGCGCCGGCCGCTTCCCGCGGGGC
CTCAGCCCACCCGCGCGTCCCCACGGCCGCCGCGAAGACGTGGGCCCCGGCCTGGGCCTG
GCGCCCTCGGCCACCCTCGTGTCGCTGTCGTCCGTGTCCGACTGCAACTCCACGCGTTCA
CTGCTGCGCTCTGACAGTGACGAGGCCGCACCGGCCGCGCCCTCCCCACCACCCTCCCCG
CCCGCGCCCACACCCACGCCCTCGCCCAGCACCAACCCCCTGGTGGACCTGGAGCTGGAG
AGCTTCAAGAAGGACCCCGGCCAGTCGCTCACGCCCACCCACGTCACGGCTGTATGCGCT
GTGAGCCGCGGGCACCGGCGGACGCCATCGGATGGGGCGCTGGGGCAGCGGGGGCCGCCC
GAGCCCGCGGGCCATGGCCCTGGCCCTCGTGACCTTCTGGACTTCCCCCGCCTGCCCGAC
CCCCAGGCTCTGTTCCCAGCCCGCCGCCGGCCCCCTGAGTTCCCAGGCCGCCCCACCACC
CTGACCTTTGCCCCGAGACCTCGGCCGGCTGCCAGTCGCCCCCGCTTGGACCCCTGGAAA
CTGGTCTCCTTCGGCCGGACACTCACCATCTCGCCTCCCAGCAGGCCAGACACTCCGGAG
AGCCCTGGGCCCCCCAGCGTGCAGCCCACACTGCTGGACATGGACATGGAGGGGCAGAAC
CAAGACAGCACAGTGCCCCTGTGCGGGGCCCACGGCTCCCACTAA

Protein Properties

Number of Residues

954

Molecular Weight

103693.4

Theoretical pI

7.0

Pfam Domain Function

Pkinase_Tyr (PF07714 )
SH3_2 (PF07653 )

Signals

None

Transmembrane Regions

None

Protein Sequence

>Mitogen-activated protein kinase kinase kinase 10
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWT
GQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGE
EVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG
ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLA
DTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGE
VPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI
EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLR
RREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGF
EHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSR
GGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHT
PIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPP
ARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRG
LSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSP
PAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPP
EPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWK
LVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH

External Links

GenBank ID Protein

971420

UniProtKB/Swiss-Prot ID

Q02779

UniProtKB/Swiss-Prot Entry Name

M3K10_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Keri G, Mann M, Daub H: Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics. 2009 Jul;8(7):1751-64. doi: 10.1074/mcp.M800588-MCP200. Epub 2009 Apr 15. [PubMed:19369195 ]
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
Dorow DS, Devereux L, Tu GF, Price G, Nicholl JK, Sutherland GR, Simpson RJ: Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2. Eur J Biochem. 1995 Dec 1;234(2):492-500. [PubMed:8536694 ]
Katoh M, Hirai M, Sugimura T, Terada M: Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain. Oncogene. 1995 Apr 6;10(7):1447-51. [PubMed:7731697 ]
Dorow DS, Devereux L, Dietzsch E, De Kretser T: Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains. Eur J Biochem. 1993 Apr 15;213(2):701-10. [PubMed:8477742 ]