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Identification
HMDB Protein ID HMDBP01404
Secondary Accession Numbers
  • 6700
Name Homeodomain-interacting protein kinase 1
Synonyms Not Available
Gene Name HIPK1
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. May be involved in malignant squamous cell tumor formation
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Nucleus
  2. Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 1p13.2
SNPs HIPK1
Gene Sequence
>3633 bp
ATGGCATCACAGCTGCAAGTGTTTTCGCCCCCATCAGTGTCGTCGAGTGCCTTCTGCAGT
GCGAAGAAACTGAAAATAGAGCCCTCTGGCTGGGATGTTTCAGGACAGAGTAGCAACGAC
AAATATTATACCCACAGCAAAACCCTCCCAGCCACACAAGGGCAAGCCAACTCCTCTCAC
CAGGTAGCAAATTTCAACATCCCTGCTTACGACCAGGGCCTCCTCCTCCCAGCTCCTGCA
GTGGAGCATATTGTTGTAACAGCCGCTGATAGCTCGGGCAGTGCTGCTACATCAACCTTC
CAAAGCAGCCAGACCCTGACTCACAGAAGCAACGTTTCTTTGCTTGAGCCATATCAAAAA
TGTGGATTGAAACGAAAAAGTGAGGAAGTTGACAGCAACGGTAGTGTGCAGATCATAGAA
GAACATCCCCCTCTCATGCTGCAAAACAGGACTGTGGTGGGTGCTGCTGCCACAACCACC
ACTGTGACCACAAAGAGTAGCAGTTCCAGCGGAGAAGGGGATTACCAGCTGGTCCAGCAT
GAGATCCTTTGCTCTATGACCAATAGCTATGAAGTCTTGGAGTTCCTAGGCCGGGGGACA
TTTGGACAGGTGGCTAAGTGCTGGAAGAGGAGCACCAAGGAAATTGTGGCTATTAAAATC
TTGAAGAACCACCCCTCCTATGCCAGACAAGGACAGATTGAAGTGAGCATCCTTTCCCGC
CTAAGCAGTGAAAATGCTGATGAGTATAATTTTGTCCGTTCATACGAGTGCTTTCAGCAT
AAGAATCACACCTGCCTTGTTTTTGAAATGTTGGAGCAGAACTTATATGATTTTCTAAAG
CAAAACAAATTTAGCCCACTGCCACTCAAGTACATCAGACCAATCTTGCAGCAGGTGGCC
ACAGCCTTGATGAAGCTCAAGAGTCTTGGTCTGATCCACGCTGACCTTAAGCCTGAAAAC
ATCATGCTGGTTGATCCAGTTCGCCAGCCCTACCGAGTGAAGGTCATTGACTTTGGTTCT
GCTAGTCACGTTTCCAAAGCTGTGTGCTCAACCTACTTACAGTCACGTTACTACAGAGCT
CCTGAAATTATTCTTGGGTTACCATTTTGTGAAGCTATTGATATGTGGTCACTGGGCTGT
GTGATAGCTGAGCTGTTCCTGGGATGGCCTCTTTATCCTGGTGCTTCAGAATATGATCAG
ATTCGTTATATTTCACAAACACAAGGCTTGCCAGCTGAATATCTTCTCAGTGCCGGAACA
AAAACAACCAGGTTTTTCAACAGAGATCCTAATTTGGGGTACCCACTGTGGAGGCTTAAG
ACACCTGAAGAACATGAACTGGAGACTGGAATAAAATCAAAAGAAGCTCGGAAGTACATT
TTTAATTGCTTAGATGACATGGCTCAGGTGAATATGTCTACAGACCTGGAGGGAACAGAC
ATGTTGGCAGAGAAGGCAGACCGAAGAGAATACATTGATCTGTTAAAGAAAATGCTCACA
ATTGATGCAGATAAGAGAATTACCCCTCTAAAAACTCTTAACCATCAGTTTGTGACAATG
ACTCACCTTTTGGATTTTCCACATAGCAATCATGTTAAGTCTTGTTTTCAGAACATGGAG
ATCTGCAAGCGGAGGGTTCACATGTATGATACAGTGAGTCAGATCAAGAGTCCCTTCACT
ACACATGTTGCCCCAAATACAAGCACAAATCTAACCATGAGCTTCAGCAATCAGCTCAAT
ACAGTGCACAATCAGGCCAGTGTTCTAGCTTCCAGTTCTACTGCAGCAGCTGCTACTCTT
TCTCTGGCTAATTCAGATGTCTCACTACTAAACTACCAGTCAGCTTTGTACCCATCATCT
GCTGCACCAGTTCCTGGAGTTGCCCAGCAGGGTGTTTCCTTGCAGCCTGGAACCACCCAG
ATTTGCACTCAGACAGATCCATTCCAACAGACATTTATAGTATGTCCACCTGCGTTTCAA
ACTGGACTACAAGCAACAACAAAGCATTCTGGATTCCCTGTGAGGATGGATAATGCTGTA
CCGATTGTACCCCAGGCACCAGCTGCTCAGCCACTACAGATTCAGTCAGGAGTTCTCACG
CAGGGAAGCTGTACACCACTAATGGTAGCAACTCTCCACCCTCAAGTAGCCACCATCACA
CCGCAGTATGCGGTGCCCTTTACTCTGAGCTGCGCAGCCGGCCGGCCGGCGCTGGTTGAA
CAGACTGCCGCTGTACTGCAGGCGTGGCCTGGAGGGACTCAGCAAATTCTCCTGCCTTCA
ACTTGGCAACAGTTGCCTGGGGTAGCTCTACACAACTCTGTCCAGCCCACAGCAATGATT
CCAGAGGCCATGGGGAGTGGACAGCAGCTAGCTGACTGGAGGAATGCCCACTCTCATGGC
AACCAGTACAGCACTATCATGCAGCAGCCATCCTTGCTGACTAACCATGTGACATTGGCC
ACTGCTCAGCCTCTGAATGTTGGTGTTGCCCATGTTGTCAGACAACAACAATCCAGTTCC
CTCCCTTCGAAGAAGAATAAGCAGTCAGCTCCAGTCTCTTCCAAGTCCTCTCTAGATGTT
CTGCCTTCCCAAGTCTATTCTCTGGTTGGGAGCAGTCCCCTCCGCACCACATCTTCTTAT
AATTCCTTGGTCCCTGTCCAAGATCAGCATCAGCCCATCATCATTCCAGATACTCCCAGC
CCTCCTGTGAGTGTCATCACTATCCGAAGTGACACTGATGAGGAAGAGGACAACAAATAC
AAGCCCAGTAGCTCTGGACTGAAGCCAAGGTCTAATGTCATCAGTTATGTCACTGTCAAT
GATTCTCCAGACTCTGACTCTTCTTTGAGCAGCCCTTATTCCACTGATACCCTGAGTGCT
CTCCGAGGCAATAGTGGATCCGTTTTGGAGGGGCCTGGCAGAGTTGTGGCAGATGGCACT
GGCACCCGCACTATCATTGTGCCTCCACTGAAAACTCAGCTTGGTGACTGCACTGTAGCA
ACCCAGGCCTCAGGTCTCCTGAGCAATAAGACTAAGCCAGTCGCTTCAGTGAGTGGGCAG
TCATCTGGATGCTGTATCACCCCCACAGGGTATCGAGCTCAACGCGGGGGGACCAGTGCA
GCACAACCACTCAATCTTAGCCAGAACCAGCAGTCATCGGCGGCTCCAACCTCACAGGAG
AGAAGCAGCAACCCAGCCCCCCGCAGGCAGCAGGCATTTGTGGCCCCTCTCTCCCAAGCC
CCCTACACCTTCCAGCATGGCAGCCCGCTACACTCGACAGGGCACCCACACCTTGCCCCG
GCCCCTGCTCACCTGCCAAGCCAGGCTCATCTGTATACGTATGCTGCCCCGACTTCTGCT
GCTGCACTGGGCTCAACCAGCTCCATTGCTCATCTTTTCTCCCCACAGGGTTCCTCAAGG
CATGCTGCAGCCTATACCACTCACCCTAGCACTTTGGTGCACCAGGTCCCTGTCAGTGTT
GGGCCCAGCCTCCTCACTTCTGCCAGCGTGGCCCCTGCTCAGTACCAACACCAGTTTGCC
ACCCAATCCTACATTGGGTCTTCCCGAGGCTCAACAATTTACACTGGATACCCGCTGAGT
CCTACCAAGATCAGCCAGTATTCCTACTTATAG
Protein Properties
Number of Residues 1210
Molecular Weight 130841.6
Theoretical pI 8.31
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Homeodomain-interacting protein kinase 1
MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSH
QVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQK
CGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQH
EILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSR
LSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVA
TALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRA
PEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGT
KTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTD
MLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNME
ICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATL
SLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQ
TGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATIT
PQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMI
PEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSS
LPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPS
PPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSA
LRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQ
SSGCCITPTGYRAQRGGTSAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAPLSQA
PYTFQHGSPLHSTGHPHLAPAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSR
HAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLS
PTKISQYSYL
GenBank ID Protein 28411264
UniProtKB/Swiss-Prot ID Q86Z02
UniProtKB/Swiss-Prot Entry Name HIPK1_HUMAN
PDB IDs Not Available
GenBank Gene ID AB089957
GeneCard ID HIPK1
GenAtlas ID HIPK1
HGNC ID HGNC:19006
References
General References
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  3. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  4. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
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  9. Song JJ, Lee YJ: Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization. J Biol Chem. 2003 Nov 21;278(47):47245-52. Epub 2003 Sep 10. [PubMed:12968034 ]
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