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Identification
HMDB Protein ID HMDBP01464
Secondary Accession Numbers
  • 6760
  • HMDBP02772
Name Ectonucleoside triphosphate diphosphohydrolase 2
Synonyms
  1. CD39 antigen-like 1
  2. Ecto-ATP diphosphohydrolase 2
  3. Ecto-ATPDase 2
  4. Ecto-ATPase 2
  5. NTPDase 2
Gene Name ENTPD2
Protein Type Unknown
Biological Properties
General Function Involved in ATP binding
Specific Function In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.
Pathways
  • Purine metabolism
Reactions
Adenosine triphosphate + Water → ADP + Phosphate details
GO Classification
Biological Process
platelet activation
G-protein coupled receptor signaling pathway
purine ribonucleoside diphosphate catabolic process
Cellular Component
basal lamina
integral to membrane
Function
catalytic activity
hydrolase activity
Molecular Function
nucleoside-diphosphatase activity
nucleoside-triphosphatase activity
ATP binding
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Potential)
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs ENTPD2
Gene Sequence
>1488 bp
ATGGCCGGGAAGGTGCGGTCACTGCTGCCGCCGCTGCTGCTGGCCGCCGCGGGCCTCGCC
GGCCTCCTACTGCTGTGCGTCCCCACCCGCGACGTCCGGGAGCCGCCCGCCCTCAAGTAT
GGCATCGTCCTGGACGCTGGTTCTTCACACACGTCCATGTTTATCTACAAGTGGCCGGCA
GACAAGGAGAACGACACAGGCATTGTGGGCCAGCACAGCTCCTGTGATGTTCCAGGTGGG
GGCATCTCCAGCTATGCAGACAACCCTTCTGGGGCCAGCCAGAGTCTTGTTGGATGCCTC
GAACAGGCGCTTCAGGATGTGCCCAAAGAGAGACACGCGGGCACACCCCTCTACCTGGGA
GCCACAGCGGGTATGCGCCTGCTCAACCTGACCAATCCAGAGGCCTCGACCAGTGTGCTC
ATGGCAGTGACTCACACACTGACCCAGTACCCCTTTGACTTCCGGGGTGCACGCATCCTC
TCGGGCCAGGAAGAGGGGGTGTTTGGCTGGGTGACTGCCAACTACCTGCTGGAGAACTTC
ATCAAGTACGGCTGGGTGGGCCGGTGGTTCCGGCCACGGAAGGGGACACTGGGGGCCATG
GACCTGGGGGGTGCCTCTACCCAGATCACTTTTGAGACAACCAGTCCAGCTGAGGACAGA
GCCAGCGAGGTCCAGCTGCATCTCTACGGCCAGCACTACCGAGTCTACACCCACAGCTTC
CTCTGCTATGGCCGTGACCAGGTCCTCCAGAGGCTGCTGGCCAGCGCCCTCCAGACCCAC
GGCTTCCACCCCTGCTGGCCGAGGGGCTTTTCCACCCAAGTGCTGCTCGGGGATGTGTAC
CAGTCACCATGCACCATGGCCCAGCGGCCCCAGAACTTCAACAGCAGTGCCAGGGTCAGC
CTGTCAGGGAGCAGTGACCCCCACCTCTGCCGAGATCTGGTTTCTGGGCTCTTCAGCTTC
TCCTCCTGCCCCTTCTCCCGATGCTCTTTCAATGGGGTCTTCCAGCCCCCAGTGGCTGGG
AACTTTGTGGCCTTCTCTGCCTTCTTCTACACTGTGGACTTTTTGCGGACTTCGATGGGG
CTGCCCGTGGCCACCCTGCAGCAGCTGGAGGCAGCCGCAGTGAATGTCTGCAACCAGACC
TGGGCTCAGCTGCAAGCTCGGGTGCCAGGGCAACGGGCCCGCCTGGCCGACTACTGCGCC
GGGGCCATGTTCGTGCAGCAGCTGCTGAGTCGCGGCTACGGCTTCGACGAGCGCGCCTTC
GGCGGCGTGATCTTCCAGAAGAAGGCCGCGGACACTGCAGTGGGCTGGGCGCTCGGCTAC
ATGCTGAACCTGACCAACCTGATCCCCGCCGACCCGCCGGGGCTGCGCAAGGGCACAGAC
TTCAGCTCCTGGGTCGTCCTCCTGCTGCTCTTCGCCTCCGCGCTCCTGGCTGCGCTTGTC
CTGCTGCTGCGTCAGGTGCACTCCGCCAAGCTGCCAAGCACCATTTAG
Protein Properties
Number of Residues 495
Molecular Weight Not Available
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Ectonucleoside triphosphate diphosphohydrolase 2
MAGKVRSLLPPLLLAAAGLAGLLLLCVPTRDVREPPALKYGIVLDAGSSHTSMFIYKWPA
DKENDTGIVGQHSSCDVPGGGISSYADNPSGASQSLVGCLEQALQDVPKERHAGTPLYLG
ATAGMRLLNLTNPEASTSVLMAVTHTLTQYPFDFRGARILSGQEEGVFGWVTANYLLENF
IKYGWVGRWFRPRKGTLGAMDLGGASTQITFETTSPAEDRASEVQLHLYGQHYRVYTHSF
LCYGRDQVLQRLLASALQTHGFHPCWPRGFSTQVLLGDVYQSPCTMAQRPQNFNSSARVS
LSGSSDPHLCRDLVSGLFSFSSCPFSRCSFNGVFQPPVAGNFVAFSAFFYTVDFLRTSMG
LPVATLQQLEAAAVNVCNQTWAQLQARVPGQRARLADYCAGAMFVQQLLSRGYGFDERAF
GGVIFQKKAADTAVGWALGYMLNLTNLIPADPPGLRKGTDFSSWVVLLLLFASALLAALV
LLLRQVHSAKLPSTI
GenBank ID Protein 5114239
UniProtKB/Swiss-Prot ID Q9Y5L3
UniProtKB/Swiss-Prot Entry Name ENTP2_HUMAN
PDB IDs Not Available
GenBank Gene ID AF144748
GeneCard ID ENTPD2
GenAtlas ID ENTPD2
HGNC ID HGNC:3364
References
General References
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  2. Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blocker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I: DNA sequence and analysis of human chromosome 9. Nature. 2004 May 27;429(6990):369-74. [PubMed:15164053 ]
  3. Chadwick BP, Frischauf AM: Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes. Mamm Genome. 1997 Sep;8(9):668-72. [PubMed:9271669 ]
  4. Mateo J, Harden TK, Boyer JL: Functional expression of a cDNA encoding a human ecto-ATPase. Br J Pharmacol. 1999 Sep;128(2):396-402. [PubMed:10510450 ]