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Identification
HMDB Protein ID HMDBP01497
Secondary Accession Numbers
  • 6793
Name Tyrosine-protein kinase STYK1
Synonyms
  1. Novel oncogene with kinase domain
  2. Protein PK-unique
  3. Serine/threonine/tyrosine kinase 1
Gene Name STYK1
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
protein tyrosine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein binding
protein kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Membrane
  2. Single-pass membrane protein (Potential)
Gene Properties
Chromosome Location Chromosome:1
Locus 12p13.2
SNPs STYK1
Gene Sequence
>1269 bp
ATGGGCATGACACGGATGCTCCTGGAATGCAGTCTCAGTGACAAGTTGTGTGTCATCCAG
GAGAAGCAGTATGAAGTGATTATCGTCCCAACTTTGTTGGTTACTATCTTCCTCATCCTT
CTTGGGGTCATCCTGTGGCTTTTTATCAGAGAACAAAGAACTCAACAGCAGCGTTCTGGA
CCTCAAGGCATTGCCCCTGTTCCTCCACCTAGGGACCTAAGCTGGGAAGCAGGACATGGA
GGAAATGTGGCTTTGCCACTTAAGGAGACATCCGTGGAAAACTTTCTGGGAGCTACCACA
CCTGCCCTGGCTAAGCTGCAGGTGCCGCGGGAGCAACTCTCTGAAGTTCTGGAGCAGATT
TGCAGTGGTAGCTGTGGGCCCATCTTTCGAGCCAATATGAACACTGGGGACCCTTCTAAG
CCCAAGAGTGTTATTCTCAAGGCTTTAAAAGAACCAGCTGGGCTCCATGAGGTACAAGAT
TTCTTAGGGCGAATCCAATTCCATCAATACCTGGGGAAACACAAAAACCTGGTGCAGCTG
GAAGGCTGCTGCACTGAAAAGCTGCCACTCTATGTGGTGTTGGAGGATGTGGCCCAGGGG
GACCTGCTCGGCTTTCTCTGGACCTGTCGGCGGGATGTGATGACTATGGATGGTCTTCTC
TATGATCTCACAGAAAAACAAGTATATCACATCGGAAAGCAGGTCCTTTTGGCGCTGGAA
TTCCTGCAGGAGAAGCATTTGTTCCATGGGGATGTGGCAGCCAGGAATATTCTGATGCAA
AGTGATCTCACTGCTAAGCTCTGTGGATTAGGCCTGGCTTATGAAGTTTACACCCGAGGG
GCCATCTCCTCTACTCAAACCATACCTCTCAAGTGGCTTGCCCCAGAACGGCTTCTCCTG
AGACCTGCTCGCATCAGAGCAGATGTCTGGTCTTTTGGGATCCTGCTCTATGAGATGGTG
ACTCTAGGAGCACCACCGTATCCTGAAGTCCCTCCTACCAGCATCCTAGAGCATCTCCAA
AGAAGGAAAATCATGAAGAGACCCAGTAGCTGCACACATACCATGTACAGTATCATGAAG
TCCTGCTGGCGCTGGCGTGAGGCTGACCGCCCCTCACCTAGAGAGCTGCGCTTGCGCCTA
GAAGCTGCCATTAAAACTGCAGATGACGAGGCTGTGTTACAAGTACCAGAGTTGGTGGTA
CCTGAACTGTATGCAGCTGTGGCCGGCATCAGAGTGGAGAGCCTCTTCTACAACTATAGC
ATGCTTTGA
Protein Properties
Number of Residues 422
Molecular Weight 47546.3
Theoretical pI 7.45
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 26-46
Protein Sequence
>Tyrosine-protein kinase STYK1
MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG
PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI
CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL
EGCCTEKLPLYMVLEDVAQGDLLGFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE
FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL
RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK
SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS
ML
GenBank ID Protein 13625180
UniProtKB/Swiss-Prot ID Q6J9G0
UniProtKB/Swiss-Prot Entry Name STYK1_HUMAN
PDB IDs Not Available
GenBank Gene ID AF251059
GeneCard ID STYK1
GenAtlas ID STYK1
HGNC ID HGNC:18889
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  4. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
  5. Ye X, Ji C, Huang Q, Cheng C, Tang R, Xu J, Zeng L, Dai J, Wu Q, Gu S, Xie Y, Mao Y: Isolation and characterization of a human putative receptor protein kinase cDNA STYK1. Mol Biol Rep. 2003 Jun;30(2):91-6. [PubMed:12841579 ]
  6. Liu L, Yu XZ, Li TS, Song LX, Chen PL, Suo TL, Li YH, Wang SD, Chen Y, Ren YM, Zhang SP, Chang ZJ, Fu XY: A novel protein tyrosine kinase NOK that shares homology with platelet- derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice. Cancer Res. 2004 May 15;64(10):3491-9. [PubMed:15150103 ]
  7. Amachika T, Kobayashi D, Moriai R, Tsuji N, Watanabe N: Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers. Lung Cancer. 2007 Jun;56(3):337-40. Epub 2007 Feb 12. [PubMed:17298854 ]