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Identification
HMDB Protein ID HMDBP01825
Secondary Accession Numbers
  • 7186
Name Dehydrogenase/reductase SDR family member 2
Synonyms
  1. Dicarbonyl reductase HEP27
  2. Protein D
Gene Name DHRS2
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. May inhibit cell replication
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
oxidoreductase activity
Process
metabolic process
oxidation reduction
Cellular Location
  1. Nucleus
Gene Properties
Chromosome Location Chromosome:1
Locus 14q11.2
SNPs DHRS2
Gene Sequence
>843 bp
ATGCTGTCAGCAGTTGCCCGGGGCTACCAGGGCTGGTTTCATCCCTGTGCTAGGCTTTCT
GTGAGGATGAGCAGCACCGGGATAGACAGGAAGGGCGTCCTGGCTAACCGGGTAGCCGTG
GTCACGGGGTCCACCAGTGGGATCGGCTTTGCCATCGCCCGACGTCTGGCCCGGGACGGG
GCCCACGTGGTCATCAGCAGCCGGAAGCAGCAGAACGTGGACCGGGCCATGGCCAAGCTG
CAGGGGGAGGGGCTGAGTGTGGCGGGCATTGTGTGCCACGTGGGGAAGGCTGAGGACCGG
GAGCAGCTGGTGGCCAAGGCCCTGGAGCACTGTGGGGGCGTCGACTTCCTGGTGTGCAGC
GCAGGGGTCAACCCTCTGGTAGGGAGCACTCTGGGGACCAGTGAGCAGATCTGGGACAAG
ATCCTAAGTGTGAACGTGAAGTCCCCAGCCCTGCTGCTGAGCCAGTTGCTGCCCTACATG
GAGAACAGGAGGGGTGCTGTCATCCTGGTCTCTTCCATTGCAGCTTATAATCCAGTAGTG
GCGCTGGGTGTCTACAATGTCAGCAAGACAGCGCTGCTGGGTCTCACTAGAACACTGGCA
TTGGAGCTGGCCCCCAAGGACATCCGGGTAAACTGCGTGGTTCCAGGAATTATCAAAACT
GACTTCAGCAAAGTGTTTCATGGGAATGAGTCTCTCTGGAAGAACTTCAAGGAACATCAT
CAGCTGCAGAGGATTGGGGAGTCAGAGGACTGTGCAGGAATCGTGTCCTTCCTGTGCTCT
CCAGATGCCAGCTACGTCAACGGGGAGAACATTGCGGTGGCAGGCTACTCCACTCGGCTC
TGA
Protein Properties
Number of Residues 258
Molecular Weight 27438.4
Theoretical pI 8.81
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Dehydrogenase/reductase SDR family member 2
MSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQG
EGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKIL
SVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALE
LAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPD
ASYVNGENIAVAGYSTRL
GenBank ID Protein 5031737
UniProtKB/Swiss-Prot ID Q13268
UniProtKB/Swiss-Prot Entry Name DHRS2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_005794
GeneCard ID DHRS2
GenAtlas ID DHRS2
HGNC ID HGNC:18349
References
General References
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  2. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
  3. Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Bruls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Segurens B, Aniere F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Menard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufosse-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guerin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quetier F, Waterston R, Hood L, Weissenbach J: The DNA sequence and analysis of human chromosome 14. Nature. 2003 Feb 6;421(6923):601-7. Epub 2003 Jan 1. [PubMed:12508121 ]
  4. Gabrielli F, Donadel G, Bensi G, Heguy A, Melli M: A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family. Eur J Biochem. 1995 Sep 1;232(2):473-7. [PubMed:7556196 ]
  5. Pellegrini S, Censini S, Guidotti S, Iacopetti P, Rocchi M, Bianchi M, Covacci A, Gabrielli F: A human short-chain dehydrogenase/reductase gene: structure, chromosomal localization, tissue expression and subcellular localization of its product. Biochim Biophys Acta. 2002 Apr 12;1574(3):215-22. [PubMed:11997086 ]
  6. Donadel G, Garzelli C, Frank R, Gabrielli F: Identification of a novel nuclear protein synthesized in growth-arrested human hepatoblastoma HepG2 cells. Eur J Biochem. 1991 Feb 14;195(3):723-9. [PubMed:1847869 ]
  7. Shafqat N, Shafqat J, Eissner G, Marschall HU, Tryggvason K, Eriksson U, Gabrielli F, Lardy H, Jornvall H, Oppermann U: Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue. Cell Mol Life Sci. 2006 May;63(10):1205-13. [PubMed:16685466 ]