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Identification
HMDB Protein ID HMDBP02857
Secondary Accession Numbers
  • 8364
Name Rho-related GTP-binding protein Rho6
Synonyms
  1. Rho family GTPase 1
  2. Rnd1
Gene Name RND1
Protein Type Unknown
Biological Properties
General Function Involved in GTP binding
Specific Function Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
purine nucleotide binding
binding
nucleotide binding
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
Process
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
intracellular signal transduction
small gtpase mediated signal transduction
Cellular Location
  1. Cell membrane
  2. Lipid-anchor
  3. Cytoplasm
  4. Cytoplasmic side
  5. cytoskeleton
Gene Properties
Chromosome Location Chromosome:1
Locus 12q12
SNPs RND1
Gene Sequence
>699 bp
ATGAAGGAGAGACGGGCCCCCCAGCCAGTCGTGGCCAGATGTAAGCTCGTTCTGGTCGGG
GACGTGCAGTGTGGGAAGACCGCGATGTTGCAAGTGTTAGCGAAGGATTGCTATCCAGAG
ACCTATGTGCCCACCGTGTTCGAAAATTACACAGCCTGTTTGGAGACAGAGGAACAGAGG
GTGGAGCTTAGTCTCTGGGATACCTCAGGATCTCCCTACTACGATAATGTCCGTCCACTC
TGCTACAGCGACTCGGATGCAGTATTACTATGTTTTGACATCAGCCGTCCAGAGACAGTG
GACAGCGCACTGAAGAAGTGGAGGACAGAAATCCTAGATTATTGTCCCAGCACCCGCGTT
TTGCTCATTGGCTGCAAGACAGACCTGCGAACAGACCTGAGTACTCTGATGGAGCTGTCC
CACCAGAAGCAGGCGCCCATCTCCTATGAGCAGGGTTGTGCAATAGCAAAGCAGCTGGGT
GCAGAAATCTACCTGGAAGGCTCAGCTTTCACCTCAGAAAAGAGCATCCACAGCATCTTT
CGGACGGCATCCATGCTGTGTCTGAACAAGCCTAGCCCACTGCCCCAGAAGAGCCCTGTC
CGAAGCCTCTCCAAACGACTGCTCCACCTCCCCAGTCGCTCTGAACTCATCTCTTCTACC
TTCAAGAAGGAAAAGGCCAAAAGCTGTTCCATTATGTGA
Protein Properties
Number of Residues 232
Molecular Weight 26055.8
Theoretical pI 8.03
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Rho-related GTP-binding protein Rho6
MKERRAPQPVVARCKLVLVGDVQCGKTAMLQVLAKDCYPETYVPTVFENYTACLETEEQR
VELSLWDTSGSPYYDNVRPLCYSDSDAVLLCFDISRPETVDSALKKWRTEILDYCPSTRV
LLIGCKTDLRTDLSTLMELSHQKQAPISYEQGCAIAKQLGAEIYLEGSAFTSEKSIHSIF
RTASMLCLNKPSPLPQKSPVRSLSKRLLHLPSRSELISSTFKKEKAKSCSIM
GenBank ID Protein 1546902
UniProtKB/Swiss-Prot ID Q92730
UniProtKB/Swiss-Prot Entry Name RND1_HUMAN
PDB IDs Not Available
GenBank Gene ID Y07923
GeneCard ID RND1
GenAtlas ID RND1
HGNC ID HGNC:18314
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P: A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. J Cell Biol. 1998 Apr 6;141(1):187-97. [PubMed:9531558 ]
  4. Aoki J, Katoh H, Mori K, Negishi M: Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells. Biochem Biophys Res Commun. 2000 Nov 30;278(3):604-8. [PubMed:11095956 ]
  5. Vayssiere B, Zalcman G, Mahe Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J: Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family. FEBS Lett. 2000 Feb 4;467(1):91-6. [PubMed:10664463 ]
  6. Katoh H, Harada A, Mori K, Negishi M: Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. Mol Cell Biol. 2002 May;22(9):2952-64. [PubMed:11940653 ]
  7. Oinuma I, Katoh H, Harada A, Negishi M: Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. J Biol Chem. 2003 Jul 11;278(28):25671-7. Epub 2003 May 1. [PubMed:12730235 ]