Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP03073
Secondary Accession Numbers
  • 8609
Name Heparan-sulfate 6-O-sulfotransferase 2
Synonyms
  1. HS6ST-2
Gene Name HS6ST2
Protein Type Enzyme
Biological Properties
General Function Involved in sulfotransferase activity
Specific Function 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
Pathways
  • Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Reactions
Phosphoadenosine phosphosulfate + [heparan sulfate]-glucosamine → Adenosine 3',5'-diphosphate + [heparan sulfate]-glucosamine 6-sulfate details
GO Classification
Biological Process
small molecule metabolic process
glycosaminoglycan biosynthetic process
carbohydrate metabolic process
Cellular Component
integral to membrane
Golgi membrane
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
catalytic activity
transferase activity
transferase activity, transferring sulfur-containing groups
sulfotransferase activity
Molecular Function
sulfotransferase activity
Process
metabolic process
primary metabolic process
carbohydrate metabolic process
carbohydrate biosynthetic process
Cellular Location
  1. Membrane
  2. Single-pass type II membrane protein (Potential)
Gene Properties
Chromosome Location X
Locus Xq26.2
SNPs HS6ST2
Gene Sequence
>1818 bp
ATGGCACTGCCTGCGTGTGCAGTCCGGGAGTTCGAGCCGCCGCGGCAACCGGAGCGAGGA
GCGCCCGTCCGCACCACCTGTCCCCGCCGGCATTCCAGAGTAGAGGCCGAATTGGCAGCG
AGCCGGCCCGGGTCGGTCGCCGCCTCAGTTCGCGCGGGCCCTCCTAGGGGTGTGTCTCAC
GGATTCCACACCCGGCCGCTCCTGGACAAGCCCCGAAAGGCGTCTTCTTCCCTGGCGGGA
GCCGCGTGCGCCCCGCTTTTCGCGCTGCTGTCCCGGGGCCGCCGCAGGCGGATGCACGTC
CTCAGGCGACGCTGGGACCTGGGCTCCCTCTGCCGGGCCCTGCTCACTCGGGGCCTGGCC
GCCCTGGGCCACTCGCTGAAGCACGTGCTCGGTGCGATCTTCTCCAAGATTTTCGGCCCC
ATGGCCAGCGTCGGGAACATGGATGAGAAATCCAACAAGCTGCTGCTAGCTTTGGTGATG
CTCTTCCTATTTGCCGTGATCGTCCTCCAATACGTGTGCCCCGGCACAGAATGCCAGCTC
CTCCGCCTGCAGGCGTTCAGCTCCCCGGTGCCGGACCCGTACCGCTCGGAGGATGAGAGC
TCCGCCAGGTTCGTGCCCCGCTACAATTTCACCCGCGGCGACCTCCTGCGCAAGGTAGAC
TTCGACATCAAGGGCGATGACCTGATCGTGTTCCTGCACATCCAGAAGACCGGGGGCACC
ACTTTCGGCCGCCACTTGGTGCGTAACATCCAGCTGGAGCAGCCGTGCGAGTGCCGCGTG
GGTCAGAAGAAATGCACTTGCCACCGGCCGGGTAAGCGGGAAACCTGGCTCTTCTCCAGG
TTCTCCACGGGCTGGAGCTGCGGGTTGCACGCCGACTGGACCGAGCTCACCAGCTGTGTG
CCCTCCGTGGTGGACGGCAAGCGCGACGCCAGGCTGAGACCGTCCAGGAACTTCCACTAC
ATCACCATCCTCCGAGACCCAGTGTCCCGGTACTTGAGTGAGTGGAGGCATGTCCAGAGA
GGGGCAACATGGAAAGCATCCCTGCATGTCTGCGATGGAAGGCCTCCAACCTCCGAAGAG
CTGCCCAGCTGCTACACTGGCGATGACTGGTCTGGCTGCCCCCTCAAAGAGTTTATGGAC
TGTCCCTACAATCTAGCCAACAACCGCCAGGTGCGCATGCTCTCCGACCTGACCCTGGTA
GGCTGCTACAACCTCTCTGTCATGCCTGAAAAGCAAAGAAACAAGGTCCTTCTGGAAAGT
GCCAAGTCAAATCTGAAGCACATGGCGTTCTTCGGCCTCACTGAGTTTCAGCGGAAGACC
CAATATCTGTTTGAGAAAACCTTCAACATGAACTTTATTTCGCCATTTACCCAGTATAAT
ACCACTAGGGCCTCTAGTGTAGAGATCAATGAGGAAATTCAAAAGCGTATTGAGGGACTG
AATTTTCTGGATATGGAGTTGTACAGCTATGCCAAAGACCTTTTTTTGCAGAGGTATCAG
TTTATGAGGCAGAAAGAGCATCAGGAGGCCAGGCGAAAGCGTCAGGAACAACGCAAATTT
CTGAAGGGAAGGCTCCTTCAGACCCATTTCCAGAGCCAGGGTCAGGGCCAGAGCCAGAAT
CCGAATCAGAATCAGAGTCAGAACCCAAATCCGAATGCCAATCAGAACCTGACTCAGAAT
CTGATGCAGAATCTGACTCAGAGTTTGAGCCAGAAGGAGAACCGGGAAAGCCCGAAGCAG
AACTCAGGCAAGGAGCAGAATGATAACACCAGCAATGGCACCAACGACTACATAGGCAGT
GTAGAGAAATGGCGTTAA
Protein Properties
Number of Residues 605
Molecular Weight 73389.99
Theoretical pI 9.869
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Heparan-sulfate 6-O-sulfotransferase 2
MALPACAVREFEPPRQPERGAPVRTTCPRRHSRVEAELAASRPGSVAASVRAGPPRGVSH
GFHTRPLLDKPRKASSSLAGAACAPLFALLSRGRRRRMHVLRRRWDLGSLCRALLTRGLA
ALGHSLKHVLGAIFSKIFGPMASVGNMDEKSNKLLLALVMLFLFAVIVLQYVCPGTECQL
LRLQAFSSPVPDPYRSEDESSARFVPRYNFTRGDLLRKVDFDIKGDDLIVFLHIQKTGGT
TFGRHLVRNIQLEQPCECRVGQKKCTCHRPGKRETWLFSRFSTGWSCGLHADWTELTSCV
PSVVDGKRDARLRPSRNFHYITILRDPVSRYLSEWRHVQRGATWKASLHVCDGRPPTSEE
LPSCYTGDDWSGCPLKEFMDCPYNLANNRQVRMLSDLTLVGCYNLSVMPEKQRNKVLLES
AKSNLKHMAFFGLTEFQRKTQYLFEKTFNMNFISPFTQYNTTRASSVEINEEIQKRIEGL
NFLDMELYSYAKDLFLQRYQFMRQKEHQEARRKRQEQRKFLKGRLLQTHFQSQGQGQSQN
PNQNQSQNPNPNANQNLTQNLMQNLTQSLSQKENRESPKQNSGKEQNDNTSNGTNDYIGS
VEKWR
GenBank ID Protein 116295254
UniProtKB/Swiss-Prot ID Q96MM7
UniProtKB/Swiss-Prot Entry Name H6ST2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_147175.3
GeneCard ID HS6ST2
GenAtlas ID HS6ST2
HGNC ID HGNC:19133
References
General References
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